The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy
Open accessAbstract
BACKGROUND: Hypothermia is protective against brain injury after asphyxiation in animal models. However, the safety and effectiveness of hypothermia in term infants with encephalopathy is uncertain. METHODS: We conducted a randomized trial of hypothermia in infants with a gestational age of at least 36 weeks who were admitted to the hospital at or before six hours of age with either severe acidosis or perinatal complications and resuscitation at birth and who had moderate or severe encephalopathy. Infants were randomly assigned to usual care (control group) or whole-body cooling to an esophageal temperature of 33.5 degrees C for 72 hours, followed by slow rewarming (hypothermia group). Neurodevelopmental outcome was assessed at 18 to 22 months of age. The primary outcome was a combined end point of death or moderate or severe disability. RESULTS: Of 239 eligible infants, 102 were assigned to the hypothermia group and 106 to the control group. Adverse events were similar in the two groups during the 72 hours of cooling. Primary outcome data were available for 205 infants. Death or moderate or severe disability occurred in 45 of 102 infants (44 percent) in the hypothermia group and 64 of 103 infants (62 percent) in the control group (risk ratio, 0.72; 95 percent confidence interval, 0.54 to 0.95; P=0.01). Twenty-four infants (24 percent) in the hypothermia group and 38 (37 percent) in the control group died (risk ratio, 0.68; 95 percent confidence interval, 0.44 to 1.05; P=0.08). There was no increase in major disability among survivors; the rate of cerebral palsy was 15 of 77 (19 percent) in the hypothermia group as compared with 19 of 64 (30 percent) in the control group (risk ratio, 0.68; 95 percent confidence interval, 0.38 to 1.22; P=0.20). CONCLUSIONS: Whole-body hypothermia reduces the risk of death or disability in infants with moderate or severe hypoxic-ischemic encephalopathy.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Despite TH, some infants with HIE will exhibit poor long-term neurologic outcomes across a spectrum of severity including neurodevelopmental impairment (NDI) (3–6).”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Palisano, R. J., Rosenbaum, P., Walter, S. D., Russell, D., Wood, E. P., & Galuppi, B. E. (1997) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.1997.tb07414.x · Cited by 6,728
Bayley Scales of Infant Development
(2007) · Sage eBooks · doi:10.4135/9781412952644.n48 · Cited by 4,242
Gluckman, P. D., Wyatt, J. S., Azzopardi, D., Ballard, R., Edwards, A. D., Ferriero, D. M., Polin, R. A., Robertson, C. M., Thoresen, M., Whitelaw, A., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)17946-x · Cited by 2,270
Busto, R., Dietrich, W. D., Globus, M. Y. ‐., Valdés, I., Scheinberg, P., & Ginsberg, M. D. (1987) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1987.127 · Cited by 1,786
Dramatic neuronal rescue with prolonged selective head cooling after ischemia in fetal lambs.
Gunn, A. J., Gunn, T. R., de Haan, H. H., Williams, C. E., & Gluckman, P. D. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119153 · Cited by 622
Moderate hypothermia in neonatal encephalopathy: Efficacy outcomes
Eicher, D. J., Wagner, C. L., Katikaneni, L., Hulsey, T. C., Bass, W. T., Kaufman, D. A., Horgan, M. J., Languani, S., Bhatia, J. J. S., Givelichian, L. M., et al. (2004) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2004.06.014 · Cited by 581
Prediction of neuromotor outcome in perinatal asphyxia: evaluation of MR scoring systems.
Barkovich, A. J., Hajnal, B. L., Vigneron, D. B., Sola, A. M., Partridge, J. C., Allen, F., & Ferriero, D. M. (1998) · PubMed Central · Cited by 525
Assessment of Neonatal Encephalopathy by Amplitude-integrated Electroencephalography
Al-Naqeeb, N., Edwards, A. D., Cowan, F. M., & Azzopardi, D. (1999) · PEDIATRICS · doi:10.1542/peds.103.6.1263 · Cited by 458
Toet, M. C., Hellström-Westas, L. K., Groenendaal, F., Eken, P., & de Vries, L. S. (1999) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/fn.81.1.f19 · Cited by 439
Delayed and prolonged post-ischemic hypothermia is neuroprotective in the gerbil
Colbourne, F., & Corbett, D. (1994) · Brain Research · doi:10.1016/0006-8993(94)90488-x · Cited by 418
Flagged first, then by citations
Research works printed but not linked: 2
- Kuluz JW, 1993, Am J Physiol, 265, H824
- Barkovich AJ, 1998, AJNR Am J Neuroradiol, 19, 143
Cited by
Sorted by citations
Items 1,001–1,006 of 1,006
Therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy: clinical report
Zanelli, S. A., Wusthoff, C. J., Lucke, A. M., Kaufman, D. A., Committee on Fetus and Newborn, Eichenwald, E., Ambalavanan, N., Guillory, C., Hudak, M., Kaufman, D., et al. (2026) · Pediatrics · doi:10.1542/peds.2025-073627 · Cited by 26
Early determination of prognosis in neonatal moderate or severe hypoxic-ischemic encephalopathy
Ambalavanan, N., Shankaran, S., Laptook, A. R., Carper, B. A., Das, A., Carlo, W. A., Cotten, C. M., Duncan, A. F., & Higgins, R. D. (2021) · PEDIATRICS · doi:10.1542/peds.2020-048678 · Cited by 20
Self-citationKang, O.-H., Jahn, P., Eichhorn, J. G., Dresbach, T., Müller, A., & Sabir, H. (2023) · Children · doi:10.3390/children10081295 · Cited by 17
Early prediction of mortality after birth asphyxia with the nSOFA
Dathe, A.-K., Stein, A., Bruns, N., Craciun, E.-D., Tuda, L., Bialas, J., Brasseler, M., Felderhoff-Mueser, U., & Huening, B. M. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12134322 · Cited by 13
Yilmaz, A., Uygur, A., Celik, B., Akdag, A. M., Baser, D., & Ozturk, S. I. (2024) · Turkish Archives of Pediatrics · doi:10.5152/turkarchpediatr.2024.24152 · Cited by 3
Lagnese, K., Sheth, S., Vice, S., Rajderkar, D., Roig, J. C., Weiss, M., & Wynn, J. L. (2026) · Frontiers in Pediatrics · doi:10.3389/fped.2026.1844058
Metadata
- Authors
- Shankaran, S., Laptook, A. R., Ehrenkranz, R. A., Tyson, J. E., McDonald, S. A., Donovan, E. F., Fanaroff, A. A., Poole, W. K., Wright, L. L., Higgins, R. D., Finer, N. N., Carlo, W. A., Duara, S., Oh, W., Cotten, C. M., Stevenson, D. K., Stoll, B. J., Lemons, J. A., Guillet, R., & Jobe, A. H.
- Affiliations
- Wayne State University (US)
- Women & Infants Hospital of Rhode Island (US)
- Yale University (US)
- RTI International (US)
- University of Cincinnati (US)
- Rainbow Babies & Children's Hospital (US)
- National Institutes of Health (US)
- University of California San Diego (US)
- University of Alabama at Birmingham (US)
- University of Miami (US)
- Duke Medical Center (US)
- Stanford University (US)
- Emory University (US)
- Indiana University School of Medicine (US)
- University of Rochester (US)
- ORCID
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2005-10-13
- Volume
- 353
- Issue
- 15
- Pages
- 1574-1584
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2164127547
- Cited by
- 2,862
- References
- 36
- Citations by year
- 2026: 95 · 2025: 152 · 2024: 157 · 2023: 121 · 2022: 118 · 2021: 155 · 2020: 123 · 2019: 129 · 2018: 152 · 2017: 152 · 2016: 143 · 2015: 170 · 2014: 131 · 2013: 141 · 2012: 166
- FWCI
- 89.20
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- UWA Profiles and Research Repository (UWA) (submittedVersion)
- Funders
- National Center for Research Resources (5-M01-RR-00044, M01RR008084, M01-RR00039, M01RR000125, M01-RR 00750, M01 RR-00125, M01 RR 0039-43, M01RR000750, M-01 RR 00070, M01RR000044, M01RR000070, M01RR000039, M01-RR-08084)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (U10HD040498, (U10 HD27871, U10 HD 27853, U10HD027880, U10 HD27880, U10 HD 40461, U10HD40521, U10HD21385, U10HD 21397, U10HD40498, U10HD27851, U10 HD34216, U10HD40492, U01HD36790, U10‐HD‐27904, U10HD021397, U10HD027904, U10HD027856, U10HD040689, U10HD027871, U10-HD21373, U10HD027853, U10HD040492, U10HD034216, U10HD021373, U10HD021385, U10HD40689, U10 HD27856, U10HD040521, U01HD036790, U10HD027851, U10HD040461)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Thermal Regulation in Medicine
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Development and Preterm Care
- Keywords
- whole-body hypothermia, hypoxic-ischemic encephalopathy, neonates, neuroprotection, cerebral palsy, neurodevelopmental outcomes, perinatal asphyxia, acidosis, term infants, mortality, disability
- MeSH terms
- Acidosis, Asphyxia Neonatorum, Blindness, Cerebral Palsy, Developmental Disabilities, Female, Follow-Up Studies, Humans, Hypothermia, Induced, Infant, Newborn, Obstetric Labor Complications, Male, Pregnancy, Pregnancy Complications, Hypoxia-Ischemia, Brain, Hearing Loss
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
