Cited by 1,224Folate and B Vitamins ResearchPorphyrin Metabolism and DisordersHematological disorders and diagnostics

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Vitamin B12Deficiency

Stabler, Sally P.·2013·New England Journal of Medicine

DOI 10.1056/nejmcp1113996

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Abstract

Vitamin B12 deficiency causes reversible megaloblastic anemia, demyelinating disease, or both. Current assays have insufficient sensitivity and specificity; methylmalonic acid levels are useful to confirm diagnosis. Parenteral or high-dose oral vitamin B12 is effective therapy.

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Authors: Stabler, S. P.
Affiliations: University of Colorado Anschutz (US)
Corresponding author: Stabler, Sally P.
ORCID: Stabler, Sally P.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2013-01-10
Volume: 368
Issue: 2
Pages: 149-160
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmcp1113996
OpenAlex: W3215299411
Cited by: 1,224
References: 47
Citations by year: 2026: 104 · 2025: 90 · 2024: 104 · 2023: 98 · 2022: 105 · 2021: 95 · 2020: 121 · 2019: 112 · 2018: 76 · 2017: 80 · 2016: 69 · 2015: 73 · 2014: 60 · 2013: 35
FWCI: 12.54
Type: journal article
Language: en
Open access: closed
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Folate and B Vitamins Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Porphyrin Metabolism and Disorders
Health Sciences › Medicine › Hematology › Hematological disorders and diagnostics
Keywords: vitamin B12 deficiency, megaloblastic anemia, demyelinating disease, methylmalonic acid, sensitivity and specificity, treatment
MeSH terms: Administration, Oral, Anemia, Pernicious, Child, Diagnostic Errors, Female, Homocysteine, Humans, Infant, Infant Nutrition Disorders, Injections, Intestinal Absorption, Methylmalonic Acid, Middle Aged, Paresthesia, Vitamin B 12, Vitamin B 12 Deficiency, Child Nutrition Disorders, Practice Guidelines as Topic

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