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Absence of Cross-Reactivity between Sulfonamide Antibiotics and Sulfonamide Nonantibiotics
Open accessAbstract
BACKGROUND: The safety of sulfonamide nonantibiotics is unclear in patients with prior allergic reactions to sulfonamide antibiotics. METHODS: We conducted a retrospective cohort study using the General Practice Research Database in the United Kingdom, examining the risk of allergic reactions within 30 days after the receipt of a sulfonamide nonantibiotic. Patients with evidence of prior hypersensitivity after the receipt of a sulfonamide antibiotic were compared with those without such evidence. Similar analyses were also performed with the use of penicillins instead of sulfonamides, to determine whether any risk was specific to sulfonamide cross-reactivity. RESULTS: Of 969 patients with an allergic reaction after a sulfonamide antibiotic, 96 (9.9 percent) had an allergic reaction after subsequently receiving a sulfonamide nonantibiotic. Of 19,257 who had no allergic reaction after a sulfonamide antibiotic, 315 (1.6 percent) had an allergic reaction after receiving a sulfonamide nonantibiotic (adjusted odds ratio, 2.8; 95 percent confidence interval, 2.1 to 3.7). However, the risk of allergic reactions was even greater after the receipt of a penicillin among patients with a prior hypersensitivity reaction to a sulfonamide antibiotic, as compared with patients with no such history (adjusted odds ratio, 3.9; 95 percent confidence interval, 3.5 to 4.3). Furthermore, among those with a prior hypersensitivity reaction after the receipt of a sulfonamide antibiotic, the risk of an allergic reaction after the subsequent receipt of a sulfonamide nonantibiotic was lower than the risk of an allergic reaction after the subsequent receipt of a penicillin (adjusted odds ratio, 0.7; 95 percent confidence interval, 0.5 to 0.9). Finally, the risk of an allergic reaction after the receipt of a sulfonamide nonantibiotic was lower among patients with a history of hypersensitivity to sulfonamide antibiotics than among patients with a history of hypersensitivity to penicillins (adjusted odds ratio, 0.6; 95 percent confidence interval, 0.5 to 0.8). CONCLUSIONS: There is an association between hypersensitivity after the receipt of sulfonamide antibiotics and a subsequent allergic reaction after the receipt of a sulfonamide nonantibiotic, but this association appears to be due to a predisposition to allergic reactions rather than to cross-reactivity with sulfonamide-based drugs.
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“Most of our allergy alerts were triggered by narcotic allergies, or by cross-reactions of unknown significance [29,30].”
From Drug interaction alert override rates in the Meaningful Use era: No evidence of progress (2014) · cites this paper as [30]
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Cites
(1990) · Choice Reviews Online · doi:10.5860/choice.27-3338 · Cited by 35,305
Simulation Study of Confounder-Selection Strategies
Maldonado, G., & Greenland, S. (1993) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a116813 · Cited by 2,491
Modeling and variable selection in epidemiologic analysis
Greenland, S. (1989) · American Journal of Public Health · doi:10.2105/ajph.79.3.340 · Cited by 2,208
Best Subsets Logistic Regression
Hosmer, D. W., Jovanovic, B. D., & Lemeshow, S. A. (1989) · Biometrics · doi:10.2307/2531779 · Cited by 1,175
Jick, H., Jick, S. S., & Derby, L. E. (1991) · BMJ · doi:10.1136/bmj.302.6779.766 · Cited by 839
Bigby, M. E. (1986) · JAMA · doi:10.1001/jama.256.24.3358 · Cited by 464
Venous leg ulcer: Incidence and prevalence in the elderly
Margolisa, B. D. J., Bilkerb, C. W., Santannab, C. J., & Baumgartenc, D. M. (2002) · Journal of the American Academy of Dermatology · doi:10.1067/mjd.2002.121739 · Cited by 461
Mauri-Hellweg, D., Bettens, F., Mauri, D., Brander, C., Hunziker, T., & Pichler, W. J. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.1.462 · Cited by 349
Studies on the Epidemiology of Adverse Drug Reactions
Smith, J. W., Johnson, J. E., & Cluff, L. E. (1966) · New England Journal of Medicine · doi:10.1056/nejm196605052741804 · Cited by 317
Jick, H., Terris, B. Z., Derby, L. E., & Jick, S. S. (1992) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.2630010607 · Cited by 265
Flagged first, then by citations
Research works printed but not linked: 8
- Greenberger PA. Drug allergy. B. Allergic reactions to individual drugs: low molecular weight. In: Grammer LC, Greenberger PA, eds. Patterson's allergic diseases. 6th ed. Philadelphia: Lippincott Williams & Wilkins, 2002:335-59.
- Cribb AE, 1996, Adverse Drug React Toxicol Rev, 15, 9
- Hoigne R, 1993, Monogr Allergy, 31, 147
- Enright T, 1989, Ann Allergy, 62, 302
- Hosoya T, 2000, Radiat Med, 18, 39
- Park J, 2000, Can J Clin Pharmacol, 7, 38
- Landor M, 1993, Ann Allergy, 70, 196
- Bretza JA, 1982, Wis Med J, 81, 21
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Metadata
- Authors
- Strom, B. L., Schinnar, R., Apter, A. J., Margolis, D. J., Lautenbach, E., Hennessy, S., Bilker, W. B., & Pettitt, D.
- Affiliations
- University of Pennsylvania (US)
- Pfizer (United States) (US)
- ORCID
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2003-10-23
- Volume
- 349
- Issue
- 17
- Pages
- 1628-1635
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2099552063
- Cited by
- 349
- References
- 34
- Citations by year
- 2026: 14 · 2025: 11 · 2024: 15 · 2023: 8 · 2022: 13 · 2021: 8 · 2020: 13 · 2019: 18 · 2018: 17 · 2017: 18 · 2016: 12 · 2015: 12 · 2014: 12 · 2013: 23 · 2012: 14
- FWCI
- 12.30
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Drug-Induced Adverse Reactions
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Keywords
- sulfonamide antibiotics, drug cross-reactivity, drug hypersensitivity, allergic reactions, penicillin allergy, general practice patients, drug allergy testing
- MeSH terms
- Anti-Bacterial Agents, Cross Reactions, Diuretics, Drug Hypersensitivity, Humans, Retrospective Studies, Sulfonamides, Cohort Studies, Databases, Factual
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