Cited by 78Drug-Induced Hepatotoxicity and ProtectionPharmacovigilance and Adverse Drug ReactionsTreatment of Major Depression

Antidepressant-induced hepatotoxicity

Lucena, M Isabel, Carvajal, Alfonso, Andrade, Raúl J, Velasco, Alfonso·2003·Expert Opinion on Drug Safety

Abstract

Depression is a chronic, severe and increasingly prevalent illness associated with substantial morbidity, mortality and healthcare costs. Antidepressant drugs, the cornerstone of depression treatment, are not devoid of adverse effects, including hepatotoxicity. To review the risk of liver toxicity related to major antidepressants, the authors have followed structural criteria focusing on the underlying mechanism presumably involved and the role of particular chemical structures. The clinicopathological expression goes from transient increases in liver enzymes to fulminant liver failure. Classical antidepressants such as monoamine oxidase inhibitors (MAOIs) or tricyclic antidepressants (TCAs) seem to have the highest potential to induce liver damage compared with the newer drugs such as selective serotonin re-uptake inhibitors (SSRIs). The potential for severe hepatotoxicity associated with nefazodone is stressed. Guidelines for therapy and prevention of antidepressant-induced hepatotoxicity are also discussed.

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Crossref · 10.1517/14740338.2.3.249

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Authors
Lucena, M. I., Carvajal, A., Andrade, R. J., & Velasco, A.
Affiliations
Universidad de Valladolid (ES)
Venue
Expert Opinion on Drug Safety
Published
2003-05
Volume
2
Issue
3
Pages
249-262
ISSN
  • 1474-0338 (ISSN-L)
  • 1744-764X
OpenAlex
W2025716972
Cited by
78
References
143
Citations by year
2025: 2 · 2024: 6 · 2023: 5 · 2022: 1 · 2020: 2 · 2018: 3 · 2017: 4 · 2016: 3 · 2015: 8 · 2014: 3 · 2013: 3 · 2012: 1
FWCI
0.25
Type
journal article
Language
en
Open access
closed
Locations
  • Expert Opinion on Drug Safety (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords
drug-induced liver injury, depression, monoamine oxidase inhibitors, tricyclic antidepressants, selective serotonin reuptake inhibitors, nefazodone, liver failure, drug safety, adverse drug reactions
MeSH terms
Antidepressive Agents, Depressive Disorder, Humans, Liver, Chemical and Drug Induced Liver Injury

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