The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Uneasy alliance—clinical investigators and the pharmaceutical industry
Abstract
Clinical practice is changing rapidly. New cardiovascular drugs, antiinflammatory drugs, cancer chemotherapy, and other pharmacologic weapons are being added to physicians' therapeutic armamentarium virtually daily. Most clinical studies that bring new drugs from bench to bedside are financed by pharmaceutical companies. Many of these drug trials are rigorously designed, employing the skills of outstanding clinical researchers at leading academic institutions.But academic medical centers are no longer the sole citadels of clinical research. The past 10 years have seen the spectacular growth of a new research model. Commercially oriented networks of contract-research organizations (CROs) and site-management organizations (SMOs) have altered . . .
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“COVID-19 case surges may cause disruption over a wide spectrum of societal and healthcare system activities. 1,385 387”
From European Resuscitation Council Guidelines 2021: Ethics of resuscitation and end of life decisions (2021) · cites this paper as [387]
Citations
Cites
Conflict of Interest in the Debate over Calcium-Channel Antagonists
Stelfox, H. T., Chua, G., O'Rourke, K., & Detsky, A. S. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801083380206 · Cited by 615
Source of funding and outcome of clinical trials
Davidson, R. A. (1986) · Journal of General Internal Medicine · doi:10.1007/bf02602327 · Cited by 397
Problems in the Design and Reporting of Trials of Antifungal Agents Encountered During Meta-analysis
Johansen, H. K. (1999) · JAMA · doi:10.1001/jama.282.18.1752 · Cited by 128
Research works printed but not linked: 29
- Cho MK, 1996, Ann Intern Med, 124, 485, 10.7326/0003-4819-124-5-199603010-00004 · DOI
- 10.1001/jama.282.15.1453 · DOI
- Chow S-C, Liu J-P. Design and analysis of clinical trials. New York: John Wiley, 1998.
- 10.1001/jama.282.8.786 · DOI
- 10.1001/jama.282.20.1947 · DOI
- 1997, CenterWatch, 4, 1, 9
- Henderson L, 1999, CenterWatch, 6, 1, 4
- Vogel JR, 1999, Appl Clin Trials, 8, 56
- 1997, CenterWatch, 4, 1
- 10.1017/S0266462300009582 · DOI
- Rochon PA, 1998, CMAJ, 159, 1373
- 10.1001/archinte.154.2.157 · DOI
- 10.1001/jama.282.8.790 · DOI
- 10.1001/jama.277.15.1224 · DOI
- 10.1001/jama.263.10.1405 · DOI
- 10.1056/NEJM199808133390701 · DOI
- Phillips RA, 1998, CMAJ, 159, 955
- 10.1001/jama.277.15.1238 · DOI
- 10.1001/jama.277.4.297a · DOI
- 10.1016/S0140-6736(05)75272-7 · DOI
- 10.1016/S0140-6736(05)80075-3 · DOI
- 10.1001/jama.271.6.469 · DOI
- 10.1056/NEJM199409083311012 · DOI
- 10.1001/jama.280.3.222 · DOI · Paper page
- 10.1001/jama.277.11.927 · DOI
- 10.1056/NEJM199812173392512 · DOI
- Kunin CM, 1978, Ann Intern Med, 89, 842, 10.7326/0003-4819-89-5-842 · DOI
- 10.1001/jama.278.3.245 · DOI
- 10.1056/NEJM200005183422009 · DOI
Cited by
Sorted by citations
Items 601–641 of 641
Helmchen, H. (2013) · Springer eBooks · doi:10.1007/978-3-642-35055-9_5
Ethics in Biomedical Research and Practice
Plutynski, A. (2013) · History, philosophy and theory of the life sciences · doi:10.1007/978-94-007-6537-5_30
Conflitto di interessi: Considerazioni e raccomandazioni
Pelaia, P., Adrario, E., & Buglioni, L. (2012) · doi:10.1007/978-88-470-2793-0_24
Alfonso, F., Timmis, A., Pinto, F. J., Ambrosio, G., Ector, H., Kułakowski, P., & Vardas, P. E. (2012) · Rational Pharmacotherapy in Cardiology · doi:10.20996/1819-6446-2012-8-2-132-140
Alfonso, F., Timmis, A., Pinto, F. J., Ambrosio, G., Ector, H., Kułakowski, P., & Vardas, P. (2012) · Circulation Journal · doi:10.1016/j.rec.2012.02.001
“28 This could be a result of their ability to complete trials more rapidly than academic institutions.(8,25) This phenomenon explains the gradual loss of the academic establishment’s influence on the ‘research agenda’.”
BackgroundGhost-authors, improvement article communication, and medical publications.
Matías-Guíu, J., & García-Ramos, R. (2011) · Neurología (English Edition) · doi:10.1016/s2173-5808(11)70056-6
[Clinical practice guidelines and pulmonary hypertension: more disagreements than facts].
Laffaye, N., & Comignani, P. (2009) · Revista Española de Cardiología · doi:10.1016/s1885-5857(09)71523-3
Guías de práctica clínica en la hipertensión pulmonar: más conflictos que evidencia
Laffaye, N., & Comignani, P. (2009) · doi:10.1016/s0300-8932(09)70030-2
Harrington, B. (2008) · doi:10.31390/gradschool_theses.83
“This study‟s data may also benefit the in-house and contract research organizations of the pharmaceutical industry (Yen, 22 June 2001, ¶ 1) by introducing new facets of direct-to-consumer advertising for future study (Bodenheimer, 2000, ¶ 1).”
BackgroundEthical Issues in Clinical Research
Colby, K. A. (2008) · Elsevier eBooks · doi:10.1016/b978-1-4160-0016-7.50418-5 · Cited by 1
Scientific data from clinical trials: Investigators’ responsibilities and rights
Polk, H., Bowden, T., Rikkers, L., Balch, C., Organ, C., Murie, J., Pories, W., Buechler, M., Neoptolemos, J., Fazio, V., et al. (2007) · Annals of Surgical Oncology · doi:10.1007/bf02557260
21 – Gestión de la investigación biomédica en los hospitales
Trilla, A., Gomis, R., & Rodés, J. (2006) · doi:10.1016/b978-84-458-1666-0.50021-6
de Almeida, A. D., & Mattos, Z. P. D. B. (2005) · doi:10.1590/s1414-753x2005000100007
Sargent, M. (2005) · Cambridge University Press eBooks · doi:10.1017/cbo9780511546419.017
Experiencesin UteroAffect Later Life
Sargent, M. G. (2005) · Cambridge University Press eBooks · doi:10.1017/cbo9780511546419.006
Epilogue: Signposts to “Wonderland”
Sargent, M. G. (2005) · Cambridge University Press eBooks · doi:10.1017/cbo9780511546419.016
Sargent, M. G. (2005) · Cambridge University Press eBooks · doi:10.1017/cbo9780511546419.004
Sargent, M. G. (2005) · Cambridge University Press eBooks · doi:10.1017/cbo9780511546419.005
Sargent, M. G. (2005) · Cambridge University Press eBooks · doi:10.1017/cbo9780511546419.010
Cancer and the Body Plan: A Darwinian Struggle
Sargent, M. G. (2005) · Cambridge University Press eBooks · doi:10.1017/cbo9780511546419.009
Sargent, M. G. (2005) · Cambridge University Press eBooks · doi:10.1017/cbo9780511546419.001
Are Devastating Epidemics Still Possible?
Sargent, M. G. (2005) · Cambridge University Press eBooks · doi:10.1017/cbo9780511546419.011
Discovering Medicines: Infinite Variety through Chemistry
Sargent, M. G. (2005) · Cambridge University Press eBooks · doi:10.1017/cbo9780511546419.012
Protein Medicines from Gene Technology
Sargent, M. G. (2005) · Cambridge University Press eBooks · doi:10.1017/cbo9780511546419.013
Sargent, M. G. (2005) · Cambridge University Press eBooks · doi:10.1017/cbo9780511546419.014
Infection, Nutrition, and Poisons: Avoiding an Unhealthy Life
Sargent, M. G. (2005) · Cambridge University Press eBooks · doi:10.1017/cbo9780511546419.007
Learning to Breed Successfully
Sargent, M. G. (2005) · Cambridge University Press eBooks · doi:10.1017/cbo9780511546419.003
Living with the Genetic Legacy
Sargent, M. G. (2005) · Cambridge University Press eBooks · doi:10.1017/cbo9780511546419.015
Signs of Ageing: When Renovation Slows
Sargent, M. G. (2005) · Cambridge University Press eBooks · doi:10.1017/cbo9780511546419.008
Challenges, Risks, and Rewards: Learning to Control Our Biological Fate
Sargent, M. G. (2005) · Cambridge University Press eBooks · doi:10.1017/cbo9780511546419.002 · Cited by 2
El reto de las enfermedades infecciosas al paradigma biomédico
Autor, S. (2005) · Complutensian Scientific Journals (Complutense University of Madrid) · doi:10.5209/noma.27884
Pallàs, J. M. A., & Villa, J. J. (2004) · Elsevier eBooks · doi:10.1016/b978-84-8174-709-6.50003-8 · Cited by 3
Joint policy statement of surgical journals
Macfadyen, B., & Tompkins, R. (2003) · Pediatric surgery international (Print) · doi:10.1007/s00383-002-0904-2
Brimonidine and latanoprost as adjunctive therapy.
Camras, C. (2003) · Ophthalmology (Rochester, Minn.) · doi:10.1016/s0161-6420(02)01553-1
Scientific data from clinical trials: investigators' responsibilities and rights.
Polk, H., Bowden, T., Rikkers, L., Balch, C., Organ, C., Murie, J., Pories, W., Büchler, M., Neoptolemos, J., Fazio, V., et al. (2002) · British Journal of Surgery · doi:10.1006/jsre.2002.6456
Scientific data from clinical trials: investigators' responsibilities and rights.
Polk, H., Bowden, T., Rikkers, L., Balch, C., Organ, C., Murie, J., Pories, W., Buechler, M. W., Neoptolemos, J., Faxio, V. W., et al. (2002) · Journal of Gastrointestinal Surgery · doi:10.1053/jpsu.20020809
Scientific data from clinical trials
Polk, H., Bowden, T., Rikkers, L., Balch, C., Organ, C., Murie, J., Pories, W., Buechler, M., Neoptolemos, J., Fazio, V., et al. (2002) · Surgical Endoscopy · doi:10.1007/s00464-002-0004-3
“According to recent reports [1-3, 5-9], there are increasing concerns about the control of scientific data obtained from clinical trials sponsored by industry.”
Scientific data from clinical trials: investigators' responsibilities and rights.
Polk, H., Bowden, T., Rikkers, L., Balch, C., Organ, C., Murie, J., Pories, W., Buechler, M., Neoptolemos, J., Fazio, V., et al. (2002) · Archives of Surgery · doi:10.1067/mva.2002.123717
Polk, H., Bowden, T., Rikkers, L., Balch, C., Organ, C., Murie, J., Pories, W., Buechler, M., Neoptolemos, J., Fazio, V., et al. (2002) · American Journal of Surgery · doi:10.1016/s0002-9610(02)00873-5
Regulating Ethical Research Involving Cognitively Impaired Elderly Subjects
Tomossy, G. F., Weisstub, D., & Gauthier, S. (2001) · International library of ethics, law, and the new medicine/The international library of ethics, law, and the new medicine · doi:10.1007/978-94-015-9682-4_12
Sobre nuevas proposiciones terapéuticas antimicrobianas
Lurie, P. H. P. C. D., Wolfe, S., Chávez, A., Mendoza, C., Rojas, C., Boghero, A., Cerpa, R., Hobermann, A., Walde, R., HickeyR, W., et al. (2000) · Revista chilena de infectología · doi:10.4067/s0716-10182000000400012
Self-citation
Metadata
- Authors
- Bodenheimer, T.
- Corresponding author
- Bodenheimer, Thomas
- ORCID
- Bodenheimer, Thomas
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2000-05-18
- Volume
- 342
- Issue
- 20
- Pages
- 1539-1544
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2337821671
- Cited by
- 765
- References
- 0
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 8 · 2022: 10 · 2021: 10 · 2020: 17 · 2019: 11 · 2018: 14 · 2017: 18 · 2016: 11 · 2015: 14 · 2014: 20 · 2013: 31 · 2012: 34
- FWCI
- 51.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- DigitalGeorgetown (Georgetown University Library) (submittedVersion)
- Topics
- Health Sciences › Nursing › Issues, ethics and legal aspects › Pharmaceutical industry and healthcare
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Health and Medical Research Impacts
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Pharmaceutical Economics and Policy
- Keywords
- clinical investigators, pharmaceutical industry, contract research organizations, academic medical centers, clinical trials, conflicts of interest, drug development
- MeSH terms
- Academic Medical Centers, Authorship, Clinical Trials as Topic, Drug Evaluation, Drug Industry, Interinstitutional Relations, Publishing, Research Support as Topic, Social Change, United States, United States Food and Drug Administration, Conflict of Interest, Drug Approval, Disclosure, Contracts, Biomedical Research
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
