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Cited by 1,709Diabetes, Cardiovascular Risks, and LipoproteinsObesity, Physical Activity, DietDiabetes Management and Research

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Prevalence of Impaired Glucose Tolerance among Children and Adolescents with Marked Obesity

Open access
Sinha, Ranjana, Fisch, Gene, Teague, Barbara, Tamborlane, William V., Banyas, Bruna, Allen, Karin, Savoye, Mary, Rieger, Vera, Taksali, Sara, Barbetta, Gina, Sherwin, Robert S., Caprio, Sonia·2002·New England Journal of Medicine
DOI 10.1056/nejmoa012578
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Abstract

BACKGROUND: Childhood obesity, epidemic in the United States, has been accompanied by an increase in the prevalence of type 2 diabetes among children and adolescents. We determined the prevalence of impaired glucose tolerance in a multiethnic cohort of 167 obese children and adolescents. METHODS: All subjects underwent a two-hour oral glucose-tolerance test (1.75 g [DOSAGE ERROR CORRECTED] of glucose per kilogram of body weight), and glucose, insulin, and C-peptide levels were measured. Fasting levels of proinsulin were obtained, and the ratio of proinsulin to insulin was calculated. Insulin resistance was estimated by homeostatic model assessment, and beta-cell function was estimated by calculating the ratio between the changes in the insulin level and the glucose level during the first 30 minutes after the ingestion of glucose. RESULTS: Impaired glucose tolerance was detected in 25 percent of the 55 obese children (4 to 10 years of age) and 21 percent of the 112 obese adolescents (11 to 18 years of age); silent type 2 diabetes was identified in 4 percent of the obese adolescents. Insulin and C-peptide levels were markedly elevated after the glucose-tolerance test in subjects with impaired glucose tolerance but not in adolescents with diabetes, who had a reduced ratio of the 30-minute change in the insulin level to the 30-minute change in the glucose level. After the body-mass index had been controlled for, insulin resistance was greater in the affected cohort and was the best predictor of impaired glucose tolerance. CONCLUSIONS: Impaired glucose tolerance is highly prevalent among children and adolescents with severe obesity, irrespective of ethnic group. Impaired oral glucose tolerance was associated with insulin resistance while beta-cell function was still relatively preserved. Overt type 2 diabetes was linked to beta-cell failure.

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Citations

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Research works printed but not linked: 7

  1. 10.1001/jama.263.21.2893 · DOI · Paper page
  2. Hammer LD, 1991, Am J Dis Child, 145, 259
  3. Tanner JM. Growth at adolescence. 2nd ed. Oxford, England: Blackwell Scientific, 1962.
  4. 1999, Diabetes Care, 22, S5
  5. DeFronzo R, 1997, Diabetes Rev, 5, 177
  6. 10.1210/jc.76.1.44 · DOI · Paper page
  7. Fagot-Compagna A, 2001, Diabetes Care, 24, S134

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Metadata

Authors
Sinha, R., Fisch, G., Teague, B., Tamborlane, W. V., Banyas, B., Allen, K., Savoye, M., Rieger, V., Taksali, S., Barbetta, G., Sherwin, R. S., & Caprio, S.
Affiliations
Yale University (US)
ORCID
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
2002-03-14
Volume
346
Issue
11
Pages
802-810
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejmoa012578
OpenAlex
W2067262787
Semantic Scholar
0e6b33798ee36c635a2c1e99c405ac1fa5d5233c
Cited by
1,709
References
28
Citations by year
2026: 7 · 2025: 11 · 2024: 27 · 2023: 29 · 2022: 46 · 2021: 35 · 2020: 37 · 2019: 35 · 2018: 49 · 2017: 44 · 2016: 60 · 2015: 65 · 2014: 65 · 2013: 87 · 2012: 90
FWCI
73.16
Type
journal article
Language
en
Open access
Locations
  • New England Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Center for Research Resources (M01RR000125, M01RR006022, M01 RR-00125, M01 RR-06022)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01-HD- 28016, R01HD028016, R01-HD40787, K24HD001464, R01HD040787, K24-HD01464)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords
impaired glucose tolerance, childhood obesity, adolescent obesity, type 2 diabetes, insulin resistance, beta-cell function, proinsulin/insulin ratio, C-peptide, oral glucose tolerance test, prevalence, ethnic differences
MeSH terms
Insulin Secretion, Adolescent, Blood Glucose, C-Peptide, Child, Child, Preschool, Cross-Sectional Studies, Diabetes Mellitus, Female, Glucose, Glucose Tolerance Test, Hispanic or Latino, Humans, Insulin, Male, Obesity, Proinsulin, Risk Factors, Prevalence, Black People, White People

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