The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Drug-Induced Hepatotoxicity
Abstract
Drug-induced liver injury is a potential complication of nearly every medication that is prescribed, because the liver is central to the metabolic disposition of virtually all drugs and foreign substances.13 Although drugs are usually metabolized without injury to the liver, many fatal and near-fatal drug reactions occur each year. A few compounds produce metabolites that cause liver injury in a uniform, dose-dependent fashion.46 Most agents form a toxic byproduct only in rare persons. Injury to hepatocytes results either directly from the disruption of intracellular function or membrane integrity or indirectly from immune-mediated membrane damage. Factors promoting the accumulation . . .
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Early indicators of prognosis in fulminant hepatic failure
O'Grady, J. G., Alexander, G. J. M., Hayllar, K. M., & Williams, R. (1989) · Gastroenterology · doi:10.1016/0016-5085(89)90081-4 · Cited by 2,085
Efficacy of Oral N-Acetylcysteine in the Treatment of Acetaminophen Overdose
Smilkstein, M. J., Knapp, G. L., Kulig, K. W., & Rumack, B. H. (1988) · New England Journal of Medicine · doi:10.1056/nejm198812153192401 · Cited by 1,102
McKenzie, R., Fried, M. W., Sallie, R., Conjeevaram, H., Di Bisceglie, A. M., Park, Y., Savarese, B., Kleiner, D., Tsokos, M., Luciano, C., et al. (1995) · New England Journal of Medicine · doi:10.1056/nejm199510263331702 · Cited by 616
Acetaminophen Hepatotoxicity in Alcoholics: A Therapeutic Misadventure
SEEFF, L. B., CUCCHERINI, B. A., ZIMMERMAN, H. J., ADLER, E., & BENJAMIN, S. B. (1986) · Annals of Internal Medicine · doi:10.7326/0003-4819-104-3-399 · Cited by 424
Chronic Excessive Acetaminophen Use and Liver Damage
BARKER, J. D., de CARLE, D. J., & ANURAS, S. (1977) · Annals of Internal Medicine · doi:10.7326/0003-4819-87-3-299 · Cited by 142
Acetaminophen Poisoning and Liver Function
(1994) · New England Journal of Medicine · doi:10.1056/nejm199411103311913 · Cited by 45
Cited by
Diclofenac: an update on its mechanism of action and safety profile
Gan, T. J. (2010) · Current Medical Research and Opinion · doi:10.1185/03007995.2010.486301 · Cited by 600
Acetaminophen Toxicity in an Urban County Hospital
Schiødt, F. V., Rochling, F. A., Casey, D. L., & Lee, W. M. (1997) · New England Journal of Medicine · doi:10.1056/nejm199710163371602 · Cited by 422
Self-citationAcetaminophen Hepatotoxicity and Acute Liver Failure
Chun, L. J., Tong, M. J., Busuttil, R. W., & Hiatt, J. R. (2009) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e31818a3854 · Cited by 348
Rosenberg, P., Urwitz, H., Johannesson, A., Ros, A.-M., Lindholm, J., Kinnman, N., & Hultcrantz, R. (2007) · Journal of Hepatology · doi:10.1016/j.jhep.2007.01.024 · Cited by 185
Antidepressant-induced hepatotoxicity
Lucena, M. I., Carvajal, A., Andrade, R. J., & Velasco, A. (2003) · Expert Opinion on Drug Safety · doi:10.1517/14740338.2.3.249 · Cited by 78
Metadata
- Authors
- Lee, W. M.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1995-10-26
- Volume
- 333
- Issue
- 17
- Pages
- 1118-1127
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W4235509352
- Cited by
- 305
- References
- 6
- FWCI
- 10.28
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Drug-Induced Hepatotoxicity. https://app.cochat.ai/papers/10.1056/nejm199510263331706
- The paper
- Lee, W. M. (1995). Drug-Induced Hepatotoxicity. New England Journal of Medicine. https://doi.org/10.1056/nejm199510263331706
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
