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Hypoglycemia due to an insulin-secreting small-cell carcinoma of the cervix.
Open accessAbstract
Hypoglycemia is a condition commonly seen in the emergency department and is usually caused by insulin or sulfonylurea therapy for diabetes mellitus. Tumor-induced hypoglycemia occurs more rarely and can involve several mechanisms, according to whether the tumor is of pancreatic islet-cell origin or of extrapancreatic, non–islet-cell origin.1 The pancreatic islet beta-cell tumors (insulinomas) cause hypoglycemia by producing excessive insulin. In contrast, non–islet-cell tumors can cause hypoglycemia in any of several ways. They include release by the tumor of insulin-like growth factor II or its high-molecular-weight precursor,2–4 multiple metastases to the liver, massive tumor burden, or rarely, the production of . . .
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Ectopic insulin secretion must be very rare.
“Although seemingly convincing cases have been reported (see Ref. 67), ectopic insulin secretion must be very rare.”
From Evaluation and Management of Adult Hypoglycemic Disorders: An Endocrine Society Clinical Practice Guideline (2009) · cites this paper as [67]
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Metadata
- Authors
- Seckl, M. J., Mulholland, P. J., Bishop, A. E., Teale, J. D., Hales, C. N., Glaser, M., Watkins, S., & Seckl, J. R.
- Affiliations
- Imperial College London (GB)
- Royal Surrey County Hospital (GB)
- University of Cambridge (GB)
- Western General Hospital (GB)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1999-09-02
- Volume
- 341
- Issue
- 10
- Pages
- 733-736
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2021517668
- Cited by
- 75
- References
- 24
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 5 · 2019: 1 · 2018: 1 · 2017: 5 · 2016: 1 · 2015: 7 · 2014: 3 · 2013: 2 · 2012: 1
- FWCI
- 2.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Neuroendocrine Tumor Research Advances
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
- Keywords
- tumor-induced hypoglycemia, small cell carcinoma, cervical cancer, insulin secretion, insulin-like growth factor II, liver metastasis, tumor burden
- MeSH terms
- Insulin Secretion, Adult, C-Peptide, Uterine Cervical Neoplasms, Female, Glucose, Humans, Hypoglycemia, Insulin, Proinsulin, Fatal Outcome, Carcinoma, Small Cell
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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