The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of pima indians
Open accessAbstract
BACKGROUND: The relative roles of obesity, insulin resistance, insulin secretory dysfunction, and excess hepatic glucose production in the development of non-insulin-dependent diabetes mellitus (NIDDM) are controversial. We conducted a prospective study to determine which of these factors predicted the development of the disease in a group of Pima Indians. METHODS: A body-composition assessment, oral and intravenous glucose-tolerance tests, and a hyperinsulinemic--euglycemic clamp study were performed in 200 non-diabetic Pima Indians (87 women and 113 men; mean [+/- SD] age, 26 +/- 6 years). The subjects were followed yearly thereafter for an average of 5.3 years. RESULTS: Diabetes developed in 38 subjects during follow-up. Obesity, insulin resistance (independent of obesity), and low acute plasma insulin response to intravenous glucose (with the degree of obesity and insulin resistance taken into account) were predictors of NIDDM: The six-year cumulative incidence of NIDDM was 39 percent in persons with values below the median for both insulin action and acute insulin response, 27 percent in those with values below the median for insulin action but above that for acute insulin response, 13 percent in those with values above the median for insulin action and below that for acute insulin response, and 0 in those with values originally above the median for both characteristics. CONCLUSIONS: Insulin resistance is a major risk factor for the development of NIDDM: A low acute insulin response to glucose is an additional but weaker risk factor.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Insulin resistance and concurrent relative insulin deficiency and glucagon dysregulation underlie T2D pathophysiology.33–35”
From American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update. (2022) · cites this paper as [35]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“However, progressive β-cell failure is required and ultimately responsible for type 2 diabetes to become fully manifest ( 1 , 34 , 35 , 37 , 38 ).”
From Skeletal Muscle Insulin Resistance Is the Primary Defect in Type 2 Diabetes (2009) · cites this paper as [35]
Experimental — accuracy not yet measuredIn the citing paper
“Thus, re-examination of data from some other studies of high risk subjects with NGT would suggest that the conclusions in those papers disputing the presence of beta-cell dysfunction are erroneous because no difference in the insulin responses existed between groups despite the presence of insulin resistance, indicating impaired beta-cell adaptation [108, 109, 110, 111, 112, 113, 114].”
From The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes (2003) · cites this paper as [113]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Triumvirate: β-Cell, Muscle, Liver: A Collusion Responsible for NIDDM
DeFronzo, R. A. (1988) · Diabetes · doi:10.2337/diab.37.6.667 · Cited by 2,456
INFLUENCES OF GLUCOSE LOADING AND OF INJECTED INSULIN ON HEPATIC GLUCOSE OUTPUT*
Steele, R. D. (1959) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1959.tb44923.x · Cited by 1,680
Shulman, G. I., Rothman, D. L., Jue, T., Stein, P., DeFronzo, R. A., & Shulman, R. G. (1990) · New England Journal of Medicine · doi:10.1056/nejm199001253220403 · Cited by 1,248
Martin, B. C., Warram, J. H., Krolewski, A. S., Soeldner, J. S., Kahn, C. R., Martin, B. C., & Bergman, R. N. (1992) · The Lancet · doi:10.1016/0140-6736(92)92814-v · Cited by 1,158
Ohlson, L., Larsson, B., Svärdsudd, K., Welin, L., Eriksson, H., Wilhelmsen, L., Björntorp, P., & Tibblin, G. (1985) · Diabetes · doi:10.2337/diab.34.10.1055 · Cited by 1,143
Warram, J. H., Martin, B. C., Krolewski, A. S., Soeldner, J. S., & Kahn, C. R. (1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-113-12-909 · Cited by 1,038
Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus
Vionnet, N., Stoffel, M., Takeda, J., Yasuda, K., Bell, G. I., Zouali, H., Lesage, S., Velho, G., Iris, F., Passa, P., et al. (1992) · Nature · doi:10.1038/356721a0 · Cited by 604
Diabetes mellitus in the Pima Indians: Incidence, risk factors and pathogenesis
Knowler, W. C., Pettitt, D. J., Saad, M. F., & Bennett, P. H. (1990) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610060101 · Cited by 578
Self-citationImpaired Glucose Tolerance as a Disorder of Insulin Action
Lillioja, S., Mott, D. M., Howard, B. V., Bennett, P. H., Yki-Järvinen, H., Freymond, D., Nyomba, B. L., Zurlo, F., Swinburn, B., & Bogardus, C. (1988) · New England Journal of Medicine · doi:10.1056/nejm198805123181901 · Cited by 578
Self-citationBogardus, C., Lillioja, S., Howard, B. V., Reaven, G. M., & Mott, D. M. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111533 · Cited by 397
Self-citation
Research works printed but not linked: 2
- 1985, World Health Organ Tech Rep Ser, 727, 9
- Gottesman I, 1983, Am J Physiol, 244, E632
Cited by
Sorted by citations
Items 901–1,000 of 1,003
Chang, D. C., Basolo, A., Piaggi, P., Votruba, S. B., & Krakoff, J. A. (2019) · European Journal of Clinical Nutrition · doi:10.1038/s41430-019-0445-6 · Cited by 17
Lipid levels in obese and nonobese subjects as predictors of fasting and postload glucose metabolism
Giannini, S., Bardini, G., Dicembrini, I., Monami, M., Rotella, C. M., & Mannucci, E. (2011) · Journal of clinical lipidology · doi:10.1016/j.jacl.2011.09.005 · Cited by 17
II Consenso de la Sociedad Chilena de Endocrinología y Diabetes sobre resistencia a la insulina
Felipe Pollak, C., Araya, V., Lanas, A., SAPUNAR, J., Arrese, M. A., Aylwin, C. G., Bezanilla, C. G., Carrasco, E., Fernando Carrasco, N., Ethel Codner, D., et al. (2015) · Revista médica de Chile · doi:10.4067/s0034-98872015000500012 · Cited by 17
Kim, J., Lee, D.-Y., Park, S. E., Park, C., Lee, W., Oh, K.-W., Park, S., & Rhee, E. (2017) · Precision and Future Medicine · doi:10.23838/pfm.2017.00059 · Cited by 17
Effects of dietary fat on insulin secretion in subjects with the metabolic syndrome
Gulseth, H. L., Gjelstad, I. M. F., Tierney, A. C., McCarthy, D., Lovegrove, J. A., Defoort, C., Blaak, E. E., López‐Miranda, J., Dembinska-Kiec, A., Risérus, U., et al. (2019) · European Journal of Endocrinology · doi:10.1530/eje-19-0022 · Cited by 17
Nonglycemic effects of insulin
Yki‐Järvinen, H. (2003) · Clinical cornerstone · doi:10.1016/s1098-3597(03)90061-5 · Cited by 17
Pioglitazone has anti-inflammatory effects in patients with Type 2 diabetes
Heliövaara, M. K., Herz, M., Teppo, A.-M., Leinonen, E. S., & Ebeling, P. R. (2007) · Journal of Endocrinological Investigation · doi:10.1007/bf03346296 · Cited by 17
Impact of Acute Biochemical Castration on Insulin Sensitivity in Healthy Adult Men
Rabiee, A., Dwyer, A. A., Caronia, L. M., Hayes, F. J., Yialamas, M. A., Andersen, D. K., Thomas, B. J., Torriani, M., & Elahi, D. (2010) · Endocrine Research · doi:10.3109/07435801003705601 · Cited by 17
β-Cell stimulus–secretion coupling defects in rodent models of obesity
Chan, C. B. (1995) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y95-197 · Cited by 17
Progress in Population Analyses of the Insulin Resistance Syndrome
Haffner, S. M. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb51818.x · Cited by 17
Effects of metformin in obese patients with impaired glucose tolerance
Scheen, A. J., Letiexhe, M. R., & Lefèbvre, P. J. (1995) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610110511 · Cited by 17
Perry, I. J., Wannamethee, S. G., Shaper, A. G., & Alberti, K. G. M. M. (1999) · International Journal of Epidemiology · doi:10.1093/ije/28.4.735 · Cited by 17
The newly developed sulfonylurea glimepiride: a new ingredient, an old recipe
Veneman, T. F. (1998) · The Netherlands Journal of Medicine · doi:10.1016/s0300-2977(98)00048-5 · Cited by 17
Yang, X., Pratley, R. E., Tokraks, S., Tataranni, P. A., & Permana, P. A. (2002) · Molecular Genetics and Metabolism · doi:10.1016/s1096-7192(02)00008-2 · Cited by 17
Validation of a simple index (SIisOGTT) of insulin sensitivity in a population of sedentary men
Pigeon, E., Riou, M. E., St-Onge, J., Couillard, E., Tremblay, A., Marette, A., Weisnagel, S. J., & Joanisse, D. R. (2009) · Diabetes & Metabolism · doi:10.1016/j.diabet.2009.04.007 · Cited by 16
Lee, H.-O., Yim, J., Kim, Y.-S., & Choue, R. (2014) · Nutrition Research and Practice · doi:10.4162/nrp.2014.8.4.469 · Cited by 16
Insulin resistance at the crossroads of metabolic syndrome: Systemic analysis using microarrays
Kim, E.-J. (2010) · Biotechnology Journal · doi:10.1002/biot.201000048 · Cited by 16
Vieira‐Lara, M. A., & Bakker, B. M. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2024.167172 · Cited by 16
Mirmiran, P., Davari, M., Hashemi, R., Hedayati, M., Sahranavard, S., Bahreini, S., Tavakoly, R., & Talaei, B. (2019) · European Journal of Clinical Nutrition · doi:10.1038/s41430-019-0523-9 · Cited by 16
Mthembu, S. X. H., Dludla, P. V., Nyambuya, T. M., Kappo, A. P., Madoroba, E., Ziqubu, K., Nyawo, T. A., Nkambule, B. B., Silvestri, S., Muller, C. J. F., et al. (2021) · Biochimie · doi:10.1016/j.biochi.2021.09.010 · Cited by 16
Insulin secretion and action in different stages of glucose tolerance in Asian Indians
Snehalatha, C., Satyavani, K., Sivasankari, S., Viswanathan, V., & Ramachandran, A. (1999) · Diabetic Medicine · doi:10.1046/j.1464-5491.1999.00084.x · Cited by 16
Metabolomic Signature of Coronary Artery Disease in Type 2 Diabetes Mellitus
Stratmann, B., Richter, K., Wang, R., Yu, Z., Xu, T., Prehn, C. P., Adamski, J., Illig, T., Tschoepe, D., & Wang‐Sattler, R. (2017) · International Journal of Endocrinology · doi:10.1155/2017/7938216 · Cited by 16
Role of the Adipocyte in Metabolism and Endocrine Function
Ravussin, É., & Smith, S. R. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-18907-1.00036-6 · Cited by 16
Nijpels, G., Boorsma, W., Dekker, J. M., Hoeksema, F., Kostense, P. J., Bouter, L. M., & Heine, R. J. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2837 · Cited by 16
de Souza, C. J., Gagen, K., Chen, W., & Dragonas, N. (2001) · Diabetes Obesity and Metabolism · doi:10.1046/j.1463-1326.2001.00115.x · Cited by 16
Jeppesen, J. (2003) · Metabolic Syndrome and Related Disorders · doi:10.1089/154041903321648243 · Cited by 16
Genetic epidemiology of non‐insulin‐dependent diabetes
Valsania, P., & Micossi, P. (1994) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610100404 · Cited by 16
de Souza, C. J., Russo, P. A., Lozito, R. J., & Dunning, B. E. (2001) · Diabetes Obesity and Metabolism · doi:10.1046/j.1463-1326.2001.00114.x · Cited by 16
Takemura, Y. C., Kikuchi, S., Inaba, Y., Yasuda, H., & Nakagawa, K. (1999) · Preventive Medicine · doi:10.1006/pmed.1998.0389 · Cited by 16
Insights into Molecular Pathogenesis of Type 2 Diabetes from Knockout Mouse Models.
Terauchi, Y., & Kadowaki, T. (2002) · Endocrine Journal · doi:10.1507/endocrj.49.247 · Cited by 15
Ionescu-Tirgoviste, C., & Guja, C. (2007) · Cited by 15
Gestational diabetes mellitus and macrosomia predispose to diabetes in the Lebanese population
Ghassibe‐Sabbagh, M., Mehanna, Z., Farraj, L. A., Salloum, A. K., & Zalloua, P. (2019) · Journal of Clinical & Translational Endocrinology · doi:10.1016/j.jcte.2019.100185 · Cited by 15
Characterizing skeletal muscle dysfunction in women with polycystic ovary syndrome
McDonnell, T., Cussen, L., McIlroy, M., & O’Reilly, M. (2022) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/20420188221113140 · Cited by 15
Ding, L., Qu, Z., Chi, J., Shi, R., Wang, L., Hou, L., Wang, Y., & Pang, S. (2015) · PubMed · Cited by 15
Process of care compliance is associated with fewer diabetes complications.
Bayer, F. J., Galusha, D. H., Slade, M. D., Chu, I. M., Taiwo, O. A., & Cullen, M. R. (2014) · PubMed · Cited by 15
Randhawa, V., Sharma, P., Bhushan, S., & Bagler, G. (2013) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2012.0115 · Cited by 15
Is diagnosing metabolic syndrome a uniquely simple way to predict incident type 2 diabetes mellitus?
Reaven, G. M. (2009) · Canadian Medical Association Journal · doi:10.1503/cmaj.090092 · Cited by 15
Childhood Predictors of Adult Acute Insulin Response and Insulin Action
Thearle, M. S., Bunt, J. C., Knowler, W. C., & Krakoff, J. A. (2009) · Diabetes Care · doi:10.2337/dc08-1833 · Cited by 15
Self-citationPan, S. Y., de Groh, M., Aziz, A. A., & MORRISON, H. I. (2015) · Journal of Diabetes & Metabolic Disorders · doi:10.1186/s40200-016-0253-7 · Cited by 15
Zhao, Y., Wang, B., Wang, G., Huang, L., Yin, T., Li, X., Liu, X., Wang, Q., Jing, J., Yang, J., et al. (2020) · Lipids in Health and Disease · doi:10.1186/s12944-020-1194-1 · Cited by 15
Xu, Y., Zhou, Y., Liu, J., Wang, C., Qu, Z., Wei, Z., & Zhou, D. (2020) · Medicine · doi:10.1097/md.0000000000023672 · Cited by 15
Engler, D. (2007) · Acta bio-medica dell'Ateneo parmense/Acta biomedica · Cited by 15
Glucose Response to an Oral Glucose Tolerance Test Predicts Weight Change in Non‐diabetic Subjects
Pannacciulli, N., Ortega, E., Koška, J., Salbe, A. D., Bunt, J. C., & Krakoff, J. A. (2007) · Obesity · doi:10.1038/oby.2007.572 · Cited by 15
Iwanishi, M., Obata, T., Yamada, S., Maegawa, H., Tachikawa-Ide, R., Ugi, S., Hasegawa, M., Kojima, H., Oguni, T., Toudo, R., et al. (1995) · Diabetes Research and Clinical Practice · doi:10.1016/0168-8227(95)01108-0 · Cited by 15
Zethelius, B., Berglund, L., Haenni, A., & Berne, C. (2008) · Upsala Journal of Medical Sciences · doi:10.3109/2000-1967-226 · Cited by 15
Study Protocol: insulin and its role in cancer
Harish, K., Dharmalingam, M., & Himanshu, M. (2007) · BMC Endocrine Disorders · doi:10.1186/1472-6823-7-10 · Cited by 15
Positional Cloning of an Obesity/Diabetes Susceptibility Gene(s) on Chromosome 11 in Pima Indians
Baier, L. J., Kovacs, P. L., Wiedrich, C., Cray, K., SCHEMIDT, A., Shen, G.-Q., SUTHERLAND, J., Thuillez, P., Muller, Y. L., Traurig, M. T., et al. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04281.x · Cited by 15
Self-citationAnalysis of PBX1 as a candidate gene for type 2 diabetes mellitus in Pima Indians
Thameem, F., DiStefano, J. K., Bogardus, C., & Procházka, M. (2001) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(01)00189-0 · Cited by 15
Self-citationHattori, A., Uemura, K., Miura, H., UEDA, M., Tamaya, N., Iwata, F., Muraguchi, M., Ohmoto, Y., & Iguchi, A. (2000) · Endocrine Journal · doi:10.1507/endocrj.47.615 · Cited by 15
Clustering of Cardiovascular Risk Factors
Haffner, S. M. (1998) · Medical science symposia series · doi:10.1007/978-94-011-5022-4_27 · Cited by 15
High Prevalence of Metabolic Syndrome among Young Women with Nonfatal Myocardial Infarction
Lawry, L. L., Ridker, P. M., Rifai, N., Loughrey, C. M., & Komaroff, A. L. (2004) · Journal of Women s Health · doi:10.1089/154099904322966146 · Cited by 15
Metabolic and Molecular Pathogenesis of Type 2 Diabetes Mellitus
DeFronzo, R. A., Mandarino, L. J., & Ferrannini, E. (2003) · Wiley eBooks · doi:10.1002/0470862092.d0310 · Cited by 15
Lee, H. J., Yeom, J. W., Yun, J. H., Jang, H. B., Yoo, M., Kim, H.-L., Koo, S. K., & Lee, H. (2023) · Journal of Diabetes · doi:10.1111/1753-0407.13429 · Cited by 14
Insulin Resistance in Type 2 Diabetes
Roden, M., Petersen, K. F., & Shulman, G. I. (2024) · Wiley eBooks · doi:10.1002/9781119697473.ch17 · Cited by 14
Short Sleep Duration Disrupts Glucose Metabolism: Can Exercise Turn Back the Clock?
Maloney, A., & Kanaley, J. A. (2024) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000339 · Cited by 14
Pavlik, V., Massman, P. J., Barber, R. C., & Doody, R. S. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-121999 · Cited by 14
Keenan, D. M., Basu, R., Liu, Y., Basu, A., Bock, G., & Veldhuis, J. D. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00494.2011 · Cited by 14
Non‐hematopoietic effects of endogenous erythropoietin on lean mass and body weight regulation
Reinhardt, M., Dey, S., Noguchi, C. T., Zhang, Y., Krakoff, J. A., & Thearle, M. S. (2016) · Obesity · doi:10.1002/oby.21537 · Cited by 14
Blum, M. R., Popat, R. A., Nagy, A., Cataldo, N. A., & McLaughlin, T. (2021) · Journal of Endocrinological Investigation · doi:10.1007/s40618-020-01430-2 · Cited by 14
YOUNGREN, J. F., Goldfine, I. D., & Pratley, R. E. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.276.5.e990 · Cited by 14
Clément, K., Stunff, C. L., Meirhaeghe, A., Dechartres, A., Ferrières, J., Basdevant, A., Boîtard, C., Amouyel, P., & Bougneres, P. F. (2008) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2008.11.160 · Cited by 14
The Metabolic Syndrome in American Indians: The Strong Heart Study
Russell, M., SIMONE, G. D., Resnick, H. E., & Howard, B. V. (2007) · Journal of the CardioMetabolic Syndrome · doi:10.1111/j.1559-4564.2007.07457.x · Cited by 14
Pathophysiologic heterogeneity in the development of type 2 diabetes mellitus in Korean subjects
Kang, H. W., Kim, D. J., Lee, M., Kim, K., & Lee, M. (2005) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2004.12.011 · Cited by 14
Pontiroli, A. E., Monti, L., Costa, S., Sandoli, P. E., Pizzini, A., Sb, S., Mantovani, E., & Piatti, P. M. (2000) · European Journal of Endocrinology · doi:10.1530/eje.0.1430681 · Cited by 14
Pathogenesis of Type 2 Diabetes Mellitus
DeFronzo, R. A. (2018) · Endocrinology · doi:10.1007/978-3-319-45015-5_8 · Cited by 14
Definition and Diagnostic Criteria for Metabolic Syndrome
Howard, W. J., SIMONE, G. D., & Howard, B. V. (2011) · Wiley eBooks · doi:10.1002/9781444318456.ch11 · Cited by 14
Association Analysis of Krüppel-Like Factor 11 Variants with Type 2 Diabetes in Pima Indians
Ma, L., Hanson, R. L., Que, L. N., Mack, J. L., Franks, P. W., Infante, A. M., Kobes, S., Bogardus, C., & Baier, L. J. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0546 · Cited by 14
Self-citationBonora, E., Targher, G., Alberiche, M., Bonadonna, R. C., Zenere, M. B., Saggiani, F., & Muggeo, M. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.5.7455 · Cited by 14
Fillmore, N., Keung, W., Kelly, S. E., Proctor, S. D., Lopaschuk, G. D., & Ussher, J. R. (2015) · Experimental Physiology · doi:10.1113/ep085052 · Cited by 14
Martínez‐López, E., Ruiz‐Madrigal, B., Hernández‐Cañaveral, I., & Panduro, A. (2007) · Diabetes and Vascular Disease Research · doi:10.3132/dvdr.2007.046 · Cited by 14
Genetic models of Insulin Resistance:Alterations in β-cell biology
Kulkarni, R., & Kahn, C. R. (2001) · Endocrine updates · doi:10.1007/978-1-4615-1669-9_18 · Cited by 14
Toyoda, K., Fukushima, M., Mitsui, R., Harada, N., Suzuki, H., Takeda, T., Taniguchi, A., Nakai, Y., Kawakita, T., Yamada, Y., et al. (2008) · Metabolism · doi:10.1016/j.metabol.2007.10.002 · Cited by 14
Jawa, A., & Fonseca, V. A. (2005) · Cardiology Clinics · doi:10.1016/j.ccl.2004.06.001 · Cited by 14
In vivo β-cell function at the transition to early non-insulin-dependent diabetes mellitus
Swinburn, B. A., Gianchandani, R. Y., Saad, M. F., & Lillioja, S. (1995) · Metabolism · doi:10.1016/0026-0495(95)90189-2 · Cited by 14
Self-citationPlatelet count and 8-year incidence of diabetes: The Korean Genome and Epidemiology Study
Hwang, J. Y., Kwon, Y., Choi, W., & Jung, D. (2018) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2018.07.033 · Cited by 13
Cheng, J., Xu, L., Yu, Q., Lin, G., Ma, X., Li, M., Guan, F., Liu, Y., Huang, X., Xie, J., et al. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175234 · Cited by 13
The role of m6A modification in type 2 diabetes: A systematic review and integrative analysis
Li, Y., Zhang, Y., Chen, N., & Yan, Y. (2024) · Gene · doi:10.1016/j.gene.2024.148130 · Cited by 13
Haffner, C. D., Thomson, S. A., Guo, Y. C., Petrov, K. G., Larkin, A. L., Banker, P., Schaaf, G. M., Dickerson, S. H., Gobel, J., Gillie, D., et al. (2010) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2010.09.131 · Cited by 13
Johansson, A., Olsson, T., Cederquist, K., Forsberg, H., Holst, J. J., Seckl, J. R., & Ahren, B. (2002) · European Journal of Endocrinology · doi:10.1530/eje.0.1460397 · Cited by 13
Koška, J., Ortega, E., Bogardus, C., Krakoff, J. A., & Bunt, J. C. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00662.2006 · Cited by 13
Self-citationTop, C., Şahan, B., & Önde, M. E. (2007) · Journal of International Medical Research · doi:10.1177/147323000703500621 · Cited by 13
Glucose Dysregulation in Obese Children: Predictive, Risk, and Potential Protective Factors
Xekouki, P., Nikolakopoulou, N. M., Papageorgiou, A., Livadas, S., Voutetakis, A., Magiakou, M. A., Chrousos, G. P., Spiliotis, B. E., & Dacou‐Voutetakis, C. (2007) · Obesity · doi:10.1038/oby.2007.600 · Cited by 13
Weir, G. C. (1995) · JAMA · doi:10.1001/jama.1995.03520470086039 · Cited by 13
Physical Activity and Type 2 Diabetes
Bhaskarabhatla, K. V., & Birrer, R. B. (2004) · The Physician and Sportsmedicine · doi:10.3810/psm.2004.01.80 · Cited by 13
Sheu, W. H., Jeng, C.-Y., Fuh, M. M.-T., Chen, Y. I., & Reaven, G. M. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.81.3.1156 · Cited by 13
Usual Blood Pressure and New-Onset Diabetes Risk
Knowles, J. W., & Reaven, G. M. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.12.065 · Cited by 13
Green, C., Zaman, V., Blumenstock, K., Banik, N. L., & Haque, A. (2025) · Biomedicines · doi:10.3390/biomedicines13010132 · Cited by 12
Wongwananuruk, T., Prasongvej, P., Chantrapanichkul, P., Indhavivadhana, S., Tanmahasamut, P., Rattanachaiyanont, M., Techatraisak, K., & Angsuwathana, S. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14051452 · Cited by 12
Marjańska, M., Eberly, L. E., Adriany, G., Verdoliva, S. N., Garwood, M., & Chow, L. S. (2012) · Magnetic Resonance in Medicine · doi:10.1002/mrm.24198 · Cited by 12
The metabolic syndrome entanglement: cutting the Gordian knot
Fisman, E. Z., & Tenenbaum, A. (2013) · Cardiology Journal · doi:10.5603/cj.a2013.0054 · Cited by 12
The determinants of complication trajectories in American Indians with type 2 diabetes
Reynolds, E. L., Akıncı, G., Banerjee, M., Looker, H. C., Patterson, A., Nelson, R. G., Feldman, E. L., & Callaghan, B. C. (2021) · JCI Insight · doi:10.1172/jci.insight.146849 · Cited by 12
Nair, A. K., Muller, Y. L., McLean, N. A., Abdussamad, M., Piaggi, P., Kobes, S., Weil, E. J., Curtis, J. M., Nelson, R. G., Knowler, W. C., et al. (2014) · Diabetologia · doi:10.1007/s00125-014-3351-4 · Cited by 12
Self-citationMiller, M. R., Zhang, W., Sibbel, S. P., Langefeld, C. D., Bowden, D. W., Haffner, S. M., Bergman, R. N., Norris, J. M., & Fingerlin, T. E. (2009) · Obesity · doi:10.1038/oby.2009.303 · Cited by 12
PPARα: its role in the human metabolic syndrome
Azhar, S., & Kelley, G. (2007) · Future Lipidology · doi:10.2217/17460875.2.1.31 · Cited by 12
Mohammadzadeh, G., Zarghami, N., & Mobasseri, M. (2008) · Intern J Endocrinol Metab · Cited by 12
The TRIB3 Q84R polymorphism, insulin resistance and related metabolic alterations
Prudente, S., & Trischitta, V. (2015) · Biochemical Society Transactions · doi:10.1042/bst20150115 · Cited by 12
Dumpati, R., Dulapalli, R., Kondagari, B., Ramatenki, V., Vellanki, S., Vadija, R., & Vuruputuri, U. (2016) · ChemistrySelect · doi:10.1002/slct.201600640 · Cited by 12
Lee, S. A., Koh, G., Cho, S. J., Yoo, S., & Chin, S. O. (2016) · Endocrinology and Metabolism · doi:10.3803/enm.2016.31.3.439 · Cited by 12
Inference on chains of disease progression based on disease networks
Lee, D. A., Kim, M.-J., & Shin, H. (2019) · PLoS ONE · doi:10.1371/journal.pone.0218871 · Cited by 12
Azoramide improves mitochondrial dysfunction in palmitate-induced insulin resistant H9c2 cells
Okatan, E. N., Olğar, Y., Tuncay, E., & Turan, B. (2019) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-019-03590-z · Cited by 12
Metadata
- Authors
- Lillioja, S., Mott, D. M., Spraul, M., Ferraro, R., Foley, J. E., Ravussin, E., Knowler, W. C., Bennett, P. H., & Bogardus, C.
- Affiliations
- National Institutes of Health (US)
- ORCID
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1993-12-30
- Volume
- 329
- Issue
- 27
- Pages
- 1988-1992
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2334309509
- Cited by
- 1,508
- References
- 27
- Citations by year
- 2026: 13 · 2025: 16 · 2024: 30 · 2023: 22 · 2022: 34 · 2021: 38 · 2020: 39 · 2019: 37 · 2018: 40 · 2017: 30 · 2016: 40 · 2015: 52 · 2014: 44 · 2013: 45 · 2012: 44
- FWCI
- 30.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Research Online (University of Wollongong) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- insulin resistance, type 2 diabetes, Pima Indians, obesity, acute insulin response, hepatic glucose production, insulin action, diabetes risk factors, hyperinsulinemic-euglycemic clamp, glucose tolerance
- MeSH terms
- Insulin Secretion, Adult, Arizona, Body Composition, Diabetes Mellitus, Type 2, Female, Follow-Up Studies, Glucose, Glucose Tolerance Test, Humans, Indians, North American, Insulin, Insulin Resistance, Liver, Male, Obesity, Prospective Studies, Risk Factors, Proportional Hazards Models
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
