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The Control of Pain in Peripheral Tissue by Opioids
Abstract
Pain can be effectively diminished by various endogenous mechanisms within the central nervous system. One region where these mechanisms have been well characterized is the dorsal horn of the spinal cord, in which impulses from peripheral nerves are modulated before they are transmitted centrally to evoke perception and response. Recent research has shown that, in addition to these mechanisms in the central nervous system, intrinsic modulation of nociception can occur at the peripheral terminals of afferent nerves. Specifically, these studies indicate that the immune system can interact with peripheral sensory-nerve endings to inhibit pain.This neuroimmune link was discovered during . . .
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Cited by
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Opioid Therapy and Immunosuppression: A Review
Vallejo, R., de Leon-Casasola, O., & Benyamin, R. (2004) · American Journal of Therapeutics · doi:10.1097/01.mjt.0000132250.95650.85 · Cited by 386
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Metadata
- Authors
- Stein, C.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1995-06-22
- Volume
- 332
- Issue
- 25
- Pages
- 1685-1690
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2053732295
- Cited by
- 718
- References
- 0
- FWCI
- 15.62
- Type
- journal article
- Language
- en
- Open access
- closed
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