Volanesorsen to Prevent Acute Pancreatitis in Hypertriglyceridemia
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The trial findings are consistent with a meta-analysis of three randomized, placebo-controlled trials of volanesorsen, which showed an association between treatment and a reduction in the incidence of acute pancreatitis.
“Our findings are consistent with the results of a meta-analysis of three randomized, placebocontrolled trials of volanesorsen, which showed an association between treatment and a reduction in the incidence of acute pancreatitis. 35”
From Olezarsen, Acute Pancreatitis, and Familial Chylomicronemia Syndrome (2024) · cites this paper as [35]
Cites
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- Authors
- Alexander, V. J., Karwatowska-Prokopczuk, E., Prohaska, T. A., Li, L., Geary, R. S., Gouni-Berthold, I., Oral, E. A., Hegele, R. A., Stroes, E. S. G., Witztum, J. L., & Tsimikas, S.
- Affiliations
- Ionis Pharmaceuticals (United States) (US)
- Ionis Pharmaceuticals, Carlsbad, CA
- University of Cologne, Cologne, Germany
- University of Michigan (US)
- Western University (CA)
- Amsterdam UMC Location University of Amsterdam (NL)
- University of California San Diego (US)
- ORCID
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2024-02
- Volume
- 390
- Issue
- 5
- Pages
- 476-477
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W4391378948
- Cited by
- 85
- References
- 4
- Citations by year
- 2026: 23 · 2025: 39 · 2024: 23
- FWCI
- 35.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Funders
- Ionis Pharmaceuticals
- Topics
- Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- volanesorsen, acute pancreatitis, hypertriglyceridemia, triglyceride-lowering therapy, apolipoprotein C-III, triglyceride-rich lipoproteins
- MeSH terms
- Acute Disease, Humans, Hyperlipidemias, Oligonucleotides, Pancreatitis, Triglycerides, Hypertriglyceridemia
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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