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Cited by 82Viral Infections and VectorsMosquito-borne diseases and controlVirology and Viral Diseases

Second Human Case of Cache Valley Virus Disease

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Campbell, Grant L., Mataczynski, James D., Reisdorf, Erik S., Powell, James W., Martin, Denise A., Lambert, Amy J., Haupt, Thomas E., Davis, Jeffrey P. +1 more·2006·Emerging Infectious Diseases
DOI 10.3201/eid1205.051625PMC PMC3374447
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Abstract

We document the second known case of Cache Valley virus disease in a human.Cache Valley virus disease is rarely diagnosed in North America, in part because laboratories rarely test for it.Its true incidence, effect on public health, and full clinical spectrum remain to be determined.C ache Valley virus (CVV), a mosquitoborne member of the Bunyamwera serogroup, family Bunyaviridae, genus Orthobunyavirus, is geographically widespread in North America, where it circulates between mosquitoes and mammals (1).It has previously been associated with only a single case of human disease, a fatal case of acute encephalitis in the southeastern United States (2).We describe the second documented human case of CVV disease. Case ReportIn late October 2003, a 41-year-old, generally healthy Wisconsin man, who lived near a landfill in the suburbs of a small city on the Lake Michigan shore, became acutely ill with severe headache, nausea, vomiting, and fatigue.The next day, he was hospitalized with a diagnosis of acute aseptic meningitis.On admission, his body temperature was 38.4°C (101.1°F);no neck stiffness, rash, or focal neurologic abnormalities were detected.Computerized tomographic and magnetic resonance imaging scans of the brain were normal.The peripheral leukocyte count was 13,900/mm 3 , with 87% neutrophils and 7% lymphocytes.Cerebrospinal fluid (CSF) examination showed 865 leukocytes/mm 3 , with 73% lymphocytes, 15% monocytes, 12% neutrophils, and no erythrocytes; a protein concentration of 105 mg/dL, (normal 15-45 mg/dL); a glucose concentration of 47 mg/dL (normal 50-80 mg/dL); negative Gram

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  • Four of the five viruses found to contaminate human and primate cell lines are known to be pathogenic in humans, whereas only one of the viruses found to contaminate CHO cell culture has been reported to cause disease in humans.

    “In terms of safety implications, four (herpesvirus, human adenovirus type 1, parainfluenza virus type 3, and reovirus type 3) of the five viruses found to contaminate human and primate cell lines are known to be pathogenic in humans, whereas only one (Cache Valley virus) of the viruses found to contaminate CHO cell culture has been reported to cause disease in humans 36,37 .”

    From Viral contamination in biologic manufacture and implications for emerging therapies (2020) · cites this paper as [37]

    The Conclusions report a fatal, culture-confirmed case of Cache Valley virus encephalitis in a human, supporting the claim that this virus can cause human disease. The paper does not establish that Cache Valley virus contaminated CHO cell culture, that it was the only such contaminant reported to cause human disease, or the comparison with viruses contaminating human and primate cell lines. (LLM, conf=0.86)

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Authors
Campbell, G. L., Mataczynski, J. D., Reisdorf, E. S., Powell, J. W., Martin, D. A., Lambert, A. J., Haupt, T. E., Davis, J. P., & Lanciotti, R. S.
Affiliations
  • Centers for Disease Control and Prevention (US)
  • All Saints Healthcare System, Racine, Wisconsin, USA;
  • Wisconsin State Laboratory of Hygiene, Madison, Wisconsin, USA;
  • Wisconsin Department of Health Services (US)
Corresponding author
Campbell, Grant L.
ORCID
Venue
Emerging Infectious Diseases
Publisher
Centers for Disease Control and Prevention (CDC)
Published
2006-05
Volume
12
Issue
5
Pages
854-856
ISSN
  • 1080-6040 (ISSN-L)
  • 1080-6059
DOI
10.3201/eid1205.051625
PMC
PMC3374447
OpenAlex
W2092205764
Cited by
82
References
19
Citations by year
2026: 2 · 2025: 3 · 2024: 6 · 2023: 2 · 2022: 5 · 2021: 5 · 2020: 7 · 2019: 3 · 2018: 5 · 2017: 6 · 2016: 6 · 2015: 3 · 2014: 7 · 2013: 4 · 2012: 5
FWCI
1.65
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Emerging infectious diseases (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Centers for Disease Control and Prevention
Topics
  • Health Sciences › Medicine › Infectious Diseases › Viral Infections and Vectors
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Mosquito-borne diseases and control
  • Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
Keywords
Cache Valley virus, human infection, aseptic meningitis, Orthobunyavirus, Bunyaviridae, mosquito-borne arboviruses, acute encephalitis, cerebrospinal fluid findings
MeSH terms
Adult, Base Sequence, Bunyamwera virus, Bunyaviridae Infections, Humans, Male, Meningitis, Aseptic, RNA, Viral, Wisconsin, Sequence Alignment

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