Management of hypertension in patients with chronic kidney disease
Abstract
Hypertension is the leading factor in the global burden of disease. It is the predominant modifiable risk factor for stroke, heart disease, and kidney failure. Chronic kidney disease (CKD) is both a common cause and sequel of uncontrolled hypertension. The pathophysiology of CKD-associated hypertension is complex and multi-factorial. This paper reviews the key pathogenic mechanisms of CKD-associated hypertension, the importance of standardized blood pressure (BP) measurement in establishing the diagnosis and management plus the significance of ambulatory BP monitoring for assessment of diurnal BP variation commonly seen in CKD. The optimal BP target in CKD remains a matter of discussion despite recent clinical trials. Medical therapy can be difficult and challenging. In addition to lifestyle modification and dietary salt restriction, treatment may need to be individualized based on co-morbidities. Combination of antihypertensive drugs, including appropriate diuretic choice and dose, is of great significance in hypertension management in CKD.
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Elevated blood pressure is an excellent clinical sign in many cardiovascular diseases, but by itself it does not provide information regarding mechanisms of any given disorder.
“However, despite blood pressure’s association with many unique dis- eases, by itself it does not provide information regarding the mechanisms of any given disorder.”
From Methods and challenges for assessing heterogeneity (2020) · cites this paper as [43]
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Methods and challenges for assessing heterogeneity
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- Authors
- Hamrahian, S. M.
- Affiliations
- Thomas Jefferson University (US)
- Corresponding author
- Hamrahian, Seyed Mehrdad
- Venue
- Current Hypertension Reports
- Published
- 2017-04-27
- Volume
- 19
- Issue
- 5
- Pages
- 43-43
- ISSN
- 1522-6417 (ISSN-L)
- 1534-3111
- OpenAlex
- W2607670991
- Cited by
- 26
- References
- 91
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 5 · 2022: 5 · 2021: 5 · 2020: 2 · 2019: 4 · 2018: 2
- FWCI
- 0.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Hypertension Reports (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
- Keywords
- hypertension, chronic kidney disease, blood pressure measurement, ambulatory blood pressure monitoring, diurnal blood pressure variation, blood pressure targets, antihypertensive therapy, diuretics, salt restriction, lifestyle modification, comorbidities
- MeSH terms
- Blood Pressure, Humans, Hypertension, Risk Factors, Blood Pressure Monitoring, Ambulatory, Renal Insufficiency, Chronic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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