Cited by 2,862Neonatal and fetal brain pathologyThermal Regulation in MedicineInfant Development and Preterm Care

The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.

Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy

Open access

Shankaran, Seetha, Laptook, Abbot R., Ehrenkranz, Richard A., Tyson, Jon E., McDonald, Scott A., Donovan, Edward F., Fanaroff, Avroy A., Poole, W. Kenneth, Wright, Linda L., Higgins, Rosemary D., Finer, Neil N., Carlo, Waldemar A., Duara, Shahnaz, Oh, William, Cotten, C. Michael, Stevenson, David K., Stoll, Barbara J., Lemons, James A., Guillet, Ronnie, Jobe, Alan H.·2005·New England Journal of Medicine

DOI 10.1056/nejmcps050929

Open this paper in CoChat — free account Open PDF

Abstract

BACKGROUND: Hypothermia is protective against brain injury after asphyxiation in animal models. However, the safety and effectiveness of hypothermia in term infants with encephalopathy is uncertain. METHODS: We conducted a randomized trial of hypothermia in infants with a gestational age of at least 36 weeks who were admitted to the hospital at or before six hours of age with either severe acidosis or perinatal complications and resuscitation at birth and who had moderate or severe encephalopathy. Infants were randomly assigned to usual care (control group) or whole-body cooling to an esophageal temperature of 33.5 degrees C for 72 hours, followed by slow rewarming (hypothermia group). Neurodevelopmental outcome was assessed at 18 to 22 months of age. The primary outcome was a combined end point of death or moderate or severe disability. RESULTS: Of 239 eligible infants, 102 were assigned to the hypothermia group and 106 to the control group. Adverse events were similar in the two groups during the 72 hours of cooling. Primary outcome data were available for 205 infants. Death or moderate or severe disability occurred in 45 of 102 infants (44 percent) in the hypothermia group and 64 of 103 infants (62 percent) in the control group (risk ratio, 0.72; 95 percent confidence interval, 0.54 to 0.95; P=0.01). Twenty-four infants (24 percent) in the hypothermia group and 38 (37 percent) in the control group died (risk ratio, 0.68; 95 percent confidence interval, 0.44 to 1.05; P=0.08). There was no increase in major disability among survivors; the rate of cerebral palsy was 15 of 77 (19 percent) in the hypothermia group as compared with 19 of 64 (30 percent) in the control group (risk ratio, 0.68; 95 percent confidence interval, 0.38 to 1.22; P=0.20). CONCLUSIONS: Whole-body hypothermia reduces the risk of death or disability in infants with moderate or severe hypoxic-ischemic encephalopathy.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1056/nejmcps050929

Cites

36 of 36 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Development and reliability of a system to classify gross motor function in children with cerebral palsy
Palisano, R. J., Rosenbaum, P., Walter, S. D., Russell, D., Wood, E. P., & Galuppi, B. E. (1997) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.1997.tb07414.x · Cited by 6,728
Bayley Scales of Infant Development
(2007) · Sage eBooks · doi:10.4135/9781412952644.n48 · Cited by 4,242
Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial
Gluckman, P. D., Wyatt, J. S., Azzopardi, D., Ballard, R., Edwards, A. D., Ferriero, D. M., Polin, R. A., Robertson, C. M., Thoresen, M., Whitelaw, A., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)17946-x · Cited by 2,270
Small Differences in Intraischemic Brain Temperature Critically Determine the Extent of Ischemic Neuronal Injury
Busto, R., Dietrich, W. D., Globus, M. Y. ‐., Valdés, I., Scheinberg, P., & Ginsberg, M. D. (1987) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1987.127 · Cited by 1,786
Dramatic neuronal rescue with prolonged selective head cooling after ischemia in fetal lambs.
Gunn, A. J., Gunn, T. R., de Haan, H. H., Williams, C. E., & Gluckman, P. D. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119153 · Cited by 622
Moderate hypothermia in neonatal encephalopathy: Efficacy outcomes
Eicher, D. J., Wagner, C. L., Katikaneni, L., Hulsey, T. C., Bass, W. T., Kaufman, D. A., Horgan, M. J., Languani, S., Bhatia, J. J. S., Givelichian, L. M., et al. (2004) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2004.06.014 · Cited by 581
Prediction of neuromotor outcome in perinatal asphyxia: evaluation of MR scoring systems.
Barkovich, A. J., Hajnal, B. L., Vigneron, D. B., Sola, A. M., Partridge, J. C., Allen, F., & Ferriero, D. M. (1998) · PubMed Central · Cited by 525
Assessment of Neonatal Encephalopathy by Amplitude-integrated Electroencephalography
Al-Naqeeb, N., Edwards, A. D., Cowan, F. M., & Azzopardi, D. (1999) · PEDIATRICS · doi:10.1542/peds.103.6.1263 · Cited by 458
Amplitude integrated EEG 3 and 6 hours after birth in full term neonates with hypoxic–ischaemic encephalopathy
Toet, M. C., Hellström-Westas, L. K., Groenendaal, F., Eken, P., & de Vries, L. S. (1999) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/fn.81.1.f19 · Cited by 439
Delayed and prolonged post-ischemic hypothermia is neuroprotective in the gerbil
Colbourne, F., & Corbett, D. (1994) · Brain Research · doi:10.1016/0006-8993(94)90488-x · Cited by 418

Flagged first, then by citations

Show all 36 references

Research works printed but not linked: 2

Kuluz JW, 1993, Am J Physiol, 265, H824
Barkovich AJ, 1998, AJNR Am J Neuroradiol, 19, 143

Sorted by citations

Items 201–300 of 1,006

“Therapeutic time window” duration decreases with increasing severity of cerebral hypoxia–ischaemia under normothermia and delayed hypothermia in newborn piglets
Iwata, O., Iwata, S., Thornton, J. S., Vita, E. D., Bainbridge, A. P., Herbert, L., Scaravilli, F., Peebles, D., Wyatt, J. S., Cady, E. B., et al. (2007) · Brain Research · doi:10.1016/j.brainres.2007.03.083 · Cited by 120
Synergistic neuroprotective therapies with hypothermia
Cilio, M. R., & Ferriero, D. M. (2010) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2010.02.002 · Cited by 119
Concurrent Erythropoietin and Hypothermia Treatment Improve Outcomes in a Term Nonhuman Primate Model of Perinatal Asphyxia
Traudt, C. M., McPherson, R. J., Bauer, L. A., Richards, T. L., Burbacher, T. M., McAdams, R. M., & Juul, S. E. (2013) · Developmental Neuroscience · doi:10.1159/000355460 · Cited by 119
Brain Perfusion in Asphyxiated Newborns Treated with Therapeutic Hypothermia
Wintermark, P., Hansen, A. R., Gregas, M. C., Soul, J. S., LaBrecque, M. A., Robertson, R. L., & Warfield, S. K. (2011) · American Journal of Neuroradiology · doi:10.3174/ajnr.a2708 · Cited by 119
Mild Hypothermia After Intravenous Thrombolysis in Patients With Acute Stroke
Piironen, K., Tiainen, M., Mustanoja, S. M., Kaukonen, K., Meretoja, A., Tatlisumak, T., & Kaste, M. (2014) · Stroke · doi:10.1161/strokeaha.113.003180 · Cited by 119
Effects of therapeutic hypothermia on death among asphyxiated neonates with hypoxic-ischemic encephalopathy: A systematic review and meta-analysis of randomized control trials
Abate, B. B., Bimerew, M., Gebremichael, B., Kassie, A. M., Kassaw, M. W., Gebremeskel, T., & Bayih, W. A. (2021) · PLoS ONE · doi:10.1371/journal.pone.0247229 · Cited by 119
Experimental treatments for acute ischaemic stroke
Sacco, R. L., Chong, J. Y., Prabhakaran, S., & Elkind, M. S. V. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60155-x · Cited by 116
Follow-up of the term infant after hypoxic-ischemic encephalopathy
Robertson, C. M. T., & Perlman, M. (2006) · Paediatrics & Child Health · doi:10.1093/pch/11.5.278 · Cited by 118
Therapeutic hypothermia for acute brain injuries
Andresen, M., Gazmuri, J. T., Marín, A., Regueira, T., & Rovegno, M. (2015) · Scandinavian Journal of Trauma Resuscitation and Emergency Medicine · doi:10.1186/s13049-015-0121-3 · Cited by 118
Xenon augmented hypothermia reduces early lactate/N‐acetylaspartate and cell death in perinatal asphyxia
Faulkner, S. D., Bainbridge, A. P., Kato, T., Chandrasekaran, M., Kapetanakis, A. B., Hristova, M., Liu, M., Evans, S., Vita, E. D., Kelen, D., et al. (2011) · Annals of Neurology · doi:10.1002/ana.22387 · Cited by 118
Current and Future Role of Therapeutic Hypothermia
Marion, D. W., & Bullock, M. R. (2009) · Journal of Neurotrauma · doi:10.1089/neu.2008.0582 · Cited by 116
Near-infrared spectroscopy versus magnetic resonance imaging to study brain perfusion in newborns with hypoxic–ischemic encephalopathy treated with hypothermia
Wintermark, P., Hansen, A. R., Warfield, S. K., Dukhovny, D., & Soul, J. S. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.04.072 · Cited by 115
A tertiary care centerʼs experience with therapeutic hypothermia after pediatric cardiac arrest*
Fink, E. L., Clark, R. S. B., Kochanek, P. M., Bell, M. J., & Watson, R. S. (2009) · Pediatric Critical Care Medicine · doi:10.1097/pcc.0b013e3181c58237 · Cited by 114
Treatment temperature and insult severity influence the neuroprotective effects of therapeutic hypothermia
Wood, T. R., Osredkar, D., Puchades, M. A., Maes, E., Falck, M., Flatebø, T., Walløe, L., Sabir, H., & Thoresen, M. (2016) · Scientific Reports · doi:10.1038/srep23430 · Cited by 114
Therapeutic hypothermia preserves antioxidant defenses after severe traumatic brain injury in infants and children*
Bayr, H., Adelson, P. D., Wisniewski, S. R., Shore, P., Lai, Y., Brown, D. E., Janesko‐Feldman, K. L., Kagan, V. E., & Kochanek, P. M. (2009) · Critical Care Medicine · doi:10.1097/ccm.0b013e318194abf2 · Cited by 114
Effect of Immediate vs Delayed Pushing on Rates of Spontaneous Vaginal Delivery Among Nulliparous Women Receiving Neuraxial Analgesia
Cahill, A. G., Srinivas, S. K., Tita, A., Caughey, A. B., Richter, H. E., Gregory, W. T., Liu, J., Woolfolk, C., Weinstein, D. L., Mathur, A., et al. (2018) · JAMA · doi:10.1001/jama.2018.13986 · Cited by 113
Advances in the evaluation and management of cortical/cerebral visual impairment in children
Chang, M. Y., & Borchert, M. (2020) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2020.03.001 · Cited by 112
Experimental models, neurovascular mechanisms and translational issues in stroke research
Lo, E. H. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707626 · Cited by 110
Placental pathology is associated with severity of neonatal encephalopathy and adverse developmental outcomes following hypothermia
Mir, I. N., Johnson-Welch, S. F., Nelson, D. B., Brown, L. S., Rosenfeld, C. R., & Chalak, L. F. (2015) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2015.09.072 · Cited by 112
Wavelet coherence analysis of dynamic cerebral autoregulation in neonatal hypoxic–ischemic encephalopathy
Tian, F., Tarumi, T., Liu, H., Zhang, R., & Chalak, L. F. (2016) · NeuroImage Clinical · doi:10.1016/j.nicl.2016.01.020 · Cited by 113
Inhibition of microRNA-210 provides neuroprotection in hypoxic–ischemic brain injury in neonatal rats
Ma, Q., Dasgupta, C., Li, Y., Bajwa, N. M., Xiong, F., Harding, B., Hartman, R. E., & Zhang, L. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.02.011 · Cited by 112
Induced Hypothermia for Acute Stroke
Hemmen, T., & Lyden, P. D. (2007) · Stroke · doi:10.1161/01.str.0000247920.15708.fa · Cited by 112
Clinical Seizures in Neonatal Hypoxic-Ischemic Encephalopathy Have No Independent Impact on Neurodevelopmental Outcome: Secondary Analyses of Data from the Neonatal Research Network Hypothermia Trial
Kwon, J. M., Guillet, R., Shankaran, S., Laptook, A. R., McDonald, S. A., Ehrenkranz, R. A., Tyson, J. E., O’Shea, T. M., Goldberg, R. N., Donovan, E. F., et al. (2010) · Journal of Child Neurology · doi:10.1177/0883073810380915 · Cited by 111
Self-citation
2018 American Heart Association Focused Update on Pediatric Advanced Life Support: An Update to the American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care
Duff, J. P., Topjian, A., Berg, M., Chan, M., Haskell, S. E., Joyner, B. L., Lasa, J. J., Ley, S. J., Raymond, T. T., Sutton, R. M., et al. (2018) · Circulation · doi:10.1161/cir.0000000000000612 · Cited by 111
Relationship between acute kidney injury and brain MRI findings in asphyxiated newborns after therapeutic hypothermia
Sarkar, S., Askenazi, D. J., Jordan, B. K., Bhagat, I., Bapuraj, J. R., Dechert, R. E., & Selewski, D. T. (2013) · Pediatric Research · doi:10.1038/pr.2013.230 · Cited by 110
Xenon Ventilation During Therapeutic Hypothermia in Neonatal Encephalopathy: A Feasibility Study
Dingley, J., Tooley, J., Liu, X., Scull-Brown, E., Elstad, M., Chakkarapani, E., Sabir, H., & Thoresen, M. (2014) · PEDIATRICS · doi:10.1542/peds.2013-0787 · Cited by 110
Are we (mis)guided by current guidelines on intrapartum fetal heart rate monitoring? Case for a more physiological approach to interpretation
Ugwumadu, A. H. N. (2014) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.12900 · Cited by 108
Perinatal brain damage: The term infant
Hagberg, H., Edwards, A. D., & Groenendaal, F. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.09.011 · Cited by 115
Systematic review: long‐term cognitive and behavioural outcomes of neonatal hypoxic–ischaemic encephalopathy in children without cerebral palsy
Schreglmann, M., Ground, A., Vollmer, B., & Johnson, M. J. (2019) · Acta Paediatrica · doi:10.1111/apa.14821 · Cited by 115
Serum glial fibrillary acidic protein as a predictive biomarker of neurological outcome after cardiac arrest
Kaneko, T., Kasaoka, S., Miyauchi, T., Fujita, M., Oda, Y., Tsuruta, R., & Maekawa, T. (2009) · Resuscitation · doi:10.1016/j.resuscitation.2009.04.003 · Cited by 109
Neonatal Encephalopathy: Treatment with Hypothermia
Shankaran, S. (2009) · Journal of Neurotrauma · doi:10.1089/neu.2008.0678 · Cited by 107
Self-citation
Apgar scores at 10 min and outcomes at 6–7 years following hypoxic-ischaemic encephalopathy
Natarajan, G., Shankaran, S., Laptook, A. R., Pappas, A., Bann, C., McDonald, S. A., Das, A., Higgins, R. D., Hintz, S. R., & Vohr, B. R. (2013) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/archdischild-2013-303692 · Cited by 107
Self-citation
Potential biomarkers for hypoxic–ischemic encephalopathy
Bennet, L., Booth, L. C., & Gunn, A. J. (2010) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2010.05.007 · Cited by 108
Arterial spin-labelling perfusion MRI and outcome in neonates with hypoxic-ischemic encephalopathy
Vis, J. B. D., Hendrikse, J., Petersen, E. T., de Vries, L. S., van Bel, F., Alderliesten, T., Negro, S., Groenendaal, F., & Benders, M. J. N. L. (2014) · European Radiology · doi:10.1007/s00330-014-3352-1 · Cited by 106
Cardiovascular Alterations and Multiorgan Dysfunction After Birth Asphyxia
Polglase, G. R., Ong, T., & Hillman, N. H. (2016) · Clinics in Perinatology · doi:10.1016/j.clp.2016.04.006 · Cited by 106
Golden hour of neonatal life: Need of the hour
Sharma, D. K. (2017) · Maternal Health Neonatology and Perinatology · doi:10.1186/s40748-017-0057-x · Cited by 106
Hypothermia for hypoxic–ischemic encephalopathy
Cotten, C. M., & Shankaran, S. (2010) · Expert Review of Obstetrics & Gynecology · doi:10.1586/eog.10.7 · Cited by 106
Self-citation
Hypoxia in the regulation of neural stem cells
Filippis, L. D., & Delia, D. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0723-5 · Cited by 111
Therapeutic hypothermia on neonatal transport: 4-year experience in a single NICU
Fairchild, K. D., Sokora, D., Scott, J. N., & Zanelli, S. A. (2009) · Journal of Perinatology · doi:10.1038/jp.2009.168 · Cited by 105
The Frequency and Severity of Magnetic Resonance Imaging Abnormalities in Infants with Mild Neonatal Encephalopathy
Walsh, B. H., Neil, J. J., Morey, J., Yang, E., Silvera, M. V., Inder, T. E., & Ortinau, C. M. (2017) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2017.03.065 · Cited by 104
Mechanism and Treatment Related to Oxidative Stress in Neonatal Hypoxic-Ischemic Encephalopathy
Qin, X., Cheng, J., Zhong, Y., Mahgoub, O. K., Akter, F., Fan, Y., Aldughaim, M. S., Xie, Q., Qin, L., Gu, L., et al. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00088 · Cited by 105
Therapeutic hypothermia following perinatal asphyxia
Edwards, A. D., & Azzopardi, D. (2006) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/adc.2005.071787 · Cited by 104
Short-Term Outcomes of Newborns with Perinatal Acidemia Who are Not Eligible for Systemic Hypothermia Therapy
DuPont, T. L., Chalak, L. F., Morriss, M. C., Burchfield, P. J., Christie, L., & Sánchez, P. J. (2012) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2012.06.042 · Cited by 103
Inflammation‐induced sensitization of the brain in term infants
Fleiss, B., Tann, C. J., Degos, V., Sigaut, S., Steenwinckel, J. V., Schang, A., Kichev, A., Robertson, N. J., Mallard, C. E., Hagberg, H., et al. (2015) · Developmental Medicine & Child Neurology · doi:10.1111/dmcn.12723 · Cited by 106
How the body controls brain temperature: the temperature shielding effect of cerebral blood flow
Zhu, M., Ackerman, J. J. H., Sukstanskii, A. L., & Yablonskiy, D. A. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00319.2006 · Cited by 102
Care for Child Development: Basic Science Rationale and Effects of Interventions
Holt, R. L., & Mikati, M. A. (2011) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2010.11.009 · Cited by 109
Comparison of B ayley‐2 and B ayley‐3 scores at 18 months in term infants following neonatal encephalopathy and therapeutic hypothermia
Jary, S., Whitelaw, A., Walløe, L., & Thoresen, M. (2013) · Developmental Medicine & Child Neurology · doi:10.1111/dmcn.12208 · Cited by 101
School-age outcomes of children without cerebral palsy cooled for neonatal hypoxic–ischaemic encephalopathy in 2008–2010
Lee‐Kelland, R., Jary, S., Tonks, J., Cowan, F. M., Thoresen, M., & Chakkarapani, E. (2019) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/archdischild-2018-316509 · Cited by 100
Therapeutic hypothermia in neonatal hypoxic encephalopathy: A systematic review and meta-analysis
Mathew, J. L., Kaur, N., & Dsouza, J. M. (2022) · Journal of Global Health · doi:10.7189/jogh.12.04030 · Cited by 99
Neurocritical Care for Neonates
Glass, H. C., Bonifacio, S. L., Peloquin, S., Shimotake, T. K., Sehring, S. A., Sun, Y., Sullivan, J. E., Rogers, E. E., Barkovich, A. J., Rowitch, D. H., et al. (2010) · Neurocritical Care · doi:10.1007/s12028-009-9324-7 · Cited by 98
Pediatric Traumatic Brain Injury: Quo Vadis?
Kochanek, P. M. (2006) · Developmental Neuroscience · doi:10.1159/000094151 · Cited by 98
Brain Resuscitation in the Drowning Victim
Topjian, A., Berg, R. A., Bierens, J. J. L. M., Branche, C. M., Clark, R. S. B., Friberg, H., Hoedemaekers, C., Holzer, M. S., Katz, L. M., Knape, J. T. A., et al. (2012) · Neurocritical Care · doi:10.1007/s12028-012-9747-4 · Cited by 97
Predictive Value of an Early Amplitude Integrated Electroencephalogram and Neurologic Examination
Shankaran, S., Pappas, A., McDonald, S. A., Laptook, A. R., Bara, R., Ehrenkranz, R. A., Tyson, J. E., Goldberg, R. N., Donovan, E. F., Fanaroff, A. A., et al. (2011) · PEDIATRICS · doi:10.1542/peds.2010-2036 · Cited by 97
Self-citation
Apoptotic Mechanisms in the Immature Brain: Involvement of Mitochondria
Hagberg, H., Mallard, C. E., Rousset, C. I., & Wang, X. (2009) · Journal of Child Neurology · doi:10.1177/0883073809338212 · Cited by 97
Therapeutic hypothermia alters microRNA responses to traumatic brain injury in rats
Truettner, J. S., Alonso, O. F., Bramlett, H. M., & Dietrich, W. D. (2011) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2011.33 · Cited by 97
Pathophysiology of Perinatal Asphyxia in Humans and Animal Models
Mota‐Rojas, D., Villanueva‐García, D., Solimano, A. J., Muns, R., Ibarra‐Ríos, D., & Mota-Reyes, A. (2022) · Biomedicines · doi:10.3390/biomedicines10020347 · Cited by 96
Risk-adjusted models for adverse obstetric outcomes and variation in risk-adjusted outcomes across hospitals
Bailit, J. L., Grobman, W. A., Rice, M. M., Spong, C. Y., Wapner, R. J., Varner, M. W., Thorp, J. M., Leveno, K. J., Caritis, S. N., Shubert, P. J., et al. (2013) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2013.07.019 · Cited by 96
Novel interventions to reduce oxidative-stress related brain injury in neonatal asphyxia
Solevåg, A. L., Schmölzer, G. M., & Cheung, P. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.04.028 · Cited by 95
Overview of Therapeutic Hypothermia
Song, S. S., & Lyden, P. D. (2012) · Current Treatment Options in Neurology · doi:10.1007/s11940-012-0201-x · Cited by 95
Standardised formal resuscitation training programmes for reducing mortality and morbidity in newborn infants
Dempsey, E. M., Pammi, M., Ryan, C. A., & Barrington, K. J. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009106.pub2 · Cited by 95
Prospective research on infants with mild encephalopathy: the PRIME study
Prempunpong, C., Chalak, L. F., Garfinkle, J., Shah, B. A., Kalra, V., Rollins, N. K., Boyle, R., Nguyen, K.-A., Mir, I. N., Pappas, A., et al. (2017) · Journal of Perinatology · doi:10.1038/jp.2017.164 · Cited by 94
Self-citation
RBM3 promotes neurogenesis in a niche-dependent manner via IMP2-IGF2 signaling pathway after hypoxic-ischemic brain injury
Zhu, X., Yan, J., Brégère, C., Marten, A., Görne, T., Kapfhammer, J. P., Guzman, R. G., & Wellmann, S. M. (2019) · Nature Communications · doi:10.1038/s41467-019-11870-x · Cited by 92
Erythropoietin for infants with hypoxic–ischemic encephalopathy
McPherson, R. J., & Juul, S. E. (2010) · Current Opinion in Pediatrics · doi:10.1097/mop.0b013e328336eb57 · Cited by 94
Methods of cooling: Practical aspects of therapeutic temperature management
Seder, D. B., & der Kloot, T. E. V. (2009) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181aa5bad · Cited by 95
Impaired cerebral autoregulation and brain injury in newborns with hypoxic-ischemic encephalopathy treated with hypothermia
Massaro, A. N., Govindan, R. B., Vézina, G., Chang, T., Andescavage, N. N., Wang, Y., Al‐Shargabi, T., Metzler, M., Harris, K., & du Plessis, A. J. (2015) · Journal of Neurophysiology · doi:10.1152/jn.00353.2015 · Cited by 94
Allopurinol for preventing mortality and morbidity in newborn infants with suspected hypoxic-ischaemic encephalopathy
Chaudhari, T., & McGuire, W. L. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006817.pub2 · Cited by 94
Birth Asphyxia and Hypoxic-Ischemic Brain Injury in the Preterm Infant
Laptook, A. R. (2016) · Clinics in Perinatology · doi:10.1016/j.clp.2016.04.010 · Cited by 93
Self-citation
Hypoxic-Ischemic encephalopathy and therapeutic hypothermia: the hemodynamic perspective
Giesinger, R. E., Bailey, L. J., Deshpande, P., & McNamara, P. J. (2017) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2016.09.009 · Cited by 92
Short-Term Outcome Prediction by Electroencephalographic Features in Children Treated with Therapeutic Hypothermia After Cardiac Arrest
Kessler, S. K., Topjian, A., Gutierrez‐Colina, A. M., Ichord, R., Donnelly, M., Nadkarni, V., Berg, R. A., Dlugos, D., Clancy, R. R., & Abend, N. S. (2010) · Neurocritical Care · doi:10.1007/s12028-010-9450-2 · Cited by 92
An overview of medical ECMO for neonates
Fletcher, K. L., Chapman, R. L., & Keene, S. D. (2018) · Seminars in Perinatology · doi:10.1053/j.semperi.2017.12.002 · Cited by 92
Sleep Disturbances in Newborns
Barbeau, D. Y., & Weiss, M. D. (2017) · Children · doi:10.3390/children4100090 · Cited by 84
Hypothermia attenuates ischemia/reperfusion‐induced endothelial cell apoptosis via alterations in apoptotic pathways and JNK signaling
Yang, D., Guo, S., Zhang, T., & Li, H. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.07.006 · Cited by 91
Effects of combination therapy using hypothermia and erythropoietin in a rat model of neonatal hypoxia–ischemia
Fang, A. Y., Gonzalez, F. F., Sheldon, R. A., & Ferriero, D. M. (2012) · Pediatric Research · doi:10.1038/pr.2012.138 · Cited by 91
A new approach to define acute kidney injury in term newborns with hypoxic ischemic encephalopathy
Gupta, C., Massaro, A. N., & Ray, P. E. (2016) · Pediatric Nephrology · doi:10.1007/s00467-016-3317-5 · Cited by 91
Circulating Inflammatory-Associated Proteins in the First Month of Life and Cognitive Impairment at Age 10 Years in Children Born Extremely Preterm
Kuban, K., Joseph, R. M., O’Shea, T. M., Heeren, T., Fichorova, R. N., Douglass, L. M., Jara, H. J., Frazier, J. A., Hirtz, D., Rollins, J. V., et al. (2016) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2016.09.054 · Cited by 91
Autologous cord blood cell therapy for neonatal hypoxic-ischaemic encephalopathy: a pilot study for feasibility and safety
Tsuji, M., Sawada, M., Watabe, S., Sano, H., Kanai, M., Tanaka, E., Ohnishi, S., Sato, Y., Sobajima, H., Hamazaki, T., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-61311-9 · Cited by 91
Successful outcome utilizing hypothermia after cardiac arrest in pregnancy: A case report
Rittenberger, J. C., Kelly, E. K., Jang, D. H., Greer, K., & Heffner, A. C. (2008) · Critical Care Medicine · doi:10.1097/ccm.0b013e318169ee99 · Cited by 91
Passive induction of hypothermia during transport of asphyxiated infants: a risk of excessive cooling
Hallberg, B., Olson, L., Bartocci, M., Edqvist, I., & Blennow, M. (2009) · Acta Paediatrica · doi:10.1111/j.1651-2227.2009.01303.x · Cited by 91
Introduction of Hypothermia for Neonates with Perinatal Asphyxia in the Netherlands and Flanders
Groenendaal, F., Casaer, A., Dijkman, K. P., Gavilanes, A. W. D., de Haan, T. R., ter Horst, H. J., Laroche, S. M., Naulaers, G., Rijken, M., Straaten, H. L. M. V., et al. (2013) · Neonatology · doi:10.1159/000348823 · Cited by 91
Magnesium Sulfate in Severe Perinatal Asphyxia: A Randomized, Placebo-Controlled Trial
Bhat, M. A., Charoo, B. A., Bhat, J. I., Ahmad, S. M., Ali, S. W., & Mufti, M.-U.-H. (2009) · PEDIATRICS · doi:10.1542/peds.2007-3642 · Cited by 91
Critical Management Decisions in Patients With Acute Liver Failure
Stravitz, R. T. (2008) · CHEST Journal · doi:10.1378/chest.08-1071 · Cited by 92
Neonatal encephalopathy and hypoxic-ischemic encephalopathy: the state of the art
Chakkarapani, E., de Vries, L. S., Ferriero, D. M., & Gunn, A. J. (2025) · Pediatric Research · doi:10.1038/s41390-025-03986-2 · Cited by 90
Phenobarbital for neonatal seizures in hypoxic ischemic encephalopathy: A pharmacokinetic study during whole body hypothermia
Filippi, L., la Marca, G., Cavallaro, G., Fiorini, P., Favelli, F., Malvagia, S., Donzelli, G., & Guerrini, R. (2011) · Epilepsia · doi:10.1111/j.1528-1167.2011.02978.x · Cited by 90
Phenobarbital Augments Hypothermic Neuroprotection
Barks, J., Liu, Y.-Q., Shangguan, Y., & Silverstein, F. S. (2010) · Pediatric Research · doi:10.1203/pdr.0b013e3181d4ff4d · Cited by 90
A Randomized Trial of Intrapartum Fetal ECG ST-Segment Analysis
Belfort, M. A., Saade, G. R., Thom, E. A., Blackwell, S. C., Reddy, U. M., Thorp, J. M., Tita, A., Miller, R. S., Peaceman, A. M., McKenna, D. S., et al. (2015) · Obstetrical & Gynecological Survey · doi:10.1097/ogx.0000000000000276 · Cited by 89
Advances in Therapies to Treat Neonatal Hypoxic-Ischemic Encephalopathy
Ranjan, A. K., & Gulati, A. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12206653 · Cited by 117
Hypoxic-ischemic Encephalopathy and Novel Strategies for Neuroprotection
Shankaran, S. (2012) · Clinics in Perinatology · doi:10.1016/j.clp.2012.09.008 · Cited by 88
Self-citation
Erythropoietin and Hypothermia for Hypoxic-Ischemic Encephalopathy
Rogers, E. E., Bonifacio, S. L., Glass, H. C., Juul, S. E., Chang, T., Mayock, D. E., Durand, D. J., Song, D., Barkovich, A. J., Ballard, R. A., et al. (2014) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2014.08.010 · Cited by 88
The regulatory roles of non-coding RNAs in nerve injury and regeneration
Yu, B., Zhou, S., Yi, S., & Gu, X. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.09.006 · Cited by 87
Destruction and reconstruction: Hypoxia and the developing brain
Barrett, R. D., Bennet, L., Davidson, J. O., Dean, J. M., George, S. A., Emerald, B. S., & Gunn, A. J. (2007) · Birth Defects Research Part C Embryo Today Reviews · doi:10.1002/bdrc.20095 · Cited by 89
Hypothermia Therapy for Neonatal Hypoxic Ischemic Encephalopathy in the State of California
Kracer, B., Hintz, S. R., Meurs, K. P. V., & Lee, H. C. (2014) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2014.04.052 · Cited by 87
Subcutaneous Fat Necrosis After Moderate Therapeutic Hypothermia in Neonates
Strohm, B., Hobson, A., Brocklehurst, P., Edwards, A. D., & Azzopardi, D. (2011) · PEDIATRICS · doi:10.1542/peds.2010-3508 · Cited by 87
Neonatal Sleep–Wake Analyses Predict 18-month Neurodevelopmental Outcomes
Shellhaas, R. A., Burns, J. W., Hassan, F., Carlson, M. D., Barks, J., & Chervin, R. D. (2017) · SLEEP · doi:10.1093/sleep/zsx144 · Cited by 87
Recent trends in erythropoietin‐mediated neuroprotection
McPherson, R. J., & Juul, S. E. (2007) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2007.08.012 · Cited by 87
Therapeutics for neonatal brain injury
Gonzalez, F. F., & Ferriero, D. M. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.07.003 · Cited by 87
Using amplitude-integrated EEG in neonatal intensive care
Tao, J. D., & Mathur, A. (2010) · Journal of Perinatology · doi:10.1038/jp.2010.93 · Cited by 87
Biomarkers of Brain Injury in Neonatal Encephalopathy Treated with Hypothermia
Massaro, A. N., Chang, T., Kadom, N., Tsuchida, T. N., Scafidi, J., Glass, P., McCarter, R., Baumgart, S., Vézina, G., & Nelson, K. B. (2012) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2012.02.047 · Cited by 87
Neuroprotective effects of a combination of dexmedetomidine and hypothermia after incomplete cerebral ischemia in rats
Sato, K., Kimura, T., Nishikawa, T., Tobe, Y., & Masaki, Y. (2009) · Acta Anaesthesiologica Scandinavica · doi:10.1111/j.1399-6576.2009.02139.x · Cited by 86
The Spectrum of Abnormal Neurologic Outcomes Subsequent to Term Intrapartum Asphyxia
Al‐Macki, N., Miller, S. P., Hall, N., & Shevell, M. I. (2009) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2009.06.001 · Cited by 86
Pediatric Basic and Advanced Life Support: 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations
Kleinman, M. E., de Caen, A. R., Chameides, L., Atkins, D. L., Berg, R. A., Berg, M. D., Bhanji, F., Biarent, D., Bingham, R., Coovadia, A. H., et al. (2010) · Pediatrics · doi:10.1542/peds.2010-2972a · Cited by 86

Authors: Shankaran, S., Laptook, A. R., Ehrenkranz, R. A., Tyson, J. E., McDonald, S. A., Donovan, E. F., Fanaroff, A. A., Poole, W. K., Wright, L. L., Higgins, R. D., Finer, N. N., Carlo, W. A., Duara, S., Oh, W., Cotten, C. M., Stevenson, D. K., Stoll, B. J., Lemons, J. A., Guillet, R., & Jobe, A. H.
Affiliations: Wayne State University (US)
Women & Infants Hospital of Rhode Island (US)
Yale University (US)
RTI International (US)
University of Cincinnati (US)
Rainbow Babies & Children's Hospital (US)
National Institutes of Health (US)
University of California San Diego (US)
University of Alabama at Birmingham (US)
University of Miami (US)
Duke Medical Center (US)
Stanford University (US)
Emory University (US)
Indiana University School of Medicine (US)
University of Rochester (US)
ORCID: Shankaran, Seetha
Laptook, Abbot R.
McDonald, Scott A.
Higgins, Rosemary D.
Carlo, Waldemar A.
Duara, Shahnaz
Cotten, C. Michael
Stevenson, David K.
Stoll, Barbara J.
Guillet, Ronnie
Jobe, Alan H.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2005-10-13
Volume: 353
Issue: 15
Pages: 1574-1584
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmcps050929
OpenAlex: W2164127547
Cited by: 2,862
References: 36
Citations by year: 2026: 95 · 2025: 152 · 2024: 157 · 2023: 121 · 2022: 118 · 2021: 155 · 2020: 123 · 2019: 129 · 2018: 152 · 2017: 152 · 2016: 143 · 2015: 170 · 2014: 131 · 2013: 141 · 2012: 166
FWCI: 89.20
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
UWA Profiles and Research Repository (UWA) (submittedVersion)
Funders: National Center for Research Resources (5-M01-RR-00044, M01RR008084, M01-RR00039, M01RR000125, M01-RR 00750, M01 RR-00125, M01 RR 0039-43, M01RR000750, M-01 RR 00070, M01RR000044, M01RR000070, M01RR000039, M01-RR-08084)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (U10HD040498, (U10 HD27871, U10 HD 27853, U10HD027880, U10 HD27880, U10 HD 40461, U10HD40521, U10HD21385, U10HD 21397, U10HD40498, U10HD27851, U10 HD34216, U10HD40492, U01HD36790, U10‐HD‐27904, U10HD021397, U10HD027904, U10HD027856, U10HD040689, U10HD027871, U10-HD21373, U10HD027853, U10HD040492, U10HD034216, U10HD021373, U10HD021385, U10HD40689, U10 HD27856, U10HD040521, U01HD036790, U10HD027851, U10HD040461)
Topics: Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Thermal Regulation in Medicine
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Development and Preterm Care
Keywords: whole-body hypothermia, hypoxic-ischemic encephalopathy, neonates, neuroprotection, cerebral palsy, neurodevelopmental outcomes, perinatal asphyxia, acidosis, term infants, mortality, disability
MeSH terms: Acidosis, Asphyxia Neonatorum, Blindness, Cerebral Palsy, Developmental Disabilities, Female, Follow-Up Studies, Humans, Hypothermia, Induced, Infant, Newborn, Obstetric Labor Complications, Male, Pregnancy, Pregnancy Complications, Hypoxia-Ischemia, Brain, Hearing Loss

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks