Effect of Rifampin Therapy on Thyroid Function Tests in a Hypothyroid Patient on Replacement L-Thyroxine
Abstract
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Case reports in a single athyreotic patient and three patients with Hashimoto's hypothyroidism document a substantially increased TSH and subsequent need for increased LT4 dose with introduction of rifampin.
“Case reports in a single athyreotic patient (184) and three patients with Hashimoto's hypothyroidism (185) document a substantially increased TSH and subsequent need for increased LT4 dose with introduction of rifampin.”
From Guidelines for the Treatment of Hypothyroidism: Prepared by the American Thyroid Association Task Force on Thyroid Hormone Replacement (2014) · cites this paper as [184]
Cites
Thyroxine Metabolism in the Low Thyroxine State of Critical Nonthyroidal Illnesses*
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Gregerman, R. I., & Solomon, N. A. (1967) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-27-1-93 · Cited by 86 · see citing works
Interaction of Chronic Daily Warfarin Therapy and Rifampin
O’Reilly, R. A. (1975) · Annals of Internal Medicine · doi:10.7326/0003-4819-83-4-506 · Cited by 77 · see citing works
A link between liver microsomal enzyme activity and thyroid hormone metabolism in man.
Ohnhaus, E. E., & Studer, H. (1983) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1983.tb01466.x · Cited by 71 · see citing works
Hypothyroidism induced by anti-epileptic therapy
Aanderud, S., & Strandjord, R. E. (2009) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1980.tb01501.x · Cited by 57 · see citing works
Brent, G. A., Hershman, J. M., & Braunstein, G. D. (1986) · The American Journal of Medicine · doi:10.1016/0002-9343(86)90300-1 · Cited by 54 · see citing works
The effect of antipyrine, phenobarbitol and rifampicin on thyroid hormone metabolism in man
OHNHAUS, E. E., BÜRGI, H., BURGER, A., & STUDER, H. (1981) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1981.tb02000.x · Cited by 50 · see citing works
Thyroxine Replacement Requirements in Hypothyroid Patients Receiving Phenytoin
BLACKSHEAR, J. L., SCHULTZ, A. L., NAPIER, J. S., & STUART, D. D. (1983) · Annals of Internal Medicine · doi:10.7326/0003-4819-99-3-341 · Cited by 41 · see citing works
Abnormalities in Thyroid Function Tests in Patients Admitted to a Medical Service
Gooch, B. R. (1982) · Archives of Internal Medicine · doi:10.1001/archinte.1982.00340230041008 · Cited by 35 · see citing works
The effect of different doses of rifampicin on thyroid hormone metabolism [proceedings]
Ee, O., & Studer, H. (1980) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1980.tb04845.x · Cited by 9 · see citing works
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Jonklaas, J., Bianco, A. C., Bauer, A. J., Burman, K. D., Cappola, A. R., Celi, F. S., Cooper, D. S., Kim, B. W., Peeters, R. P., Rosenthal, M. S., et al. (2014) · Thyroid® · doi:10.1089/thy.2014.0028 · Cited by 1,928 · see citing works
“Case reports in a single athyreotic patient (184) and three patients with Hashimoto’s hypothyroidism (185) document a substantially increased TSH and subsequent need for increased LT4 dose with introduction of rifampin.”
Roberts, C. G., & Ladenson, P. W. (2004) · The Lancet · doi:10.1016/s0140-6736(04)15696-1 · Cited by 567 · see citing works
Medications and Food Interfering with the Bioavailability of Levothyroxine: A Systematic Review
Liu, H., Lu, M., Hu, J., Fu, G., Feng, Q., Sun, S., & Chen, C. (2023) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s414460 · Cited by 29 · see citing works
Rifampin-Induced Hypothyroidism in Patients with Hashimoto's Thyroiditis
Takasu, N., Takara, M., & Komiya, I. (2005) · New England Journal of Medicine · doi:10.1056/nejm200502033520524 · Cited by 27 · see citing works
Ciprofloxacin and Rifampin have opposite effects on levothyroxine absorption
Goldberg, A. S., Tirona, R. G., Asher, L. J., Kim, R. B., & Van Uum, S. H. M. (2013) · Thyroid · doi:10.1089/thy.2013.0014 · Cited by 25 · see citing works
Effect of Rifampin on Thyroid Function Test in Patients on Levothyroxine Medication
Kim, H. I., Kim, T. H., Kim, H., Kim, Y. N., Jang, H. W., Chung, J. H., Moon, S. M., Jhun, B. W., Lee, H., Koh, W.-J., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0169775 · Cited by 16 · see citing works
- Authors
- ISLEY, W. L.
- Affiliations
- University of Missouri–Kansas City (US)
- Corresponding author
- ISLEY, WILLIAM L.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1987-10-01
- Volume
- 107
- Issue
- 4
- Pages
- 517-518
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W1990912058
- Cited by
- 46
- References
- 10
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 1 · 2013: 1 · 2012: 1
- FWCI
- 0.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Keywords
- rifampicin, thyroid function tests, hypothyroidism, levothyroxine, drug interactions, antithyroid drug therapy
- MeSH terms
- Adult, Female, Humans, Hypothyroidism, Rifampin, Thyroid Function Tests, Thyroidectomy, Thyrotropin, Thyroxine
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