How much atrial fibrillation is too much atrial fibrillation?
Abstract
Modern cardiac pacemakers and defibrillators function as permanently implanted cardiac monitors, detecting atrial and ventricular arrhythmias. Although the principal purpose of collecting this information is to manage the patient's cardiac rhythm, these data can also be used to detect and study clinically inapparent arrhythmias and their consequences. In this issue of the Journal, Healey and coworkers1 report the results of a prospective study involving patients in whom a pacemaker or defibrillator had recently been implanted (Asymptomatic Atrial Fibrillation and Stroke Evaluation in Pacemaker Patients and the Atrial Fibrillation Reduction Atrial Pacing Trial [ASSERT]1,2; ClinicalTrials.gov number, NCT00256152). This study . . .
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
It is unclear whether AHRE imply the same therapeutic requirements as overt AF.
“Consequently, it is unclear whether AHRE imply the same therapeutic requirements as overt AF, 148 and the benefit of OAC in patients with AHRE is being evaluation in ongoing clinical trials (e.g.ARTESiA [NCT01938248] and NOAH [NCT02618577]).”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [148]
Cites
Gage, B. F., Waterman, A. D., Shannon, W., Boechler, M., Rich, M. W., & Radford, M. J. (2001) · JAMA · doi:10.1001/jama.285.22.2864 · Cited by 4,832 · see citing works
Subclinical atrial fibrillation and the risk of stroke
Healey, J. S., Connolly, S. J., Gold, M. R., Israel, C. W., Van Gelder, I. C., Capucci, A., Lau, C. P., Fain, E., Yang, S., Bailleul, C., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1105575 · Cited by 2,100 · see citing works
Glotzer, T. V., Daoud, E. G., Wyse, D. G., Singer, D. E., Ezekowitz, M. D., Hilker, C., Miller, C., Qi, D., & Ziegler, P. D. (2009) · Circulation: Arrhythmia and Electrophysiology · doi:10.1161/circep.109.849638 · Cited by 879 · see citing works
Glotzer, T. V., Hellkamp, A. S., Zimmerman, J., Sweeney, M. O., Yee, R., Marinchak, R., Cook, J., Paraschos, A., Love, J., Radoslovich, G., et al. (2003) · Circulation · doi:10.1161/01.cir.0000057981.70380.45 · Cited by 750 · see citing works
Hohnloser, S. H., Capucci, A., Fain, E. S., Gold, M. R., Gelder, I. C. V., Healey, J. S., Israel, C. W., Lau, C., Morillo, C. A., & Connolly, S. J. (2006) · American Heart Journal · doi:10.1016/j.ahj.2006.02.016 · Cited by 129 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P. F., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castellà, M., Diener, H., Heidbüchel, H., Hendriks, J., et al. (2016) · EP Europace · doi:10.1093/europace/euw295 · Cited by 6,438 · see citing works
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castella, M., Diener, H.-C., Heidbuchel, H., Hendriks, J., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw210 · Cited by 6,418 · see citing works
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castella, M., Diener, H.-C., Heidbuchel, H., Hendriks, J., et al. (2016) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezw313 · Cited by 1,403 · see citing works
Temporal relationship between subclinical atrial fibrillation and embolic events
Brambatti, M., Connolly, S. J., Gold, M. R., Morillo, C. A., Capucci, A., Muto, C., Lau, C. P., Van Gelder, I. C., Hohnloser, S. H., Carlson, M., et al. (2014) · Circulation · doi:10.1161/circulationaha.113.007825 · Cited by 676 · see citing works
Boriani, G., Glotzer, T. V., Santini, M., West, T. M., De Melis, M., Sepsi, M., Gasparini, M., Lewalter, T., Camm, J. A., & Singer, D. E. (2014) · European Heart Journal · doi:10.1093/eurheartj/eht491 · Cited by 427 · see citing works
Boriani, G., Glotzer, T. V., Ziegler, P., Melis, M. D., Stefano, L. M. D. S., Sepši, M., Landolina, M., Lunati, M., Lewalter, T., & Camm, A. J. (2017) · Heart Rhythm · doi:10.1016/j.hrthm.2017.11.007 · Cited by 120 · see citing works
Subclinical Atrial Fibrillation and the Risk of Stroke
Wachter, R., Stahrenberg, R., & Gröschel, K. (2012) · New England Journal of Medicine · doi:10.1056/nejmc1201844 · Cited by 115 · see citing works
Healey, J. S., Martin, J. L., Duncan, A., Connolly, S. J., Ha, A. H., Morillo, C. A., Nair, G. M., Eikelboom, J. W., Divakaramenon, S., & Dokainish, H. (2012) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2012.08.019 · Cited by 87 · see citing works
Boriani, G., & Pettorelli, D. (2016) · Vascular Pharmacology · doi:10.1016/j.vph.2016.03.006 · Cited by 85 · see citing works
AF burden is important - fact or fiction?
Boriani, G., Diemberger, I., Ziacchi, M., Valzania, C., Gardini, B., Cimaglia, P., Martignani, C., & Biffi, M. (2014) · International Journal of Clinical Practice · doi:10.1111/ijcp.12326 · Cited by 59 · see citing works
Device-Detected Atrial Fibrillation
Chen-Scarabelli, C. A., Scarabelli, T. M., Ellenbogen, K. A., & Halperin, J. L. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.10.045 · Cited by 55 · see citing works
Stroke Prevention for Patients with Atrial Fibrillation: Beyond the Guidelines
McIntyre, W. F., & Healey, J. S. (2017) · Journal of Atrial Fibrillation · doi:10.4022/jafib.1475 · Cited by 40 · see citing works
Management of atrial fibrillation in bradyarrhythmias
Boriani, G., & Padeletti, L. (2015) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2015.30 · Cited by 35 · see citing works
Impact of the Pattern of Atrial Fibrillation on Stroke Risk and Mortality
Botto, G. L., Tortora, G., Casale, M. C., Canevese, F. L., & Brasca, F. M. A. (2021) · Arrhythmia & Electrophysiology Review · doi:10.15420/aer.2021.01 · Cited by 32 · see citing works
Schaefer, J. R., Leussler, D., Rosin, L., Pittrow, D. B., & Hepp, T. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089328 · Cited by 29 · see citing works
Silent Atrial Fibrillation and Cryptogenic Strokes
Dalen, J. E., & Alpert, J. S. (2016) · The American Journal of Medicine · doi:10.1016/j.amjmed.2016.09.027 · Cited by 24 · see citing works
PPP1R12C Promotes Atrial Hypocontractility in Atrial Fibrillation
Perike, S., González-González, F. J., Abu-Taha, I., Damen, F. W., Hanft, L. M., Lizama, K. S., Aboonabi, A., Capote, A. E., Aguilar-Sánchez, Y., Levin, B. S., et al. (2023) · Circulation Research · doi:10.1161/circresaha.123.322516 · Cited by 19 · see citing works
Chu, S., Jiang, J., Wang, Y., Sheng, Q., Zhou, J., & Ding, Y. (2019) · Heart & Lung · doi:10.1016/j.hrtlng.2019.07.007 · Cited by 16 · see citing works
Zhou, M., Mao, S., Wu, Z., Ya, L., Yang, Z., Liu, X., Ling, W., Li, J., Cui, B., Guo, Y. F., et al. (2023) · Science Advances · doi:10.1126/sciadv.adi5451 · Cited by 10 · see citing works
Boulos, M. N. K., & Haywood, G. A. (2021) · mHealth · doi:10.21037/mhealth-19-204 · Cited by 8 · see citing works
Device-identified atrial fibrillation at pacing clinics. Should it guide anticoagulation?
Merinopoulos, I., Raphael, C. E., Yardley, A., Goonewardene, M., & Vassiliou, V. S. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.01.040 · Cited by 6 · see citing works
Yedlapati, N., & Fisher, J. D. (2014) · Pacing and Clinical Electrophysiology · doi:10.1111/pace.12392 · Cited by 5 · see citing works
Catheter ablation for atrial fibrillation: who, why and does it work?
Eyre-Brook, S. N., & Rajappan, K. (2012) · Postgraduate Medical Journal · doi:10.1136/postgradmedj-2012-130896 · Cited by 4 · see citing works
Perike, S., González-González, F. J., Abu-Taha, I., Damen, F. W., Lizama, K. S., Aboonabi, A., Capote, A. E., Aguilar-Sánchez, Y., Levin, B. S., Han, Z., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.19.537590 · Cited by 2 · see citing works
Chung, M.-C., Huang, C.-H., Hsu, Y., & Lin, I. (2015) · European Geriatric Medicine · doi:10.1016/j.eurger.2015.09.004 · Cited by 1 · see citing works
Anticoagulation d’une fibrillation auriculaire aux urgences
Taboulet, P. (2012) · Annales françaises de médecine d’urgence · doi:10.1007/s13341-012-0227-4
Healey, J. S., Martin, J. L., Duncan, A., Connolly, S. J., Ha, A. H., Morillo, C. A., Nair, G. M., Eikelboom, J. W., & Dokainish, H. (2013)
Meesmann, M. (2013) · Herzschrittmachertherapie + Elektrophysiologie · doi:10.1007/s00399-013-0269-3
Nowek, A., Chudzik, M., & Wranicz, J. K. (2016) · Medical Studies · doi:10.5114/ms.2016.62309
Even Subclinical AF Is Associated with Stroke
Link, M. S. (2012) · Journal watch · doi:10.1056/jc201201180000001
Detection and Predictors of Atrial Fibrillations in patients after pacemaker implantations.
Chudzik, M., & Nowek, A. (2017) · Heart Beat Journal · doi:10.24255/hbj/68145
Subclinical Atrial Fibrillation Is Associated with Increased Stroke Risk
Brett, A. S. (2012) · Journal watch · doi:10.1056/jw201202020000005
Hayes, D. L., Tabatabaei, N., Glikson, M., Asirvatham, S. J., & Friedman, P. A. (2012) · Wiley eBooks · doi:10.1002/9781118483923.ch13
Analysis of the Database of Cardiac Implants and Establishment of Early Warning Indicators
张, 雁. (2020) · Advances in Clinical Medicine · doi:10.12677/acm.2020.103070
Sugrue, A. M., Vaidya, V. R., Hayes, D. L., Glikson, M., Friedman, P. A., & Asirvatham, S. J. (2021) · Wiley eBooks · doi:10.1002/9781119264002.ch13
Atrial fibrillation detection using beat-to-beat RR intervals and deep learning in large databases
Santos, P. H., Crema, J. P. W., Rocha, P. R., Domingues, D. M., Giampá, S. Q. D. C., Gruppi, C. J., & Lorenzi‐Filho, G. (2026) · Biomedical Signal Processing and Control · doi:10.1016/j.bspc.2026.111118
- Authors
- Lamas, G.
- Affiliations
- Mount Sinai Medical Center (US)
- Corresponding author
- Lamas, Gervasio
- ORCID
- Lamas, Gervasio
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2012-01-12
- Volume
- 366
- Issue
- 2
- Pages
- 178-180
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2052774849
- Cited by
- 36
- References
- 5
- Citations by year
- 2026: 1 · 2023: 3 · 2021: 3 · 2020: 1 · 2019: 1 · 2017: 3 · 2016: 7 · 2015: 3 · 2014: 4 · 2013: 3 · 2012: 7
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Keywords
- atrial fibrillation, asymptomatic atrial fibrillation, cardiac pacemaker, implantable cardioverter-defibrillator, cardiac monitoring, stroke risk, atrial arrhythmias
- MeSH terms
- Atrial Fibrillation, Embolism, Female, Humans, Male, Pacemaker, Artificial, Defibrillators, Implantable, Stroke
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review