Cited by 2,862Neonatal and fetal brain pathologyThermal Regulation in MedicineInfant Development and Preterm Care

The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.

Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy

Open access

Shankaran, Seetha, Laptook, Abbot R., Ehrenkranz, Richard A., Tyson, Jon E., McDonald, Scott A., Donovan, Edward F., Fanaroff, Avroy A., Poole, W. Kenneth, Wright, Linda L., Higgins, Rosemary D., Finer, Neil N., Carlo, Waldemar A., Duara, Shahnaz, Oh, William, Cotten, C. Michael, Stevenson, David K., Stoll, Barbara J., Lemons, James A., Guillet, Ronnie, Jobe, Alan H.·2005·New England Journal of Medicine

DOI 10.1056/nejmcps050929

Open this paper in CoChat — free account Open PDF

Abstract

BACKGROUND: Hypothermia is protective against brain injury after asphyxiation in animal models. However, the safety and effectiveness of hypothermia in term infants with encephalopathy is uncertain. METHODS: We conducted a randomized trial of hypothermia in infants with a gestational age of at least 36 weeks who were admitted to the hospital at or before six hours of age with either severe acidosis or perinatal complications and resuscitation at birth and who had moderate or severe encephalopathy. Infants were randomly assigned to usual care (control group) or whole-body cooling to an esophageal temperature of 33.5 degrees C for 72 hours, followed by slow rewarming (hypothermia group). Neurodevelopmental outcome was assessed at 18 to 22 months of age. The primary outcome was a combined end point of death or moderate or severe disability. RESULTS: Of 239 eligible infants, 102 were assigned to the hypothermia group and 106 to the control group. Adverse events were similar in the two groups during the 72 hours of cooling. Primary outcome data were available for 205 infants. Death or moderate or severe disability occurred in 45 of 102 infants (44 percent) in the hypothermia group and 64 of 103 infants (62 percent) in the control group (risk ratio, 0.72; 95 percent confidence interval, 0.54 to 0.95; P=0.01). Twenty-four infants (24 percent) in the hypothermia group and 38 (37 percent) in the control group died (risk ratio, 0.68; 95 percent confidence interval, 0.44 to 1.05; P=0.08). There was no increase in major disability among survivors; the rate of cerebral palsy was 15 of 77 (19 percent) in the hypothermia group as compared with 19 of 64 (30 percent) in the control group (risk ratio, 0.68; 95 percent confidence interval, 0.38 to 1.22; P=0.20). CONCLUSIONS: Whole-body hypothermia reduces the risk of death or disability in infants with moderate or severe hypoxic-ischemic encephalopathy.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1056/nejmcps050929

Cites

36 of 36 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Development and reliability of a system to classify gross motor function in children with cerebral palsy
Palisano, R. J., Rosenbaum, P., Walter, S. D., Russell, D., Wood, E. P., & Galuppi, B. E. (1997) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.1997.tb07414.x · Cited by 6,728
Bayley Scales of Infant Development
(2007) · Sage eBooks · doi:10.4135/9781412952644.n48 · Cited by 4,242
Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial
Gluckman, P. D., Wyatt, J. S., Azzopardi, D., Ballard, R., Edwards, A. D., Ferriero, D. M., Polin, R. A., Robertson, C. M., Thoresen, M., Whitelaw, A., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)17946-x · Cited by 2,270
Small Differences in Intraischemic Brain Temperature Critically Determine the Extent of Ischemic Neuronal Injury
Busto, R., Dietrich, W. D., Globus, M. Y. ‐., Valdés, I., Scheinberg, P., & Ginsberg, M. D. (1987) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1987.127 · Cited by 1,786
Dramatic neuronal rescue with prolonged selective head cooling after ischemia in fetal lambs.
Gunn, A. J., Gunn, T. R., de Haan, H. H., Williams, C. E., & Gluckman, P. D. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119153 · Cited by 622
Moderate hypothermia in neonatal encephalopathy: Efficacy outcomes
Eicher, D. J., Wagner, C. L., Katikaneni, L., Hulsey, T. C., Bass, W. T., Kaufman, D. A., Horgan, M. J., Languani, S., Bhatia, J. J. S., Givelichian, L. M., et al. (2004) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2004.06.014 · Cited by 581
Prediction of neuromotor outcome in perinatal asphyxia: evaluation of MR scoring systems.
Barkovich, A. J., Hajnal, B. L., Vigneron, D. B., Sola, A. M., Partridge, J. C., Allen, F., & Ferriero, D. M. (1998) · PubMed Central · Cited by 525
Assessment of Neonatal Encephalopathy by Amplitude-integrated Electroencephalography
Al-Naqeeb, N., Edwards, A. D., Cowan, F. M., & Azzopardi, D. (1999) · PEDIATRICS · doi:10.1542/peds.103.6.1263 · Cited by 458
Amplitude integrated EEG 3 and 6 hours after birth in full term neonates with hypoxic–ischaemic encephalopathy
Toet, M. C., Hellström-Westas, L. K., Groenendaal, F., Eken, P., & de Vries, L. S. (1999) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/fn.81.1.f19 · Cited by 439
Delayed and prolonged post-ischemic hypothermia is neuroprotective in the gerbil
Colbourne, F., & Corbett, D. (1994) · Brain Research · doi:10.1016/0006-8993(94)90488-x · Cited by 418

Flagged first, then by citations

Show all 36 references

Research works printed but not linked: 2

Kuluz JW, 1993, Am J Physiol, 265, H824
Barkovich AJ, 1998, AJNR Am J Neuroradiol, 19, 143

Sorted by citations

Items 801–900 of 1,006

Collaborative Pediatric Critical Care Research Network: Looking back and moving forward
Willson, D. F., Dean, J. M., Meert, K. L., Newth, C. J. L., Anand, K. J. S., BERGER, J. T., Harrison, R. E., Zimmerman, J. J., Carcillo, J. A., Pollack, M. M., et al. (2009) · Pediatric Critical Care Medicine · doi:10.1097/pcc.0b013e3181c01302 · Cited by 33
Passive cooling to initiate hypothermia for transported encephalopathic newborns
Anderson, M. E., Longhofer, T. A., Phillips, W., & McRay, D. E. (2007) · Journal of Perinatology · doi:10.1038/sj.jp.7211781 · Cited by 33
Stem Cells for Neonatal Brain Disorders
Ahn, S. Y., Chang, Y. S., & Park, W. S. (2016) · Neonatology · doi:10.1159/000444905 · Cited by 33
Effect of erythropoietin combined with hypothermia on serum tau protein levels and neurodevelopmental outcome in neonates with hypoxic-ischemic encephalopathy
Li, L., Lv, H., Wu, S., Wang, Q., Yang, L., Ren, P., Qiao, B., Wang, Z., Li, J.-H., & Gu, X.-L. (2017) · Neural Regeneration Research · doi:10.4103/1673-5374.217338 · Cited by 33
Use of Therapeutic Hypothermia for Term Infants with Hypoxic-Ischemic Encephalopathy
Laptook, A. R. (2009) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2009.03.007 · Cited by 33
Self-citation
Therapeutic Hypothermia for Acute Liver Failure: Toward a Randomized, Controlled Trial in Patients with Advanced Hepatic Encephalopathy
Stravitz, R. T., Lee, W. M., Kramer, A. H., Kramer, D. J., Hynan, L. S., & Blei, A. T. (2008) · Neurocritical Care · doi:10.1007/s12028-008-9090-y · Cited by 33
Temperature control during therapeutic moderate whole-body hypothermia for neonatal encephalopathy: Figure 1
Strohm, B., & Azzopardi, D. (2009) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/adc.2009.163816 · Cited by 33
Kommentar zu den Leitlinien 2010 zur kardiopulmonalen Reanimation des European Resuscitation Council
Wenzel, V., Russo, S. G., Arntz, H. R., Bahr, J., Baubin, M., Böttiger, B. W., Dirks, B., Kreimeier, U., Fries, M., & Eich, C. B. (2010) · Der Anaesthesist · doi:10.1007/s00101-010-1820-9 · Cited by 30
Pediatric Neurocritical Care
Murphy, S. A. (2011) · Neurotherapeutics · doi:10.1007/s13311-011-0093-6 · Cited by 32
Rationale, methodology, and implementation of a nationwide multicenter randomized controlled trial of long-term mild hypothermia for severe traumatic brain injury (the LTH-1 trial)
Lei, J., Gao, G., Mao, Q., Feng, J., Wang, L., You, W., & Jiang, J. (2014) · Contemporary Clinical Trials · doi:10.1016/j.cct.2014.11.008 · Cited by 32
Microarray analysis of the global gene expression profile following hypothermia and transient focal cerebral ischemia
Nagel, S., Papadakis, M., Pfleger, K., Grond-Ginsbach, C., Buchan, A. M., & Wagner, S. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.01.048 · Cited by 32
Brain Temperature in Neonates with Hypoxic-Ischemic Encephalopathy during Therapeutic Hypothermia
Wu, T.-W., McLean, C. W., Friedlich, P. S., Wisnowski, J. L., Grimm, J., Panigrahy, A., Blüml, S., & Seri, I. (2014) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2014.07.022 · Cited by 32
The bleeding newborn: A review of presentation, diagnosis, and management
Jaffray, J., Young, G. A., & Ko, R. H. (2016) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2015.12.002 · Cited by 32
Endovascular Cooling Catheter for Selective Brain Hypothermia: An Animal Feasibility Study of Cooling Performance
Cattaneo, G. F. M., Schumacher, M., Maurer, C. J., Wolfertz, J., Jost, T., chert, M. B., Keuler, A., Boos, L., Shah, M. J., Foerster, K., et al. (2015) · American Journal of Neuroradiology · doi:10.3174/ajnr.a4625 · Cited by 32
Advantages of Bayesian monitoring methods in deciding whether and when to stop a clinical trial: an example of a neonatal cooling trial
Pedroza, C., Tyson, J. E., Das, A., Laptook, A. R., Bell, E. F., & Shankaran, S. (2016) · Trials · doi:10.1186/s13063-016-1480-4 · Cited by 32
Self-citation
Xenon Combined With Hypothermia in Perinatal Hypoxic-Ischemic Encephalopathy: A Noble Gas, a Noble Mission
Amer, A. R., & Oorschot, D. E. (2018) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2018.02.009 · Cited by 32
The neurorestorative effect of human amniotic fluid stem cells on the chronic phase of neonatal hypoxic–ischemic encephalopathy in mice
Otani, T., Ochiai, D., Masuda, H., Abe, Y., Fukutake, M., Matsumoto, T., Miyakoshi, K., & Tanaka, M. (2018) · Pediatric Research · doi:10.1038/s41390-018-0131-8 · Cited by 32
Placental findings among newborns with hypoxic ischemic encephalopathy
Bingham, A., Gündoğan, F., Rand, K., & Laptook, A. R. (2019) · Journal of Perinatology · doi:10.1038/s41372-019-0334-9 · Cited by 32
Self-citation
Therapeutic Hypothermia and Neuroprotection in Acute Neurological Disease
Kurisu, K., Kim, J. Y., You, J. S., & Yenari, M. A. (2019) · Current Medicinal Chemistry · doi:10.2174/0929867326666190506124836 · Cited by 32
Urine Biomarkers for the Assessment of Acute Kidney Injury in Neonates with Hypoxic Ischemic Encephalopathy Receiving Therapeutic Hypothermia
Rumpel, J. A., Spray, B. J., Chock, V. Y., Kirkley, M. J., Slagle, C. L., Frymoyer, A. R., Cho, S.-H., Gist, K. M., Blaszak, R. T., Poindexter, B. B., et al. (2021) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2021.08.090 · Cited by 32
Hypothermia
Azzopardi, D., & Edwards, A. D. (2007) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2007.01.022 · Cited by 32
Predictors of Outcome in Term Infants With Neonatal Seizures Subsequent to Intrapartum Asphyxia
Garfinkle, J., & Shevell, M. I. (2011) · Journal of Child Neurology · doi:10.1177/0883073810382907 · Cited by 32
Hypothermia and rewarming injury in hippocampal neurons involve intracellular Ca2+ and glutamate excitotoxicity
Warren, D. E., Bickler, P. E., Clark, J. P., Gregersen, M., Brosnan, H., McKleroy, W., & Gabatto, P. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2011.12.034 · Cited by 32
Therapeutic Hypothermia for Acute Neurological Injuries
Rivera‐Lara, L., Zhang, J., & Muehlschlegel, S. (2011) · Neurotherapeutics · doi:10.1007/s13311-011-0092-7 · Cited by 32
Effects of inter-alpha inhibitor proteins on neonatal brain injury: Age, task and treatment dependent neurobehavioral outcomes
Threlkeld, S. W., Gaudet, C. M., Rue, M. L., Dugas, E., Hill, C. A., Lim, Y., & Stonestreet, B. S. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.07.012 · Cited by 32
State of the Science
Selway, L. D. (2010) · Advances in Neonatal Care · doi:10.1097/anc.0b013e3181d54b30 · Cited by 32
Hypothermia and Rapid Rewarming Is Associated With Worse Outcome Following Traumatic Brain Injury
Thompson, H. J., Kirkness, C. J., & Mitchell, P. H. (2010) · Journal of Trauma Nursing · doi:10.1097/jtn.0b013e3181ff272e · Cited by 32
Combined Selective Cerebral Hypothermia and Mechanical Artery Recanalization in Acute Ischemic Stroke: In Vitro Study of Cooling Performance
Cattaneo, G. F. M., Schumacher, M., Wolfertz, J., Jost, T., & Meckel, S. (2015) · American Journal of Neuroradiology · doi:10.3174/ajnr.a4434 · Cited by 33
Management of therapeutic hypothermia for neonatal hypoxic ischaemic encephalopathy in a tertiary centre in South Africa
Kali, G. T. J., Martínez-Biarge, M., van Zyl, J. I., Smith, J., & Rutherford, M. (2015) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/archdischild-2015-308398 · Cited by 32
Systemic effects of whole-body cooling to 35 °C, 33.5 °C, and 30 °C in a piglet model of perinatal asphyxia: implications for therapeutic hypothermia
Kerenyi, A., Kelen, D., Faulkner, S. D., Bainbridge, A. P., Chandrasekaran, M., Cady, E. B., Golay, X., & Robertson, N. J. (2012) · Pediatric Research · doi:10.1038/pr.2012.8 · Cited by 32
Animal models of hypoxic-ischemic encephalopathy: optimal choices for the best outcomes
Huang, L. J., Zhao, F., Qu, Y., Zhang, L., Wang, Y., & Mu, D. (2016) · Reviews in the Neurosciences · doi:10.1515/revneuro-2016-0022 · Cited by 32
Characterization of Death in Neonatal Encephalopathy in the Hypothermia Era
Lemmon, M. E., Boss, R. D., Bonifacio, S. L., Foster‐Barber, A., Barkovich, A. J., & Glass, H. C. (2016) · Journal of Child Neurology · doi:10.1177/0883073816681904 · Cited by 32
Inflammatory cytokine response and reduced heart rate variability in newborns with hypoxic-ischemic encephalopathy
Al‐Shargabi, T., Govindan, R. B., Dave, R., Metzler, M., Wang, Y., du Plessis, A., & Massaro, A. N. (2017) · Journal of Perinatology · doi:10.1038/jp.2017.15 · Cited by 32
Hypothermia: An Evolving Treatment for Neonatal Hypoxic Ischemic Encephalopathy
Gunn, A. J., Hoehn, T., Hansmann, G., Bührer, C., Simbruner, G., Yager, J. Y., Levene, M. I., Hamrick, S. E. G., Shankaran, S., & Thoresen, M. (2008) · PEDIATRICS · doi:10.1542/peds.2007-3310 · Cited by 32
Self-citation
Cardiac biomarkers in neonatal hypoxic ischaemia
Sweetman, D., Armstrong, K. R., Murphy, J., & Molloy, E. J. (2011) · Acta Paediatrica · doi:10.1111/j.1651-2227.2011.02539.x · Cited by 31
Detrended fluctuation analysis of non-stationary cardiac beat-to-beat interval of sick infants
Govindan, R. B., Massaro, A. N., Al‐Shargabi, T., Andescavage, N. N., Chang, T., Glass, P., & du Plessis, A. J. (2014) · Europhysics Letters (EPL) · doi:10.1209/0295-5075/108/40005 · Cited by 31
Effect of Therapeutic Hypothermia in Neonates with Hypoxic-Ischemic Encephalopathy on Platelet Function
Christensen, R. D., Sheffield, M. J., Lambert, D. K., & Baer, V. L. (2011) · Neonatology · doi:10.1159/000329818 · Cited by 31
Mechanisms and consequences of acquired brain injury during development
Morrison, G. C., Fraser, D. D., & Cepinskas, G. (2012) · Pathophysiology · doi:10.1016/j.pathophys.2012.02.006 · Cited by 31
Translational Research in Acute Central Nervous System Injury
Warner, D. S., James, M. L., Laskowitz, D. T., & Wijdicks, E. F. M. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2014.1238 · Cited by 32
2019 American Heart Association Focused Update on Pediatric Advanced Life Support: An Update to the American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care
Duff, J. P., Topjian, A., Berg, M., Chan, M., Haskell, S. E., Joyner, B. L., Lasa, J. J., Ley, S. J., Raymond, T. T., Sutton, R. M., et al. (2019) · PEDIATRICS · doi:10.1542/peds.2019-1361 · Cited by 31
Prognostic Value of Continuous Electroencephalogram Delta Power in Neonates With Hypoxic-Ischemic Encephalopathy
Kota, S., Massaro, A. N., Chang, T., Al‐Shargabi, T., Cristante, C., Vézina, G., du Plessis, A., & Govindan, R. B. (2020) · Journal of Child Neurology · doi:10.1177/0883073820915323 · Cited by 31
Morphine and fentanyl exposure during therapeutic hypothermia does not impair neurodevelopment
Gundersen, J. K., Chakkarapani, E., Jary, S., Menassa, D. A., Scull-Brown, E., Frymoyer, A. R., Walløe, L., & Thoresen, M. (2021) · EClinicalMedicine · doi:10.1016/j.eclinm.2021.100892 · Cited by 31
Neonatal Seizures
Abend, N. S., Jensen, F. E., Inder, T. E., & Volpe, J. J. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-42876-7.00012-0 · Cited by 31
Impact of hypothermia in the rural, pediatric trauma patient*
Waibel, B. H., Durham, C. A., Newell, M. A., Schlitzkus, L. L., Sagraves, S. G., & Rotondo, M. F. (2010) · Pediatric Critical Care Medicine · doi:10.1097/pcc.0b013e3181b80500 · Cited by 31
Cerebral Palsy after Neonatal Encephalopathy: How Much Is Preventable?
Garfinkle, J., Wintermark, P., Shevell, M. I., Platt, R. W., Oskoui, M., Andersen, J. C., Buckley, D. J., Fehlings, D. L., Kirton, A., Moore, A., et al. (2015) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2015.02.035 · Cited by 31
Therapeutic hypothermia during neonatal transport: data from the California Perinatal Quality Care Collaborative (CPQCC) and California Perinatal Transport System (CPeTS) for 2010
Akula, V. P., Gould, J. B., Davis, A. S., Hackel, A., Oehlert, J. W., & Meurs, K. P. V. (2012) · Journal of Perinatology · doi:10.1038/jp.2012.144 · Cited by 31
A decrease of cell proliferation by hypothermia in the hippocampus of the neonatal rat
Kanagawa, T., Fukuda, H., Tsubouchi, H., Komoto, Y., Hayashi, S., Fukui, O., Shimoya, K., & Murata, Y. (2006) · Brain Research · doi:10.1016/j.brainres.2006.06.112 · Cited by 31
Incidencia y prevalencia de la encefalopatía hipoxico-isquémica en la primera década del siglo xxi
Garcı́a-Alix, A., Martínez-Biarge, M., Diez, J., Gayá, F., & Quero, J. (2009) · Anales de Pediatría · doi:10.1016/j.anpedi.2009.07.021 · Cited by 32
Long-Term Neuroprotective Effect of Postischemic Hypothermia in a Neonatal Rat Model of Severe Hypoxic Ischemic Encephalopathy: A Comparative Study on the Duration and Depth of Hypothermia
Lee, B. S., Woo, C., Kim, S., & Kim, K. S. (2010) · Pediatric Research · doi:10.1203/pdr.0b013e3181ef3007 · Cited by 31
Therapeutic Hypothermia (Different Depths, Durations, and Rewarming Speeds) for Acute Ischemic Stroke: A Meta-analysis
Wan, Y.-H., Chen, N., Wang, H., & Huang, C.-Y. (2014) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2014.06.017 · Cited by 31
Mechanisms of hypothermia-induced cell protection in the brain
Schmitt, K. R. L., Tong, G., & Berger, F. F. (2014) · Molecular and Cellular Pediatrics · doi:10.1186/s40348-014-0007-x · Cited by 31
Palliative care in neonatal neurology: robust support for infants, families and clinicians
Lemmon, M. E., Bidegain, M., & Boss, R. D. (2015) · Journal of Perinatology · doi:10.1038/jp.2015.188 · Cited by 31
Challenges in neurologic prognostication after neonatal brain injury
Natarajan, N., & Pardo, A. C. (2017) · Seminars in Perinatology · doi:10.1053/j.semperi.2016.11.008 · Cited by 31
Erratum to: Biomarkers of hepatic injury and function in neonatal hypoxic ischemic encephalopathy and with therapeutic hypothermia
Muniraman, H., Gardner, D., Skinner, J. S., Paweletz, A., Vayalakkad, A., Chee, Y. H., Clifford, C., Sanka, S., Venkatesh, V., Curley, A., et al. (2017) · European Journal of Pediatrics · doi:10.1007/s00431-017-2980-2 · Cited by 31
High-dose erythropoietin population pharmacokinetics in neonates with hypoxic–ischemic encephalopathy receiving hypothermia
Frymoyer, A. R., Juul, S. E., Massaro, A. N., Bammler, T. K., & Wu, T.-W. (2017) · Pediatric Research · doi:10.1038/pr.2017.15 · Cited by 30
Safety of Moderate Hypothermia for Perinatal Hypoxic-Ischemic Encephalopathy: A Meta-analysis
Zhang, W., Ma, J., Danzeng, Q., Tang, Y., Lu, M., & Kang, Y. (2017) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2017.04.023 · Cited by 30
Residual brain injury after early discontinuation of cooling therapy in mild neonatal encephalopathy
Lally, P., Montaldo, P., Oliveira, V., Swamy, R. S., Soe, A., Shankaran, S., & Thayyil, S. (2017) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/archdischild-2017-313321 · Cited by 30
Self-citation
Phase Changing Material for Therapeutic Hypothermia in Neonates with Hypoxic Ischemic Encephalopathy — A Multi-centric Study
Thomas, N., Abiramalatha, T., Bhat, V. B., Manoj, V. C., Rao, S. P., Wazir, S., Lewis, L., Balakrishnan, U., Murki, S., Mittal, J., et al. (2017) · Indian Pediatrics · doi:10.1007/s13312-018-1317-1 · Cited by 30
Neonatal Neurocritical Care: Providing Brain-Focused Care for All at Risk Neonates
Bonifacio, S. L., & Meurs, K. P. V. (2019) · Seminars in Pediatric Neurology · doi:10.1016/j.spen.2019.08.010 · Cited by 30
Therapeutic Hypothermia in Critically Ill Patients: A Systematic Review and Meta-Analysis of High Quality Randomized Trials*
Kim, J. H., Nagy, Á., Putzu, A., Belletti, A., Biondi‐Zoccai, G., Likhvantsev, V. V., Yavorovskiy, A. G., & Landoni, G. (2020) · Critical Care Medicine · doi:10.1097/ccm.0000000000004364 · Cited by 30
Cost-Effectiveness of Therapeutic Hypothermia to Treat Neonatal Encephalopathy
Regier, D. A., Petrou, S., Henderson, J., Eddama, O., Patel, N. V., Strohm, B., Brocklehurst, P., Edwards, A. D., & Azzopardi, D. (2010) · Value in Health · doi:10.1111/j.1524-4733.2010.00731.x · Cited by 30
Effects of Whole Body Therapeutic Hypothermia on Gastrointestinal Morbidity and Feeding Tolerance in Infants with Hypoxic Ischemic Encephalopathy
Thornton, K. M., Dai, H. D., Septer, S. S., & Petrikin, J. E. (2014) · International Journal of Pediatrics · doi:10.1155/2014/643689 · Cited by 30
Therapeutic Hypothermia for Neonatal Encephalopathy and Extracorporeal Membrane Oxygenation
Massaro, A. N., Rais‐Bahrami, K., Chang, T., Glass, P., Short, B. L., & Baumgart, S. (2010) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2010.04.011 · Cited by 30
Xenon offers stable haemodynamics independent of induced hypothermia after hypoxia–ischaemia in newborn pigs
Chakkarapani, E., Thoresen, M., Liu, X., Walløe, L., & Dingley, J. (2011) · Intensive Care Medicine · doi:10.1007/s00134-011-2442-7 · Cited by 30
Evaluating a Simple Method of Neuroprotective Hypothermia for Newborn Infants
Horn, A. R., Harrison, M. C., & Linley, L. L. (2009) · Journal of Tropical Pediatrics · doi:10.1093/tropej/fmp089 · Cited by 30
Therapeutic hypothermia for neonatal hypoxic‐ischaemic encephalopathy had favourable outcomes at a referral hospital in a middle‐income country
Kali, G. T. J., Martínez-Biarge, M., van Zyl, J. I., Smith, J., & Rutherford, M. (2016) · Acta Paediatrica · doi:10.1111/apa.13392 · Cited by 30
Intracranial Pressure and Collateral Blood Flow
Beard, D. J., Murtha, L. A., McLeod, D. D., & Spratt, N. J. (2016) · Stroke · doi:10.1161/strokeaha.115.011147 · Cited by 30
Clinical trials for pediatric traumatic brain injury: definition of insanity?
Appavu, B. L., Foldes, S. T., & Adelson, P. D. (2019) · Journal of Neurosurgery Pediatrics · doi:10.3171/2019.2.peds18384 · Cited by 30
Ischemic Conditioning and neonatal hypoxic ischemic encephalopathy: a literature review.
Adstamongkonkul, D., & Hess, D. C. (2017) · PubMed · Cited by 30
Xenon/Hypothermia Neuroprotection Regimes in Spontaneously Breathing Neonatal Rats After Hypoxic-Ischemic Insult: The Respiratory and Sedative Effects
Dingley, J., Hobbs, C., Ferguson, J., Stone, J., & Thoresen, M. (2008) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e3181618669 · Cited by 30
Evaluation of selection criteria for validating paired umbilical cord blood gas samples: an observational study
White, C., Doherty, D., Kohan, R., Newnham, J., & Pennell, C. (2012) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2012.03308.x · Cited by 28
Umbilical Cord pH Levels and Neonatal Morbidity and Mortality
Andersson, C. B., Klingenberg, C., Thellesen, L., Johnsen, S. P., Kesmodel, U. S., & Petersen, J. P. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.27604 · Cited by 29
Neurotrophin-Induced Migration and Neuronal Differentiation of Multipotent Astrocytic Stem Cells In Vitro
Douglas‐Escobar, M., Rossignol, C., Steindler, D. A., Zheng, T., & Weiss, M. D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051706 · Cited by 29
Therapeutic Hypothermia: Applications in Pediatric Cardiac Arrest
Kochanek, P. M., Fink, E. L., Bell, M. J., Bayır, H., & Clark, R. S. B. (2009) · Journal of Neurotrauma · doi:10.1089/neu.2008.0587 · Cited by 29
Moving to human trials for argon neuroprotection in neurological injury: a narrative review
Gardner, A. J., & Menon, D. K. (2017) · British Journal of Anaesthesia · doi:10.1016/j.bja.2017.10.017 · Cited by 29
Combination therapy with erythropoietin, magnesium sulfate and hypothermia for hypoxic-ischemic encephalopathy: an open-label pilot study to assess the safety and feasibility
Miho, N., Harada, S., Asada, Y., Matsumura, H., Iwami, H., Tanaka, Y., & Ichiba, H. (2019) · BMC Pediatrics · doi:10.1186/s12887-018-1389-z · Cited by 29
Perspectives from the Society for Pediatric Research. Neonatal encephalopathy clinical trials: developing the future
Benninger, K. L., Inder, T. E., Goodman, A. M., Cotten, C. M., Nordli, D. R., Shah, T. A., Slaughter, J. C., & Maitre, N. L. (2020) · Pediatric Research · doi:10.1038/s41390-020-0859-9 · Cited by 29
Self-citation
Aminophylline for renal protection in neonatal hypoxic–ischemic encephalopathy in the era of therapeutic hypothermia
Chock, V. Y., Cho, S.-H., & Frymoyer, A. R. (2020) · Pediatric Research · doi:10.1038/s41390-020-0999-y · Cited by 29
Waixenicin A, a marine-derived TRPM7 inhibitor: a promising CNS drug lead
Sun, H.-S., Horgen, F., Romo, D., Hull, K. G., Kiledal, S. A., Fleig, A., & Feng, Z.-P. (2020) · Acta Pharmacologica Sinica · doi:10.1038/s41401-020-00512-4 · Cited by 25
Association between cerebral oxygen saturation and brain injury in neonates receiving therapeutic hypothermia for neonatal encephalopathy
Szakmár, E., Smith, J., Yang, E., Volpe, J. J., Inder, T. E., & El‐Dib, M. (2021) · Journal of Perinatology · doi:10.1038/s41372-020-00910-w · Cited by 29
Induction of therapeutic hypothermia by pharmacological modulation of temperature-sensitive TRP channels: theoretical framework and practical considerations
Feketa, V. V., & Marrelli, S. P. (2015) · Temperature · doi:10.1080/23328940.2015.1024383 · Cited by 29
Seizures Are Common in Term Infants Undergoing Head Cooling
Yap, V. L., Engel, M., Takenouchi, T., & Perlman, J. M. (2009) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2009.05.004 · Cited by 29
Technical Aspects of Starting a Neonatal Cooling Program
Barks, J. (2008) · Clinics in Perinatology · doi:10.1016/j.clp.2008.07.009 · Cited by 29
Cerebral Palsy and Growth Failure at 6 to 7 Years
Vohr, B. R., Stephens, B. E., McDonald, S. A., Ehrenkranz, R. A., Laptook, A. R., Pappas, A., Hintz, S. R., Shankaran, S., Higgins, R. D., & Das, A. (2013) · PEDIATRICS · doi:10.1542/peds.2012-3915 · Cited by 29
Self-citation
Estetrol attenuates neonatal hypoxic–ischemic brain injury
Tskitishvili, E., Nisolle, M., Munaut, C., Péqueux, C., Gérard, C., Noël, A., & Foidart, J. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.07.015 · Cited by 29
Volumetric and anatomical MRI for hypoxic–ischemic encephalopathy: relationship to hypothermia therapy and neurosensory impairments
Parikh, N. A., Lasky, R. E., Garza, C., Bonfante-Mejia, E. E., Shankaran, S., & Tyson, J. E. (2008) · Journal of Perinatology · doi:10.1038/jp.2008.184 · Cited by 31
Self-citation
Hypothermia for perinatal asphyxial encephalopathy
Hagmann, C. F., Brotschi, B., Bernet, V., Latal, B., Berger, T., & Robertson, N. J. (2011) · Swiss Medical Weekly · doi:10.4414/smw.2011.13145 · Cited by 29
Neonatal Hypercalcemia Secondary to Subcutaneous Fat Necrosis Successfully Treated with Pamidronate: A Case Series and Literature Review
Yusuf, K., Yee, W. H., Obaid, H., Awad, E. A., & Samedi, V. (2014) · American Journal of Perinatology Reports · doi:10.1055/s-0034-1395987 · Cited by 29
Prevention, Diagnosis, and Treatment of Cerebral Palsy in Near-term and Term Infants
Shankaran, S. (2008) · Clinical Obstetrics & Gynecology · doi:10.1097/grf.0b013e3181870c35 · Cited by 29
Self-citation
Comparison of selective head cooling versus whole‐body cooling
Çelik, Y., Atıcı, A., Gülaşı, S., Okuyaz, Ç., Makharoblıdze, K., & Sungur, M. A. (2015) · Pediatrics International · doi:10.1111/ped.12747 · Cited by 29
Effects of age, experience and inter-alpha inhibitor proteins on working memory and neuronal plasticity after neonatal hypoxia-ischemia
Gaudet, C. M., Lim, Y., Stonestreet, B. S., & Threlkeld, S. W. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.01.016 · Cited by 30
Performance of informative priors skeptical of large treatment effects in clinical trials: A simulation study
Pedroza, C., Han, W., Truong, V. T. T., Green, C., & Tyson, J. E. (2015) · Statistical Methods in Medical Research · doi:10.1177/0962280215620828 · Cited by 30
Self-citation
Automatic quantification of ischemic injury on diffusion-weighted MRI of neonatal hypoxic ischemic encephalopathy
Murphy, K., van der Aa, N. E., Negro, S., Groenendaal, F., de Vries, L. S., Viergever, M. A., Boylan, G. B., Benders, M. J. N. L., & Išgum, I. (2017) · NeuroImage Clinical · doi:10.1016/j.nicl.2017.01.005 · Cited by 29
Safety of Autologous Cord Blood Cells for Preterms: A Descriptive Study
Yang, J., Ren, Z., Zhang, C., Rao, Y., Zhong, J., Wang, Z., Liu, Z., Wei, W., Lu, L., Wen, J., et al. (2018) · Stem Cells International · doi:10.1155/2018/5268057 · Cited by 29
Withdrawal of Life-Support in Neonatal Hypoxic-Ischemic Encephalopathy
Natarajan, G., Mathur, A., Zaniletti, I., DiGeronimo, R., Lee, K., Rao, R., Dizon, M. L. V., Hamrick, S. E. G., Rudine, A. C., Cook, N., et al. (2018) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2018.08.027 · Cited by 29
The impact of epidural analgesia on the mode of delivery in nulliparous women that attain the second stage of labor
Srebnik, N., Barkan, O., Rottenstreich, M., Ioscovich, A., Farkash, R., Rotshenker-Olshinka, K., Samueloff, A., & Grisaru‐Granovsky, S. (2019) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2018.1554045 · Cited by 29
Inter-rater reliability of the modified Sarnat examination in preterm infants at 32–36 weeks’ gestation
Pavageau, L., Sánchez, P. J., Brown, L. S., & Chalak, L. F. (2019) · Pediatric Research · doi:10.1038/s41390-019-0562-x · Cited by 29
Predictive Performance of a Gentamicin Population Pharmacokinetic Model in Neonates Receiving Full-Body Hypothermia
Sampson, M. R., Frymoyer, A. R., Rattray, B., Cotten, C. M., Smith, P. B., Capparelli, E. V., Bonifacio, S. L., & Cohen‐Wolkowiez, M. (2014) · Therapeutic Drug Monitoring · doi:10.1097/ftd.0000000000000056 · Cited by 29
Self-citation
Regional variability in therapeutic hypothermia eligibility criteria for neonatal hypoxic-ischemic encephalopathy
Proietti, J., Boylan, G. B., & Walsh, B. H. (2024) · Pediatric Research · doi:10.1038/s41390-024-03184-6 · Cited by 28
Clinical and Preclinical Use of LOX-1-Specific Antibodies in Diagnostics and Therapeutics
Siqueira, J. D., Abdul‐Zani, I., Russell, D., Wheatcroft, S. B., Ponnambalam, S., & Homer‐Vanniasinkam, S. (2015) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-015-9655-z · Cited by 29

Authors: Shankaran, S., Laptook, A. R., Ehrenkranz, R. A., Tyson, J. E., McDonald, S. A., Donovan, E. F., Fanaroff, A. A., Poole, W. K., Wright, L. L., Higgins, R. D., Finer, N. N., Carlo, W. A., Duara, S., Oh, W., Cotten, C. M., Stevenson, D. K., Stoll, B. J., Lemons, J. A., Guillet, R., & Jobe, A. H.
Affiliations: Wayne State University (US)
Women & Infants Hospital of Rhode Island (US)
Yale University (US)
RTI International (US)
University of Cincinnati (US)
Rainbow Babies & Children's Hospital (US)
National Institutes of Health (US)
University of California San Diego (US)
University of Alabama at Birmingham (US)
University of Miami (US)
Duke Medical Center (US)
Stanford University (US)
Emory University (US)
Indiana University School of Medicine (US)
University of Rochester (US)
ORCID: Shankaran, Seetha
Laptook, Abbot R.
McDonald, Scott A.
Higgins, Rosemary D.
Carlo, Waldemar A.
Duara, Shahnaz
Cotten, C. Michael
Stevenson, David K.
Stoll, Barbara J.
Guillet, Ronnie
Jobe, Alan H.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2005-10-13
Volume: 353
Issue: 15
Pages: 1574-1584
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmcps050929
OpenAlex: W2164127547
Cited by: 2,862
References: 36
Citations by year: 2026: 95 · 2025: 152 · 2024: 157 · 2023: 121 · 2022: 118 · 2021: 155 · 2020: 123 · 2019: 129 · 2018: 152 · 2017: 152 · 2016: 143 · 2015: 170 · 2014: 131 · 2013: 141 · 2012: 166
FWCI: 89.20
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
UWA Profiles and Research Repository (UWA) (submittedVersion)
Funders: National Center for Research Resources (5-M01-RR-00044, M01RR008084, M01-RR00039, M01RR000125, M01-RR 00750, M01 RR-00125, M01 RR 0039-43, M01RR000750, M-01 RR 00070, M01RR000044, M01RR000070, M01RR000039, M01-RR-08084)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (U10HD040498, (U10 HD27871, U10 HD 27853, U10HD027880, U10 HD27880, U10 HD 40461, U10HD40521, U10HD21385, U10HD 21397, U10HD40498, U10HD27851, U10 HD34216, U10HD40492, U01HD36790, U10‐HD‐27904, U10HD021397, U10HD027904, U10HD027856, U10HD040689, U10HD027871, U10-HD21373, U10HD027853, U10HD040492, U10HD034216, U10HD021373, U10HD021385, U10HD40689, U10 HD27856, U10HD040521, U01HD036790, U10HD027851, U10HD040461)
Topics: Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Thermal Regulation in Medicine
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Development and Preterm Care
Keywords: whole-body hypothermia, hypoxic-ischemic encephalopathy, neonates, neuroprotection, cerebral palsy, neurodevelopmental outcomes, perinatal asphyxia, acidosis, term infants, mortality, disability
MeSH terms: Acidosis, Asphyxia Neonatorum, Blindness, Cerebral Palsy, Developmental Disabilities, Female, Follow-Up Studies, Humans, Hypothermia, Induced, Infant, Newborn, Obstetric Labor Complications, Male, Pregnancy, Pregnancy Complications, Hypoxia-Ischemia, Brain, Hearing Loss

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks