The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Lamotrigine for Generalized Seizures Associated with the Lennox–Gastaut Syndrome
Open accessAbstract
BACKGROUND: The Lennox-Gastaut syndrome, a severe form of epilepsy that usually begins in early childhood, is difficult to treat. Dose-related drug toxicity is common. METHODS: We conducted a double-blind, placebo-controlled trial of the antiepileptic drug lamotrigine in patients with the Lennox-Gastaut syndrome. Eligible patients had more than one type of predominantly generalized seizure, including tonic-clonic, atonic, tonic, and major myoclonic, and had seizures on average at least every other day. After a 4-week base-line period in which all participants received placebo, we randomly assigned 169 patients (age range, 3 to 25 years) to 16 weeks of lamotrigine (n= 79) or placebo (n=90) in addition to their other antiepileptic drugs. RESULTS: The median frequency of all major seizures changed from base-line levels of 16.4 and 13.5 per week in the lamotrigine and placebo groups, respectively, to 9.9 and 14.2 per week after 16 weeks of treatment (P=0.002). Thirty-three percent of the patients in the lamotrigine group and 16 percent of those in the placebo group had a reduction of at least 50 percent in the frequency of seizures (P= 0.01). There were no significant differences between groups in the incidence of adverse events, except for colds or viral illnesses, which was more common in the lamotrigine group (P=0.05). CONCLUSIONS: Lamotrigine was an effective and well-tolerated treatment for seizures associated with the Lennox-Gastaut syndrome.
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Citations
Cites
The Prevalence and Incidence of Convulsive Disorders in Children
Hauser, W. A. (1994) · Epilepsia · doi:10.1111/j.1528-1157.1994.tb05932.x · Cited by 684
Double-blind comparison of lamotrigine and carbamazepine in newly diagnosed epilepsy
Brodie, M. J., UK Lamotrigine/Carbamazepine Monotherapy Trial Group, Richens, A., & Yuen, A. (1995) · The Lancet · doi:10.1016/s0140-6736(95)90581-2 · Cited by 615
GASTAUT, H., ROGER, J., SOULAYROL, R., TASSINARI, C. A., RÉGIS, H., DRAVET, C., BERNARD, R., PINSARD, N., & SAINT‐JEAN, M. (1966) · Epilepsia · doi:10.1111/j.1528-1167.1966.tb06263.x · Cited by 431
Efficacy of Felbamate in Childhood Epileptic Encephalopathy (Lennox-Gastaut Syndrome)
(1993) · New England Journal of Medicine · doi:10.1056/nejm199301073280105 · Cited by 407
Outcomes of Add‐on Treatment with Lamotrigine in Partial Epilepsy
Smith, D., Baker, G., Davies, G., Dewey, M., & Chadwick, D. W. (1993) · Epilepsia · doi:10.1111/j.1528-1157.1993.tb02417.x · Cited by 330
Lamotrigine: A Review of its Pharmacological Properties and Clinical Efficacy in Epilepsy
Goa, K. L., Ross, S. R., & Chrisp, P. (1993) · Drugs · doi:10.2165/00003495-199346010-00009 · Cited by 307
Placebo‐controlled study of the efficacy and safety of lamotrigine in patients with partial seizures
Matsuo, F., Bergen, D., Faught, E., Messenheimer, J. A., Dren, A. T., Rudd, G. D., & Lineberry, C. G. (1993) · Neurology · doi:10.1212/wnl.43.11.2284 · Cited by 280
Messenheimer, J., Ramsay, R. E., Willmore, L. J., Leroy, R. F., Zielinski, J., Mattson, R., Pellock, J. M., Valakas, A. M., Womble, G., & Risner, M. (1994) · Epilepsia · doi:10.1111/j.1528-1157.1994.tb02920.x · Cited by 217
Lamotrigine in Treatment of 120 Children with Epilepsy
Schlumberger, E., Chavez, F., Palacios, L., Rey, E., Pajot, N., & Dulac, O. (1994) · Epilepsia · doi:10.1111/j.1528-1157.1994.tb02445.x · Cited by 211
Cited by
Guerrini, R. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68182-8 · Cited by 848
Chiron, C., Marchand, M., Tran, A., Rey, E., d'Athis, P., Vincent, J., Dulac, O., & Pons, G. (2000) · The Lancet · doi:10.1016/s0140-6736(00)03157-3 · Cited by 568
Lamotrigine‐Associated Rash: Risk/Benefit Considerations in Adults and Children
Guberman, A. H., Besag, F. M. C., Brodie, M. J., Dooley, J. M., Duchowny, M. S., Pellock, J. M., Richens, A., Stern, R. S., & Trevathan, E. (1999) · Epilepsia · doi:10.1111/j.1528-1157.1999.tb00807.x · Cited by 339
Self-citationPatients with Refractory Seizures
Devinsky, O. (1999) · New England Journal of Medicine · doi:10.1056/nejm199905203402008 · Cited by 257
Safety Review of Adult Clinical Trial Experience with Lamotrigine
Messenheimer, J., Mullens, E. L., Giorgi, L., & Young, F. (1998) · Drug Safety · doi:10.2165/00002018-199818040-00004 · Cited by 252
Self-citation
Metadata
- Authors
- Motte, J., Trevathan, E., Arvidsson, J. F. V., Barrera, M. N., Mullens, E. L., & Manasco, P.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1997-12-18
- Volume
- 337
- Issue
- 25
- Pages
- 1807-1812
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2614859754
- Cited by
- 359
- References
- 23
- FWCI
- 16.59
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Motte, J., Trevathan, E., Arvidsson, J. F. V., Barrera, M. N., Mullens, E. L., & Manasco, P. (1997). Lamotrigine for Generalized Seizures Associated with the Lennox–Gastaut Syndrome. New England Journal of Medicine. https://doi.org/10.1056/nejm199712183372504
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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