Rociletinib in EGFR-Mutated Non–Small-Cell Lung Cancer
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Rociletinib is a specific mutant agent for the treatment of NSCLC, belonging to the third-generation EGFR TKIs, developed by Clovis Oncology.
“Rociletinib (XegafriTM, CO-1686) (65), developed by Clovis Oncology, is a specific mutant agent for the treatment of NSCLC, belonging to the third-generation EGFR TKIs.190,191”
From Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials (2023) · cites this paper as [191]
Second- and third-generation TKIs are available for tumors with certain EGFR and ALK resistance mutations.
“second- and third-generation TKIs are now available for tumors harboring certain EGFR and ALK resistance mutations (12, 13).”
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- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2015-08-06
- Volume
- 373
- Issue
- 6
- Pages
- 578-579
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W4235389138
- Cited by
- 61
- References
- 4
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 3 · 2022: 3 · 2021: 6 · 2020: 6 · 2019: 4 · 2018: 8 · 2017: 11 · 2016: 15 · 2015: 3
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Treatments and Mutations
- Health Sciences › Medicine › Oncology › HER2/EGFR in Cancer Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Diagnosis and Treatment
- Keywords
- rociletinib, EGFR mutation, non-small cell lung cancer, tyrosine kinase inhibitors, targeted therapy
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