The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Low Serum Thyrotropin Concentrations as a Risk Factor for Atrial Fibrillation in Older Persons
Open accessAbstract
BACKGROUND: Low serum thyrotropin concentrations are a sensitive indicator of hyperthyroidism but can also occur in persons who have no clinical manifestations of the disorder. We studied whether low serum thyrotropin concentrations in clinically euthyroid older persons are a risk factor for subsequent atrial fibrillation. METHODS: We studied 2007 persons (814 men and 1193 women) 60 years of age or older who did not have atrial fibrillation in order to determine the frequency of this arrhythmia during a 10-year follow-up period. The subjects were classified according to their serum thyrotropin concentrations: those with low values (< or = 0.1 mU per liter; 61 subjects); those with slightly low values (> 0.1 to 0.4 mU per liter; 187 subjects); those with normal values (> 0.4 to 5.0 mU per liter; 1576 subjects); and those with high values (> 5.0 mU per liter; 183 subjects). RESULTS: During the 10-year follow-up period, atrial fibrillation occurred in 13 persons with low initial values for serum thyrotropin, 23 with slightly low values, 133 with normal values, and 23 with high values. The cumulative incidence of atrial fibrillation at 10 years was 28 percent among the subjects with low serum thyrotropin values (< or = 0.1 mU per liter), as compared with 11 percent among those with normal values; the age-adjusted incidence of atrial fibrillation was 28 per 1000 person-years among those with low values and 10 per 1000 person-years among those with normal values (P = 0.005). After adjustment for other known risk factors, the relative risk of atrial fibrillation in elderly subjects with low serum thyrotropin concentrations, as compared with those with normal concentrations, was 3.1 (95 percent confidence interval, 1.7 to 5.5; P < 0.001). The 10-year incidence of atrial fibrillation in the groups with slightly low and high serum thyrotropin values was not significantly different from that in the group with normal values. CONCLUSIONS: Among people 60 years of age or older, a low serum thyrotropin concentration is associated with a threefold higher risk that atrial fibrillation will develop in the subsequent decade.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Cardiovascular symptoms are the most frequent indicators of mild thyroid hormone excess in the elderly, similar to overt hyperthyroidism [52,53] .”
From The 2015 European Thyroid Association Guidelines on Diagnosis and Treatment of Endogenous Subclinical Hyperthyroidism (2015) · cites this paper as [52]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“An increased incidence of AF has also been observed in elderly persons with low serum TSH (0.1-0.5 mIU/l) with an HR of 1.6 (95% CI: 1.0-2.5)[52] and 1.85 (95% CI: 1.14-3.00)[53] .”
From The 2015 European Thyroid Association Guidelines on Diagnosis and Treatment of Endogenous Subclinical Hyperthyroidism (2015) · cites this paper as [52]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“A 2-to 3-fold increased risk of atrial fibrillation (AF) was associated with SHyper in elderly subjects in two large prospective studies [52,53] .”
From The 2015 European Thyroid Association Guidelines on Diagnosis and Treatment of Endogenous Subclinical Hyperthyroidism (2015) · cites this paper as [52]
The cited source says what the claim attributes to it.
In the citing paper
“Excess thyroid hormone can also increase the risk of arrhythmias24 25 and muscle weakness23 in older people, which can contribute to a greater risk of falls.”
From Levothyroxine dose and risk of fractures in older adults: nested case-control study (2011) · cites this paper as [24]
The cited source says what the claim attributes to it.
In the citing paper
“lower serum TSH levels are associated with increased risk of atrial fibrillation (AF) (60)”
From Liothyronine and Desiccated Thyroid Extract in the Treatment of Hypothyroidism (2020) · cites this paper as [60]
In the citing paper
“Older patients with low TSH and higher fT4 have a higher prevalence and incidence of atrial fibrillation compared with euthyroid subjects (94–98)”
From Levothyroxine therapy in elderly patients with hypothyroidism (2021) · cites this paper as [97]
In the citing paper
“Twenty years ago, a low serum TSH level was first associated with an increased risk of atrial fibrillation (AF) (12)”
From Serum Thyroid Function, Mortality and Disability in Advanced Old Age: The Newcastle 85+ Study (2016) · cites this paper as [12]
In the citing paper
“in cohort studies, subclinical hyperthyroidism or lower serum TSH have been associated with many involutional disease states including dementia, osteoporosis, AF, muscle weakness, low bone density, and fracture (12–14, 18, 20, 48, 49).”
From Serum Thyroid Function, Mortality and Disability in Advanced Old Age: The Newcastle 85+ Study (2016) · cites this paper as [12]
In the citing paper
“In contrast with subclinical hypothyroidism, many previous studies have shown that low serum TSH is associated with poor outcomes, either increased all-cause or vascular mortality, or AF (12–14, 17, 29, 36, 37).”
From Serum Thyroid Function, Mortality and Disability in Advanced Old Age: The Newcastle 85+ Study (2016) · cites this paper as [12]
In the citing paper
“Sawin et al. (399) first reported a 2.8-fold increased risk of atrial fibrillation in SH subjects over age 60 years in 1994, and subsequent studies have confirmed that the risk of arrhythmias, particularly atrial fibrillation, is increased in SH (381,384,388,391,400,401).”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [399]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Regression Models and Life-Tables
Cox, D. R. (1972) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1972.tb00899.x · Cited by 39,793
Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1958) · Journal of the American Statistical Association · doi:10.1080/01621459.1958.10501452 · Cited by 39,158
Epidemiologic Features of Chronic Atrial Fibrillation
Kannel, W. B., Abbott, R. D., Savage, D. D., & McNamara, P. M. (1982) · New England Journal of Medicine · doi:10.1056/nejm198204293061703 · Cited by 2,304
The Statistical Analysis of Failure Time Data
Klein, J. P., Kalbfleisch, J. D., & Prentice, R. L. (1982) · Technometrics · doi:10.1080/00401706.1982.10487769 · Cited by 2,248
Atrial Fibrillation: A Major Contributor to Stroke in the Elderly: The Framingham Study
Wolf, P. A. (1987) · Archives of Internal Medicine · doi:10.1001/archinte.1987.00370090041008 · Cited by 1,108
Fade, J. V., Franklyn, J. A., Cross, K. W., Jones, S. C., & Sheppard, M. C. (1991) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1991.tb01739.x · Cited by 567
Duration of atrial fibrillation and imminence of stroke: the Framingham study.
Wolf, P. A., Kannel, W. B., McGee, D., Meeks, S. L., Bharucha, N. E., & Pm, M. (1983) · Stroke · doi:10.1161/01.str.14.5.664 · Cited by 336
Thyroid Dysfunction in Adults Over Age 55 Years
Bagchi, N. (1990) · Archives of Internal Medicine · doi:10.1001/archinte.150.4.785 · Cited by 275
Arterial embolism in thyrotoxicosis with atrial fibrillation.
Staffurth, J., Gibberd, M. C., & Fui, S. N. T. (1977) · BMJ · doi:10.1136/bmj.2.6088.688 · Cited by 181
Stroke in thyrotoxicosis with atrial fibrillation.
Petersen, P., & Hansen, J. M. (1988) · Stroke · doi:10.1161/01.str.19.1.15 · Cited by 178
Research works printed but not linked: 5
- 10.1001/archinte.147.9.1561 · DOI · Paper page
- Furszyfer J, 1970, Mayo Clin Proc, 45, 636
- 10.1001/archinte.151.3.549 · DOI
- 10.2307/2281868 · DOI · Paper page
- Sandler G, 1959, Q J Med, 52, 347
Cited by
Sorted by citations
Items 901–1,000 of 1,001
Thyroid and Cardiovascular Risk
den Elzen, W. P. J., Mooijaart, S. P., Ballieux, B. E. P. B., Cappola, A. R., & Gussekloo, J. (2020) · Springer eBooks · doi:10.1007/978-3-030-36871-5_16 · Cited by 2
Stamate, S. C., Andronescu, A. M., Nechita, A. C., Delcea, C., Mihu, E. M., & VINTILA, M. M. (2013) · Europe PMC (PubMed Central) · Cited by 2
Treatment Options for Primary Thyroid Disease in Patients with Heart Failure
Toft, A. D., & Gaskell, K. M. (2009) · Springer eBooks · doi:10.1007/978-88-470-1143-4_19 · Cited by 2
EVALUATION OF THE PATIENT WITH A SUSPECTED THYROID DISORDER
Bryer‐Ash, M. (2001) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/s0889-8545(05)70209-6 · Cited by 2
Rajini, B., & Haragopal, R. (2018) · International Journal of Contemporary Medical Research [IJCMR] · doi:10.21276/ijcmr.2018.5.12.13 · Cited by 2
Smith, J. R., & Huang, S. A. (2018) · Springer eBooks · doi:10.1007/978-3-319-73782-9_18 · Cited by 2
Völzke, H. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.03.022 · Cited by 2
Zelmanovitz, F. (1999) · Annals of Internal Medicine · doi:10.7326/0003-4819-130-2-199901190-00015 · Cited by 2
Thyroid function tests and hypothyroidism: Authors' reply
Toft, A. D., & Beckett, G. J. (2003) · BMJ · doi:10.1136/bmj.326.7398.1087 · Cited by 2
“In the Framingham study a low serum thyroid stimulating hormone concentration was shown to be a risk factor for the development of atrial fibrillation,”
BackgroundMigration of an implantable cardioverter-defibrillator generator into the small bowel.
Broadhurst, P., Sayer, J., & Nathan, A. W. (1996) · Heart · doi:10.1136/hrt.75.4.368 · Cited by 2
Thyroid hormone and arrhythmogenic activity
Auer, J., Berent, R., Weber, T., & Eber, B. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)01995-2 · Cited by 2
Subklinische Schilddrüsenfunktionsstörungen in der Peri- und Postmenopause
Bojunga, J. (2015) · Journal für Kardiologie (Krause & Pachernegg GmbH) · Cited by 2
Thyroid hormone in the treatment of thyroid cancer: rationale and regimen differentiated
Burmeister, L. A. (1999) · Current Opinion in Endocrinology & Diabetes · doi:10.1097/00060793-199912000-00005 · Cited by 2
Thyroid suppression therapy: risks and indications
Steward, D., Falciglia, M., & Kim, P. S. (2002) · Current Opinion in Otolaryngology & Head & Neck Surgery · doi:10.1097/00020840-200206000-00007 · Cited by 2
Detecting and managing subclinical hyperthyroidism
WILKE, W. S., & SAADI, H. (1998) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.65.2.65 · Cited by 2
Who should be screened for thyroid dysfunction?
Stockigt, J. R. (1999) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1999.tb123558.x · Cited by 2
Busaidy, N. L., & Kloos, R. T. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4160-4745-2.00026-2 · Cited by 2
Selmer, C., & Faber, J. O. (2017) · Circulation · doi:10.1161/circulationaha.117.031283 · Cited by 2
Subclinical hypothyroidism revisited
Goldmann, D. R. (1996) · Journal of General Internal Medicine · doi:10.1007/bf02598999 · Cited by 2
Managing subclinical hypothyroidism
BMJ Publishing Group Ltd (1998) · Drug and Therapeutics Bulletin · doi:10.1136/dtb.1998.3611 · Cited by 2
Guitard-Moret, M., & Bournaud, C. (2009) · EMC - Endocrinologie - Nutrition · doi:10.1016/s1155-1941(09)50474-x · Cited by 2
Schilddrüsenautonomie: Gibt es eine "Organhyperthyreose" bei "euthyreoten" Patienten?
Wawrzyn, H., & Hesch, R. D. (2000) · Medizinische Klinik - Intensivmedizin und Notfallmedizin · doi:10.1007/s000630050001 · Cited by 1
“[19] wird dabei für Patienten im Alter von 60 Jahren oder älter, die laborchemisch eine latente Hyperthyreose haben, ein dreifach erhöhtes Risiko für eine absolute Ar❑ Hintergrund: Gegenwärtig kennen wir zwei verschiedene Formen der Hyperthyreose, und zwar die klassische oder manifeste und die subklinische oder latent…”
BackgroundKounis, N. G., Koniari, I. C., Kounis, G. N., Soufras, G. D., Tsigkas, G., Plotas, P., Davlouros, P. A., & Hahalis, G. N. (2020) · Angiology · doi:10.1177/0003319720958555 · Cited by 1
“Hyperthyroidism can induce AF in 10% to 15% of patients.(12) The arrhythmogenic activity of thyroxine is due to altering the electrophysiological characteristics of atrial myocytes by shortening the duration of action potential, enhancing automaticity and triggering activity in pulmonary vein cardio myocytes.”
BackgroundThyroid gland and heart: a cardiologist’s view on an endocrinological pathology. Review
Кondratiuk, V. Y., & Стахова, А. (2023) · Clinical endocrinology and endocrine surgery · doi:10.30978/cees-2023-3-41 · Cited by 1
Association of Serum Thyroxine and Atrial Fibrillation in Patients on Levothyroxine
Kravchenko, M. I., Forbes, W. L., & Graybill, S. D. (2024) · Military Medicine · doi:10.1093/milmed/usae324 · Cited by 1
Zhang, L.-S., Zhang, Y., Deng, F.-X., & Jiang, W. (2024) · Endocrine Practice · doi:10.1016/j.eprac.2024.12.015 · Cited by 1
Jensen, A., Gottschau, M., Christensen, J., Lindquist, S., Aalborg, G. L., Rosthøj, S., Grand, M. K., Pedersen, J., Kjær, S. K., & Nøhr, B. (2025) · International Journal of Cancer · doi:10.1002/ijc.70007 · Cited by 1
Yang, L., Mao, M., & Duan, L. (2026) · International Journal of Endocrinology · doi:10.1155/ije/8820514 · Cited by 1
“Discontinuing unnecessary thyroxine replacement therapy could avoid side efects such as increased risk of arrhythmias, angina, osteoporosis, and fractures [2–4].”
Tuesta-Nole, J. R., Serruto, M. E. S., Román, L. A. P., Llamo-Barboza, M. D. L. Á., Chujutalli, M. A. V., & Vega, J. E. C. (2026) · BMC Geriatrics · doi:10.1186/s12877-026-07369-y · Cited by 1
RetractedThyroid Nodules: Approaches to Diagnosis and Management
Kudva, Y. C., & Gharib, H. (1998) · Endocrine updates · doi:10.1007/978-1-4615-4945-1_6 · Cited by 1
“Atrial fibrillation in the elderly may be increased threefold when TSH is suppressed ( 47 ).”
BackgroundSpecial Considerations for the Elderly Patient with Atrial Fibrillation
Aronow, W. S. (2001) · Cardiac Electrophysiology Review · doi:10.1023/a:1011409622823 · Cited by 1
Subclinical Hyperthyroidism and Cardiovascular System
Быстрова, Т. В., Troshina, E. A., Abdulchabirova, F. M., Panchenkova, L. A., Ilyn, A. V., & Chirkova, L. P. (2006) · Clinical and experimental thyroidology · doi:10.14341/ket20062238-42 · Cited by 1
Complications of Hyperthyroidism
Sayın, İ., Ertek, S., & Cesur, M. (2014) · InTech eBooks · doi:10.5772/58196 · Cited by 2
Depression: An unrecognized presentation of hyperthyroidism in old age
Madeira, N. G. G. F., & dos Santos, T. F. (2011) · European Geriatric Medicine · doi:10.1016/j.eurger.2011.05.008 · Cited by 1
“It should be noted that subclinical hyperthyroidism has significant consequences in terms of morbidity and mortality, namely due to increased risk of atrial fibrillation and osteoporosis [6,7].”
BackgroundModern paradigm of postoperative management in patients with well-differentiated thyroid cancer
Makolina, N. P., & Platonova, N. M. (2011) · Clinical and experimental thyroidology · doi:10.14341/ket2011738-21 · Cited by 1
Treatment for subclinical hyperthyroidism in adults
Mugunthan, K., Mugunthan, N., & van Driel, M. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010371 · Cited by 1
RetractedLuk, A. C., Ezzat, S., & BUTANY, J. W. (2013) · Seminars in Diagnostic Pathology · doi:10.1053/j.semdp.2013.06.008 · Cited by 3
Subclinical Thyroid Dysfunction in the Elderly
Ko, K. D. (2014) · Journal of the Korean Geriatrics Society · doi:10.4235/jkgs.2014.18.3.111 · Cited by 1
Thyroid Cancer Survivorship Management
Flores, S. L., & Habra, M. A. (2014) · Springer eBooks · doi:10.1007/978-1-4939-0986-5_14 · Cited by 1
Effects of Metformin on Thyroid Function in Patients of Subclinical Hypothyroidism
Rajput, R., Saini, M., Rajput, M., & Shankar, V. (2013) · Journal of Endocrinology and Metabolism · doi:10.4021/jem.v3i4-5.188 · Cited by 1
Prévalence des hypothyroïdies infracliniques
de Talancé, N., Steinmetz, J., Spyckrelle, Y., Jp, G., & Boulange, M. (2001) · Immuno-analyse & Biologie Spécialisée · doi:10.1016/s0923-2532(01)80007-7 · Cited by 1
Schilddrüsenfunktion und -dysfunktion im Alter / Thyroid function and dysfunction in the elderly
WEISSEL, M. (2007) · Journal of Laboratory Medicine · doi:10.1515/jlm.2007.004 · Cited by 1
Asymmetric Septal Hypertrophy Associated With “Subclinical Hypothyroidism”
Nieto, A. F., Cuevas, J. Q., Barrero, A. G., González, A. C., Chozas, J. M. L., & Aragón, L. M. Á. (2004) · Revista Española de Cardiología (English Edition) · doi:10.1016/s1885-5857(06)60316-2 · Cited by 1
The role of long term use of antithyroid drugs in Graves’ disease
Abhayaratna, S., & Somasundaram, N. (2013) · Sri Lanka Journal of Diabetes Endocrinology and Metabolism · doi:10.4038/sjdem.v3i1.5503 · Cited by 1
Screening for thyroid disease: defining high-risk populations
Stein, S. A., & Wartofsky, L. (2010) · Expert Review of Endocrinology & Metabolism · doi:10.1586/eem.10.34 · Cited by 1
Thyroid Cancer 1 Controversies in primary treatment of low-risk papillary thyroid cancer
McLeod, D. S. A., Sawka, A. M., & Cooper, D. S. (2013) · Cited by 1
Subclinical Thyroid Disorders: Clinical Significance and When to Treat?
Ng, M. C. W., Loo, Y. X., & Poon, Z. M. (2014) · Proceedings of Singapore Healthcare · doi:10.1177/201010581402300308 · Cited by 1
Галикович, В. В., Shalnova, S. A., Аркадьевна, М. Г., Artamonova, G. V., Гатагонова, Т. М., Grinshtein, Y. I., Duplyakov, D. V., Efanov, А. Y., Zhernakova, Y. V., Ilyin, V. A., et al. (2015) · Russian Journal of Preventive Medicine · doi:10.17116/profmed201518428-32 · Cited by 1
Disorders of the Hypothalamic–Pituitary–Thyroid Axis
Sidhaye, A. R., & Wondisford, F. E. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-375097-6.10031-9 · Cited by 1
Thyroid Disease in the Elderly
Cappola, A. R., Miller, M., & Gambert, S. R. (2009) · CRC Press eBooks · doi:10.3109/9781420070651-11 · Cited by 1
Subkliniczna dysfunkcja tarczycy – czy i kiedy leczyć?
Kuliczkowska-Płaksej, J., Tupikowska, M., Zatońska, K., & Bednarek-Tupikowska, G. (2013) · Family Medicine & Primary Care Review · Cited by 1
Patología tiroidea en atención primaria
González, A. L., Vázquez, Á. N., Carballido, F. C., Gómez, N. G., Rodríguez, M. L., & Carro, M. C. (2016) · FMC - Formación Médica Continuada en Atención Primaria · doi:10.1016/j.fmc.2015.12.012 · Cited by 1
Perkins, J. M. (2017) · Springer eBooks · doi:10.1007/978-3-319-54493-9_18 · Cited by 1
Aging and the Endocrine System
Chahal, H., & Drake, W. M. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-6231-8.10020-0 · Cited by 1
National Consensus Statement for the Management of Hypothyroidism in Nepal
Shrestha, D. (2018) · Journal of Diabetes and Endocrine Association of Nepal · doi:10.3126/jdean.v2i2.22364 · Cited by 1
Aronow, W. S. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-6231-8.10045-5 · Cited by 1
Sidhaye, A. R. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4160-4745-2.00018-3 · Cited by 1
Hyperthyreose – Fokus Immunthyreopathie Basedow
Theiler‐Schwetz, V., Trummer, C., & Pilz, S. (2020) · Journal für Klinische Endokrinologie und Stoffwechsel · doi:10.1007/s41969-020-00112-x · Cited by 1
Pearce, S. H. S. (2022) · doi:10.1093/med/9780198870197.003.0057 · Cited by 1
Differentiated Thyroid Carcinoma
Sipos, J. A., & Mazzaferri, E. L. (2009) · CRC Press eBooks · doi:10.3109/9781420070651-7 · Cited by 1
Diagnosis and Treatment of Hypothyroidism
Ashraff, S., & Razvi, S. (2017) · Endocrinology · doi:10.1007/978-3-319-29195-6_14-1 · Cited by 1
Hyperthyroidism Due to Graves’ Disease, Toxic Nodules and Toxic Multinodular Goiter
Burman, K. D. (2009) · CRC Press eBooks · doi:10.3109/9781420070651-3 · Cited by 1
Hypopituitarism: replacement of adrenal, thyroid, and gonadal axes
Howlett, T. A. (2011) · doi:10.1093/med/9780199235292.003.2083 · Cited by 1
Franklyn, J. A. (2013) · Medicine · doi:10.1016/j.mpmed.2013.06.003 · Cited by 1
Franklyn, J. A. (2009) · Medicine · doi:10.1016/j.mpmed.2009.05.002 · Cited by 1
Maurer, E., & Holzer, K. (2022) · Springer Reference Medizin · doi:10.1007/978-3-662-63317-5_9 · Cited by 1
Prevalence of Hyperthyroidism in Patients with Atrial Fibrillation
Ullah, I., Ghaffar, S., Ilyas, M., Zeb, F., Tahir, S., & Zaman, M. H. (2022) · Pakistan Journal of Medical and Health Sciences · doi:10.53350/pjmhs221610869 · Cited by 1
Frequency of Hyperthyroidism in patients of Atrial Fibrillation
Arshad, A., Ather, C. A. A., Sulehria, S. B., Choudhary, S., Rehman, M., & Mehmood, Z. (2023) · Pakistan Journal of Medical and Health Sciences · doi:10.53350/pjmhs202317173 · Cited by 1
Management of thyroid disorders in older people
Godbole, G., Joshi, T., & Majumder, M. (2023) · Journal of Pharmacy Practice and Research · doi:10.1002/jppr.1883 · Cited by 1
Pérez-Soto, R. H., Clemente-Gutiérrez, U., Alvarado-Bachmann, R., Basurto-Kuba, E. O. P., Domínguez-Fonseca, C. B., Barajas-Fregoso, E. M., España‐Gómez, M. N., Hurtado‐López, L. M., Medina-Escobedo, S. G., Montalvo-Hernández, J., et al. (2023) · Cirujano General · doi:10.35366/112923 · Cited by 1
Incidence of hyperthyroidism among in-patients with atrial fibrillation
Chanyavanich, P. (2013) · Chulalongkorn Medical Journal · doi:10.58837/chula.cmj.57.5.4 · Cited by 1
Vitamin D3 Deficiency's Impact on Atrial Fibrillation in Hyperthyroidism Patients
Dhefer, I. H. (2024) · Diyala Journal of Medicine · doi:10.26505/djm.26028011119 · Cited by 1
Sakr, M. F. (2024) · Springer eBooks · doi:10.1007/978-3-031-64102-2_12 · Cited by 1
Genetic drivers of etiologic heterogeneity in thyroid cancer
Jee, Y. H., Pozdeyev, N. V., Gignoux, C. R., White, S., Haugen, B. R., Verma, A., Pečulis, R., Rovīte, V., Mulford, A. J., Sanders, A. R., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-75111-8 · Cited by 1
“Although even mildly alteredthyroidstatuscanaffectheartrhythm 86 andrate 87 ,thefrequent occurrence of cardiac manifestations in hyperthyroid patients may result from thyrotoxicosis itself, pre-existing heart disease exacerbated by hyperthyroidism, or speci fi c hyperthyroidism-induced cardiac…”
Clinical thyroidology: beyond the 1970s’ TSH-T4 Paradigm
Lindner, H. H. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1529791 · Cited by 2
Ettleson, M. D., Thomas, N., Wan, W., Hedeker, D., Cappola, A. R., Laiteerapong, N., & Bianco, A. C. (2025) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaf675 · Cited by 1
Fibrilasi Atrium Pada Penyakit Hipertiroidisme Patogenesis dan Tatalaksana
Firdaus, I. (2007) · DOAJ (DOAJ: Directory of Open Access Journals) · doi:10.30701/ijc.v28i5.224 · Cited by 1
Diagnostic Imaging of the Thyroid and Radioiodine Therapy
Wiesner, W., Engel, H., Steinbrich, W., Nitzsche, E. U., Mueller‐Brand, J., Niemann, T., & Bongartz, G. M. (2012) · Springer eBooks · doi:10.1007/978-3-642-23459-0_4 · Cited by 1
Hypothyroidism after hemithyroidectomy for colloid goiter: Is it a reality
Gupta, K., Panda, N., Jain, P., Bakshi, J. B., & Verma, R. K. (2015) · Thyroid Research and Practice · doi:10.4103/0973-0354.159527 · Cited by 1
Importance of Thyroid Hormone Replacement Therapy in Patients with Medullary Thyroid Cancer
Jonklaas, J. (2016) · Springer eBooks · doi:10.1007/978-3-319-39412-1_13 · Cited by 1
Treatment Regimens in Toxic and Diffuse Goiters in Iodine Deficiency
Hoermann, R. (2009) · Elsevier eBooks · doi:10.1016/b978-0-12-374135-6.00081-9 · Cited by 1
Imam, S. K. (2016) · Springer eBooks · doi:10.1007/978-3-319-25871-3_1 · Cited by 1
Thyroid Nodules and Multinodular Goiter
Gharib, H. (2009) · CRC Press eBooks · doi:10.3109/9781420070651-6 · Cited by 1
An Overview of Endogenous Subclinical Hyperthyroidism and Cardiac Disease
Woeber, K. A. (2016) · Endocrine Practice · doi:10.4158/ep161437.co · Cited by 1
Kaneko, Y., Nakajima, A., Nakahara, F., Matsumoto, Y., Fukazawa, C., Yoshida, C., Sasaki, S., Masuda, K., & Takeda, K. (2017) · Health Evaluation and Promotion · doi:10.7143/jhep.44.485 · Cited by 1
Thyroid Function in Healthy Ageing and Longevity
Aggarwal, N., & Razvi, S. (2017) · Healthy ageing and longevity · doi:10.1007/978-3-319-63001-4_6 · Cited by 1
Treatment options of subclinical hyperthyroidism and cardiovascular risk
Kyrilli, A., Lytrivi, M., Lassen, P. B., & Corvilain, B. (2018) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2018.01.008 · Cited by 2
A Case Report On Congestive Cardiac Failure Due To Hyperthyroidism
Yakasai, B., & Yakasai, H. (2017) · Journal of Clinical Trials in Cardiology · doi:10.15226/2374-6882/5/1/00143 · Cited by 1
“In addition to overt thyrotoxicosis, the risk of atrial fibrillation is increased with subclinical hyperthyroidism [16].”
Substitution mit Schilddrüsenhormonen im höheren Lebensalter
von Werder, A., & von Werder, K. (2018) · Der Internist · doi:10.1007/s00108-018-0458-6 · Cited by 1
AlQahtani, S. Y., Ouf, S., & Ghazal, S. N. (2019) · Saudi Journal of Medicine and Medical Sciences · doi:10.4103/sjmms.sjmms_139_17 · Cited by 1
“AF is a common cardiac arrhythmia worldwide, and is considered a common cardiac complication in patients with hyperthyroidism.[1,2] AF can cause atrial remodeling, atrial dilatation and significant functional MR even with a normal LV size.”
BackgroundÜreyen, Ç. M., Coşansu, K., Vural, M. G., Sahin, S. E., Çakar, M. A., Kılıç, H., Ağaç, M. T., Gündüz, H., Akdemir, R., & Tatlı, E. (2019) · Medical Principles and Practice · doi:10.1159/000503553 · Cited by 1
Sonawale, A., & Chichkhede, A. (2018) · PubMed · Cited by 1
Sakr, M. F. (2020) · Springer eBooks · doi:10.1007/978-3-030-48775-1_7 · Cited by 1
Bahloul, A., Bouattour, N., Triki, F., Hammami, R., Charfeddine, S., Ellouze, T., Mhiri, C., Abid, L., & Kammoun, S. (2021) · Pan African Medical Journal · doi:10.11604/pamj.2021.38.31.25569 · Cited by 1
“Certaines n ́ont pas trouvé une association significative [21, 22] tel est le cas dans notre étude, d ́autres ont trouvé une association positive [23, 24].”
BackgroundCardiovascular morbidity and mortality as a confounder of prognosis in thyroid cancer
Izkhakov, E., Keinan‐Boker, L., & Stern, N. (2021) · Journal of Cancer Metastasis and Treatment · doi:10.20517/2394-4722.2021.24 · Cited by 1
CLINICAL FACTORS ASSOCIATED WITH NON-VALVULAR ATRIAL FIBRILLATION
Соловьев, О. В., & Lukianova, I. Y. (2019) · Juvenis scientia · doi:10.32415/jscientia.2019.07.02 · Cited by 1
(2007) · Springer eBooks · doi:10.1007/978-1-84628-748-0_5 · Cited by 1
Multinodular and Retrosternal Goiter
Rosenthal, R., & Oertli, D. (2007) · Springer eBooks · doi:10.1007/978-3-540-68043-7_14 · Cited by 1
Schilddrüse und Röntgenkontrastmittel
RENDL, J., & Saller, B. (2000) · De Gruyter eBooks · doi:10.1515/9783110812282.338 · Cited by 1
Carceller, D. B., Segundo, P. L., Beltrán, P. N., París, A. S., Hernández, P. D. C., Villanueva, M. M., & Olivares, D. A. (2011) · Revista Española de Medicina Nuclear · doi:10.1016/s1578-200x(11)70021-3 · Cited by 1
Metadata
- Authors
- Sawin, C. T., Geller, A., Wolf, P. A., Belanger, A. J., Baker, E., Bacharach, P., Wilson, P., Benjamin, E. J., & D'Agostino, R. B.
- Affiliations
- Boston University (US)
- Veterans Health Administration (US)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1994-11-10
- Volume
- 331
- Issue
- 19
- Pages
- 1249-1252
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2335515807
- Cited by
- 1,259
- References
- 31
- Citations by year
- 2026: 16 · 2025: 20 · 2024: 27 · 2023: 25 · 2022: 46 · 2021: 37 · 2020: 27 · 2019: 38 · 2018: 41 · 2017: 44 · 2016: 48 · 2015: 45 · 2014: 44 · 2013: 63 · 2012: 65
- FWCI
- 16.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (n01hc038038-022, 5r01hl040423-06)
- National Heart, Lung, and Blood Institute (R01-HL-40423-04, N01-HC-38038)
- National Institute of Neurological Disorders and Stroke (2-R01-NS-17950-12, R01NS017950)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Keywords
- thyroid-stimulating hormone, subclinical hyperthyroidism, older adults, hyperthyroidism, arrhythmia risk, thyroid function, incidence, risk factors, euthyroid patients, parathyroid hormone, parathyroidectomy, parathyroid hormone replacement, hypoparathyroidism
- MeSH terms
- Age Factors, Aged, Atrial Fibrillation, Female, Follow-Up Studies, Humans, Hyperthyroidism, Male, Middle Aged, Risk Factors, Thyrotropin, Thyroxine, Incidence, Confidence Intervals
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
