Temporal relationship between subclinical atrial fibrillation and embolic events
Open accessAbstract
BACKGROUND: Among patients with implantable pacemakers and defibrillators, subclinical atrial fibrillation (SCAF) is associated with an increased risk of stroke; however, there is limited understanding of their temporal relationship. METHODS AND RESULTS: The Asymptomatic Atrial Fibrillation and Stroke Evaluation in Pacemaker Patients and the Atrial Fibrillation Reduction Atrial Pacing Trial (ASSERT) enrolled 2580 pacemaker and defibrillator patients aged ≥65 years with a history of hypertension but without a history of atrial fibrillation. Pacemakers and implantable cardioverter-defibrillators precisely logged the time and duration of all episodes of SCAF and recorded electrograms that were adjudicated by experts. We examined the temporal relationship between SCAF >6 minutes in duration and stroke or systemic embolism. Of 51 patients who experienced stroke or systemic embolism during follow-up, 26 (51%) had SCAF. In 18 patients (35%), SCAF was detected before stroke or systemic embolism. However, only 4 patients (8%) had SCAF detected within 30 days before stroke or systemic embolism, and only 1 of these 4 patients was experiencing SCAF at the time of the stroke. In the 14 patients with SCAF detected >30 days before stroke or systemic embolism, the most recent episode occurred at a median interval of 339 days (25th to 75th percentile, 211-619) earlier. Eight patients (16%) had SCAF detected only after their stroke, despite continuous monitoring for a median duration of 228 days (25th to 75th percentile, 202-719) before their event. CONCLUSIONS: Although SCAF is associated with an increased risk of stroke and embolism, very few patients had SCAF in the month before their event. CLINICAL TRIAL REGISTRATION URL: http://www.clinicaltrials.gov. Unique identifier: NCT00256152.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Supraventricular tachycardia is associated with the development of AF and an increased risk of stroke even in patients without AF.
“The detection of supraventricular tachycardia (SVT) may be important as well as it is associated with the development of AF and an increased risk of stroke even in patients without AF (4–6).”
From Diagnostic Yield of Extended Cardiac Patch Monitoring in Patients with Stroke or TIA (2015) · cites this paper as [5]
The Abstract (page not provided) reports that subclinical atrial fibrillation (SCAF) can progress to clinically documented AF and is associated with increased stroke or systemic-embolism risk in patients without a prior history of AF. The Methods identify the monitored episodes as SCAF, not supraventricular tachycardia (SVT). The source therefore does not establish the claim for SVT generally or for patients without AF, as opposed to patients without previously diagnosed AF. (LLM, conf=0.87)
Experimental — accuracy not yet measuredStrokes often occur without AHRE detected within 30 days before the event.
“Strokes often occur without AHRE detected within 30 days before the event.143-147”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [143]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Atrial fibrillation as an independent risk factor for stroke: the Framingham study
Wolf, P. A., Abbott, R. D., & Kannel, W. B. (1991) · Stroke · doi:10.1161/01.str.22.8.983 · Cited by 7,388 · see citing works
Lip, G. Y. H., Nieuwlaat, R., Pisters, R., Lane, D. A., & Crijns, H. J. G. M. (2010) · Chest · doi:10.1378/chest.09-1584 · Cited by 6,879 · see citing works
Kearon (2012) · doi:10.1378/chest.11-2301 · Cited by 6,119 · see citing works
Subclinical atrial fibrillation and the risk of stroke
Healey, J. S., Connolly, S. J., Gold, M. R., Israel, C. W., Van Gelder, I. C., Capucci, A., Lau, C. P., Fain, E., Yang, S., Bailleul, C., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1105575 · Cited by 2,100 · see citing works
Kannel, W. B., Wolf, P. A., Benjamin, E. J., & Levy, D. (1998) · The American Journal of Cardiology · doi:10.1016/s0002-9149(98)00583-9 · Cited by 2,033 · see citing works
Mechanisms of thrombogenesis in atrial fibrillation: Virchow's triad revisited
Watson, T., Shantsila, E., & Lip, G. Y. H. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60040-4 · Cited by 1,124 · see citing works
Antithrombotic Therapy for Atrial Fibrillation
You, J. J., Singer, D. E., Howard, P. A., Lane, D. A., Eckman, M. H., Fang, M. C., Hylek, E. M., Schulman, S., Go, A. S., Hughes, M., et al. (2012) · CHEST Journal · doi:10.1378/chest.11-2304 · Cited by 924 · see citing works
Glotzer, T. V., Daoud, E. G., Wyse, D. G., Singer, D. E., Ezekowitz, M. D., Hilker, C., Miller, C., Qi, D., & Ziegler, P. D. (2009) · Circulation: Arrhythmia and Electrophysiology · doi:10.1161/circep.109.849638 · Cited by 879 · cited 1× · see citing works
“190 Systemic embolism 4 (16) 1 (4) 5 (10) 0.”
Inflammation in Atrial Fibrillation
Guo, Y., Lip, G. Y. H., & Apostolakis, S. Z. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.04.063 · Cited by 868 · see citing works
Glotzer, T. V., Hellkamp, A. S., Zimmerman, J., Sweeney, M. O., Yee, R., Marinchak, R., Cook, J., Paraschos, A., Love, J., Radoslovich, G., et al. (2003) · Circulation · doi:10.1161/01.cir.0000057981.70380.45 · Cited by 750 · see citing works
Manning, W. J., Silverman, D. I., Katz, S. E., Riley, M. F., Come, P. C., Doherty, R. M., Munson, J. T., & Douglas, P. S. (1994) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(94)90652-1 · Cited by 532 · see citing works
Long-term risk of recurrent atrial fibrillation as documented by an implantable monitoring device
Israel, C. W., Grönefeld, G., Ehrlich, J. R., Li, Y., & Hohnloser, S. H. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.08.027 · Cited by 478 · see citing works
Left atrial spontaneous echo contrast: A clinical and echocardiographic analysis
Black, I. W., Hopkins, A. P., Lee, L. C. L., & Walsh, W. (1991) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(91)90592-w · Cited by 432 · see citing works
Hindricks, G., Pokushalov, E., Urban, L., Taborsky, M., Kuck, K.-H., Lebedev, D., Rieger, G., & Pürerfellner, H. (2010) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.109.877852 · Cited by 422 · see citing works
Flaker, G. C., Belew, K., Beckman, K., Vidaillet, H., Kron, J., Safford, R., Mickel, M., & Barrell, P. (2005) · American Heart Journal · doi:10.1016/j.ahj.2004.06.032 · Cited by 341 · see citing works
Liao, J., Khalid, Z., Scallan, C., Morillo, C., & O’Donnell, M. (2007) · Stroke · doi:10.1161/strokeaha.106.478685 · Cited by 331 · see citing works
Self-citationDaoud, E. G., Glotzer, T. V., Wyse, D. G., Ezekowitz, M. D., Hilker, C., Koehler, J., & Ziegler, P. D. (2011) · Heart Rhythm · doi:10.1016/j.hrthm.2011.04.022 · Cited by 326 · see citing works
Atrial fibrillation detected by mobile cardiac outpatient telemetry in cryptogenic TIA or stroke
Tayal, A. H., Tian, M., Kelly, K., Jones, S. C., Wright, D. G., Singh, D., Jarouse, J., Brillman, J. S., Murali, S., & Gupta, R. (2008) · Neurology · doi:10.1212/01.wnl.0000325059.86313.31 · Cited by 316 · see citing works
Weigner, M. J., Caulfield, T. A., Danias, P. G., Silverman, D. I., & Manning, W. J. (1997) · Annals of Internal Medicine · doi:10.7326/0003-4819-126-8-199704150-00005 · Cited by 238 · see citing works
Healey, J. S., Hart, R. G., Pogue, J. M., Pfeffer, M. A., Hohnloser, S. H., Caterina, R. D., Flaker, G., Yusuf, S., & Connolly, S. J. (2008) · Stroke · doi:10.1161/strokeaha.107.500199 · Cited by 225 · see citing works
Oldgren, J., Alings, M., Darius, H., Diener, H.-C., Eikelboom, J., Ezekowitz, M. D., Kamensky, G., Reilly, P. A., Yang, S., Yusuf, S., et al. (2011) · Annals of Internal Medicine · doi:10.7326/0003-4819-155-10-201111150-00004 · Cited by 196 · see citing works
Ziegler, P. D., Glotzer, T. V., Daoud, E. G., Wyse, D. G., Singer, D. E., Ezekowitz, M. D., Koehler, J. L., & Hilker, C. E. (2010) · Stroke · doi:10.1161/strokeaha.109.571455 · Cited by 173 · see citing works
Cryptogenic Stroke and underlying Atrial Fibrillation (CRYSTAL AF): Design and rationale
Sinha, A. M., Diener, H., Morillo, C. A., Sanna, T., Bernstein, R. A., Lazzaro, V. D., PASSMAN, R. S., Beckers, F., & Brachmann, J. (2010) · American Heart Journal · doi:10.1016/j.ahj.2010.03.032 · Cited by 134 · see citing works
Hohnloser, S. H., Capucci, A., Fain, E. S., Gold, M. R., Gelder, I. C. V., Healey, J. S., Israel, C. W., Lau, C., Morillo, C. A., & Connolly, S. J. (2006) · American Heart Journal · doi:10.1016/j.ahj.2006.02.016 · Cited by 129 · see citing works
Ip, J. E., Waldo, A. L., Lip, G. Y. H., Rothwell, P. M., Martin, D. T., BERSOHN, M. M., Choucair, W. K., Akar, J. G., Wathen, M. S., Rohani, P., et al. (2009) · American Heart Journal · doi:10.1016/j.ahj.2009.07.002 · Cited by 106 · see citing works
Healey, J. S., Martin, J. L., Duncan, A., Connolly, S. J., Ha, A. H., Morillo, C. A., Nair, G. M., Eikelboom, J. W., Divakaramenon, S., & Dokainish, H. (2012) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2012.08.019 · Cited by 87 · see citing works
Regional left atrial stasis during fibrillation and flutter determinants and relation to stroke
Shively, B. K., Gelgand, E. A., & Crawford, M. H. (1996) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(96)00049-6 · Cited by 85 · see citing works
Inoue, H., Nozawa, T., Okumura, K., Jong-Dae, L., Shimizu, A., & Yano, K. (2004) · CHEST Journal · doi:10.1378/chest.126.3.687 · Cited by 77 · see citing works
Khan, I. A. (2002) · American Heart Journal · doi:10.1067/mhj.2002.123113 · Cited by 66 · see citing works
The endothelium and atrial fibrillation
Freestone, B., & Lip, G. Y. H. (2008) · Hämostaseologie · doi:10.1055/s-0037-1617102 · Cited by 40 · see citing works
How much atrial fibrillation is too much atrial fibrillation?
Lamas, G. (2012) · New England Journal of Medicine · doi:10.1056/nejme1111948 · Cited by 36 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- Kannel WB, Wolf PA, Benjamin EJ, Levy D. Prevalence, incidence, prog- nosis, and predisposing conditions for atrial fibrillation: population-based estimates. Am J Cardiol. 1998;82:2N-9N.
- Anderson K, Benzauquen BS. Do patients with pacemaker-detected atrial fibrillation receive appropriate anticoagulation? Europace. 2011;13:519.
Cited by
Sorted by citations
Hindricks, G., Potpara, T., Dagres, N., Arbelo, E., Bax, J., Blomström-Lundqvist, C., Boriani, G., Castellá, M., Dan, G., Dilaveris, P. E., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa612 · Cited by 2,605 · see citing works
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P. F., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castellà, M., Diener, H., Heidbüchel, H., Hendriks, J., et al. (2016) · EP Europace · doi:10.1093/europace/euw295 · Cited by 6,438 · see citing works
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castella, M., Diener, H.-C., Heidbuchel, H., Hendriks, J., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw210 · Cited by 6,418 · see citing works
Joglar, J. A., Chung, M. K., Armbruster, A. L., Benjamin, E. J., Chyou, J. Y., Cronin, E. M., Deswal, A. M., Eckhardt, L. L., Goldberger, Z. D., Gopinathannair, R., et al. (2023) · Circulation · doi:10.1161/cir.0000000000001193 · Cited by 2,989 · see citing works
Stroke risk factors, genetics, and prevention
Boehme, A. K., Esenwa, C., & Elkind, M. S. V. (2017) · Circulation Research · doi:10.1161/circresaha.116.308398 · Cited by 1,952 · see citing works
Epidemiology of Atrial Fibrillation in the 21st Century
Kornej, J., Börschel, C. S., Benjamin, E. J., & Schnabel, R. B. (2020) · Circulation Research · doi:10.1161/circresaha.120.316340 · Cited by 1,550 · see citing works
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castella, M., Diener, H.-C., Heidbuchel, H., Hendriks, J., et al. (2016) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezw313 · Cited by 1,403 · see citing works
Pathophysiology and treatment of stroke: present status and future perspectives
Kuriakose, D., & Xiao, Z. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207609 · Cited by 1,350 · see citing works
Atrial fibrillation in patients with cryptogenic stroke
Gladstone, D. J., Spring, M., Dorian, P., Panzov, V., Thorpe, K. E., Hall, J., Vaid, H., O'Donnell, M., Laupacis, A., Côté, R., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1311376 · Cited by 1,276 · see citing works
Antithrombotic Therapy for Atrial Fibrillation
Lip, G. Y. H., Banerjee, A., Boriani, G., Chiang, C. E., Fargo, R. A., Freedman, B., Lane, D. A., Ruff, C. T., Turakhia, M. P., Werring, D. J., et al. (2018) · CHEST Journal · doi:10.1016/j.chest.2018.07.040 · Cited by 952 · see citing works
2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation
Joglar, J. A., Chung, M. K., Armbruster, A. L., Benjamin, E. J., Chyou, J. Y., Cronin, E. M., Deswal, A., Eckhardt, L. L., Goldberger, Z. D., Gopinathannair, R., et al. (2024) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2023.08.017 · Cited by 933 · see citing works
Tzeis, S. E., Gerstenfeld, E. P., Kalman, J. M., Saad, E., Shamloo, A. S., Andrade, J. G., Barbhaiya, C. R., Baykaner, T., Bovéda, S., Calkins, H. G., et al. (2024) · EP Europace · doi:10.1093/europace/euae043 · Cited by 692 · see citing works
Atrial Fibrillation and Mechanisms of Stroke: Time for a New Model
Kamel, H., Okin, P. M., Elkind, M. S. V., & Iadecola, C. (2016) · Stroke · doi:10.1161/strokeaha.115.012004 · Cited by 627 · see citing works
Mass Screening for Untreated Atrial Fibrillation: The STROKESTOP Study
Svennberg, E., Engdahl, J., Al-Khalili, F., Friberg, L., Frykman, V., & Rosenqvist, M. (2015) · Circulation · doi:10.1161/circulationaha.114.014343 · Cited by 605 · see citing works
Duration of device-detected subclinical atrial fibrillation and occurrence of stroke in ASSERT
Gelder, I. C. V., Healey, J. S., Crijns, H. J. G. M., Wang, J., Hohnloser, S. H., Gold, M. R., Capucci, A., Lau, C., Morillo, C. A., Hobbelt, A. H., et al. (2017) · European Heart Journal · doi:10.1093/eurheartj/ehx042 · Cited by 604 · see citing works
Svendsen, J. H., Diederichsen, S. Z., Højberg, S., Krieger, D. W., Graff, C., Kronborg, C., Olesen, M. S., Nielsen, J. B., Holst, A. G., Brandes, A., et al. (2021) · The Lancet · doi:10.1016/s0140-6736(21)01698-6 · Cited by 550 · see citing works
Screening for Atrial Fibrillation
Freedman, B., Camm, A. J., Calkins, H. G., Healey, J. S., Rosenqvist, M., Wang, J., Albert, C. M., Anderson, C. S., Antoniou, S., Benjamin, E. J., et al. (2017) · Circulation · doi:10.1161/circulationaha.116.026693 · Cited by 548 · see citing works
Slotwiner, D. J., Varma, N., Akar, J. G., Annas, G. J., Beardsall, M., Fogel, R. I., Galizio, N. O., Glotzer, T. V., Leahy, R. A., Love, C. J., et al. (2015) · Heart Rhythm · doi:10.1016/j.hrthm.2015.05.008 · Cited by 533 · see citing works
Stroke prevention in atrial fibrillation
Freedman, B., Potpara, T., & Lip, G. Y. H. (2016) · The Lancet · doi:10.1016/s0140-6736(16)31257-0 · Cited by 484 · see citing works
Verma, A., Cairns, J. A., Mitchell, L. B., Macle, L., Stiell, I. G., Gladstone, D. J., McMurtry, M. S., Connolly, S. J., Cox, J. L., Dorian, P., et al. (2014) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2014.08.001 · Cited by 475 · see citing works
Li, L.-X., Yiin, G., Geraghty, O., Schulz, U., Küker, W., Mehta, Z., & Rothwell, P. (2015) · Lancet Neurology · doi:10.1016/s1474-4422(15)00132-5 · Cited by 397 · see citing works
Kamel, H., & Healey, J. S. (2017) · Circulation Research · doi:10.1161/circresaha.116.308407 · Cited by 435 · see citing works
Martin, D. T., BERSOHN, M. M., Waldo, A. L., Wathen, M. S., Choucair, W. K., Lip, G. Y. H., Ip, J. E., Holcomb, R. G., Akar, J. G., & Halperin, J. L. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv115 · Cited by 361 · see citing works
Perioperative atrial fibrillation and the long-term risk of ischemic stroke
Gialdini, G., Nearing, K., Bhave, P. D., Bonuccelli, U., Iadecola, C., Healey, J. S., & Kamel, H. (2014) · JAMA · doi:10.1001/jama.2014.9143 · Cited by 355 · see citing works
Goette, A., Corradi, D., Dobrev, D., Aguinaga, L., Cabrera, J. Á., Chugh, S. S., de Groot, J. R., Soulat-Dufour, L., Fenelon, G., Hatem, S. N., et al. (2024) · EP Europace · doi:10.1093/europace/euae204 · Cited by 341 · see citing works
Tzeis, S. E., Gerstenfeld, E. P., Kalman, J. M., Saad, E., Shamloo, A. S., Andrade, J. G., Barbhaiya, C. R., Baykaner, T., Bovéda, S., Calkins, H. G., et al. (2024) · Heart Rhythm · doi:10.1016/j.hrthm.2024.03.017 · Cited by 312 · see citing works
Lópes, R. D., Alings, M., Connolly, S. J., Beresh, H., Granger, C. B., Mazuecos, J. B., Boriani, G., Nielsen, J. C., Conen, D., Hohnloser, S. H., et al. (2017) · American Heart Journal · doi:10.1016/j.ahj.2017.04.008 · Cited by 287 · see citing works
Atrial Failure as a Clinical Entity
Bisbal, F., Baranchuk, A. M., D, E. B. M., Bayés‐Genís, A., & Bayés‐Genís, A. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.11.013 · Cited by 286 · see citing works
Mahajan, R., Perera, T., Elliott, A. D., Twomey, D. J., Kumar, S. K., Munwar, D. A., Khokhar, K. B., Thiyagarajah, A., Middeldorp, M. E., Nalliah, C. J., et al. (2017) · European Heart Journal · doi:10.1093/eurheartj/ehx731 · Cited by 279 · see citing works
Mairesse, G., Moran, P., van Gelder, I. V., Elsner, C., Rosenqvist, M., Mant, J., Banerjee, A., Gorenek, B., Brachmann, J., Varma, N., et al. (2018) · Europace · doi:10.1093/europace/eux177 · Cited by 191 · see citing works
Embolic Stroke of Undetermined Source
Ntaios, G. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.11.024 · Cited by 257 · see citing works
Görenek, B., Bax, J. J., Boriani, G., Chen, S., Dagres, N., Glotzer, T. V., Healey, J. S., Israel, C. W., Kudaiberdieva, G., Levin, L., et al. (2017) · EP Europace · doi:10.1093/europace/eux163 · Cited by 249 · see citing works
Searching for Atrial Fibrillation Poststroke
Schnabel, R. B., Hæusler, K. G., Healey, J. S., Freedman, B., Boriani, G., Brachmann, J., Brandes, A., Bustamante, A., Casadei, B., Crijns, H. J. G. M., et al. (2019) · Circulation · doi:10.1161/circulationaha.119.040267 · Cited by 248 · see citing works
Shen, M. J., Arora, R., & Jalife, J. (2019) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2019.05.005 · Cited by 243 · see citing works
Lip, G. Y. H., Fauchier, L., Freedman, S. B., Gelder, I. C. V., Natale, A., Gianni, C., Nattel, S., Potpara, T., Rienstra, M., Tse, H., et al. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.16 · Cited by 238 · see citing works
Andrade, J. G., Verma, A., Mitchell, L. B., Parkash, R., Leblanc, K., Atzema, C. L., Healey, J. S., Bell, A., Cairns, J. A., Connolly, S. J., et al. (2018) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2018.08.026 · Cited by 235 · see citing works
Kirchhof, P. F., Blank, B. F., Calvert, M., Camm, A. J., CHLOUVERAKIS, G. I., Diener, H., Goette, A., Huening, A., Lip, G. Y. H., SIMANTIRAKIS, E. N., et al. (2017) · American Heart Journal · doi:10.1016/j.ahj.2017.04.015 · Cited by 225 · see citing works
Guichard, J.-B., & Nattel, S. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.06.033 · Cited by 226 · see citing works
Lip, G. Y. H., Coca, A., Kahan, T., Boriani, G., Manolis, A. S., Olsen, M. H., Oto, A., Potpara, T., Steffel, J., Marín, F. R., et al. (2017) · EP Europace · doi:10.1093/europace/eux091 · Cited by 225 · see citing works
Fibrotic Atrial Cardiomyopathy, Atrial Fibrillation, and Thromboembolism
Hirsh, B. J., Copeland-Halperin, R. S., & Halperin, J. L. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.03.557 · Cited by 214 · see citing works
Early or Delayed Cardioversion in Recent-Onset Atrial Fibrillation
Pluymaekers, N. A. H. A., Dudink, E. A. M. P., LUERMANS, J. G. L. M., Meeder, J. G., Lenderink, T., Widdershoven, J. W. M. G., Bucx, J. J. J., Rienstra, M., Otto Kamp, B., van Opstal, J. M., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1900353 · Cited by 214 · see citing works
Atrial Premature Beats Predict Atrial Fibrillation in Cryptogenic Stroke
Gladstone, D. J., Dorian, P., Spring, M., Panzov, V., Mamdani, M., Healey, J. S., Thorpe, K. E., Aviv, R. I., Boyle, K., Blakely, J. A., et al. (2015) · Stroke · doi:10.1161/strokeaha.115.008714 · Cited by 200 · see citing works
Turakhia, M. P., Ziegler, P. D., Schmitt, S. K., Chang, Y., Fan, J., Than, C. T., Keung, E. K., & Singer, D. E. (2015) · Circulation: Arrhythmia and Electrophysiology · doi:10.1161/circep.114.003057 · Cited by 197 · see citing works
Silent atrial fibrillation: epidemiology, diagnosis, and clinical impact
Dilaveris, P., & Kennedy, H. (2017) · Clinical Cardiology · doi:10.1002/clc.22667 · Cited by 175 · see citing works
King, J. B., Azadani, P. N., Suksaranjit, P., Bress, A. P., Witt, D. M., Han, F. T., Chelu, M. G., Silver, M. A., BISKUPIAK, J. E., Wilson, B. D., et al. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.07.758 · Cited by 195 · see citing works
Uncovering Atrial Fibrillation Beyond Short-Term Monitoring in Cryptogenic Stroke Patients
Brachmann, J., Morillo, C. A., Sanna, T., Lazzaro, V. D., Diener, H., Bernstein, R. A., Rymer, M., Ziegler, P., Liu, S., & PASSMAN, R. S. (2016) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.115.003333 · Cited by 183 · see citing works
Atrial Cardiopathy: A Broadened Concept of Left Atrial Thromboembolism Beyond Atrial Fibrillation
Kamel, H., Okin, P. M., Longstreth, W. T., Elkind, M. S. V., & Soliman, E. Z. (2015) · Future Cardiology · doi:10.2217/fca.15.22 · Cited by 175 · see citing works
Left Atrial Appendage Function and Stroke Risk
Yaghi, S. R., Song, C., Gray, W. A., Furie, K. L., Elkind, M. S. V., & Kamel, H. (2015) · Stroke · doi:10.1161/strokeaha.115.011273 · Cited by 176 · see citing works
New-Onset Atrial Fibrillation in the Critically Ill*
Moss, T. J., Calland, J. F., Enfield, K. B., Gomez-Manjarres, D. C., Ruminski, C., Dimarco, J., Lake, D. E., & Moorman, J. R. (2017) · Critical Care Medicine · doi:10.1097/ccm.0000000000002325 · Cited by 172 · see citing works
Noseworthy, P. A., Kaufman, E. S., Chen, L. Y., Chung, M. K., Elkind, M. S. V., Joglar, J. A., Leal, M. A., McCabe, P. J., Pokorney, S. D., Yao, X., et al. (2019) · Circulation · doi:10.1161/cir.0000000000000740 · Cited by 171 · see citing works
Atrial fibrillation and stroke prevention: 25 years of research at EP Europace journal
Lip, G. Y. H., Proietti, M., Potpara, T., MANSOUR, M. C., Savelieva, I., Tse, H., Goette, A., Camm, A. J., Blomström‐Lundqvist, C., Gupta, D., et al. (2023) · EP Europace · doi:10.1093/europace/euad226 · Cited by 171 · see citing works
Atrial Cardiopathy and the Risk of Ischemic Stroke in the CHS (Cardiovascular Health Study)
Kamel, H., Bartz, T. M., Elkind, M. S. V., Okin, P. M., Thacker, E. L., Patton, K. K., Stein, P. K., deFilippi, C. R., Gottesman, R. F., Heckbert, S. R., et al. (2018) · Stroke · doi:10.1161/strokeaha.117.020059 · Cited by 164 · see citing works
Atrial fibrillation burden: a new outcome predictor and therapeutic target
Becher, N., Metzner, A., Toennis, T., Kirchhof, P. F., & Schnabel, R. B. (2024) · European Heart Journal · doi:10.1093/eurheartj/ehae373 · Cited by 163 · see citing works
Swiryn, S., Orlov, M. V., Benditt, D. G., Dimarco, J., Lloyd‐Jones, D. M., Karst, E., Qu, F., Slawsky, M., Turkel, M., & Waldo, A. L. (2016) · Circulation · doi:10.1161/circulationaha.115.020252 · Cited by 154 · see citing works
Age and sex differences in atrial fibrosis among patients with atrial fibrillation
AKOUM, N. W., Mahnkopf, C., Kholmovski, E. G., Brachmann, J., & MARROUCHE, N. F. (2017) · EP Europace · doi:10.1093/europace/eux260 · Cited by 154 · see citing works
2018 Korean Guideline of Atrial Fibrillation Management
Joung, B., Lee, J., Lee, K. H., Kim, T., Choi, E., Lim, W., Kang, K., Uhm, J., Lim, H. E., Park, J., et al. (2018) · Korean Circulation Journal · doi:10.4070/kcj.2018.0339 · Cited by 154 · see citing works
Sposato, L. A., Chaturvedi, S., Hsieh, C., Morillo, C. A., & Kamel, H. (2022) · Stroke · doi:10.1161/strokeaha.121.034777 · Cited by 146 · see citing works
Kamel, H., O’Neal, W. T., Okin, P. M., Loehr, L. R., Alonso, Á., & Soliman, E. Z. (2015) · Annals of Neurology · doi:10.1002/ana.24482 · Cited by 135 · see citing works
Electrocardiographic Left Atrial Abnormality and Risk of Stroke
Kamel, H., Hunter, M. D., Moon, Y. P., Yaghi, S. R., Cheung, K., Tullio, M. R. D., Okin, P. M., Sacco, R. L., Soliman, E. Z., & Elkind, M. S. V. (2015) · Stroke · doi:10.1161/strokeaha.115.009989 · Cited by 132 · see citing works
P-Wave Indices and Risk of Ischemic Stroke
He, J., Tse, G., Korantzopoulos, P. G., Letsas, Κ. P., Ali‐Hasan‐Al‐Saegh, S., Kamel, H., Li, G., Lip, G. Y. H., & Liu, T. (2017) · Stroke · doi:10.1161/strokeaha.117.017293 · Cited by 131 · see citing works
Atrial fibrillation and stroke
Choi, S. E., Sagris, D., Hill, A. M., Lip, G. Y. H., & Abdul‐Rahim, A. H. (2022) · Expert Review of Cardiovascular Therapy · doi:10.1080/14779072.2023.2160319 · Cited by 136 · see citing works
Mental Stress and Cardiovascular Health—Part I
Vancheri, F., Longo, G., Vancheri, E., & Henein, M. Y. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11123353 · Cited by 137 · see citing works
Spotlight on the 2024 ESC/EACTS management of atrial fibrillation guidelines: 10 novel key aspects
Rienstra, M., Tzeis, S., Bunting, K. V., Caso, V., Crijns, H. J. G. M., De Potter, T. J. R., Sanders, P., Svennberg, E., Casado-Arroyo, R., Dwight, J., et al. (2024) · Europace · doi:10.1093/europace/euae298 · Cited by 128 · see citing works
Comprehensive Evaluation of Rhythm Monitoring Strategies in Screening for Atrial Fibrillation
Diederichsen, S. Z., Haugan, K., Kronborg, C., Graff, C., Højberg, S., Køber, L., Krieger, D. W., Holst, A. G., Nielsen, J. B., Brandes, A., et al. (2020) · Circulation · doi:10.1161/circulationaha.119.044407 · Cited by 127 · see citing works
Etiologic classification of ischemic stroke: Where do we stand?
Radu, R. A., Terecoasă, E., Bajenaru, O. A., & Tiu, C. (2017) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2017.05.019 · Cited by 129 · see citing works
Tailoring the Approach to Embolic Stroke of Undetermined Source
Kamel, H., Merkler, A. E., Iadecola, C., Gupta, A. K., & Navi, B. B. (2019) · JAMA Neurology · doi:10.1001/jamaneurol.2019.0591 · Cited by 122 · see citing works
Management of atrial high-rate episodes detected by cardiac implanted electronic devices
Freedman, B., Boriani, G., Glotzer, T. V., Healey, J. S., Kirchhof, P. F., & Potpara, T. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2017.94 · Cited by 120 · see citing works
Chyou, J. Y., Barkoudah, E., Dukes, J. W., Goldstein, L. B., Joglar, J. A., Lee, A. M., Lubitz, S. A., Marill, K. A., Sneed, K., Streur, M. M., et al. (2023) · Circulation · doi:10.1161/cir.0000000000001133 · Cited by 125 · see citing works
Left Atrial Mechanical Function and Incident Ischemic Cerebrovascular Events Independent of AF
Habibi, M., Zareian, M., Ambale‐Venkatesh, B., Samiei, S., Imai, M., Wu, C. O., Launer, L. J., Shea, S., Gottesman, R. F., Heckbert, S. R., et al. (2019) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2019.02.021 · Cited by 118 · see citing works
Arnar, D. O., Mairesse, G. H., Boriani, G., Calkins, H. G., Chin, A., Coats, A. J. S., Deharo, J., Svendsen, J. H., Heidbüchel, H., Isa, R., et al. (2019) · EP Europace · doi:10.1093/europace/euz046 · Cited by 120 · see citing works
Kotecha, D., BREITHARDT, G. E., Camm, A. J., Lip, G. Y. H., Schotten, U., Ahlsson, A., Arnar, D. O., Atar, D., Auricchio, A., Bax, J. J., et al. (2018) · EP Europace · doi:10.1093/europace/eux318 · Cited by 115 · see citing works
PASSMAN, R., LEONG‐SIT, P., ANDREI, A., HUSKIN, A., TOMSON, T. T., BERNSTEIN, R., ELLIS, E., WAKS, J. W., & ZIMETBAUM, P. (2016) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.12864 · Cited by 115 · see citing works
Review and update of the concept of embolic stroke of undetermined source
Diener, H., Easton, J. D., Hart, R. G., Kasner, S. E., Kamel, H., & Ntaios, G. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-022-00663-4 · Cited by 115 · see citing works
Packer, M. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.119.015343 · Cited by 110 · see citing works
Zou, R., Zhang, D., Lv, L., Shi, W., Song, Z., Yi, B., Lai, B., Chen, Q., Yang, S., & Hua, P. (2019) · Journal of Translational Medicine · doi:10.1186/s12967-019-1790-x · Cited by 110 · see citing works
Atrial cardiopathy: a mechanism of cryptogenic stroke
Yaghi, S. R., Kamel, H., & Elkind, M. S. V. (2017) · Expert Review of Cardiovascular Therapy · doi:10.1080/14779072.2017.1355238 · Cited by 109 · see citing works
Demonstration of Patient-Specific Simulations to Assess Left Atrial Appendage Thrombogenesis Risk
García‐Villalba, M., Rossini, L., Gonzalo, A., Vigneault, D. M., Martínez‐Legazpi, P., Durán, E., Flores, Ó., Bermejo, J., McVeigh, E. R., Kahn, A. M., et al. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.596596 · Cited by 107 · see citing works
Atrial high-rate episodes and stroke prevention
Camm, A. J., SIMANTIRAKIS, E. N., Goette, A., Lip, G. Y. H., Vardas, P. E., Calvert, M., CHLOUVERAKIS, G. I., Diener, H., & Kirchhof, P. F. (2016) · EP Europace · doi:10.1093/europace/euw279 · Cited by 103 · see citing works
Temporal Association Between Episodes of Atrial Fibrillation and Risk of Ischemic Stroke
Singer, D. E., Ziegler, P., Koehler, J. L., Sarkar, S., & PASSMAN, R. S. (2021) · JAMA Cardiology · doi:10.1001/jamacardio.2021.3702 · Cited by 103 · see citing works
Hart, R. G., Sharma, M., Mundl, H., Shoamanesh, A., Kasner, S. E., Berkowitz, S. D., Paré, G., Kirsch, B., Pogue, J., Pater, C., et al. (2016) · European Stroke Journal · doi:10.1177/2396987316663049 · Cited by 97 · see citing works
Boriani, G., Vitolo, M., Diemberger, I., Proietti, M., Valenti, A. C., Malavasi, V. L., & Lip, G. Y. H. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab147 · Cited by 102 · see citing works
A Computational Framework for Personalized Blood Flow Analysis in the Human Left Atrium
Otani, T., Alissa, A., Pourmorteza, A., McVeigh, E. R., Wada, S., & Ashikaga, H. (2016) · Annals of Biomedical Engineering · doi:10.1007/s10439-016-1590-x · Cited by 94 · see citing works
Verma, A., Ha, A. C. T., Kirchhof, P. F., Hindricks, G., Healey, J. S., Hill, M. D., Sharma, M., Wyse, D. G., Champagne, J., Essebag, V., et al. (2017) · American Heart Journal · doi:10.1016/j.ahj.2017.12.007 · Cited by 91 · see citing works
Apixaban versus Aspirin for Embolic Stroke of Undetermined Source
Geisler, T., Keller, T., Martus, P., Poli, K., Serna-Higuita, L. M., Schreieck, J., Gawaz, M., Tünnerhoff, J., Bombach, P., Nägele, T., et al. (2023) · NEJM Evidence · doi:10.1056/evidoa2300235 · Cited by 89 · see citing works
Embolic Strokes of Unknown Source and Cryptogenic Stroke: Implications in Clinical Practice
Nouh, A. M., Hussain, M., Mehta, T., & Yaghi, S. R. (2016) · Frontiers in Neurology · doi:10.3389/fneur.2016.00037 · Cited by 87 · see citing works
Stroke as the First Manifestation of Atrial Fibrillation
Jaakkola, J., Mustonen, P. E., Kiviniemi, T., Hartikainen, J. E. K., Palomäki, A., Hartikainen, P. H., Nuotio, I. O., Ylitalo, A., & Airaksinen, J. K. E. (2016) · PLoS ONE · doi:10.1371/journal.pone.0168010 · Cited by 84 · see citing works
Boriani, G., & Pettorelli, D. (2016) · Vascular Pharmacology · doi:10.1016/j.vph.2016.03.006 · Cited by 85 · see citing works
Atrial Fibrillation and Endothelial Dysfunction
Corban, M., Toya, T., Ahmad, A., Lerman, L. O., Lee, H.-C., & Lerman, A. (2021) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2020.11.005 · Cited by 85 · see citing works
Atrial Fibrillation Burden Signature and Near-Term Prediction of Stroke
Han, L., Askari, M., Altman, R. B., Schmitt, S. K., Fan, J., Bentley, J., Narayan, S. M., & Turakhia, M. P. (2019) · Circulation Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.118.005595 · Cited by 79 · see citing works
Sposato, L. A., Field, T. S., Schnabel, R. B., Wachter, R., Andrade, J. G., & Hill, M. D. (2023) · The Lancet Neurology · doi:10.1016/s1474-4422(23)00326-5 · Cited by 78 · see citing works
Atrial Cardiopathy and Cryptogenic Stroke: A Cross-sectional Pilot Study
Yaghi, S. R., Boehme, A. K., Hazan, R., Hod, E. A., Canaan, A., Andrews, H., Kamel, H., Marshall, R. S., & Elkind, M. S. V. (2015) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2015.09.001 · Cited by 78 · see citing works
Cohen, A. A., Donal, E., Delgado, V., Pepi, M., Tsang, T. S. M., Gerber, B. L., Soulat-Dufour, L., Habib, G., Lancellotti, P., Evangelista, A., et al. (2021) · European Heart Journal - Cardiovascular Imaging · doi:10.1093/ehjci/jeab008 · Cited by 76 · see citing works
Diederichsen, S. Z., Haugan, K., Køber, L., Højberg, S., Brandes, A., Kronborg, C., Graff, C., Holst, A. G., Nielsen, J. B., Krieger, D. W., et al. (2017) · American Heart Journal · doi:10.1016/j.ahj.2017.02.017 · Cited by 74 · see citing works
Bertaglia, E., Blank, B., Blomström‐Lundqvist, C., Brandes, A., Cabanelas, N., Dan, G. A., Dichtl, W., Goette, A., de Groot, J. R., Lubiński, A., et al. (2019) · EP Europace · doi:10.1093/europace/euz172 · Cited by 72 · see citing works
Tzeis, S. E., Gerstenfeld, E. P., Kalman, J. M., Saad, E., Shamloo, A. S., Andrade, J. G., Barbhaiya, C. R., Baykaner, T., Bovéda, S., Calkins, H. G., et al. (2024) · Journal of Arrhythmia · doi:10.1002/joa3.13082 · Cited by 76 · see citing works
Witt, C. T., Kronborg, M. B., Nohr, E. A., Mortensen, P. T., Gerdes, C., & Nielsen, J. C. (2015) · Heart Rhythm · doi:10.1016/j.hrthm.2015.07.007 · Cited by 72 · see citing works
Sajeev, J., Kalman, J. M., Dewey, H. M., Cooke, J. C., & Teh, A. W. (2020) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2019.12.013 · Cited by 72 · see citing works
Lim, D. J., Ambale‐Venkatesh, B., Ostovaneh, M. R., Zghaib, T., Ashikaga, H., Wu, C. O., Watson, K. E., Hughes, T. M., Shea, S., Heckbert, S. R., et al. (2019) · European Heart Journal - Cardiovascular Imaging · doi:10.1093/ehjci/jez176 · Cited by 69 · see citing works
Atrial cardiopathy in patients with embolic strokes of unknown source and other stroke etiologies
Jalini, S., Rajalingam, R., Nisenbaum, R. A., Javier, A. D., Woo, A., & Pikula, A. (2018) · Neurology · doi:10.1212/wnl.0000000000006748 · Cited by 69 · see citing works
Cryptogenic stroke and atrial fibrillation.
Malnick, S. D. H., Somin, M., & Goland, S. (2014) · PubMed · doi:10.1056/nejmc1409495 · Cited by 42 · see citing works
- Authors
- Brambatti, M., Connolly, S. J., Gold, M. R., Morillo, C. A., Capucci, A., Muto, C., Lau, C. P., Van Gelder, I. C., Hohnloser, S. H., Carlson, M., Fain, E., Nakamya, J., Mairesse, G. H., Halytska, M., Deng, W. Q., Israel, C. W., & Healey, J. S.
- Affiliations
- Goethe University Frankfurt (DE)
- From the Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada (M.B., S.J.C., C.A.M., J.N., M.H., W.Q.D., J.S.H.); Clinica di Cardiologia, Università Politecnica delle Marche, Ancona, Italy (M.B., A.C.); Medical University of South Carolina, Charleston (M.R.G.); Cardiology Department, Loreto Mare, Napoli, Italy (C.M.); Queen Mary Hospital, Department of Medicine, University of Hong Kong, Hong Kong, China (C.P.L.); University of Groningen, University Medical Center...
- ORCID
- Venue
- Circulation
- Published
- 2014-05-27
- Volume
- 129
- Issue
- 21
- Pages
- 2094-2099
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2024497977
- Cited by
- 676
- References
- 31
- Citations by year
- 2026: 21 · 2025: 35 · 2024: 52 · 2023: 66 · 2022: 62 · 2021: 67 · 2020: 55 · 2019: 63 · 2018: 57 · 2017: 66 · 2016: 58 · 2015: 57 · 2014: 15 · 2012: 1
- FWCI
- 44.81
- Type
- journal article
- Language
- en
- Open access
- Licence
- other-oa
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- INFM-OAR (INFN Catania) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cardiovascular and Diving-Related Complications
- Keywords
- subclinical atrial fibrillation, stroke, systemic embolism, implantable cardioverter-defibrillator, cardiac pacemaker, temporal relations, asymptomatic atrial fibrillation, hypertension
- MeSH terms
- Aged, Aged, 80 and over, Atrial Fibrillation, Embolism, Female, Follow-Up Studies, Humans, Male, Pacemaker, Artificial, Prospective Studies, Risk Factors, Time Factors, Stroke
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
