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Effect of Pneumonia and Whooping Cough in Childhood on Adult Lung Function
Abstract
BACKGROUND: Previous studies have suggested that respiratory infection during childhood is associated with respiratory disease in adulthood, but the link is unclear because of retrospective ascertainment of childhood infection, selection bias, and confounding factors. METHODS: We studied the effects of childhood pneumonia and whooping cough in 1392 British adults followed from birth in 1958. Of these, 193 had a history of pneumonia and 215 a history of whooping cough by the age of seven years. When the subjects were 34 or 35 years old, their forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) were measured before and after they inhaled albuterol. RESULTS: A history of pneumonia was associated with deficits (+/-95 percent confidence limits) in both FEV1 (102+/-73 ml, P=0.006) and FVC (173+/-70 ml, P=0.001) when the analysis was adjusted for sex, height, and smoking, with no change in the ratio of FEV1 to FVC. These deficits persisted after inhalation of albuterol. In subjects with no history of wheezing, the deficit in FEV1 was 155+/-122 ml (P=0.01), in those with past wheezing it was 41+/-128 ml (P=0.53), and in those with current wheezing it was 119+/-133 ml (P=0.08). The effect was no greater for the subjects who had pneumonia at less than two years of age than for those who had it between the ages of two and seven years and was not diminished after control for multiple confounding factors. The deficits associated with whooping cough were smaller (FEV1, 41+/-70 ml; P=0.25; FVC, 81+/-76 ml; P=0.04). CONCLUSIONS: Childhood pneumonia is associated with reduced ventilatory function in adults. This reduction is independent of a history of wheezing and is not explained by other confounding factors.
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“These findings are consistent with large population-based studies of children in the early 1990s,46, 47, 48 which showed a 6–7% increased risk of reduced lung capacity after childhood pneumonia.”
From Global burden of childhood pneumonia and diarrhoea (2013) · cites this paper as [46]
Citations
Cites
Standardization of Spirometry—1987 Update
(1987) · American Review of Respiratory Disease · doi:10.1164/ajrccm/136.5.1285 · Cited by 2,326
Barker, D. J., Godfrey, K. M., Fall, C., Osmond, C., Winter, P. D., & Shaheen, S. O. (1991) · BMJ · doi:10.1136/bmj.303.6804.671 · Cited by 889
Diminished Lung Function as a Predisposing Factor for Wheezing Respiratory Illness in Infants
Martínez, F. D., Morgan, W. J., Wright, A. L., Holberg, C. J., & Taussig, L. M. (1988) · New England Journal of Medicine · doi:10.1056/nejm198810273191702 · Cited by 690
Strachan, D. P., Butland, B. K., & ANDERSON, H. R. (1996) · BMJ · doi:10.1136/bmj.312.7040.1195 · Cited by 654
Self-citationThurlbeck, W. M. (1982) · Thorax · doi:10.1136/thx.37.8.564 · Cited by 610
Pullan, C. R., & Hey, E. N. (1982) · BMJ · doi:10.1136/bmj.284.6330.1665 · Cited by 603
Longitudinal Study of the Effects of Maternal Smoking on Pulmonary Function in Children
Tager, I. B., Weiss, S. T., Muñoz, Á., ROSNER, B. A., & Speizer, F. E. (1983) · New England Journal of Medicine · doi:10.1056/nejm198309223091204 · Cited by 344
Effects of prematurity and intrauterine growth on respiratory health and lung function in childhood.
Rona, R. J., Gulliford, M. C., & Chinn, S. (1993) · BMJ · doi:10.1136/bmj.306.6881.817 · Cited by 274
The relationship of childhood respiratory illness to adult obstructive airway disease.
Burrows, B. A., Knudson, R. J., & Lebowitz, M. D. (1977) · PubMed · doi:10.1164/arrd.1977.115.5.751 · Cited by 273
Samet, J. M., Tager, I. B., & Speizer, F. E. (1983) · American Review of Respiratory Disease · doi:10.1164/arrd.1983.127.4.508 · Cited by 252
Research works printed but not linked: 5
- Burrows B, 1977, Am Rev Respir Dis, 115, 751
- Hasselblad V, 1981, Am Rev Respir Dis, 123, 479
- Leeder SR, 1976, Br J Prev Soc Med, 30, 203
- Johnston IDA, 1986, Am Rev Respir Dis, 134, 270
- Weiss ST, 1995, Eur Respir Rev, 5, 31, 303
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Metadata
- Authors
- Johnston, I. D. A., Strachan, D. P., & Anderson, H. R.
- Affiliations
- Queen's Medical Centre (GB)
- St George's, University of London (GB)
- ORCID
- Strachan, David P.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1998-02-26
- Volume
- 338
- Issue
- 9
- Pages
- 581-587
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2011356989
- Cited by
- 169
- References
- 38
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 6 · 2020: 4 · 2019: 4 · 2018: 6 · 2017: 8 · 2016: 4 · 2015: 6 · 2014: 2 · 2013: 10 · 2012: 6
- FWCI
- 5.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- Topics
- Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Keywords
- pediatric pneumonia, pertussis, adult lung function, respiratory infections, FEV1, forced vital capacity, wheezing, lung function, birth cohort
- MeSH terms
- Adult, Albuterol, Asthma, Child, Child, Preschool, Female, Forced Expiratory Volume, Humans, Infant, Lung Diseases, Male, Pneumonia, Respiratory Sounds, Spirometry, Vital Capacity, Whooping Cough, Cohort Studies
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