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Cited by 3,977

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Long-Term Use of a Left Ventricular Assist Device for End-Stage Heart Failure

Rose, Eric A., Gelijns, Annetine C., Moskowitz, Alan J., Heitjan, Daniel F., Stevenson, Lynne W., Dembitsky, Walter, Long, James W., Ascheim, Deborah D., Tierney, Anita R., Levitan, Ronald G., Watson, John T., Ronan, Nuala S., Shapiro, Peter A., Lazar, Ronald M., Miller, Leslie W., Gupta, Lopa, Frazier, O. Howard, Desvigne-Nickens, Patrice, Oz, Mehmet C., Poirier, Victor L., Meier, Paul·2001·New England Journal of Medicine
DOI 10.1056/nejmoa012175
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Abstract

BACKGROUND: Implantable left ventricular assist devices have benefited patients with end-stage heart failure as a bridge to cardiac transplantation, but their long-term use for the purpose of enhancing survival and the quality of life has not been evaluated. METHODS: We randomly assigned 129 patients with end-stage heart failure who were ineligible for cardiac transplantation to receive a left ventricular assist device (68 patients) or optimal medical management (61). All patients had symptoms of New York Heart Association class IV heart failure. RESULTS: Kaplan-Meier survival analysis showed a reduction of 48 percent in the risk of death from any cause in the group that received left ventricular assist devices as compared with the medical-therapy group (relative risk, 0.52; 95 percent confidence interval, 0.34 to 0.78; P=0.001). The rates of survival at one year were 52 percent in the device group and 25 percent in the medical-therapy group (P=0.002), and the rates at two years were 23 percent and 8 percent (P=0.09), respectively. The frequency of serious adverse events in the device group was 2.35 (95 percent confidence interval, 1.86 to 2.95) times that in the medical-therapy group, with a predominance of infection, bleeding, and malfunction of the device. The quality of life was significantly improved at one year in the device group. CONCLUSIONS: The use of a left ventricular assist device in patients with advanced heart failure resulted in a clinically meaningful survival benefit and an improved quality of life. A left ventricular assist device is an acceptable alternative therapy in selected patients who are not candidates for cardiac transplantation.

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Metadata

Authors
Rose, E. A., Gelijns, A. C., Moskowitz, A. J., Heitjan, D. F., Stevenson, L. W., Dembitsky, W., Long, J. W., Ascheim, D. D., Tierney, A. R., Levitan, R. G., Watson, J. T., Ronan, N. S., Shapiro, P. A., Lazar, R. M., Miller, L. W., Gupta, L., Frazier, O. H., Desvigne-Nickens, P., Oz, M. C., Poirier, V. L., & Meier, P.
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
2001-11-15
Volume
345
Issue
20
Pages
1435-1443
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejmoa012175
OpenAlex
W1997780004
Cited by
3,977
References
2
FWCI
97.99
Type
journal article
Language
en
Open access
closed

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