Life-Threatening Cache Valley Virus Infection
Abstract
The Bunyamwera serogroup (family Bunyaviridae, genus bunyavirus) contains more than 20 serologically cross-reactive viruses, 7 of which have been isolated in North America.1 Cache Valley virus, first isolated in Utah in 1956,2 has been recovered mainly from mosquitoes (genera culiseta, aedes, and anopheles) and occasionally from vertebrates and has the widest apparent distribution among this serogroup of viruses. Antibodies against Cache Valley virus and other viruses of the Bunyamwera serogroup are prevalent in livestock, large wild mammals, and humans from Alaska to Argentina.3 An association between Cache Valley virus infections and congenital malformations (various musculoskeletal and central nervous system defects) . . .
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The in vitro virus (IVV) assay is a cell-based assay used to test harvest cell culture samples for potential viral contaminants.
“The in vitro virus (IVV) assay is a cell-based assay used to test harvest cell culture samples for potential viral contaminants 38 .”
From Viral contamination in biologic manufacture and implications for emerging therapies (2020) · cites this paper as [38]
The IVV assay takes between 14 to 28 days to complete.
“An additional challenge is that the IVV assay takes between 14 to 28 days to complete 38,53,59,60 and is not amenable to the rapid release required of some ATMP products.”
From Viral contamination in biologic manufacture and implications for emerging therapies (2020) · cites this paper as [38]
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Viral contamination in biologic manufacture and implications for emerging therapies
Barone, P. W., Wiebe, M. E., Leung, J. C., Hussein, I. T. M., Keumurian, F. J., Bouressa, J., Brussel, A., Chen, D., Chong, M., Dehghani, H., et al. (2020) · Nature Biotechnology · doi:10.1038/s41587-020-0507-2 · Cited by 212 · see citing works
Second Human Case of Cache Valley Virus Disease
Campbell, G. L., Mataczynski, J. D., Reisdorf, E. S., Powell, J. W., Martin, D. A., Lambert, A. J., Haupt, T. E., Davis, J. P., & Lanciotti, R. S. (2006) · Emerging Infectious Diseases · doi:10.3201/eid1205.051625 · Cited by 82 · see citing works
- Authors
- Sexton, D. J., Rollin, P. E., Breitschwerdt, E. B., Corey, G. R., Myers, S. A., Dumais, M. R., Bowen, M. D., Goldsmith, C. S., Zaki, S. R., Nichol, S. T., Peters, C. J., & Ksiazek, T. G.
- Affiliations
- Centers for Disease Control and Prevention (US)
- North Carolina State University (US)
- ORCID
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1997-02-20
- Volume
- 336
- Issue
- 8
- Pages
- 547-550
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2312889183
- Cited by
- 97
- References
- 0
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 5 · 2023: 2 · 2022: 4 · 2021: 6 · 2020: 4 · 2019: 4 · 2018: 5 · 2017: 8 · 2016: 4 · 2015: 4 · 2014: 8 · 2013: 6 · 2012: 3
- FWCI
- 1.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Vectors
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Mosquito-borne diseases and control
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Keywords
- Cache Valley virus, Bunyaviridae, arbovirus infection, mosquito-borne viruses, congenital malformations, seroprevalence, zoonotic transmission, life-threatening infection
- MeSH terms
- Adult, Bunyamwera virus, Bunyaviridae Infections, Humans, Male, Microscopy, Electron, Multiple Organ Failure, North Carolina, Viremia, Fatal Outcome, Encephalitis, Viral
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