The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Opioid Therapy and Immunosuppression: A Review
Abstract
The idea that opioids modulate the immune system is not new. By the late 19th century, Cantacuzene, used morphine to suppress cellular immunity and lower the resistance of guinea pigs to bacterial infection. While exogenous opioids mediate immunosuppression, endogenous opiates exert opposite actions. Acute and chronic opioid administration is known to have inhibitory effects on humoral and cellular immune responses including antibody production, natural killer cell activity, cytokine expression, and phagocytic activity. Opiates behave like cytokines, modulating the immune response by interaction with their receptors in the central nervous system and in the periphery. Potential mechanisms by which central opiates modulate peripheral immune functions may involve both the hypothalamic-pituitary-adrenal axis and the autonomic nervous system. The presence of opioid receptors outside the central nervous system is increasingly recognized. Those receptors have been identified not only in peripheral nerves but also in immune inflammatory cells. The immunosuppression mediated by opiates may explain the increased incidence of infection in heroin addicts. Opiates may also promote immunodeficiency virus infection by decreasing the secretion of alpha and beta chemokines (important inhibitory cytokines for the expression of HIV) and at the same time increasing the expression of chemoreceptors CCR5 and CCR3, coreceptors for the virus. The fact that peripheral immunosupression is mediated at least in part by opioid receptors located in the central nervous system and that intrathecally administered opioids do not exert the same immunosuppressive effects may have important clinical implications for those patients receiving long-term opioid therapy for malignant and nonmalignant pain.
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Cites
Nucleotide sequence of cloned cDNA for bovine corticotropin-β-lipotropin precursor
Nakanishi, S., Inoue, A., Kita, T., Inoue, A., Nakamura, M., Chang, A. C. Y., Cohen, S. N., & Numa, S. (1979) · Nature · doi:10.1038/278423a0 · Cited by 1,762
Cloning and sequence analysis of cDNA for bovine adrenal preproenkephalin
Noda, M., Furutani, Y., Takahashi, H., Toyosato, M., Hirose, T., Inayama, S., Nakanishi, S., & Numa, S. (1982) · Nature · doi:10.1038/295202a0 · Cited by 934
Cloning and sequence analysis of cDNA for porcine β-neo-endorphin/dynorphin precursor
Kakidani, H., Furutani, Y., Takahashi, H., Noda, M., Morimoto, Y., Hirose, T., Asai, M., Inayama, S., Nakanishi, S., & Numa, S. (1982) · Nature · doi:10.1038/298245a0 · Cited by 783
The Control of Pain in Peripheral Tissue by Opioids
Stein, C. (1995) · New England Journal of Medicine · doi:10.1056/nejm199506223322506 · Cited by 718
Enhancement of natural cytotoxicity by beta-endorphin.
Mathews, P. M., Froelich, C. J., Sibbitt, W. L., & Bankhurst, A. D. (1983) · The Journal of Immunology · doi:10.4049/jimmunol.130.4.1658 · Cited by 460
Properties of Opiate-Receptor Binding in Rat Brain
Pert, C. B., & Snyder, S. H. (1973) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.70.8.2243 · Cited by 438
Kieffer, B. L. (1995) · Cellular and Molecular Neurobiology · doi:10.1007/bf02071128 · Cited by 389
The Effects of Tramadol and Morphine on Immune Responses and Pain After Surgery in Cancer Patients
Sacerdote, P., Bianchi, M., Gaspani, L., Manfredi, B., Maucione, A., TERNO, G., Ammatuna, M., & Panerai, A. E. (2000) · Anesthesia & Analgesia · doi:10.1097/00000539-200006000-00028 · Cited by 364
Evidence that postoperative pain is a mediator of the tumor-promoting effects of surgery in rats
Page, G. G., Blakely, W. P., & Ben-Eliyahu, S. (2001) · Pain · doi:10.1016/s0304-3959(00)00403-6 · Cited by 297
Szabo, I., Chen, X.-H., Xin, L., Adler, M. W., Howard, O. M. Z., Oppenheim, J. J., & Rogers, T. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.102327699 · Cited by 255
Cited by
Pharmacologic management of neuropathic pain: Evidence-based recommendations
Dworkin, R. H., O’Connor, A. B., Backonja, M., Farrar, J. T., Finnerup, N. B., Jensen, T. S., Kalso, E. A., Loeser, J. D., Miaskowski, C., Nurmikko, T. J., et al. (2007) · Pain · doi:10.1016/j.pain.2007.08.033 · Cited by 2,126
McNicol, E. D., Midbari, A., & Eisenberg, E. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006146.pub2 · Cited by 434
Roy, S., Ninkovic, J., Banerjee, S., Charboneau, R. G., Das, S., Dutta, R., Kirchner, V. A., Koodie, L., Ma, J., Meng, J., et al. (2011) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-011-9292-5 · Cited by 309
Dynorphin activates quorum sensing quinolone signaling in Pseudomonas aeruginosa
Zaborina, O., Lepine, F., Xiao, G., Valuckaite, V., Chen, Y., Li, T., Ciancio, M., Zaborin, A., Petroff, E., Turner, J. R., et al. (2007) · PLoS Pathogens · doi:10.1371/journal.ppat.0030035 · Cited by 207
Maani, C. V., Hoffman, H. G., Morrow, M., Maiers, A., Gaylord, K., McGhee, L. L., & DeSocio, P. A. (2011) · Journal of Trauma: Injury, Infection & Critical Care · doi:10.1097/ta.0b013e31822192e2 · Cited by 202
Metadata
- Authors
- Vallejo, R., de Leon-Casasola, O., & Benyamin, R.
- Venue
- American Journal of Therapeutics
- Published
- 2004-09
- Volume
- 11
- Issue
- 5
- Pages
- 354-365
- ISSN
- 1075-2765 (ISSN-L)
- OpenAlex
- W2044936430
- Cited by
- 386
- References
- 48
- FWCI
- 5.25
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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