The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Efficacy of Superovulation and Intrauterine Insemination in the Treatment of Infertility
Open accessAbstract
BACKGROUND: Induction of superovulation with gonadotropins and intrauterine insemination are frequently used to treat infertility. We conducted a large, randomized, controlled clinical trial of these treatments. METHODS: We studied 932 couples in which the woman had no identifiable infertility factor and the man had motile sperm. The couples were randomly assigned to receive intracervical insemination, intrauterine insemination, superovulation and intracervical insemination, or superovulation and intrauterine insemination. Treatment continued for four cycles unless pregnancy was achieved. RESULTS: The 231 couples in the group treated with superovulation and intrauterine insemination had a higher rate of pregnancy (33 percent) than the 234 couples in the intrauterine-insemination group (18 percent), the 234 couples in the group treated with superovulation and intracervical insemination (19 percent), or the 233 couples in the intracervical-insemination group (10 percent). Stratified, discrete-time Cox proportional-hazards analysis showed that the couples in the group treated with superovulation and intrauterine insemination were 3.2 times as likely to become pregnant as those in the intracervical-insemination group (95 percent confidence interval, 2.0 to 5.3) and 1.7 times as likely as those in the intrauterine-insemination group (95 percent confidence interval, 1.2 to 2.6). The couples in the intrauterine-insemination group and in the group treated with superovulation and intracervical insemination were nearly twice as likely to conceive as those in the intracervical-insemination group. CONCLUSIONS: Among infertile couples, treatment with induction of superovulation and intrauterine insemination is three times as likely to result in pregnancy as is intracervical insemination and twice as likely to result in pregnancy as is treatment with either superovulation and intracervical insemination or intrauterine insemination alone.
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Cites
Regression Models and Life-Tables
Cox, D. R. (1972) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1972.tb00899.x · Cited by 39,793
Cited by
Giudice, L. C. (2010) · New England Journal of Medicine · doi:10.1056/nejmcp1000274 · Cited by 1,924
Sperm Morphology, Motility, and Concentration in Fertile and Infertile Men
Guzick, D. S., Overstreet, J. W., Factor-Litvak, P., Brazil, C. K., Nakajima, S. T., Coutifaris, C., Carson, S. A., Cisneros, P., Steinkampf, M. P., Hill, J. A., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa003005 · Cited by 1,336
Self-citationInfertility and the provision of infertility medical services in developing countries
Ombelet, W., Cooke, I., Dyer, S., Serour, G., & Devroey, P. (2008) · Human Reproduction Update · doi:10.1093/humupd/dmn042 · Cited by 720
Endometriosis and infertility: a committee opinion
(2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.05.031 · Cited by 633
Goverde, A. J., McDonnell, J., Vermeiden, J. P., Schats, R., Rutten, F. F., & Schoemaker, J. (2000) · The Lancet · doi:10.1016/s0140-6736(99)04002-7 · Cited by 453
Metadata
- Authors
- Guzick, D. S., Carson, S. A., Coutifaris, C., Overstreet, J. W., Factor-Litvak, P., Steinkampf, M. P., Hill, J. A., Mastroianni, L., Buster, J. E., Nakajima, S. T., Vogel, D. L., & Canfield, R. E.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1999-01-21
- Volume
- 340
- Issue
- 3
- Pages
- 177-183
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2333023845
- Cited by
- 523
- References
- 1
- FWCI
- 22.34
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Guzick, D. S., Carson, S. A., Coutifaris, C., Overstreet, J. W., Factor-Litvak, P., Steinkampf, M. P., Hill, J. A., Mastroianni, L., Buster, J. E., Nakajima, S. T., Vogel, D. L., & Canfield, R. E. (1999). Efficacy of Superovulation and Intrauterine Insemination in the Treatment of Infertility. New England Journal of Medicine. https://doi.org/10.1056/nejm199901213400302
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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