Vitamin D–Binding Protein Concentrations Quantified by Mass Spectrometry

Hoofnagle, Andrew N.; Eckfeldt, John H.; Lutsey, Pamela L.

doi:10.1056/nejmc1502602

Cited by 103Vitamin D Research StudiesClinical practice guidelines implementationClinical Laboratory Practices and Quality Control

Vitamin D–Binding Protein Concentrations Quantified by Mass Spectrometry

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Hoofnagle, Andrew N., Eckfeldt, John H., Lutsey, Pamela L.·2015·New England Journal of Medicine

DOI 10.1056/nejmc1502602PMC PMC4654614

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Abstract

Medical Facts vs. Value JudgmentsTo the Editor: In his Perspective article (June 25 issue), 1 Ubel contends that the National Comprehensive Cancer Network (NCCN) guidelines fail to consider patient preferences and values.Clinical practice guidelines are designed to assist physicians and patients in decision making in specific clinical circumstances and do not remove the physician's or patient's autonomy in decision making, nor do they eliminate the need for shared decision making between patient and physician.The NCCN guidelines were the first in oncology to incorporate patient preference in decision making.Patient advocates with full voice and vote serve on many NCCN guidelines panels, transparency procedures are in place, and the NCCN has patient versions of selected guidelines.The NCCN is developing evidence blocks to provide patients and physicians with additional information that will stimulate discussion on patient preferences and values.These evidence blocks provide information on options for therapy, including efficacy, safety (toxicity), quality of data, consistency of data, and affordability (cost).The NCCN shares Ubel's conviction that patient preferences and values should be incorporated into the application of clinical practice guidelines and is actively evolving the NCCN guidelines to better accomplish that goal.

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Genomic sequence variation can lead to differing peptide sequences in the population.
“Genomic sequence variation can lead to differing peptide sequences in the population.(25–27)”
From Putting humpty dumpty back together again: what does protein quantification mean in bottom-up proteomics? (2022) · cites this paper as [26]

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Authors: Hoofnagle, A. N., Eckfeldt, J. H., & Lutsey, P. L.
Affiliations: University of Washington (US)
University of Minnesota (US)
ORCID: Hoofnagle, Andrew N.
Lutsey, Pamela L.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2015-10-08
Volume: 373
Issue: 15
Pages: 1480-1482
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmc1502602
PMC: PMC4654614
OpenAlex: W2255476880
Cited by: 103
References: 5
Citations by year: 2026: 3 · 2025: 4 · 2024: 5 · 2023: 2 · 2022: 3 · 2021: 14 · 2020: 16 · 2019: 15 · 2018: 12 · 2017: 14 · 2016: 15
FWCI: 10.86
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: U.S. Public Health Service (HHSN2682 01100010C, HHSN268201100007 C, HHSN2682011-00008C, HHSN268201100 006C, HHSN2682‐01100011C, HHSN2682HHSN268201100012C, HHSN268201100009C, HHSN 268201100005C)
National Heart, Lung, and Blood Institute (HHSN268201 100012C, HHSN268201100007I, HHSN268201100007C, HHSN2682 01100008C, HH-SN-268201100006C, HHSN268201100011C, HHSN2682011-00005I, HHSN2682011-00009I, HHSN268201100005C, HHSN268201100005G, HHSN268201100010C, HL103706, HHSN268201100011I, HHSN26820 1100009C, HL103706-S1, HHSN2682011-00008I, R01HL103706)
National Cancer Institute (U24CA160034)
National Institute of Diabetes and Digestive and Kidney Diseases (DK 035816, P30DK035816)
Topics: Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Clinical practice guidelines implementation
Health Sciences › Medicine › Physiology › Clinical Laboratory Practices and Quality Control
Keywords: vitamin D binding protein, serum protein quantification, mass spectrometry, patient preferences, shared decision-making, NCCN guidelines
MeSH terms: Black or African American, Chromatography, Liquid, Haplotypes, Humans, Immunoassay, Polymorphism, Genetic, Vitamin D Deficiency, Vitamin D-Binding Protein, Tandem Mass Spectrometry

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Vitamin D–Binding Protein Concentrations Quantified by Mass Spectrometry

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