Leptin-Replacement Therapy for Lipodystrophy

Oral, Elif Arioglu, Simha, Vinaya, Ruiz, Elaine, Andewelt, Alexa, Premkumar, Ahalya, Snell, Peter, Wagner, Anthony J., DePaoli, Alex M., Reitman, Marc L., Taylor, Simeon I., Gorden, Phillip, Garg, Abhimanyu·2002·New England Journal of Medicine
DOI 10.1056/nejmoa012437

Cited by (998)

Items 601–700 of 998

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    Houshang Monajemi, Erik S.G. Stroes, Robert Alexander Hegele, Eric Fliers · 2007 · Clinical Endocrinology
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    Gunjan Sinha · 2014 · Nature Biotechnology
  4. Novel perspectives on leptin in osteoarthritis: Focus on aging
    Zimo Liu, Wenqing Xie, Hengzhen Li, Xu Liu, Yao Lu, Bangbao Lu, Zhenhan Deng, Yusheng Li · 2023 · Genes & Diseases
  5. A rapid action plan to improve diagnosis and management of lipodystrophy syndromes
    Lindsay T. Fourman, Josivan Gomes Lima, Vinaya Simha, Marco Cappa, Saif Al-Yaarubi, Renan Magalhães Montenegro, Barış Akıncı, Ferruccio Santini · 2024 · Frontiers in Endocrinology
  6. Mechanisms of Simple Hepatic Steatosis
    Scott C. Matherly, Puneet Puri · 2012 · Clinics in Liver Disease
  7. SEIPIN: A Key Factor for Nuclear Lipid Droplet Generation and Lipid Homeostasis
    Yi Jin, Yanjie Tan, Pengxiang Zhao, Zhuqing Ren · 2020 · International Journal of Molecular Sciences
  8. Role of Leptin in the Digestive System
    Min‐Hyun Kim, Hyeyoung Kim · 2021 · Frontiers in Pharmacology
  9. Obesity Due to Steroid Receptor Coactivator-1 Deficiency Is Associated With Endocrine and Metabolic Abnormalities
    Tessa M. Cacciottolo, Elana Henning, Julia M. Keogh, Pierre Bel Lassen, Katherine Lawler, Rebecca Bounds, Rachel Ahmed, Aliki Perdikari, Edson Mendes de Oliveira, Miriam Smith et al. · 2022 · The Journal of Clinical Endocrinology & Metabolism
  10. Lipotoxicity on the Basis of Metabolic Syndrome and Lipodystrophy in HIV-1-Infected Patients Under Antiretroviral Treatment
    Marta Giralt, Julieta Díaz-Delfín, José Miguel Gallego-Escuredo, Joan Villarroya, Peré Domingo, Francesc Villarroya · 2010 · Current Pharmaceutical Design
  11. Berardinelli – Seip Congenital Lipodystrophy
    Ghosh J Ghosh J · 2014 · Journal of Molecular and Genetic Medicine
  12. Effects of Leptin Replacement Therapy on Pancreatic β-Cell Function in Patients With Lipodystrophy
    Ranganath Muniyappa, Rebecca J. Brown, Andrea Mari, Jalaja Joseph, Mary A. Warren, Elaine K. Cochran, Monica C. Skarulis, Phillip Görden · 2014 · Diabetes Care
  13. IGFBP2 Is Neither Sufficient nor Necessary for the Physiological Actions of Leptin on Glucose Homeostasis in Male ob/ob Mice
    Ursula H. Neumann, Sam Chen, Yuen Yi C. Tam, Robert K. Baker, Scott D. Covey, Pieter R. Cullis, Timothy J. Kieffer · 2014 · Endocrinology
  14. Identification and Saturable Nature of Signaling Pathways Induced by Metreleptin in Humans: Comparative Evaluation of In Vivo, Ex Vivo, and In Vitro Administration
    Hyun‐Seuk Moon, Joo Young Huh, Fadime Dincer, Benjamin E. Schneider, Per‐Olof Hasselgren, Christos Socrates Mantzoros · 2014 · Diabetes
  15. Leptin therapy in type 2 diabetes
    Bethany P. Cummings · 2012 · Diabetes Obesity and Metabolism
  16. Cholic acid for hepatic steatosis in patients with lipodystrophy: a randomized, controlled trial
    Zahid Ahmad, Lalitha Subramanyam, Lidia S. Szczepaniak, Vinaya Simha, BEVERLEY A. ADAMS-HUET, Abhimanyu Garg · 2013 · European Journal of Endocrinology
  17. Recent advances in understanding lipodystrophy: a focus on lipodystrophy-associated cardiovascular disease and potential effects of leptin therapy on cardiovascular function
    Thiago B Bruder-Nascimento, Taylor C. Kress, Eric J. Belin de Chantemèle · 2019 · F1000Research
  18. Body Fat Distribution Contributes to Defining the Relationship between Insulin Resistance and Obesity in Human Diseases
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  20. Adiponectin and leptin in human severe insulin resistance – Diagnostic utility and biological insights
    Matthijs P. Groeneveld, Isabel Huang‐Doran, Robert K. Semple · 2012 · Biochimie
  21. Leptin in Relation to the Lipodystrophy-Associated Metabolic Syndrome
    Christos Socrates Mantzoros · 2012 · Diabetes & Metabolism Journal
  22. Cardiac Manifestations of Congenital Generalized Lipodystrophy
    Vani P. Sanon, Yehuda Handelsman, Son V. Pham, ROBERT J. CHILTON · 2016 · Clinical Diabetes
  23. Resveratrol increases serum adiponectin level and decreases leptin and insulin level in an experimental model of hypercholesterolemia
    A. Jimoh, Yusuf Tanko, Joseph Olusegun Ayo, Abubakar Ahmed, Abdul Wasay Mohammed · 2018 · Pathophysiology
  24. The adipocyte as an endocrine cell
    Rebecca S. Mattison, Michael D. Jensen · 2003 · Current Opinion in Endocrinology & Diabetes
  25. Prediabetes is not all about obesity: association between plasma leptin and prediabetes in lean rural Chinese adults
    Guoying Wang, Xin Liu, Katherine Kaufer Christoffel, Shanchun Zhang, Binyan Wang, Rong Liu, Zhiping Li, Xue Liu, Wendy J. Brickman, Donald Zimmerman et al. · 2010 · European Journal of Endocrinology
  26. Adipose tissue metabolism, diabetes and vascular disease — lessons from in vivo studies
    Lucinda K. M. Summers · 2006 · Diabetes and Vascular Disease Research
  27. Consequences of Stopping and Restarting Leptin in an Adolescent with Lipodystrophy
    F. Kamran, K.I. Rother, Elaine K. Cochran, Elika Safar Zadeh, Phillip Görden, R.J. Brown · 2012 · Hormone Research in Paediatrics
  28. Phytotherapy as Multi-Hit Therapy to Confront the Multiple Pathophysiology in Non-Alcoholic Fatty Liver Disease: A Systematic Review of Experimental Interventions
    Ayokanmi Ore, Oluseyi Adeboye Akinloye · 2021 · Medicina
  29. Heparin-binding epidermal growth factor-like growth factor inhibits adipocyte differentiation at commitment and early induction stages
    Jeong Soon Lee, Jae Myoung Suh, Hong Gyu Park, Eun‐Jung Bak, Yun‐Jung Yoo, Jeong‐Heon Cha · 2008 · Differentiation
  30. Mouse Models of Lipodystrophy and Their Significance in Understanding Fat Regulation
    Justin J. Rochford · 2014 · Current topics in developmental biology/Current Topics in Developmental Biology
  31. Leptin Replacement Therapy But Not Dietary Polyunsaturated Fatty Acid Alleviates HIV Protease Inhibitor–Induced Dyslipidemia and Lipodystrophy in Mice
    Tara M. Riddle, Carl J. Fichtenbaum, David Y. Hui · 2003 · JAIDS Journal of Acquired Immune Deficiency Syndromes
  32. Leptin and lipid metabolism in chronic kidney failure
    Helena Kastarinen, Y. Antero Kesäniemi, Olavi H. Ukkola · 2009 · Scandinavian Journal of Clinical and Laboratory Investigation
  33. Relationship between Serum Leptin Concentration and Low-Density Muscle in Postmenopausal Women
    Julian A. Muñoz, Barbara Ann Gower · 2003 · The Journal of Clinical Endocrinology & Metabolism
  34. Energy adaptation to glucocorticoid-induced hyperleptinemia in human beings
    Hassan Askari, Jianmei Liu, Samuel E. Dagogo-Jack · 2005 · Metabolism
  35. Whither Recombinant Human Leptin Treatment for HIV-Associated Lipoatrophy and the Metabolic Syndrome?
    Christos Socrates Mantzoros · 2009 · The Journal of Clinical Endocrinology & Metabolism
  36. Molecular mechanisms and neural mediators of leptin action
    Çağrı Bodur, Allison M. Duensing, Martin Grosvenor Myers · 2025 · Genes & Development
  37. Transforming growth factor β1 signaling links extracellular matrix remodeling to intracellular lipogenesis upon physiological feeding events
    Shinichiro Toyoda, Jihoon Shin, Atsunori Fukuhara, Michio Otsuki, Iichiro Shimomura · 2022 · Journal of Biological Chemistry
  38. Potential Mechanisms for How Long-Term Physical Activity May Reduce Insulin Resistance
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  39. Preclinical, randomized phase 1, and compassionate use evaluation of REGN4461, a leptin receptor agonist antibody for leptin deficiency
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  40. Successful Renal Transplantation in a Patient with Congenital Generalized Lipodystrophy: A Case Report
    Michael McNally, Roslyn Bernstein Mannon, Edward D. Javor, S. John Swanson, Douglas A. Hale, Phillip Görden, Allan D. Kirk · 2004 · American Journal of Transplantation
  41. Translational research of novel hormones: lessons from animal models and rare human diseases for common human diseases
    Kazuwa Nakao, Akihiro Yasoda, Ken Ebihara, Kiminori Hosoda, Masashi Mukoyama · 2009 · Journal of Molecular Medicine
  42. The role of leptin in the regulation of neuroendocrine function and CNS development
    Gwendolyn W. Louis, Martin Grosvenor Myers · 2007 · Reviews in Endocrine and Metabolic Disorders
  43. Adipokines vaspin and omentin-1 are up-regulated in large for gestational age infants at term
    George Kafalidis, Τheodora Boutsikou, Despina D. Briana, Maria Boutsikou, Antonios Marmarinos, Stavroula G. Baka, Demetrios Hassiakos, Demetrios Gourgiotis, Ariadne Malamitsi‐Puchner · 2013 · Cytokine
  44. CARDIOVASCULAR AND SURVIVAL PARADOXES IN DIALYSIS PATIENTS: Role of Leptin in Reverse Epidemiology in Chronic Kidney Disease
    Alexandra Scholze, Martin Tepel · 2007 · Seminars in Dialysis
  45. Você conhece esta Síndrome?
    Priscilla Maria Rodrigues Pereira, Carlos Alberto Chirano Rodrigues, Lívia Lima de Lima, Sandra Adolfina Romero Reyes, Adriana Valkiria de Oliveira Mariano · 2010 · Anais Brasileiros de Dermatologia
  46. Panniculitis and lipodystrophy
    Barbara Anne Eberhard, Norman T. Ilowite · 2002 · Current Opinion in Rheumatology
  47. Leptin/Adiponectin Ratios Using Either Total Or High-Molecular-Weight Adiponectin as Biomarkers of Systemic Insulin Sensitivity in Normoglycemic Women
    Carolina Bravo, Luis Rodrigo Cataldo, José Eduardo Galgani, Javier Parada, José Luis Santos · 2017 · Journal of Diabetes Research
  48. Inhibin B: A Potential Marker of Gonadal Activity in Patients with Anorexia Nervosa during Weight Recovery
    Vera M. POPOVIC, Marina Nikolic Djurovic, Aleksandar Ćetković, Danilo Vojvodić, Sandra Pekić, Svetlana Spremović-Radjenović, Milan S. Petakov, Svetozar S Damjanovic, Natasa M Milic, Carlos Diéguez et al. · 2004 · The Journal of Clinical Endocrinology & Metabolism
  49. Breaking down silos: the multifaceted nature of obesity and the future of weight management
    Faith Anne N. Heeren, Valerie L. Darcey, Sarah E. Deemer, Sarada Menon, Deirdre Kay Tobias, Michelle I. Cardel · 2023 · Philosophical Transactions of the Royal Society B Biological Sciences
  50. Serum concentrations of fibroblast growth factor 21 are elevated in patients with congenital or acquired lipodystrophy
    Konstanze Miehle, Thomas Ebert, Susan Kralisch, Annett Hoffmann, Jürgen Kratzsch, Haiko Schlögl, Michael Stümvoll, Mathias Faßhauer · 2016 · Cytokine
  51. Lipodystrophy: Time for a global registry and randomized clinical trials to assess efficacy, safety and cost-effectiveness of established and novel medications
    Stergios A. Pοlyzos, Christos Socrates Mantzoros · 2017 · Metabolism
  52. Leptin therapy in lipodystrophy
    David B. Savage, Stephen O’Rahilly · 2009 · Diabetologia
  53. Antiretroviral therapy in HIV patients: aspects of metabolic complications and mitochondrial toxicity.
    H.J.M. ter Hofstede, David Marinus Burger, P.P. Koopmans · 2003 · PubMed
  54. Adiponectin, Leptin, and Erythrocyte Sodium/Lithium Countertransport Activity, But Not Resistin, Are Related to Glucose Metabolism in Growth Hormone-Deficient Adults
    Johan Svensson, Hans Herlitz, Per‐Arne Lundberg, Gudmundur Johannsson · 2005 · The Journal of Clinical Endocrinology & Metabolism
  55. Etiological investigations in apparent type 2 diabetes: when to search for lamin A/C mutations?
    Bruno Donadille, Olivier Lascols, Jacqueline Capeau, Corinne Vigouroux · 2005 · Diabetes & Metabolism
  56. Transcription factor AP-2β inhibits expression and secretion of leptin, an insulin-sensitizing hormone, in 3T3-L1 adipocytes
    Tomoya Fuke, Takeshi Yoshizaki, Masaki Kondo, Katsutaro Morino, T. Obata, Satoshi Ugi, Yoshihiko Nishio, Shiro Maeda, Atsunori Kashiwagi, Hiroshi Maegawa · 2010 · International Journal of Obesity
  57. Pharmacologic Therapy for HIV-Associated Lipodystrophy
    Sandra Benavides, Milap C Nahata · 2004 · Annals of Pharmacotherapy
  58. Effects of C-reactive protein on adipokines genes expression in 3T3-L1 adipocytes
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  59. Cord blood chemerin and obestatin levels in large for gestational age infants
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  60. Weight gain by hyperalimentation elevates C-reactive protein levels but does not affect circulating levels of adiponectin or resistin in healthy subjects
    Olov Åstrand, Martin Carlsson, Ingela Nilsson, Torbjörn Lindström, Magnus Borga, Fredrik Hans Nyström, _ _ · 2010 · European Journal of Endocrinology
  61. Soluble Leptin Receptor Predicts Insulin Sensitivity and Correlates With Upregulation of Metabolic Pathways in Men
    Christine Sommer, Sindre Lee-Ødegård, Hanne Løvdal Gulseth, Jørgen Jensen, Christian Andre Drevon, Kåre I. Birkeland · 2017 · The Journal of Clinical Endocrinology & Metabolism
  62. Central regulation of glucose metabolism in an insulin‐dependent and ‐independent manner
    Teppei Fujikawa · 2021 · Journal of Neuroendocrinology
  63. Cytokines in Type 2 Diabetes
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  64. Acquired Generalized Lipodystrophy Associated with Autoimmune Hepatitis and Low Serum C4 Level
    Erdal Eren, Tanju Özkan, Esra Deniz Papatya Çakır, Halil Sağlam, Ömer Tarım · 2010 · Journal of Clinical Research in Pediatric Endocrinology
  65. The Efficacy of Adipokines and Indices of Metabolic Syndrome as Predictors of Severe Obesity-Related Hepatic Steatosis
    Nahúm Méndez‐Sánchez, Norberto Carlos Chávez-Tapia, Roberto Medina‐Santillán, Antonio Rafael Villa, Karla Sánchez-Lara, Guadalupe Ponciano‐Rodríguez, Martha Helena Ramos, Misael Uribe · 2006 · Digestive Diseases and Sciences
  66. Ciliary neurotrophic factor influences endocrine adipocyte function: inhibition of leptin via PI 3-kinase
    Volker Ott, Mathias Faßhauer, Britta Meier, Andreas Dalski, Daniel Kraus, Thomas W. Gettys, Nina Perwitz, Johannes Christian Klein · 2004 · Molecular and Cellular Endocrinology
  67. Leptin in congenital or HIV-associated lipodystrophy and metabolic syndrome: A need for more mechanistic studies and large, randomized, placebo-controlled trials
    Joo‐Pin Foo, Christos Socrates Mantzoros · 2012 · Metabolism
  68. Endogenous Leptin Concentrations Poorly Predict Metreleptin Response in Patients With Partial Lipodystrophy
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  70. Leptin replacement therapy for the treatment of non-HAART associated lipodystrophy syndromes: a meta-analysis into the effects of leptin on metabolic and hepatic endpoints
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  73. Do adipokines link obesity to its related metabolic and cardiovascular diseases?
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  74. Treatment of diet-induced lipodystrophic C57BL/6J mice with long-acting PASylated leptin normalises insulin sensitivity and hepatic steatosis by promoting lipid utilisation
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  75. JUVENILE DERMATOMYOSITIS
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  76. Myocardial Insulin Resistance: An Overview of Its Causes, Effects, and Potential Therapy
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  78. Beneficial effects of leptin substitution on impaired eating behavior in lipodystrophy are sustained beyond 150 weeks of treatment
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  79. Effects of a four-week very low-carbohydrate high-fat diet on biomarkers of inflammation: Non-randomised parallel-group study
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  80. Leptin and the Immunosuppression of Malnutrition
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  81. Plasma leptin levels in men are not related to the development of lipoatrophy during antiretroviral therapy
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