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Cited by 169Pneumonia and Respiratory InfectionsAsthma and respiratory diseasesChronic Obstructive Pulmonary Disease (COPD) Research

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

Effect of Pneumonia and Whooping Cough in Childhood on Adult Lung Function

Johnston, Ian D.A., Strachan, David P., Anderson, H. Ross·1998·New England Journal of Medicine
DOI 10.1056/nejm199802263380904
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Abstract

BACKGROUND: Previous studies have suggested that respiratory infection during childhood is associated with respiratory disease in adulthood, but the link is unclear because of retrospective ascertainment of childhood infection, selection bias, and confounding factors. METHODS: We studied the effects of childhood pneumonia and whooping cough in 1392 British adults followed from birth in 1958. Of these, 193 had a history of pneumonia and 215 a history of whooping cough by the age of seven years. When the subjects were 34 or 35 years old, their forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) were measured before and after they inhaled albuterol. RESULTS: A history of pneumonia was associated with deficits (+/-95 percent confidence limits) in both FEV1 (102+/-73 ml, P=0.006) and FVC (173+/-70 ml, P=0.001) when the analysis was adjusted for sex, height, and smoking, with no change in the ratio of FEV1 to FVC. These deficits persisted after inhalation of albuterol. In subjects with no history of wheezing, the deficit in FEV1 was 155+/-122 ml (P=0.01), in those with past wheezing it was 41+/-128 ml (P=0.53), and in those with current wheezing it was 119+/-133 ml (P=0.08). The effect was no greater for the subjects who had pneumonia at less than two years of age than for those who had it between the ages of two and seven years and was not diminished after control for multiple confounding factors. The deficits associated with whooping cough were smaller (FEV1, 41+/-70 ml; P=0.25; FVC, 81+/-76 ml; P=0.04). CONCLUSIONS: Childhood pneumonia is associated with reduced ventilatory function in adults. This reduction is independent of a history of wheezing and is not explained by other confounding factors.

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Crossref · 10.1056/nejm199802263380904

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Citations

Cites

Research works printed but not linked: 5

  1. Burrows B, 1977, Am Rev Respir Dis, 115, 751
  2. Hasselblad V, 1981, Am Rev Respir Dis, 123, 479
  3. Leeder SR, 1976, Br J Prev Soc Med, 30, 203
  4. Johnston IDA, 1986, Am Rev Respir Dis, 134, 270
  5. Weiss ST, 1995, Eur Respir Rev, 5, 31, 303

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Metadata

Authors
Johnston, I. D. A., Strachan, D. P., & Anderson, H. R.
Affiliations
  • Queen's Medical Centre (GB)
  • St George's, University of London (GB)
ORCID
Strachan, David P.
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
1998-02-26
Volume
338
Issue
9
Pages
581-587
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejm199802263380904
OpenAlex
W2011356989
Cited by
169
References
38
Citations by year
2026: 2 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 6 · 2020: 4 · 2019: 4 · 2018: 6 · 2017: 8 · 2016: 4 · 2015: 6 · 2014: 2 · 2013: 10 · 2012: 6
FWCI
5.21
Type
journal article
Language
en
Open access
closed
Locations
  • New England Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
Wellcome Trust
Topics
  • Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
Keywords
pediatric pneumonia, pertussis, adult lung function, respiratory infections, FEV1, forced vital capacity, wheezing, lung function, birth cohort
MeSH terms
Adult, Albuterol, Asthma, Child, Child, Preschool, Female, Forced Expiratory Volume, Humans, Infant, Lung Diseases, Male, Pneumonia, Respiratory Sounds, Spirometry, Vital Capacity, Whooping Cough, Cohort Studies

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