Cited by 847Respiratory Support and MechanismsMechanical Circulatory Support DevicesNeonatal Respiratory Health Research

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Extracorporeal Membrane Oxygenation for ARDS in Adults

Brodie, Daniel, Bacchetta, Matthew·2011·New England Journal of Medicine

DOI 10.1056/nejmct1103720

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Abstract

A 41-year-old woman presents with severe community-acquired pneumococcal pneumonia. Chest radiography reveals diffuse bilateral infiltrates, and hypoxemic respiratory failure develops despite appropriate antibiotic therapy. She is intubated and mechanical ventilation is initiated with a volume- and pressure-limited approach for the acute respiratory distress syndrome (ARDS). Over the ensuing 24 hours, her partial pressure of arterial oxygen (Pao2) decreases to 40 mm Hg, despite ventilatory support with a fraction of inspired oxygen (Fio2) of 1.0 and a positive end-expiratory pressure (PEEP) of 20 cm of water. She is placed in the prone position and a neuromuscular blocking agent is administered, without improvement in her Pao2. An intensive care specialist recommends the initiation of extracorporeal membrane oxygenation (ECMO).

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Authors: Brodie, D., & Bacchetta, M.
Affiliations: NewYork–Presbyterian Hospital (US)
ORCID: Brodie, Daniel
Bacchetta, Matthew
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2011-11-17
Volume: 365
Issue: 20
Pages: 1905-1914
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmct1103720
OpenAlex: W2037145800
Cited by: 836
References: 76
Citations by year: 2026: 19 · 2025: 33 · 2024: 36 · 2023: 36 · 2022: 42 · 2021: 64 · 2020: 65 · 2019: 67 · 2018: 58 · 2017: 81 · 2016: 89 · 2015: 61 · 2014: 83 · 2013: 56 · 2012: 40
FWCI: 9.50
Type: journal article
Language: en
Open access: closed
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Mechanical Circulatory Support Devices
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Neonatal Respiratory Health Research
Keywords: extracorporeal membrane oxygenation, acute respiratory distress syndrome, community-acquired pneumonia, pneumococcal pneumonia, hypoxemic respiratory failure, mechanical ventilation, prone positioning, neuromuscular blockade, adult patients
MeSH terms: Adult, Hypoxia, Female, Humans, Pneumonia, Pneumococcal, Respiratory Distress Syndrome, Extracorporeal Membrane Oxygenation, Practice Guidelines as Topic, Community-Acquired Infections

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Extracorporeal Membrane Oxygenation for ARDS in Adults

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