Antidepressant-induced hepatotoxicity
Abstract
Depression is a chronic, severe and increasingly prevalent illness associated with substantial morbidity, mortality and healthcare costs. Antidepressant drugs, the cornerstone of depression treatment, are not devoid of adverse effects, including hepatotoxicity. To review the risk of liver toxicity related to major antidepressants, the authors have followed structural criteria focusing on the underlying mechanism presumably involved and the role of particular chemical structures. The clinicopathological expression goes from transient increases in liver enzymes to fulminant liver failure. Classical antidepressants such as monoamine oxidase inhibitors (MAOIs) or tricyclic antidepressants (TCAs) seem to have the highest potential to induce liver damage compared with the newer drugs such as selective serotonin re-uptake inhibitors (SSRIs). The potential for severe hepatotoxicity associated with nefazodone is stressed. Guidelines for therapy and prevention of antidepressant-induced hepatotoxicity are also discussed.
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The potential for severe hepatotoxicity associated with nefazodone was stressed.
“The potential for severe hepatotoxicity associated with nefazodone was also stressed.45”
From Addressing the Side Effects of Contemporary Antidepressant Drugs: A Comprehensive Review (2018) · cites this paper as [45]
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- Authors
- Lucena, M. I., Carvajal, A., Andrade, R. J., & Velasco, A.
- Affiliations
- Universidad de Valladolid (ES)
- Venue
- Expert Opinion on Drug Safety
- Publisher
- Informa UK Limited
- Published
- 2003-05
- Volume
- 2
- Issue
- 3
- Pages
- 249-262
- ISSN
- 1474-0338 (ISSN-L)
- 1744-764X
- OpenAlex
- W2025716972
- Cited by
- 78
- References
- 143
- Citations by year
- 2025: 2 · 2024: 6 · 2023: 5 · 2022: 1 · 2020: 2 · 2018: 3 · 2017: 4 · 2016: 3 · 2015: 8 · 2014: 3 · 2013: 3 · 2012: 1
- FWCI
- 0.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Expert Opinion on Drug Safety (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- drug-induced liver injury, depression, monoamine oxidase inhibitors, tricyclic antidepressants, selective serotonin reuptake inhibitors, nefazodone, liver failure, drug safety, adverse drug reactions
- MeSH terms
- Antidepressive Agents, Depressive Disorder, Humans, Liver, Chemical and Drug Induced Liver Injury
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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