Leptin-Replacement Therapy for Lipodystrophy

Oral, Elif Arioglu, Simha, Vinaya, Ruiz, Elaine, Andewelt, Alexa, Premkumar, Ahalya, Snell, Peter, Wagner, Anthony J., DePaoli, Alex M. +4 more·2002·New England Journal of Medicine

Cited by (1,000)

Items 801–900 of 1,000

  1. Non-Alcoholic Fatty Liver Disease
    Hui‐Hui Tan, Jason Pik‐Eu Chang · 2010 · Proceedings of Singapore Healthcare
  2. Role of Hormone-sensitive Lipase in Leptin-Promoted Fat Loss and Glucose Lowering
    Mikio Takanashi, Yoshino Taira, Sachiko Okazaki, Satoru Takase, Takeshi Kimura, Cheng Cheng Li, Peng Xu, Akari Noda, Ichiro Sakata, Hidetoshi Kumagai et al. · 2017 · Journal of Atherosclerosis and Thrombosis
  3. Pharmacological Treatment of the Overweight Patient
    2007 · Humana Press eBooks
  4. Leptin: a novel therapeutic role in lipodystrophy
    David B. Savage, Stephen O’Rahilly · 2002 · Journal of Clinical Investigation
  5. Clinical Guidance for Lipodystrophy Syndromes: From Diagnosis and Work-Up to Treatment
    Donatella Gilio, Maria Cristina Foss‐Freitas, Elif A Oral · 2025 · Current Diabetes Reports
  6. Approach to the Adult Patient with Chylomicronemia
    Robert Alexander Hegele · 2025 · The Journal of Clinical Endocrinology & Metabolism
  7. Navigating Lipodystrophy: Insights from Laminopathies and Beyond
    Peter Krüger, Ramona Hartinger, Karima Djabali · 2024 · International Journal of Molecular Sciences
  8. Adipokines and Their Receptors: Potential New Targets in Cardiovascular Diseases
    Nádia Gonçalves, Inês Falcão‐Pires, Adelino Ferreira Leite-Moreira · 2015 · Future Medicinal Chemistry
  9. Obesity as an effect modifier of the association between leptin and diabetic kidney disease
    Ko Hanai, Tetsuya Babazono, Michino Takagi, Naoshi Yoshida, Izumi Nyumura, Kiwako Toya, Nobue Tanaka, Yasuko Uchigata · 2013 · Journal of Diabetes Investigation
  10. Regulation of Leptin Methylation Not via Apoptosis by Melatonin in the Rescue of Chronic Programming Liver Steatosis
    Ching‐Chou Tsai, Yu‐Ju Lin, Hong‐Ren Yu, Jiunn‐Ming Sheen, I-Chun Lin, Yun‐Ju Lai, You‐Lin Tain, Li‐Tung Huang, Mao‐Meng Tiao · 2018 · International Journal of Molecular Sciences
  11. Berardinelli-Seip lipodystrophy
    Yuko Kobashi, Amy Schoenbaum, Robert Paul Hasserjian, Daniel I. Rosenthal · 2007 · Skeletal Radiology
  12. Translational Research of Leptin in Lipodystrophy and Its Related Diseases
    Ken Ebihara, Kazuwa Nakao · 2015 · Springer eBooks
  13. Leptin and Obesity
    Yuanyuan Zhang, Jun Tao Ren · 2015 · Springer eBooks
  14. Berardinelli–Seip syndrome: highlight of treatment challenge
    Nélia Ferraria, Cristina Pedrosa, Daniela Amaral, Lurdes Lopes · 2013 · BMJ Case Reports
  15. Insulin resistance in HIV-related lipodystrophy
    Nasser E. Mikhail · 2003 · Current Hypertension Reports
  16. Systemic Lupus Erythematosus, Juvenile Dermatomyositis, Scleroderma, and Vasculitis
    James T. Cassidy · 2009 · Elsevier eBooks
  17. Association between plasma leptin/adiponectin ratio and insulin resistance indexes in prepubertal children
    Carolina Bravo, Verónica Mericq G, Ana Paula Rodrigues Pereira, Camila Corvalán, Hugo E. Tobar, José Patricio Miranda, José Luis Santos · 2024 · Archives of Endocrinology and Metabolism
  18. Leptin acutely increases hepatic triglyceride secretion in patients with lipodystrophy
    Marianna Beghini, Matthäus Metz, Clemens Baumgartner, Peter S. Wolf, Magdalena Bastian, Martina Theresa Hackl, Sabina M. Baumgartner-Parzer, Rodrig Marculescu, Michael Krebs, Jürgen Harreiter et al. · 2025 · Metabolism
  19. Adipose Tissue‐Derived Adipokines in Vascular Physiology and Pathophysiology: Insights and Implications
    Ariane Bruder‐Nascimento, Thiago B Bruder-Nascimento · 2025 · Comprehensive physiology
  20. Experiences and Perspectives of Patients with Non-HIV-Associated Lipodystrophies and Their Caregivers: A Qualitative Study
    Dumingu Aparna Gomes, Keziah Cook, Alex Wong, Edward Tuttle, Andra Stratton, Rebecca Sanders · 2021 · Patient
  21. Nivolumab Associated Endocrine Abnormalities: Challenging Cases from a Reference Clinic
    Mehmet Çağrı Ünal · 2022 · Acta Endocrinologica (Bucharest)
  22. Development of an adipose-tropic AAV capsid ablating liver tropism
    Wei Huang, Rhiannon Bates, Bhavya Appana, Tawfiq Mohammed, Lei Cao · 2024 · iScience
  23. Obesity research in the next decade
    Robert H. Eckel · 2008 · International Journal of Obesity
  24. Effect of antidiabetic therapy on TNF-α, IL-18, IL-23 and IL-35 levels in T2DM patients with coincidental Helicobacter pylori infection
    Adel Abdel‐Moneim, Sanaa Mahmoud Abd El-Twab, Ahmed Nabil, Salma A. El Kazafy · 2020 · Journal of Taibah University for Science
  25. YIPF5 mutations cause neonatal diabetes and microcephaly: progress for precision medicine and mechanistic understanding
    Toni I. Pollin, Simeon I. Taylor · 2020 · Journal of Clinical Investigation
  26. Vaspin Mediates the Intraorgan Crosstalk Between Heart and Adipose Tissue in Lipoatrophic Mice
    Donghui Zhang, Hong Zhu, Enbo Zhan, Fan Wang, Yue Liu, Wei Xu, Xian Liu, Jingjin Liu, Shufeng Li, Yong Pan et al. · 2021 · Frontiers in Cell and Developmental Biology
  27. Leptin regulates glucose homeostasis via the canonical Wnt pathway in the zebrafish
    Kaj Kamstra, Mohammed Z. Rizwan, David R. Grattan, Julia A. Horsfield, Alexander Tups · 2022 · The FASEB Journal
  28. Regulation of feeding and therapeutic application of bioactive peptides
    Hiroaki Ueno, Weidong Zhang, Masamitsu Nakazato · 2022 · Pharmacology & Therapeutics
  29. Face-sparing Congenital Generalized Lipodystrophy Type 1 Associated With Nonclassical Congenital Adrenal Hyperplasia
    Sara Todo Bom Costa, Lurdes Sampaio, Ana Berta Sousa, Chao Xing, Anil K. Agarwal, Abhimanyu Garg · 2022 · The Journal of Clinical Endocrinology & Metabolism
  30. Molecular Mechanisms of Insulin Resistance, Obesity and Metabolic Syndrome
    Barbara Mlinar, Janja Marc, Marija Pfeifer · 2006 · Biochemia Medica
  31. Síndrome de Berardinelli-Seip: descrição genética e metabólica de cinco pacientes
    C. Barra, Roberta Diaz Savoldelli, Thaís Della Manna, Chong Ae Kim, Jocelyn Magre, Gilda Porta, Nuvarte Setian, Durval Damiani · 2011 · Arquivos Brasileiros de Endocrinologia & Metabologia
  32. Metabolism of chylomicrons in patients with congenital lipoatrophic diabetes: a study with emulsion models of chylomicrons
    BERNARDO LEO WAJCHENBERG, R.F. Amâncio, Ana Tereza M. G. Santomauro, Raul Cavalcante Maranhão · 2004 · Clinical Endocrinology
  33. Nuevas proyecciones fisiológicas, patológicas y terapéuticas de la leptina
    Denisse Goldenberg, José Luis Santos, María Isabel Hodgson, Vı́ctor Cortés · 2014 · Revista médica de Chile
  34. Medical Complications Resulting from Severe Obesity
    P. Kastanias, K. Mackenzie, S. Robinson, Wei Wang · 2017 · Springer eBooks
  35. Leptin Gene Transfer Improves Symptoms of Type 2 Diabetic Mice by Regulating Leptin Signaling Pathway and Insulin Resistance of Peripheral Tissues
    Lan Xiang, Jing Li, Qian Wang, Ruiqi Tang, Jianhua Qi · 2017 · Human Gene Therapy
  36. Facial soft tissue volume decreases during metreleptin treatment in patients with partial and generalized lipodystrophy
    Konstanze Miehle, Michael Stümvoll, Mathias Faßhauer, Thomas Hierl · 2017 · Endocrine
  37. Metreleptin treatment of non-HIV lipodystrophy syndromes
    Benjamin Chevalier, Madleen Lemaître, Lysiane Leguier, Kristell Le Mapihan, Claire Douillard, Arnaud Jannin, Stéphanie Espiard, Marie‐Christine Vantyghem · 2021 · La Presse Médicale
  38. Toward the Decipherment of Molecular Interactions in the Diabetic Brain
    Mária Chomová · 2022 · Biomedicines
  39. The impact of insulin resistance on woman's health and potential treatment options
    Konstantinos B. Lois, Georgios Valsamakis, George P. Mastorakos, Sudhesh Kumar · 2010 · Annals of the New York Academy of Sciences
  40. Scientific Side Trips: Six Excursions from the Beaten Path
    Michael S. Brown, Joseph L. Goldstein · 2012 · Journal of Biological Chemistry
  41. Lipoatrophic Diabetes: A Case Report with a Brief Review of the Literature
    Melissa A. Lawson · 2008 · Journal of Adolescent Health
  42. The Metabolic Syndrome
    Neil B. Ruderman, Gerald I. Shulman · 2010 · Elsevier eBooks
  43. Insulin Resistance in NAFLD: Potential Mechanisms and Therapies
    Varman T. Samuel, Gerald I. Shulman · 2004
  44. The clinical efficacy of the adipocyte-derived hormone leptin in metabolic dysfunction
    Phillip Görden, Jean Y. Park · 2006 · Archives of Physiology and Biochemistry
  45. Subcutaneous Fat
    D. McGibbon · 2010
  46. Lipodystrophies in non-insulin-dependent children: Treatment options and results from recombinant human leptin therapy
    Valeria Calcaterra, Vittoria Carlotta Magenes, Virginia Rossi, Valentina Fabiano, Chiara Mameli, Gianvincenzo Zuccotti · 2022 · Pharmacological Research
  47. Acquired Generalized Lipodystrophy as an Adverse Event of Combined Immune Checkpoint Inhibitor Therapy
    Randol Kennedy, Calvin Rei L. Macrohon, Mary Lourdes Grace V David, Meg Lee, April K.S. Salama, Afreen Idris Shariff · 2025 · JCEM Case Reports
  48. Pathology of Alcoholic and Nonalcoholic Fatty Liver Disease
    Pierre Bédossa, David Erwin Kleiner · 2015 · Springer eBooks
  49. Berardinelli Seip Congenital Lipodystrophy Syndrome: 10 Year Follow-up
    Rajesh Joshi, Shreya Sharma · 2019 · Indian Pediatrics
  50. Obesity and chronic leptin resistance foster insulin resistance
    Sananda Dey, Nensina Murmu, Marlen Böse, Shilpi Ghosh, Biplab Giri · 2021 · BLDE University Journal of Health Sciences
  51. Insulin and Body Mass Index Decrease Serum Soluble Leptin Receptor Levels in Humans
    Christine Sommer, Kjersti G Vangberg, Gunn-Helen Moen, David M. Evans, Sindre Lee-Ødegård, Ingvild Kristine Blom-Høgestøl, Line Sletner, Anne Karen Jenum, Christian Andre Drevon, Hanne Løvdal Gulseth et al. · 2022 · The Journal of Clinical Endocrinology & Metabolism
  52. Hepatokines and Adipokines in Metabolic Syndrome
    Alpana Mukhuty, Samim Ali Mondal, Satinath Mukhopadhyay · 2023 · Annals of the National Academy of Medical Sciences (India)
  53. Senescence-associated inflammation and inhibition of adipogenesis in subcutaneous fat in Werner syndrome
    Daisuke Sawada, Hisaya Kato, Hiyori Kaneko, Daisuke Kinoshita, Shinichiro Funayama, Takuya Minamizuka, Atsushi Takasaki, Katsushi Igarashi, Masaya Koshizaka, Aki Takada‐Watanabe et al. · 2023 · Aging
  54. Preclinical evaluation of tissue-selective gene therapies for congenital generalised lipodystrophy
    Mansi Tiwari, Ahlima Roumane, Nadine Sommer, Weiping Han, Mirela Delibegović, Justin J. Rochford, George D. Mcilroy · 2024 · Gene Therapy
  55. Genetic Disorders of Insulin Action: Far More than Diabetes
    Benjamin Challis, Robert K. Semple · 2013 · Current Obesity Reports
  56. Relation of leptin pulse dynamics to fat distribution in HIV-infected patients
    Polyxeni Koutkia, Bridget M. Hron, Jeffrey Breu, Michael L. Johnson, Alex M. DePaoli, Steven Kyle Grinspoon · 2004 · American Journal of Clinical Nutrition
  57. Ethnicity and type 2 diabetes in Asian Indian migrants in Auckland, New Zealand
    Ljiljana M Jowitt · 2014 · SANAMED
  58. Metreleptin in lipodystrophy: a profile of its use
    Emma D. Deeks · 2019 · Drugs & Therapy Perspectives
  59. Classification and Evaluation of the Overweight Patient
    2008 · CRC Press eBooks
  60. From scarcity to solutions: Therapeutic strategies to restore adipose tissue functionality in rare disorders of lipodystrophy
    Mansi Tiwari, George D. Mcilroy · 2023 · Diabetic Medicine
  61. Type 2 Diabetes Mellitus: Epidemiology, Genetics, Pathogenesis, and Clinical Manifestations
    Vivian Andrew Fonseca, Jennifer John‐Kalarickal · 2009 · Springer eBooks
  62. Clinical and molecular characterization of two Chinese patients with Type 2 congenital generalized lipodystrophy
    Ruimin Chen, Xin Yuan, Jian Wang, Ying Zhang · 2017 · Gene
  63. Metabolic Syndrome
    Neil B. Ruderman, Gerald I. Shulman · 2015 · Elsevier eBooks
  64. A Case of Acquired Generalized Lipodystrophy with Cerebellar Degeneration and Type 2 Diabetes Mellitus
    Pei-Jiuan Chao, Jack C.‐R. Tsai, Dao‐Ming Chang, Shyi‐Jang Shin, Yau‐Jiunn Lee · 2004 · The Review of Diabetic Studies
  65. Diabetes mellitus de difícil manejo asociada síndrome de lipodistrofia congénita generalizada
    Roque Cardona‐Hernandez, Larisa Suárez-Ortega, M. Torres · 2010 · Anales de Pediatría
  66. Role of adenosine monophosphate-activated protein kinase in the control of energy homeostasis
    Fabienne Foufelle, Pascal Ferré · 2005 · Current Opinion in Clinical Nutrition & Metabolic Care
  67. Genetic Forms of the Cardiometabolic Syndrome: What Can They Tell the Clinician?
    George Y. Yuan, Robert Alexander Hegele · 2007 · Journal of the CardioMetabolic Syndrome
  68. Monogenic Causes of Diabetes
    Angus G. Jones, Andrew Tym Hattersley · 2010 · Wiley eBooks
  69. Lipodystrophies and Diabetes
    Abhimanyu Garg, Anoop Misra · 2003
  70. One-year metreleptin in Colombian sisters with congenital leptin deficiency
    Hernan Yupanqui-Lozno, Jancy Andrea Huertas-Quintero, Maria E. Yupanqui-Velazco, Rocío A. Salinas-Osornio, Carlos Martín Restrepo, Adriana González, Edna J. Nava‐González, Luís Gustavo Celis, Constanza Neri Morales, Victor M. Hernandez-Escalante et al. · 2025 · Adipocyte
  71. Lipodystrophie-Erkrankungen
    Konstanze Miehle, Julia von Schnurbein, Mathias Faßhauer, Michael Stümvoll, Guntram Borck, Martin Wabitsch · 2017 · Medizinische Genetik
  72. Adipose Tissue as Pain Generator in the Lower Back and Lower Extremity: Application in Musculoskeletal Medicine
    Se Won Lee, Craig Van Dien, Sun Jae Won · 2020 · HCA Healthcare Journal of Medicine
  73. Severe aortic stenosis during leptin replacement therapy in a patient with generalized lipodystrophy‐associated progeroid syndrome due to an LMNA variant: A case report
    Takayoshi Sasako, Hiroko Kadowaki, Takayuki Fujiwara, Satoshi Kodera, Issei Komuro, Takashi Kadowaki, Toshimasa Yamauchi · 2022 · Journal of Diabetes Investigation
  74. The Clinical Characteristics and Potential Molecular Mechanism of LMNA Mutation‐Related Lipodystrophy
    Cheng Xiao, Jieying Liu, Chunru Yang, Xiaojun Zhai, Peng Liu, Xinhua Xiao, Miao Yu · 2023 · Advanced Biology
  75. Pathogenesis of Obstructive Sleep Apnea in Obesity
    Susheel P. Patil, Jason Paul Kirkness · 2024 · Respiratory medicine
  76. The NIH Clinical Center and the future of clinical research
    John I. Gallin · 2011 · Nature Medicine
  77. Leptin in the treatment of lipodystrophy-associated nonalcoholic fatty liver disease: are we there already?
    Mariana Verdelho Machado, Helena Cortez‐Pinto · 2013 · Expert Review of Gastroenterology & Hepatology
  78. Turner's Syndrome: Diagnosis and Management in 2005 (Part 1)
    Olga M. Calof, Mayer B. Davidson · 2005
  79. HIV Lipodystrophy Syndrome
    Olumuyiwa Omolayo, Peter Sealy · 2008
  80. Leptin Levels and Insulin Dependence in Latent Autoimmune Diabetes in Adults
    Alessandro Delitala, Franca Sanciu, Alessandra Errigo, Giuseppe Delitala, Giovanni Mario Pes · 2017 · Journal of Interferon & Cytokine Research
  81. Monogenic Forms of Diabetes
    Mark A. Sperling, Abhimanyu Garg · 2018 · Europe PMC (PubMed Central)
  82. Clinical Characterisation and Comorbidities of Acquired Generalised Lipodystrophy: A 14-Year Follow-Up Study
    Antía Fernández‐Pombo, Teresa Prado‐Moraña, Everardo Josué Díaz‐López, Sofía Sánchez‐Iglesias, Ana I. Castro, Silvia Cobelo-Gómez, David Araújo‐Vilar · 2023 · Journal of Clinical Medicine
  83. Insulin Receptor and its Relationship with Different Forms of Insulin Resistance
    Aleksandra Rojek, Marek Niedziela · 2010 · Postepy Biologii Komorki
  84. First metreleptin treatment for generalized lipodystrophy in Turkey
    İlgın Yıldırım Şimşir, Banu Şarer Yürekli, Füsun Saygılı, Canan Altay, Barış Akıncı · 2016 · Diabetes Obesity and Metabolism
  85. Parent reported nutritional risk and laboratory indices of cardiometabolic risk and in preschool-aged children
    Navindra Persaud, Hedyeh Ziai, Gerald Lebovic, Jonathon L. Maguire, Marina Khovratovich, Janis A. Randall Simpson, Khosrow Adeli, Jill K. Hamilton, Brian W. McCrindle, Patricia C. Parkin et al. · 2017 · Journal of Pediatric Endocrinology and Metabolism
  86. Risk factors for diabetic foot ulcers in metreleptin naïve patients with lipodystrophy
    Onur Saydam, Başak Özgen Saydam, Süleyman Cem Adıyaman, Melda Sonmez Ince, M. Emre Eren, FE Keskin, Habib Bilen, Murat Dağdeviren, Safak Kaya, Gülçin Akıncı et al. · 2021 · Clinical Diabetes and Endocrinology
  87. Adipokines and Metabolism
    Rexford S. Ahima, Laura M. Scolaro, Hyeong-Kyu Park · 2016 · Springer eBooks
  88. Facial Lipoatrophy Following Systemic Lupus Erythematosus
    Audrey Dup�r�, Yves P. Poulin · 2003 · Journal of Cutaneous Medicine and Surgery
  89. Leptin Response to Oral Glucose Tolerance Test in Obese and Nonobese Premenopausal Women
    Mehtap Çakır, Ramazan Sarı, Özgür Tosun, Ümit Karayalçın · 2005 · Endocrine Research
  90. Case of lipoatrophic diabetes induced by juvenile dermatomyositis
    Yusuke Baba, Hiyori Kaneko, Minoru Takemoto, Kana Ide, Yuki Haga, Tatsuo Kanda, Shinsuke Akita, Yoshitaka Kubota, Masayuki Kuroda, Yutaka Kitagawa et al. · 2017 · Journal of Diabetes Investigation
  91. Neuroendocrine Control of Energy Stores
    Roger D. Cone, Joel Keith Elmquist · 2011 · Elsevier eBooks
  92. Leptin and the Neural Circuit Regulating body Weight and Metabolism
    Mark Jay Friedman · 2002 · Research and perspectives in endocrine interactions
  93. The changing faces of diabetes
    Irl B. Hirsch · 2003 · Primary Care Clinics in Office Practice
  94. Mice lacking triglyceride synthesis enzymes in adipose tissue are resistant to diet-induced obesity
    Chandramohan Chitraju, Alexander W. Fischer, Yohannes Abere Ambaw, Kun Wang, Bo Yuan, Sheng Tony Hui, Tobias C. Walther, Robert V. Farese · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  95. Deep Phenotyping of Obesity: Electronic Health Record–Based Temporal Modeling Study
    Xiaoyang Ruan, Shuyu Lu, Liwei Wang, Andrew Wen, Sameer B. Murali, Hongfang Liu · 2025 · Journal of Medical Internet Research
  96. Central leptin pathways in metabolic homeostasis
    Yuying Zhao, Connor F. Laule, Kamal Rahmouni · 2025 · Clinical Science
  97. Leptin and melanocortin signalling in the response to infection
    Roger R. Fan, John David Beckham, Kartik N. Rajagopalan · 2025 · Nature Reviews Endocrinology
  98. Congenital Generalized Lipodystrophy Type 2 in a Patient From a High-Prevalence Area
    Gonzalo Miranda, Estefania Chumbiauca Vela · 2017 · Journal of the Endocrine Society
  99. Metreleptin Treatment in a Boy with Congenital Generalized Lipodystrophy due to Homozygous c.465_468delGACT (p.T156Rfs*8) Mutation in the BSCL2 Gene: Results From the First-year
    Şervan Özalkak, Meliha Demiral, Edip Ünal, Funda Feryal Taş, Hüseyin Önay, Hüseyin Demirbilek, Mehmet Nuri Özbek · 2022 · Journal of Clinical Research in Pediatric Endocrinology
  100. Adipose transplantation improves metabolism and atherosclerosis but not perivascular adipose tissue abnormality or vascular dysfunction in lipodystrophic Seipin/Apoe null mice
    Zhe Meng, Chuangxing Liu, Mengke Xu, Ye-Qing Tao, Haiyu Li, Xijia Wang, Jiawei Liao, Mengyu Wang · 2024 · American Journal of Physiology-Cell Physiology