The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Health Effects of Overweight and Obesity in 195 Countries
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Health Effects of Overweight and Obesity in 195 CountriesTo the Editor: The Global Burden of Disease (GBD) collaborators (July 6 issue) 1 report that more than two thirds of deaths related to high body-mass index (BMI) were due to cardiovascular disease, which suggests that BMI-defined obesity has a major effect on cardiovascular disease.Some readers may wonder whether the perceived burden of obesity could have been even larger if an accurate measure of body fat, instead of BMI, had been used.Data from the Aerobics Center Longitudinal Study, involving 30,000 persons assessed with a state-of-the-art method to determine adiposity, suggest that this may not be the case. 2 We observed that BMI had a significantly higher discriminating capacity than bodyfat percentage or fat-mass index for predicting mortality from cardiovascular disease, and our study provided a physiological explanation for this finding.Our data also strongly support the use of BMI for defining obesity at an epidemiologic level, particularly in relation to mortality from cardiovascular disease.Furthermore, these findings suggest that obesity may be defined as an excess of body weight according to height (high BMI), rather than as an excess of body fat (high body-fat percentage or fat-mass index), as is generally stated.3
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“Although obesity is theoretically reversible28, 51, 52 and addressing it could provide the biggest opportunity to limit the advance of diabetes, current trends suggest that obesity rates are likely to continue to climb.45”
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Cites
Health effects of overweight and obesity in 195 countries over 25 years
Collaborators, T. G. 2. O. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1614362 · Cited by 7,918
Body Fatness and Cancer — Viewpoint of the IARC Working Group
Lauby-Secretan, B., Scoccianti, C., Loomis, D., Grosse, Y., Bianchini, F., & Straif, K. (2016) · New England Journal of Medicine · doi:10.1056/nejmsr1606602 · Cited by 3,596
Di Angelantonio, E., Bhupathiraju, S. N., Wormser, D., Gao, P., Kaptoge, S., de Gonzalez, A. B., Cairns, B. J., Huxley, R., Jackson, C. L., Joshy, G., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)30175-1 · Cited by 2,821
Obesity and Cardiovascular Disease
Ortega, F. B., Lavie, C. J., & Blair, S. N. (2016) · Circulation Research · doi:10.1161/circresaha.115.306883 · Cited by 1,254
Okorodudu, D. O., Jumean, M. F., Montori, V. M., Romero-Corral, A., Somers, V. K., Erwin, P. J., & Lopez-Jimenez, F. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.5 · Cited by 1,028
Javed, A., Jumean, M. F., Murad, M. H., Okorodudu, D. E., Kumar, S., Somers, V. K., Sochor, O., & López-Jiménez, F. A. (2014) · Pediatric Obesity · doi:10.1111/ijpo.242 · Cited by 505
Body Mass Index, the Most Widely Used But Also Widely Criticized Index
Ortega, F. B., Sui, X., Lavie, C. J., & Blair, S. N. (2016) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2016.01.008 · Cited by 294
Reilly, J. J., Kelly, J., & Wilson, D. C. (2010) · Obesity Reviews · doi:10.1111/j.1467-789x.2009.00709.x · Cited by 149
Chioléro, A., Paradis, G., Madeleine, G., Hanley, J. A., Paccaud, F. M., & Bovet, P. (2009) · Circulation · doi:10.1161/circulationaha.108.796276 · Cited by 100
Hruschka, D. J., & Hadley, C. (2016) · Obesity Reviews · doi:10.1111/obr.12449 · Cited by 58
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Ong, K. L., Stafford, L. K., McLaughlin, S. A., Boyko, E. J., Vollset, S. E., Smith, A. E., Dalton, B. E., Duprey, J., Cruz, J. A., Hagins, H., et al. (2023) · The Lancet · doi:10.1016/s0140-6736(23)01301-6 · Cited by 4,681
“28,51,52 80 These are important considerations given that in many places in the world, increases in disability due to diabetes have outpaced diabetes mortality.”
Obesity, kidney dysfunction and hypertension: mechanistic links
Hall, J. E., do Carmo, J. M., da Silva, A. A., Wang, Z., & Hall, M. E. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0145-4 · Cited by 654
Global burden of sleep‐disordered breathing and its implications
Lyons, M. M., Bhatt, N. Y., Pack, A. I., & Magalang, U. J. (2020) · Respirology · doi:10.1111/resp.13838 · Cited by 456
m6A mRNA methylation controls autophagy and adipogenesis by targeting Atg5 and Atg7
Wang, X., Wu, R., Liu, Y., Zhao, Y., Bi, Z., Yao, Y., Liu, Q., Shi, H., Wang, F., & Wang, Y. (2019) · Autophagy · doi:10.1080/15548627.2019.1659617 · Cited by 385
A Review of Obesity, Physical Activity, and Cardiovascular Disease
Elagizi, A., Kachur, S. M., Carbone, S., Lavie, C. J., & Blair, S. N. (2020) · Current Obesity Reports · doi:10.1007/s13679-020-00403-z · Cited by 357
Metadata
- Authors
- Afshin, A., Reitsma, M. B., & Murray, C. J. L.
- Affiliations
- Institute for Health Metrics and Evaluation (US)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2017-10-12
- Volume
- 377
- Issue
- 15
- Pages
- 1495-1497
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2766120686
- Cited by
- 219
- References
- 12
- Citations by year
- 2026: 9 · 2025: 19 · 2024: 29 · 2023: 38 · 2022: 31 · 2021: 21 · 2020: 35 · 2019: 26 · 2018: 7 · 2017: 2
- Type
- journal article
- Language
- en
- Open access
- green
- serval.unil.ch
- Licence
- other-oa
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- SERVAL (Université de Lausanne) (publishedVersion, other-oa)
- IRIS (submittedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Physiology (medical) › Body Composition Measurement Techniques
- Keywords
- obesity, overweight, body mass index, cardiovascular mortality, body fat percentage, fat mass index, adiposity measurement, obesity definition, global burden of disease
- MeSH terms
- Cross-Sectional Studies, Developing Countries, Humans, Obesity, Body Mass Index, Prevalence, Overweight
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