Case 1-2009: A 57-Year-Old Man with Progressive Cognitive Decline
Abstract
A 57-year-old man was transferred to this hospital because of progressive cognitive decline. Before admission, he had a generalized seizure, after which he was confused, incoherent, and intermittently agitated; he was admitted to another hospital and transferred 5 days later. His wife reported that he had had episodes of confusion for the past 5 years and worsening memory loss and performance problems for the preceding 2 months. He had a history of cutaneous melanoma, alcohol and drug abuse, and occupational exposure to organic solvents. Magnetic resonance imaging of the brain revealed diffuse signal abnormalities in the white matter. A diagnostic procedure was performed.
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Recent reports suggest a substantial risk to develop CALD even at ages higher than 45 years.
“However, while CALD was previously considered to occur only rarely after the age of 45 years, recent reports suggest a substantial risk to develop CALD even at higher ages.27–29”
From The genetic landscape of X-linked adrenoleukodystrophy: inheritance, mutations, modifier genes, and diagnosis (2015) · cites this paper as [28]
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- Authors
- Costello, D. J., Eichler, F. S., Grant, P. E., & Auluck, P. K.
- Affiliations
- Harvard University (US)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2009-01-08
- Volume
- 360
- Issue
- 2
- Pages
- 171-181
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2314837815
- Cited by
- 9
- References
- 27
- Citations by year
- 2022: 1 · 2018: 1 · 2015: 2 · 2012: 1
- FWCI
- 1.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Medical Case Reports and Studies
- Health Sciences › Medicine › Neurology › Autoimmune Neurological Disorders and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- progressive cognitive decline, generalized seizures, confusion, memory loss, white matter abnormalities, cutaneous melanoma, alcohol and drug abuse, organic solvent exposure, neurodegenerative diseases, differential diagnosis
- MeSH terms
- Adrenoleukodystrophy, Biopsy, Brain, Dementia, Diagnosis, Differential, Fatty Acids, Humans, Magnetic Resonance Imaging, Male, Melanoma, Middle Aged, Stereotaxic Techniques, Tomography, X-Ray Computed, Fatal Outcome, Neurotoxicity Syndromes
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