Angiotensin-Receptor Blockers, Type 2 Diabetes, and Renoprotection
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Statins and angiotensin type 1 receptor blockers lower oxidative stress and inflammation and thereby improve endothelial function.
“Statins and angiotensin type 1 receptor blockers have been shown to reduce oxidative stress and inflammation, improving endothelial function.”
Statins and AT-1 receptor blockers are commonly prescribed to prevent cardiovascular disease and diabetic complications, and their ancillary effects have been attributed to strong intracellular antioxidant activity.
“Statins and angiotensin type 1 (AT-1) receptor blockers are widely used in preventing CVD and diabetic complications, and it has been suggested that many of their ancillary effects are due to strong intracellular antioxidant activity.”
Statins and AT-1 receptor blockers protect endothelial function and reduce inflammation in diabetic and nondiabetic subjects, an effect convincingly attributed to their intracellular antioxidant activity.
“Statins and AT-1 receptor blockers protect endothelial function and reduce inflammation in diabetic and nondiabetic subjects, and these effects are convincingly mediated through their intracellular antioxidant activity.”
Cites
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The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes
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[Effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes].
Parving, H., Lehnert, H., Brøchner‐Mortensen, J., Gomis, R., Andersen, S., & Arner, P. (2001) · PubMed · Cited by 2,527 · see citing works
Oxidative Stress and Diabetic Vascular Complications
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Self-citationZhang, H. (1999) · Cardiovascular Research · doi:10.1016/s0008-6363(99)00183-2 · Cited by 296 · see citing works
Angiotensin II induces superoxide anion production by mesangial cells
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Are ACE Inhibitors a “Magic Bullet” Against Oxidative Stress?
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Defective intracellular antioxidant enzyme production in type 1 diabetic patients with nephropathy.
Ceriello, A., Morocutti, A., Mercuri, F., Quagliaro, L., Moro, M., Damante, G., & Viberti, G. C. (2000) · Diabetes · doi:10.2337/diabetes.49.12.2170 · Cited by 209 · see citing works
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Prevention of End-Stage Renal Disease Due to Type 2 Diabetes
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Ceriello, A., & Motz, E. (2004) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000122852.22604.78 · Cited by 1,378 · see citing works
Self-citationCeriello, A. (2003) · Diabetes Care · doi:10.2337/diacare.26.5.1589 · Cited by 734 · see citing works
Self-citationCeriello, A., Assaloni, R., Da Ros, R., Maier, A., Piconi, L., Quagliaro, L., Esposito, K., & Giugliano, D. (2005) · Circulation · doi:10.1161/01.cir.0000165070.46111.9f · Cited by 298 · see citing works
Self-citationCeriello, A. (2006) · Current Opinion in Lipidology · doi:10.1097/01.mol.0000245256.17764.fb · Cited by 75 · see citing works
Self-citationExtracellular microRNAs and endothelial hyperglycaemic memory: a therapeutic opportunity?
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Self-citationCeriello, A., Piconi, L., Esposito, K., & Giugliano, D. (2007) · Diabetes Care · doi:10.2337/dc07-0318 · Cited by 47 · see citing works
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Processes and Outcomes of Care for Diabetic Acute Myocardial Infarction Patients in Ontario
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Effect of irbesartan on nitrotyrosine generation in non-hypertensive diabetic patients
Ceriello, A., Assaloni, R., Da Ros, R., Maier, A., Quagliaro, L., Piconi, L., Esposito, K., & Giugliano, D. (2004) · Diabetologia · doi:10.1007/s00125-004-1487-3 · Cited by 24 · see citing works
Self-citationOxidative stress detection: what for? Part I.
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INVOLVEMENT OF FREE RADICALS IN CARDIOVASCULAR COMPLICATION IN TYPE 2 DIABETES - A REVIEW
Kakadiya, J., & Township, A. (2009)
Bhuiyan, A. M., Hasan, K. M., Saha, P. P., Rahman, H. R., Sultana, Z., & Haq, M. T. (2020) · Journal of Current and Advance Medical Research · doi:10.3329/jcamr.v7i1.46422
Is nierfalen bij type-2- diabetes te voorkomen met angiotensine-II-receptorantagonisten?
(2002) · Medisch-Farmaceutische Mededelingen · doi:10.1007/bf03058043
- Authors
- Ceriello, A., & Motz, E.
- Corresponding author
- Antonio Ceriello
- ORCID
- Antonio Ceriello
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2002-02-28
- Volume
- 346
- Issue
- 9
- Pages
- 705-707
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2408970236
- Cited by
- 16
- References
- 15
- Citations by year
- 2020: 1 · 2016: 1
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System (University of Udine) (submittedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Keywords
- angiotensin receptor blockers, type 2 diabetes, renal protection, diabetic nephropathy, renin-angiotensin system
- MeSH terms
- Antihypertensive Agents, Blood Pressure, Diabetes Mellitus, Type 2, Diabetic Nephropathies, Humans, Hypertension, Angiotensin Receptor Antagonists
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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