Rifampin-Induced Hypothyroidism in Patients with Hashimoto's Thyroiditis
Abstract
To the Editor: Rifampin is often used to treat tuberculosis.1 Isley2 reported on a patient with treated hypothyroidism (euthyroid while taking stable doses of thyroxine) but who again became hypothyroid after receiving rifampin. We now report on three euthyroid patients with Hashimoto's thyroiditis who became frankly hypothyroid after the administration of rifampin. A 62-year-old man with recurrent non-Hodgkin's lymphoma was admitted one month before the onset of a productive cough. He had been euthyroid (thyrotropin level, 2.0 to 2.4 mU per liter) but had positive tests for antithyroid antibodies (thyroid peroxidase antibody level, 28 U per milliliter [normal value, <6.7]; . . .
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Case reports in a single athyreotic patient and three patients with Hashimoto's hypothyroidism document a substantially increased TSH and subsequent need for increased LT4 dose with introduction of rifampin.
“Case reports in a single athyreotic patient (184) and three patients with Hashimoto's hypothyroidism (185) document a substantially increased TSH and subsequent need for increased LT4 dose with introduction of rifampin.”
From Guidelines for the Treatment of Hypothyroidism: Prepared by the American Thyroid Association Task Force on Thyroid Hormone Replacement (2014) · cites this paper as [185]
Cites
Zulewski, H., Müller, B., Exer, P., Miserez, A. R., & Staub, J.-J. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.3.3810 · Cited by 389 · see citing works
Management of Tuberculosis in the United States
Small, P. M., & Fujiwara, P. I. (2001) · New England Journal of Medicine · doi:10.1056/nejm200107193450307 · Cited by 372 · see citing works
Ferretti, E., Persani, L., Jaffrain-Rea, M.-L., Giambona, S., Tamburrano, G., & Beck-Peccoz, P. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.3.5553 · Cited by 134 · see citing works
A link between liver microsomal enzyme activity and thyroid hormone metabolism in man.
Ohnhaus, E. E., & Studer, H. (1983) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1983.tb01466.x · Cited by 71 · see citing works
The effect of antipyrine, phenobarbitol and rifampicin on thyroid hormone metabolism in man
OHNHAUS, E. E., BÜRGI, H., BURGER, A., & STUDER, H. (1981) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1981.tb02000.x · Cited by 50 · see citing works
ISLEY, W. L. (1987) · Annals of Internal Medicine · doi:10.7326/0003-4819-107-4-517 · Cited by 46 · see citing works
Effects of rifampicin on the peripheral turnover kinetics of thyroid hormones in mice in men
Finke, C. M., Juge, C., Goumaz, M., et al. (1987) · Journal of Endocrinological Investigation · doi:10.1007/bf03347182 · Cited by 9 · see citing works
[Thyroid hormone resistance: variable clinical manifestations in five patients].
Reinhardt, W., Jockenhövel, F., Deuble, J., Chatterjee, K., REINWEIN, D., & Mann, K. (1997) · PubMed · Cited by 7 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Jonklaas, J., Bianco, A. C., Bauer, A. J., Burman, K. D., Cappola, A. R., Celi, F. S., Cooper, D. S., Kim, B. W., Peeters, R. P., Rosenthal, M. S., et al. (2014) · Thyroid® · doi:10.1089/thy.2014.0028 · Cited by 1,928 · see citing works
“Case reports in a single athyreotic patient (184) and three patients with Hashimoto’s hypothyroidism (185) document a substantially increased TSH and subsequent need for increased LT4 dose with introduction of rifampin.”
Imatinib induces hypothyroidism in patients receiving levothyroxine
DEGROOT, J., ZONNENBERG, B., PLUKKER, J., VANDERGRAAF, W., & LINKS, T. (2005) · Clinical Pharmacology & Therapeutics · doi:10.1016/j.clpt.2005.06.010 · Cited by 159 · see citing works
Thyroid Dysfunction as an Unintended Side Effect of Anticancer Drugs
Torino, F., Barnabei, A., Paragliola, R., Baldelli, R., Appetecchia, M., & Corsello, S. M. (2013) · Thyroid® · doi:10.1089/thy.2013.0241 · Cited by 117 · see citing works
Drug-induced endocrine disorders in the intensive care unit
Thomas, Z., Bandali, F., McCowen, K., & Malhotra, A. (2010) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181dda0f2 · Cited by 30 · see citing works
Drugs and Other Substances Interfering with Thyroid Function
Montanelli, L., Benvenga, S., Hegedüs, L., Vitti, P., Latrofa, F., & Duntas, L. H. (2018) · Endocrinology · doi:10.1007/978-3-319-45013-1_27 · Cited by 18 · see citing works
- Authors
- Takasu, N., Takara, M., & Komiya, I.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2005-02-03
- Volume
- 352
- Issue
- 5
- Pages
- 518-519
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2000438548
- Cited by
- 27
- References
- 8
- Citations by year
- 2018: 3 · 2015: 1 · 2014: 2 · 2013: 2 · 2012: 2
- FWCI
- 2.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Keywords
- rifampicin, drug-induced hypothyroidism, Hashimoto's thyroiditis, thyroid autoantibodies, thyroid peroxidase antibodies, tuberculosis treatment, thyroxine
- MeSH terms
- Aged, Antibiotics, Antitubercular, Female, Humans, Hypothyroidism, Male, Middle Aged, Rifampin, Thyroid Hormones, Thyroiditis, Autoimmune, Tuberculosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
