Metabolic Enzymes as Oncogenes or Tumor Suppressors

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

Parsons, D. W., Jones, S., Zhang, X., Lin, J. C.-H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Siu, I.-M., Gallia, G. L., et al. (2008) · Science · doi:10.1126/science.1164382 · Cited by 5,857

IDH1 and IDH2 Mutations in Gliomas

Yan, H., Parsons, D. W., Jin, G., McLendon, R., Rasheed, B. A., Yuan, W., Kos, I., Batinic-Haberle, I., Jones, S., Riggins, G. J., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808710 · Cited by 5,847

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

DeBerardinis, R. J., Lum, J. J., Hatzivassiliou, G., & Thompson, C. B. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.002 · Cited by 4,088

Analysis of the IDH1 codon 132 mutation in brain tumors

Balss, J., Meyer, J., Mueller, W., Korshunov, A., Hartmann, C., & von Deimling, A. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0455-2 · Cited by 1,036

Succinate dehydrogenase and fumarate hydratase: linking mitochondrial dysfunction and cancer

King, A., Selak, M. A., & Gottlieb, E. (2006) · Oncogene · doi:10.1038/sj.onc.1209594 · Cited by 672

Structures of Human Cytosolic NADP-dependent Isocitrate Dehydrogenase Reveal a Novel Self-regulatory Mechanism of Activity

Xu, X., Zhao, J., Xu, Z., Peng, B., Huang, Q., Arnold, E., & Ding, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404298200 · Cited by 407

Cell-Permeating α -Ketoglutarate Derivatives Alleviate Pseudohypoxia in Succinate Dehydrogenase-Deficient Cells

MacKenzie, E. D., Selak, M. A., Tennant, D. A., Payne, L. J., Crosby, S., Frederiksen, C. M., Watson, D. G., & Gottlieb, E. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01927-06 · Cited by 359

Disruptive mitochondrial DNA mutations in complex I subunits are markers of oncocytic phenotype in thyroid tumors

Gasparre, G., Porcelli, A. M., Bonora, E., Pennisi, L. F., Toller, M., Iommarini, L., Ghelli, A. M., Moretti, M., Betts, C. M., Martinelli, G. N., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703056104 · Cited by 316

Insights from retinitis pigmentosa into the roles of isocitrate dehydrogenases in the Krebs cycle

Hartong, D. T., Dange, M., McGee, T. L., Berson, E. L., Dryja, T. P., & Colman, R. F. (2008) · Nature Genetics · doi:10.1038/ng.223 · Cited by 172

NADPH Oxidase Promotes Pancreatic Cancer Cell Survival via Inhibiting JAK2 Dephosphorylation by Tyrosine Phosphatases

Lee, J. K., Edderkaoui, M., Truong, P. A., Ohno, I., Jang, K., Berti, A., Pandol, S. J., & Gukovskaya, A. S. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.08.022 · Cited by 157

Low circulating levels of the mitochondrial-peptide hormone SHLP2: novel biomarker for prostate cancer risk

Xiao, J., Howard, L. E., Wan, J., Wiggins, E. K., Vidal, A. C., Cohen, P., & Freedland, S. J. (2017) · Oncotarget · doi:10.18632/oncotarget.20134 · Cited by 39

Correlation between IDH1 gene mutation status and survival of patients treated for recurrent glioma.

Lv, S., Teugels, E., Sadones, J., Quartier, E., Huylebrouck, M., Four, S. D., Mercier, M. L., Witte, O. D., Salmon, I. J., Michotte, A., et al. (2011) · PubMed · Cited by 37

Facile Synthesis [5-13C-4-2H2]-L-Glutamine for Hyperpolarized MRS Imaging of Cancer Cell Metabolism

Qü, W., Zha, Z., Lieberman, B. P., Mancuso, A., Stetz, M., Rizzi, R., Plöessl, K., Wise, D. R., Thompson, C. B., & Kung, H. F. (2011) · Academic Radiology · doi:10.1016/j.acra.2011.05.002 · Cited by 37

In vitro effects of dichloroacetate and CO2 on hypoxic HeLa cells.

Anderson, K. M., Jajeh, J., Guinan, P., & Rubenstein, M. (2009) · PubMed · Cited by 37

TGFβ-Induced Deptor Suppression Recruits mTORC1 and Not mTORC2 to Enhance Collagen I (α2) Gene Expression

Das, F., Bera, A., Ghosh‐Choudhury, N., Abboud, H. E., Kasinath, B. S., & Choudhury, G. G. (2014) · PLoS ONE · doi:10.1371/journal.pone.0109608 · Cited by 37

Antiproliferation of berberine is mediated by epigenetic modification of constitutive androstane receptor (CAR) metabolic pathway in hepatoma cells

Zhang, L., Miao, X., Wang, X., Pan, H., Li, P., Ren, H., Jia, Y., Lu, C., Wang, H., Yuan, L., et al. (2016) · Scientific Reports · doi:10.1038/srep28116 · Cited by 35

Biomarker signatures of mitochondrial NDUFS3 in invasive breast carcinoma

Suhane, S., Berel, D., & Ramanujan, V. K. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.08.003 · Cited by 35

Characterizing the metabolic heterogeneity in human breast cancer xenografts by 3D high resolution fluorescence imaging

Xu, H. N., Zheng, G., Tchou, J. C., Nioka, S., & Li, L. Z. (2013) · SpringerPlus · doi:10.1186/2193-1801-2-73 · Cited by 33

NADP+-dependent IDH1R132 mutation and its relevance for glioma patient survival

Tewarie, N. M. S. B., Burgers, I. A. V., Dawood, Y., den Boon, H. C., den Brok, M. G. H. E., Klunder, J. H., Koopmans, K. B., Rademaker, E., van den Broek, H. B., van den Bersselaar, S. M., et al. (2013) · Medical Hypotheses · doi:10.1016/j.mehy.2013.02.022 · Cited by 33

Microenvironment-Derived Regulation of HIF Signaling Drives Transcriptional Heterogeneity in Glioblastoma Multiforme

Heiland, D. H., Gaebelein, A., Börries, M., Wörner, J., Pompe, N., Franco, P., Heynckes, S., Bartholomae, M., hAilín, D. Ó., Carro, M. S., et al. (2018) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-17-0680 · Cited by 34

Survival of the fittest: metabolic adaptations in cancer

Berardi, M. J., & Fantin, V. R. (2010) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2010.10.001 · Cited by 30

Differential Activity of NADPH-Producing Dehydrogenases Renders Rodents Unsuitable Models to Study IDH1 R132 Mutation Effects in Human Glioblastoma

Atai, N. A., Renkema-Mills, N. A., Bosman, J., Schmidt, N., Rijkeboer, D., Tigchelaar, W., Bosch, K. S., Troost, D., Jonker, A., Bleeker, F. E., et al. (2011) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155411400606 · Cited by 32

Imaging mitochondrial redox potential and its possible link to tumor metastatic potential

Li, L. Z. (2012) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-012-9469-5 · Cited by 32

HIF-1-alpha links mitochondrial perturbation to the dynamic acquisition of breast cancer tumorigenicity

Kuo, C., Cheng, C.-T., Hou, P., Lin, Y.-P., Ma, H., Chung, Y., Chi, K. K., Chen, Y., Li, W., Kung, H.-J., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.8570 · Cited by 32

Curative role of pantothenic acid in brain damage of gamma irradiated rats

Shedid, S. M., Saada, H. N., Na, E., & Hammad, A. (2017) · Indian Journal of Clinical Biochemistry · doi:10.1007/s12291-017-0683-0 · Cited by 30

Oncometabolites and the response to radiotherapy

Xiang, K., Jendrossek, V., & Matschke, J. (2020) · Radiation Oncology · doi:10.1186/s13014-020-01638-9 · Cited by 30

Dual role of Nrf2 in cancer: molecular mechanisms, cellular functions and therapeutic interventions

Poornashree, M., Kumar, H., AJMEER, R., Jain, R., & Jain, V. K. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-08126-1 · Cited by 28

The Multifaceted Metabolism of Glioblastoma

Quinones, A., & Le, A. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-77736-8_4 · Cited by 28

Mitochondria: 3-bromopyruvate vs. mitochondria? A small molecule that attacks tumors by targeting their bioenergetic diversity

Galina, A. (2014) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2014.05.013 · Cited by 30

Glucose Metabolism Gene Variants Modulate the Risk of Pancreatic Cancer

Dong, X., Li, Y., Chang, P., Tang, H., Hess, K. R., Abbruzzese, J. L., & Li, D. (2011) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-10-0247 · Cited by 27

Mitochondria: a new intervention target for tumor invasion and metastasis

Zhou, Q., Cao, T., Li, F., Zhang, M., Li, X., Zhao, H., & Zhou, Y. (2024) · Molecular Medicine · doi:10.1186/s10020-024-00899-4 · Cited by 26

The Emerging Role of Succinate Dehyrogenase Genes (SDHx) in Tumorigenesis

Nazar, E., Khatami, F., Saffar, H., & Tavangar, S. M. (2019) · International Journal of Hematology-Oncology and Stem Cell Research · doi:10.18502/ijhoscr.v13i2.692 · Cited by 26

Cancer plasticity: Investigating the causes for this agility

Saha, S., Pradhan, N., Neha, B., Mahadevappa, R., Minocha, S., & Kumar, S. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.12.005 · Cited by 27

The Multifaceted Glioblastoma: From Genomic Alterations to Metabolic Adaptations

Quinones, A., & Le, A. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-65768-0_4 · Cited by 25

The KISS1 metastasis suppressor appears to reverse the Warburg effect by shifting from glycolysis to mitochondrial beta-oxidation

Manley, S., Liu, W., & Welch, D. R. (2017) · Journal of Molecular Medicine · doi:10.1007/s00109-017-1552-2 · Cited by 26

Heterogeneity of the cancer cell line metabolic landscape

Shorthouse, D., Bradley, J., Critchlow, S. E., Bendtsen, C., & Hall, B. A. (2022) · Molecular Systems Biology · doi:10.15252/msb.202211006 · Cited by 24

Flavopiridol: An Old Drug With New Perspectives? Implication for Development of New Drugs

Cimini, A., d’Angelo, M., Benedetti, E., D’Angelo, B., Laurenti, G., Antonosante, A., Cristiano, L., Mambro, A. D., Barbarino, M., Castelli, V., et al. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25421 · Cited by 22

IDH2 mutation in gliomas including novel mutation

Koh, J., Cho, H.-J., Kim, H., Kim, S. I., Yun, S., Park, C., Lee, S., Choi, S. H., & Park, S. (2014) · Neuropathology · doi:10.1111/neup.12187 · Cited by 23

Brown Adipose Transplantation Improves Polycystic Ovary Syndrome-Involved Metabolome Remodeling

Yao, L., Wang, Q., Zhang, R., Wang, X., Liu, Y., Di, F., Song, L., & Xu, S. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.747944 · Cited by 21

In-Tumor Biosynthetic Construction of Upconversion Nanomachines for Precise Near-Infrared Phototherapy

Pan, Y., Luan, X., Gao, Y., Zeng, F., Wang, X., Zhou, D., Li, W., Wang, Y., He, B., & Song, Y. (2023) · ACS Nano · doi:10.1021/acsnano.2c10453 · Cited by 21

Genetic variants in genes of tricarboxylic acid cycle key enzymes are associated with prognosis of patients with non-small cell lung cancer

Guo, X., Li, D., Wu, Y., Chen, Y., Zhou, X., Wang, X., Huang, X., Li, X., Yang, H., & Xing, J. (2014) · Lung Cancer · doi:10.1016/j.lungcan.2014.12.005 · Cited by 23

Differentiation of human neuroblastoma cells toward the osteogenic lineage by mTOR inhibitor

Carpentieri, A., Cozzoli, E., Scimeca, M., Bonanno, E., Sardanelli, A. M., & Gambacurta, A. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.244 · Cited by 22

Metabolism and cancer: an up-to-date review of a mutual connection.

Mentis, A. A., & Kararizou, E. G. (2010) · PubMed · Cited by 20

Metabolomics of cancer cell cultures to assess the effects of dietary phytochemicals

Brasili, E., & Filho, V. C. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2014.964799 · Cited by 20

Chromatin remodeling factor LSH affects fumarate hydratase as a cancer driver

Liu, S., & Tao, Y. (2016) · 癌症：英文版 · doi:10.1186/s40880-016-0138-7 · Cited by 20

Hypoxia-induced mediators and neurologic disease

Benarroch, E. E. (2009) · Neurology · doi:10.1212/wnl.0b013e3181b2a719 · Cited by 20

Glioma-derived mutations in isocitrate dehydrogenase 2 beneficial to traditional chemotherapy

Fu, Y., Huang, R., Zheng, Y., Zhang, Z., & Liang, A. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.05.108 · Cited by 19

Alteration of Isocitrate Dehydrogenase Following Acute Ischemic Injury as a Means to Improve Cellular Energetic Status in Neuroadaptation

Grelli, K. N., Palubinsky, A. M., Kale, A. C., Lizama, B. N., Stankowski, J. N., Milne, G. L., Singer, R. J., & McLaughlin, B. (2013) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/18715273113129990062 · Cited by 18

The Pulmonary Toxicity of Anticancer Agents

Yoneda, K. Y., & Cross, C. E. (2010) · Elsevier eBooks · doi:10.1016/b978-0-08-046884-6.00924-6 · Cited by 19

TNFAIP8 drives metabolic reprogramming to promote prostate cancer cell proliferation

Niture, S. K., Lin, M., Odera, J. O., Moore, J. T., Zhe, H., Chen, X. L., Suy, S., Collins, S. P., & Kumar, D. (2020) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2020.105885 · Cited by 16

Metabolic Plasticity in Cancer Cells: Reconnecting Mitochondrial Function to Cancer Control

Ramanujan, V. K. (2015) · Journal of Cell Science & Therapy · doi:10.4172/2157-7013.1000211 · Cited by 16

BRCA1 overexpression attenuates breast cancer cell growth and migration by regulating the pyruvate kinase M2-mediated Warburg effect via the PI3K/AKT signaling pathway

Liu, X., Liu, H., Zeng, L., & Lv, Y. (2022) · PeerJ · doi:10.7717/peerj.14052 · Cited by 16

Marine Compounds, Mitochondria, and Malignancy: A Therapeutic Nexus

Fakhri, S., Abdian, S., Moradi, S. Z., Delgadillo, B. E., Fimognari, C., & Bishayee, A. (2022) · Marine Drugs · doi:10.3390/md20100625 · Cited by 17

Short-term survivors in glioblastomas with oligodendroglioma component: a clinical study of 186 Chinese patients from a single institution

Jiang, H., Ren, X., Wang, J., Zhang, Z., Jia, W., & Lin, S. (2013) · Journal of Neuro-Oncology · doi:10.1007/s11060-013-1311-3 · Cited by 15

Prevalence of the single-nucleotide polymorphism rs11554137 (IDH1105GGT) in brain tumors of a cohort of Italian patients

Acquaviva, G., Visani, M., de Biase, D., Marucci, G., Franceschi, E., Tosoni, A., Brandes, A. A., Rhoden, K. J., Pession, A., & Tallini, G. (2018) · Scientific Reports · doi:10.1038/s41598-018-22222-y · Cited by 14

Mitochondrial Dysfunction and Morphological Abnormality in Keloid Fibroblasts

Li, Q., Qin, Z., Chen, B., An, Y., Nie, F., Yang, X., Pan, B., & Bi, H. (2019) · Advances in Wound Care · doi:10.1089/wound.2019.0988 · Cited by 13

Sensing cellular states—signaling to chromatin pathways targeting Polycomb and Trithorax group function

Kolybaba, A. M., & Classen, A.-K. (2014) · Cell and Tissue Research · doi:10.1007/s00441-014-1824-x · Cited by 14

Quantitative Profiling of Oncometabolites in Frozen and Formalin-Fixed Paraffin-Embedded Tissue Specimens by Liquid Chromatography Coupled with Tandem Mass Spectrometry

Bao, X., Wu, J., Shuch, B. M., LoRusso, P. M., Bindra, R. S., & Li, J. (2019) · Scientific Reports · doi:10.1038/s41598-019-47669-5 · Cited by 13

The Distribution and Significance of IDH Mutations in Gliomas

Mellai, M., Caldera, V., Annovazzi, L., & Schiffer, D. (2013) · InTech eBooks · doi:10.5772/52357 · Cited by 14

Reductive stress induced by NRF2/G6PD through glucose metabolic reprogramming promotes malignant transformation in Arsenite-exposed human keratinocytes

Yang, Q., Yan, R., Zhang, J., Zhang, T., Kong, Q., Zhang, X., Xia, H., Ye, A., Qiao, X., Kato, K., et al. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.165207 · Cited by 11

Tumor Metabolism: A New Field for the Treatment of Glioma

Chai, X., Zhang, Y., Zhang, W., Feng, K., Jiang, Y., Zhu, A., Chen, X., Di, L., & Wang, R. (2024) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.4c00287 · Cited by 10

Plasma‐Based Metabolomics Profiling of High‐Risk Human Papillomavirus and their Emerging Roles in the Progression of Cervical Cancer

Chen, A., Xu, M., Chen, J., Chen, T., Wang, Q., Zhang, R., & Qiu, J. (2022) · BioMed Research International · doi:10.1155/2022/6207701 · Cited by 10

Down-regulation of metabolic proteins in hepatocellular carcinoma with portal vein thrombosis

Lee, W., Chou, H., Wu, T.-J., Lee, C., Hsu, P., Hsu, H.-Y., Wu, T., & Chan, K. (2017) · Clinical Proteomics · doi:10.1186/s12014-017-9164-y · Cited by 10

Synthesis and preliminary evaluation of a novel glutamine derivative: (2S,4S)4-[18F]FEBGln

Huang, Y., Liu, S., Wu, R., Zhang, L., Zhang, Y., Hong, H., Zhang, A., Xiao, H., Liu, Y., Wu, Z., et al. (2019) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2019.03.012 · Cited by 10

Cancer-associated isocitrate dehydrogenase mutations induce mitochondrial DNA instability

Kingsbury, J. M., Shamaprasad, N., Billmyre, R. B., Heitman, J., & Cardenas, M. E. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw195 · Cited by 10

Integrative Omics Analysis Reveals Metabolic Features of Ground-Glass Opacity-Associated Lung Cancer

Shi, S., Luo, D., Yang, Y., & Wang, X. (2024) · Journal of Cancer · doi:10.7150/jca.92437 · Cited by 9

Identification of T2W hypointense ring as a novel noninvasive indicator for glioma grade and IDH genotype

Lu, Y., Du, N., Fang, X., Shu, W., Liu, W., Xu, X., Yao, Y., Li, X., Mao, R., Li, K., et al. (2024) · Cancer Imaging · doi:10.1186/s40644-024-00726-3 · Cited by 8

Unraveling the Complex Regulatory Relationships Between Metabolism and Signal Transduction in Cancer

Wynn, M. L., Merajver, S. D., & Schnell, S. D. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-7210-1_9 · Cited by 9

IDH1105GGT single nucleotide polymorphism improves progression free survival in patients with IDH mutated grade II and III gliomas

Franceschi, E., de Biase, D., Nunno, V. D., Pession, A., Tosoni, A., Gatto, L., Lodi, R., Tallini, G., Visani, M., Bartolini, S., et al. (2021) · Pathology - Research and Practice · doi:10.1016/j.prp.2021.153445 · Cited by 8

Microenvironmental Metabolites in the Intestine: Messengers between Health and Disease

Zaurito, A. E., & Tschurtschenthaler, M. (2022) · Metabolites · doi:10.3390/metabo12010046 · Cited by 8

How Molecular Testing Can Help (and Hurt) in the Workup of Gliomas

Clark, K., Voronovich, Z. A., & Horbinski, C. (2013) · American Journal of Clinical Pathology · doi:10.1309/ajcpfo8iidnbij8y · Cited by 8

Biomarker Identification and Risk Prediction Model Development for Differentiated Thyroid Carcinoma Lung Metastasis Based on Primary Lesion Proteomics

Peng, X., Zhao, H., Ye, L., Hou, F., Yi, Z., Ren, Y., Lu, L., Chen, F., Lv, J., Wang, Y., et al. (2024) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-23-3806 · Cited by 7

Prevalence and Prognostic Value of IDH1 R132 Mutation in Newly Diagnosed AML Egyptian Patients with Normal Karyotype

Salem, D., El-Aziz, S. A., El‐Menshawy, N., Abouzeid, T., & Ebrahim, M. (2016) · Indian Journal of Hematology and Blood Transfusion · doi:10.1007/s12288-016-0649-z · Cited by 7

Single-cell profiling of D-2-hydroxyglutarate using surface-immobilized resazurin analogs

Cheng, H., Li, Z., Guo, Z., Shao, S., Mo, L., Wei, W., & Xue, M. (2021) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2021.113368 · Cited by 7

Conventional MRI-Derived Biomarkers of Adult-Type Diffuse Glioma Molecular Subtypes: A Comprehensive Review

Feraco, P., Franciosi, R., Picori, L., Scalorbi, F., & Gagliardo, C. (2022) · Biomedicines · doi:10.3390/biomedicines10102490 · Cited by 7

Mitochondrial Medicine

Wallace, D. C., Lott, M. T., & Procaccio, V. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-383834-6.00013-6 · Cited by 8

Identification of Potential Biomarkers for Artificial Cold Exposure–induced Hypertensive Stroke by Proteomic Analysis

Li, X.-P., He, L., Wang, Y., Li, Y., Li, M., & Peng, Y. (2014) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2014.06.014 · Cited by 7

Lactate detection in inducible and orthotopic Her2/neu mammary gland tumours in mouse models

Magnitsky, S. G., Belka, G. K., Sterner, C. J., Pickup, S., Chodosh, L. A., & Glickson, J. D. (2012) · NMR in Biomedicine · doi:10.1002/nbm.2816 · Cited by 6

Significant prognostic values of nuclear genes encoding mitochondrial complex I subunits in tumor patients

Li, L., Sun, H., BAI, Y., Gao, S.-P., Jiang, H., & Jin, W. (2016) · Neoplasma · doi:10.4149/neo_2016_408 · Cited by 6

Metabolic Reprogramming in Human Cancer Patients and Patient-Derived ModelsPreprint

Fan, T. W. ‐., Higashi, R. M., & Lane, A. N. (2024) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a041552 · Cited by 7

Modeling succinate dehydrogenase loss disorders in C. elegans through effects on hypoxia-inducible factor

Braun, M. M., Damjanac, T., Zhang, Y., Chen, C., Hu, J., & Maher, L. J., III (2019) · PLoS ONE · doi:10.1371/journal.pone.0227033 · Cited by 6

Cytidine deaminase deficiency in tumor cells is associated with sensitivity to a naphthol derivative and a decrease in oncometabolite levels

Mameri, H., Buhagiar‐Labarchède, G., Fontaine, G., Corcelle, C., Barette, C., Onclercq, R., Beauvineau, C., Mahuteau‐Betzer, F., & Amor-Guéret, M. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04487-9 · Cited by 5

Novel R218X mutation in the fumarate hydratase gene in a patient with Reed's syndrome

Akita, F., Kambe, N., Nakano, M., Satoh, T. K., Iwasawa, M., Togawa, Y., & Matsue, H. (2012) · The Journal of Dermatology · doi:10.1111/1346-8138.12002 · Cited by 5

Isocitrate dehydrogenase mutations in low-grade gliomas

Schiff, D., & Purow, B. W. (2009) · Nature Reviews Neurology · doi:10.1038/nrneurol.2009.57 · Cited by 5

Effects of reactive oxygen species on metabolism monitored by longitudinal1H single voxel MRS follow-up in patients with mitochondrial disease or cerebral tumors

Constans, J., Collet, S., Guillamo, J., Hossu, G., Lacombe, S., Gauduel, Y. A., Houée‐Levin, C., Dou, W., Ruan, S., Barré, L., et al. (2011) · Journal of Physics Conference Series · doi:10.1088/1742-6596/261/1/012011 · Cited by 5

Tumor biology as a basis for molecular targeting in cancer

Larson, S. M., Mariani, G., & Strausś, H. W. (2013) · Clinical and Translational Imaging · doi:10.1007/s40336-013-0044-9 · Cited by 4

RARRES2 is Downregulated in Isocitrate Dehydrogenase 1 Mutant Glioma Patients and Served as an Unfavorable Prognostic Factor of Glioma

Wang, H., Wang, X., Xu, L., & Zhang, J. (2023) · World Neurosurgery · doi:10.1016/j.wneu.2023.05.109 · Cited by 3

Metabolic Pathways of Eukaryotes and Connection to Cell Mechanics

Mierke, C. T. (2020) · Biological and medical physics, biomedical engineering · doi:10.1007/978-3-030-58532-7_17 · Cited by 2

In Vivo Metabolic Evaluation of Breast Tumor Mouse Xenografts for Predicting Aggressiveness Using the Hyperpolarized 13C-NMR Technique

Xu, H. N., Kadlececk, S., Pullinger, B. D., Profka, H., Cai, K., Hariharan, H., Rizi, R. R., & Li, L. Z. (2013) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-7411-1_32 · Cited by 3

The mRNA quantitative analysis, prokaryotic expression and structure prediction of hepatocarcinogenesis related gene idh3α under AFB1 stress

Zhenhong, Z. (2011) · African Journal of Microbiology Research · doi:10.5897/ajmr11.207 · Cited by 2

Integrating bulk and single-cell transcriptomic data to construct a risk model for histidine metabolism-related epithelial cell features in lung adenocarcinoma, predicting prognosis and immune landscape

Mao, C., & Zhou, L. (2026) · RNA Biology · doi:10.1080/15476286.2026.2662721 · Cited by 1

Metabolic Switch: A Phenotype or a Phenomenon?

Ramanujan, K., V (2014) · Journal of Cell Science & Therapy · doi:10.4172/2157-7013.1000161 · Cited by 1

Role of mitochondrial reactive oxygen species in glioblastoma drug resistance and strategies for therapeutic intervention

Dico, A. L., Salvatore, D., Diceglie, C., Martelli, C., & Ottobrini, L. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821567-8.00026-9 · Cited by 1

Cancer Biology of Molecular Imaging

Larson, S. M. (2022) · Springer eBooks · doi:10.1007/978-3-031-05494-5_1 · Cited by 1

Endothelial Cell Tumor Prevention with Berry Extracts: Clinical Problems, Molecular Mechanisms and Therapeutic Opportunities

Gordillo, G. M., & Sen, C. K. (2010) · Springer eBooks · doi:10.1007/978-1-4419-7554-6_6 · Cited by 1

The Cancer Biology of Molecular Imaging

Larson, S. M. (2012) · Springer eBooks · doi:10.1007/978-0-387-48894-3_1

Molekulare Bildgebung in der Tumortherapie

Weber, W. (2011) · Der Onkologe · doi:10.1007/s00761-011-2043-7

Studies on the Roles of PDGFRA and EGFR in the Classification and Identification of Therapeutic Targets for Human Gliomas

Dong-feng, C. (2013) · Lund University Publications (Lund University)

K-Ras in cancer metabolism

Martz, L. (2012) · Science-Business eXchange · doi:10.1038/scibx.2012.513

Unravelling the connection between metabolism, cell growth and cancer

Draganescu, C., Jacobsen, L., Hindié, E., & Baillet, G. (2015) · Médecine Nucléaire · doi:10.1016/j.mednuc.2015.01.004

Metformin: a pharmacological approach integrating hyperinsulinemia breast cáncer at the molecular, cellular clinical levels

Martı́n-Castillo, B., Vázquez‐Martín, A., Oliveras‐Ferraros, C., & Menéndez, J. A. (2010) · Avances en Diabetología · doi:10.1016/s1134-3230(10)62003-0

Molekulare Bildgebung in der Tumortherapie

Weber, W. (2010) · Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz · doi:10.1007/s00103-010-1092-1

Excellence in neurosurgical research: the neuro-oncology paradigm.

Rutka, J. T. (2010) · PubMed

Current state of the evolving MMMN cancer progression models of cancer

Thiagalingam, S. (2015) · Cambridge University Press eBooks · doi:10.1017/cbo9780511979811.022

Designing a broad-spectrum integrative approach for cancer prevention and treatment

Heiden, M. G. V., & Matthew, G. (2015) · PMC

glioblastomas display improved survival and reduced NADP + -dependent IDH activity ex vivo

Atai, N., Lamba, S., Gravendeel, L. A. M., van Tilborg, A., Leenstra, S., Frattini, M., Martı́n, V., Jonker, A., Rijkeboer, D., Tigchelaar, W., et al. (2009)

Cancer Biology of Molecular Imaging

Larson, S. M. (2016) · Springer eBooks · doi:10.1007/978-3-319-26067-9_1-1

Mitochondria Remodeling in Cancer

Dornfeld, K. J., & Skildum, A. J. (2018) · Springer eBooks · doi:10.1007/978-3-319-73344-9_9

Exploring novel roles of metabolic enzymes MTHFD2 and PFKFB3 in cancer genome stability and their potential as anticancer therapeutic targets

Villarreal, B., & Nadilly, Y. (2021) · Figshare

Cancer Biology of Molecular Imaging

Larson, S. M. (2017) · Springer eBooks · doi:10.1007/978-3-319-26236-9_1

Metabolic mutations in gliomas

(2009) · Nature reviews. Cancer · doi:10.1038/nrc2635

Oncometabolite? IDH1 Discoveries Raise Possibility of New Metabolism Targets in Brain Cancers and Leukemia

Garber, K. (2010) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djq262 · Cited by 41

Enzymes Running in Reverse: Catalytic Studies on Isocitrate Dehydrogenase Mutations Implicated in Cancer

Sohl, C. D., Matteo, D. A., Grunseth, A. J., Anselmo, S. L., Gonzalez, E. R., & Kennedy, M. A. (2016) · The FASEB Journal · doi:10.1096/fasebj.30.1_supplement.1099.15

Isocitrate dehydrogenase 1 and 2 mutations in cancer: alterations at a crossroads of cellular metabolism

Reitman, Z. J., & Yan, H. (2010) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djq187 · Cited by 562

Genetically-defined metabolic reprogramming in cancer

Mullen, A. R., & DeBerardinis, R. J. (2012) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2012.06.009 · Cited by 90