Impaired Processing of Prohormones Associated with Abnormalities of Glucose Homeostasis and Adrenal Function

Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity

Naggert, J. Κ., Fricker, L. D., Varlamov, O., Nishina, P. M., Rouillé, Y., Steiner, D. F., Carroll, R. J., Paigen, B. J., & Leiter, E. H. (1995) · Nature Genetics · doi:10.1038/ng0695-135 · Cited by 664 · see citing works

The new enzymology of precursor processing endoproteases.

Steiner, D. F., Smeekens, S. P., Ohagi, S., & Chan, S. J. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)35852-6 · Cited by 612 · see citing works

Cloning and Primary Sequence of a Mouse Candidate Prohormone Convertase PC1 Homologous to PC2, Furin, and Kex2: Distinct Chromosomal Localization and Messenger RNA Distribution in Brain and Pituitary Compared to PC2

Seidah, N. G., Marcinkiewicz, M., Benjannet, S., et al. (1991) · Molecular Endocrinology · doi:10.1210/mend-5-1-111 · Cited by 480 · see citing works

Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans.

Smeekens, S. P., Avruch, A., LaMendola, J., et al. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.2.340 · Cited by 450 · see citing works

Impaired Growth Hormone Responses to Growth Hormone–Releasing Factor in Obesity

Williams, T., Berelowitz, M., Joffe, S. N., Thorner, M. O., Rivier, J., Vale, W., & Frohman, L. A. (1984) · New England Journal of Medicine · doi:10.1056/nejm198411293112203 · Cited by 428 · see citing works

Proglucagon is processed to glucagon by prohormone convertase PC2 in alpha TC1-6 cells.

Rouillé, Y., Westermark, G. T., Martin, S. K., & Steiner, D. F. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.8.3242 · Cited by 221 · see citing works

What β-cell Defect Could Lead to Hyperproinsulinemia in NIDDM?: Some Clues From Recent Advances Made in Understanding the Proinsulin-Processing Mechanism

Rhodes, C. J., & Alarcón, C. (1994) · Diabetes · doi:10.2337/diab.43.4.511 · Cited by 157 · see citing works

Lessons Learned From Molecular Biology of Insulin-Gene Mutations

Steiner, D. F., Tager, H. S., Chan, S. J., Nanjo, K., Sanke, T., & Rubenstein, A. H. (1990) · Diabetes Care · doi:10.2337/diacare.13.6.600 · Cited by 150 · see citing works

Evidence that glicentin contains the entire sequence of glucagon

Holst, J. J. (1980) · Biochemical Journal · doi:10.1042/bj1870337 · Cited by 122 · see citing works

ACTH precursors characterize the ectopic ACTH syndrome

Stewar, P. M., Gibson, S., Crosby, S. R., et al. (1994) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1994.tb02468.x · Cited by 110 · see citing works

Direct Measurement of the Precursors of Adrenocorticotropin in Human Plasma by Two-Site Immunoradiometric Assay*

Crosby, S. R., Stewart, M. F., Ratcliffe, J. G., & White, A. E. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-67-6-1272 · Cited by 109 · see citing works

CLINICAL EVALUATION OF A TWO‐SITE IMMUNORADIOMETRIC ASSAY FOR ADRENOCORTICOTROPIC IN UNEXTRACTED HUMAN PLASMA USING MONOCLONAL ANTIBODIES

White, A. E., Smith, H. H., Hoadley, M. E., Dobson, S., & Ratcliffe, J. G. (1987) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1987.tb03637.x · Cited by 107 · see citing works

Diabetes due to secretion of a structurally abnormal insulin (insulin Wakayama). Clinical and functional characteristics of [LeuA3] insulin.

Nanjo, K., Sanke, T., Miyano, M., et al. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112331 · Cited by 105 · see citing works

The Effects of Biosynthetic Human Proinsulin on Carbohydrate Metabolism

REVERS, R. R., Henry, R. R., Schmeiser, L., Kolterman, O., Cohen, R. M., Bergenstal, R. M., Polonsky, K. S., Jaspan, J. B., Rubenstein, A. H., Frank, B. H., et al. (1984) · Diabetes · doi:10.2337/diab.33.8.762 · Cited by 99 · see citing works

Cloning and Functional Expression of a Novel Endoprotease Involved in Prohormone Processing at Dibasic Sites1

Nakayama, K., Hosaka, M., Hatsuzawa, K., et al. (1991) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a123461 · Cited by 97 · see citing works

Familial Hyperinsulinemia Due to a Structurally Abnormal Insulin

Haneda, M., Polonsky, K. S., Bergenstal, R. M., Jaspan, J. B., Shoelson, S. E., BLIX, P. M., Chan, S. J., Kwok, S. C. M., Wishner, W. B., Zeidler, A., et al. (1984) · New England Journal of Medicine · doi:10.1056/nejm198405173102004 · Cited by 92 · see citing works

Familial Hyperproinsulinemia Due to a Proposed Defect in Conversion of Proinsulin to Insulin

Gruppuso, P. A., Görden, P., Kahn, C. R., Cornblath, M., Zeller, W. P., & Schwartz, R. (1984) · New England Journal of Medicine · doi:10.1056/nejm198409063111003 · Cited by 91 · see citing works

A mutation in the B chain coding region is associated with impaired proinsulin conversion in a family with hyperproinsulinemia.

Chan, S. J., Seino, S., Gruppuso, P. A., et al. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.8.2194 · Cited by 82 · see citing works

Biochemical and clinical implications of proinsulin conversion intermediates.

Given, B. D., Cohen, R. M., Shoelson, S. E., Frank, B. H., Rubenstein, A. H., & Tager, H. S. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112116 · Cited by 76 · see citing works

Biologic and Clinical Importance of Proinsulin

Robbins, D. C., Tager, H. S., & Rubenstein, A. H. (1984) · New England Journal of Medicine · doi:10.1056/nejm198405033101807 · Cited by 72 · see citing works

How to measure plasma insulin

CLARK, P. M. S., & Hales, C. N. (1994) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610100203 · Cited by 57 · see citing works

A novel point mutation in the human insulin gene giving rise to hyperproinsulinemia (proinsulin Kyoto).

Yano, H., Kitano, N., Morimoto, M., et al. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115795 · Cited by 49 · see citing works

Molecular scanning of the insulin receptor gene in syndromes of insulin resistance

Krook, A., Kumar, S., Laing, I., et al. (1994) · Diabetes · doi:10.2337/diabetes.43.3.357 · Cited by 42 · see citing works

What beta-cell defect could lead to hyperproinsulinemia in NIDDM? Some clues from recent advances made in understanding the proinsulin-processing mechanism

Rhodes, C. J., & Alarcon, C. (1994) · Diabetes · doi:10.2337/diabetes.43.4.511 · Cited by 35 · see citing works

Insulin Wakayama: familial mutant insulin syndrome in Japan

Nanjo, K., Miyano, M., Kondo, M., Sanke, T., Nishimura, S., Miyamura, K., Inouye, K., Given, B. D., Chan, S. J., Polonsky, K. S., et al. (1987) · Diabetologia · doi:10.1007/bf00274577 · Cited by 34 · see citing works

In vitro processing of proopiomelanocortin by recombinant PC1 (SPC3).

Friedman, T. C., Loh, Y. P., & Birch, N. P. (1994) · Endocrinology · doi:10.1210/endo.135.3.8070378 · Cited by 33 · see citing works

Isolated congenital ACTH deficiency: a cleavage enzyme defect?

Soo, S. C., Bain, M. D., Gibson, S., White, A. E., Johnstone, A. P., & Nussey, S. (1994) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1994.tb02499.x · Cited by 32 · see citing works

Isolated congenital ACTH deficiency: a cleavage enzyme defect?

Nussey, S., Soo, S., Gibsonf, S., Gout, I. T., White, A. E., Bain, M., & Johnstone, A. P. (1993) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1993.tb02381.x · Cited by 31 · see citing works

The effects of biosynthetic human proinsulin on carbohydrate metabolism

Revers, R. R., Henry, R. R., Schmeiser, L., et al. (1984) · Diabetes · doi:10.2337/diabetes.33.8.762 · Cited by 29 · see citing works

In vitro processing of proopiomelanocortin by recombinant PC1 (SPC3)

Friedman, T. C. (1994) · Endocrinology · doi:10.1210/en.135.3.854 · Cited by 16 · see citing works

Hyperproinsulinemia in a Family with a Proposed Defect in Conversion Is Linked to the Insulin Gene

Elbein, S. C., Gruppuso, P. A., Schwartz, R., et al. (1985) · Diabetes · doi:10.2337/diab.34.8.821 · Cited by 11 · see citing works

Hyperproinsulinemia in a family with a proposed defect in conversion is linked to the insulin gene

Elbein, S. C., Gruppuso, P. A., Schwartz, R., et al. (1985) · Diabetes · doi:10.2337/diabetes.34.8.821 · Cited by 7 · see citing works

Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene

Jackson, R. S., Creemers, J. W. M., Ohagi, S., Raffin-Sanson, M.-L., Sanders, L., Montague, C. T., Hutton, J. C., & O'Rahilly, S. (1997) · Nature Genetics · doi:10.1038/ng0797-303 · Cited by 1,153 · see citing works

Genetics of Obesity in Humans

Farooqi, I. S., & O’Rahilly, S. (2006) · Endocrine Reviews · doi:10.1210/er.2006-0040 · Cited by 583 · see citing works

Genetics and epigenetics in obesity

Rohde, K., Keller, M., la Cour Poulsen, L., Blüher, M., Kovacs, P., & Böttcher, Y. (2019) · Metabolism · doi:10.1016/j.metabol.2018.10.007 · Cited by 355 · see citing works

The genetic and molecular basis of idiopathic hypogonadotropic hypogonadism

Bianco, S. D. C., & Kaiser, U. B. (2009) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.177 · Cited by 336 · see citing works

Sequencing of 640,000 exomes identifies <i>GPR75</i> variants associated with protection from obesity

Akbari, P., Gilani, A., Sosina, O., Kosmicki, J. A., Khrimian, L., Fang, Y.-Y., Persaud, T., Garcia, V., Sun, D., Li, A., et al. (2021) · Science · doi:10.1126/science.abf8683 · Cited by 276 · see citing works

Hyperphagia and Early-Onset Obesity due to a Novel Homozygous Missense Mutation in Prohormone Convertase 1/3

Farooqi, I. S., Volders, K., Stanhope, R., Heuschkel, R., White, A., Lank, E., Keogh, J., O’Rahilly, S., & Creemers, J. W. M. (2007) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2007-0687 · Cited by 218 · see citing works

Circadian rhythms in the development of obesity: potential role for the circadian clock within the adipocyte

Bray, M. S., & Young, M. E. (2007) · Obesity Reviews · doi:10.1111/j.1467-789x.2006.00277.x · Cited by 213 · see citing works

Obesity, hyperphagia and increased metabolic efficiency in Pc1 mutant mice

Lloyd, D. J., Bohan, S., & Gekakis, N. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl111 · Cited by 142 · see citing works

Study of glucose tolerance in consecutive patients harbouring incidental adrenal tumours

Fernández‐Real, J. M., Ricart Engel, W., Simó, R., Salinas, I., Webb, S. M., & and the Study Group of Incidental Adrenal Adenoma (1998) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1998.00437.x · Cited by 109 · see citing works

The promise of new anti-obesity therapies arising from knowledge of genetic obesity traits

Hinney, A., Körner, A., & Fischer-Posovszky, P. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00716-0 · Cited by 101 · see citing works

Thyroid hormones selectively regulate the posttranslational processing of prothyrotropin-releasing hormone in the paraventricular nucleus of the hypothalamus

Perello, M., Friedman, T., Paez-Espinosa, V., Shen, X., Stuart, R. C., & Nillni, E. A. (2006) · Endocrinology · doi:10.1210/en.2005-1609 · Cited by 64 · see citing works

The ventromedial hypothalamic nucleus: watchdog of whole-body glucose homeostasis

Tu, L., Fukuda, M., Tong, Q., & Xu, Y. (2022) · Cell & Bioscience · doi:10.1186/s13578-022-00799-2 · Cited by 45 · see citing works

The impact of hypoxia exposure on glucose homeostasis in metabolically compromised humans: A systematic review

van Hulten, V., van Meijel, R. L. J., & Goossens, G. H. (2021) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-021-09654-0 · Cited by 27 · see citing works

CNS GLP-1 regulation of peripheral glucose homeostasis

Sandoval, D. A. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2008.04.018 · Cited by 59 · see citing works

The Measurement of Whole-Body Glucose Homeostasis in Mice

Xu, Y. X. Z., Ande, S. R., & Mishra, S. (2020) · Methods in molecular biology · doi:10.1007/978-1-0716-0802-9_16 · Cited by 1 · see citing works

A composite computational model of liver glucose homeostasis. II. Exploring system behaviour

Sumner, T., Hetherington, J., Seymour, R. M., Li, L., Varela‐Rey, M., Yamaji, S., Saffrey, P., Margoninski, O., Bogle, I. D. L., Finkelstein, A., et al. (2012) · Journal of The Royal Society Interface · doi:10.1098/rsif.2011.0783 · Cited by 19 · see citing works