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Cited by 706

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Molecular Pathogenesis of Cholestasis

Trauner, Michael, Meier, Peter J., Boyer, James L.·1998·New England Journal of Medicine
DOI 10.1056/nejm199810223391707
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Abstract

The formation of bile is a vital function, and its impairment by drugs or infectious, autoimmune, metabolic, or genetic disorders results in the syndrome commonly known as cholestasis.1 The secretion of bile normally depends on the function of a number of membrane transport systems in hepatocytes and bile-duct epithelial cells (cholangiocytes) and on the structural and functional integrity of the bile-secretory apparatus. This review summarizes the molecular defects in hepatocellular membrane transporters that are associated with various forms of cholestatic liver disease in humans.Molecular Mechanisms of Bile FormationBile formation is an osmotic secretory process that is driven by . . .

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Metadata

Authors
Trauner, M., Meier, P. J., & Boyer, J. L.
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
1998-10-22
Volume
339
Issue
17
Pages
1217-1227
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejm199810223391707
OpenAlex
W4293201222
Cited by
706
References
3
FWCI
12.10
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Molecular Pathogenesis of Cholestasis. https://app.cochat.ai/papers/10.1056/nejm199810223391707
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Trauner, M., Meier, P. J., & Boyer, J. L. (1998). Molecular Pathogenesis of Cholestasis. New England Journal of Medicine. https://doi.org/10.1056/nejm199810223391707

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