Cited by 473Folate and B Vitamins ResearchPorphyrin Metabolism and DisordersMetabolism and Genetic Disorders

Effect of vitamin B12 deficiency on neurodevelopment in infants: current knowledge and possible mechanisms: Nutrition Reviews©, Vol. 66, No. 5

Dror, Daphna K, Allen, Lindsay H·2008·Nutrition Reviews

Abstract

Severe vitamin B(12) deficiency produces a cluster of neurological symptoms in infants, including irritability, failure to thrive, apathy, anorexia, and developmental regression, which respond remarkably rapidly to supplementation. The underlying mechanisms may involve delayed myelination or demyelination of nerves; alteration in the S-adenosylmethionine:S-adenosylhomocysteine ratio; imbalance of neurotrophic and neurotoxic cytokines; and/or accumulation of lactate in brain cells. This review summarizes the current knowledge concerning infantile vitamin B(12) deficiency, including a pooled analysis of case studies of infants born to mothers with untreated pernicious anemia or a strict vegetarian lifestyle and a discussion of the mechanisms that may underlie the manifestations of deficiency.

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Crossref · 10.1111/j.1753-4887.2008.00031.x

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Authors
Dror, D. K., & Allen, L. H.
Affiliations
Western Human Nutrition Research Center (US)
Venue
Nutrition Reviews
Published
2008-05-01
Volume
66
Issue
5
Pages
250-255
ISSN
0029-6643 (ISSN-L)
OpenAlex
W2140719667
Cited by
473
References
59
Citations by year
2026: 26 · 2025: 26 · 2024: 33 · 2023: 35 · 2022: 29 · 2021: 22 · 2020: 31 · 2019: 30 · 2018: 35 · 2017: 29 · 2016: 27 · 2015: 22 · 2014: 20 · 2013: 28 · 2012: 19
FWCI
2.90
Type
journal article
Language
en
Open access
closed
Locations
  • Nutrition Reviews (publishedVersion)
  • PubMed (publishedVersion)
Funders
University of California, Davis
Topics
  • Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Porphyrin Metabolism and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
Keywords
vitamin B12 deficiency, brain development, developmental regression, myelination, demyelination, S-adenosylmethionine, S-adenosylhomocysteine, cytokines, lactate accumulation, pernicious anemia, vegetarian diet
MeSH terms
Adult, Anemia, Pernicious, Brain, Developmental Disabilities, Failure to Thrive, Female, Humans, Infant, Infant Nutritional Physiological Phenomena, Infant, Newborn, Male, Mothers, Nervous System Diseases, Pregnancy, Psychomotor Disorders, Diet, Vegetarian, Vitamin B Complex, Vitamin B 12, Vitamin B 12 Deficiency

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