Potential Pitfall of Pluripotent Stem Cells
Abstract
Stem cells (either embryonic or induced) sometimes develop mutations in tumor-suppressor genes in vitro.
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For pluripotent stem cells (ESCs or iPSCs), there appears to be a selection advantage for mutations of some oncogenes, in particular TP53 and BCOR, which can become fixed in culture.
“For pluripotent stem cells—embryonic stem cells (ESCs) or induced pluripotent stem cells (iPSCs)—there appears to be a selection advantage for mutations of some oncogenes, in particular for TP53 and BCOR, which can become fixed in culture74,75.”
From How to design preclinical studies in nanomedicine and cell therapy to maximize the prospects of clinical translation (2018) · cites this paper as [75]
Cites
Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations
Merkle, F. T., Ghosh, S., Kamitaki, N., Mitchell, J., Avior, Y., Mello, C., Kashin, S., Mekhoubad, S., Ilic, D., Charlton, M., et al. (2017) · Nature · doi:10.1038/nature22312 · Cited by 506 · see citing works
Pluripotent stem cells progressing to the clinic
Trounson, A. O., & DeWitt, N. D. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.10 · Cited by 380 · see citing works
Self-citationGaritaonandia, I., Amir, H., Boscolo, F. S., Wambua, G. K., Schultheisz, H. L., Sabatini, K., Morey, R., Waltz, S., Wang, Y.-C., Tran, H., et al. (2015) · PLOS ONE · doi:10.1371/journal.pone.0118307 · Cited by 150 · see citing works
Multiple Roles of p53-Related Pathways in Somatic Cell Reprogramming and Stem Cell Differentiation
Yi, L., Lu, C.-W., Hu, W., Sun, Y., & Levine, A. J. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-1451 · Cited by 85 · see citing works
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Ioannidis, J. P. A., Kim, B. Y. S., & Trounson, A. (2018) · Nature Biomedical Engineering · doi:10.1038/s41551-018-0314-y · Cited by 175 · see citing works
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- Authors
- Trounson, A.
- Affiliations
- Hudson Institute of Medical Research (AU)
- Corresponding author
- Trounson, Alan
- ORCID
- Trounson, Alan
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2017-08-03
- Volume
- 377
- Issue
- 5
- Pages
- 490-491
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2741975582
- Cited by
- 15
- References
- 4
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 5
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › CRISPR and Genetic Engineering
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Keywords
- pluripotent stem cells, induced pluripotent stem cells, embryonic stem cells, tumor suppressor, somatic mutations, in vitro culture, cancer risk
- MeSH terms
- Human Embryonic Stem Cells, Cell Differentiation, Humans, Mutation, Proto-Oncogene Proteins, Repressor Proteins, Genes, p53, Tumor Suppressor Protein p53, Pluripotent Stem Cells, Induced Pluripotent Stem Cells
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