The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Radiofrequency ablation in children with asymptomatic Wolff-Parkinson-White syndrome
Open accessAbstract
BACKGROUND: Ventricular fibrillation can be the presenting arrhythmia in children with asymptomatic Wolff-Parkinson-White syndrome. Deaths due to this arrhythmia are potentially preventable. METHODS: We performed a randomized study in which prophylactic radiofrequency catheter ablation of accessory pathways was compared with no ablation in asymptomatic children (age range, 5 to 12 years) with the Wolff-Parkinson-White syndrome who were at high risk for arrhythmias. The primary end point was the occurrence of arrhythmic events during follow-up. RESULTS: Of the 165 eligible children, 60 were determined to be at high risk for arrhythmias. After randomization, but before any ablation had been performed, the parents withdrew 13 children from the study. Of the remaining children, 20 underwent prophylactic ablation and 27 had no treatment. The characteristics of the two groups were similar. There were three ablation-related complications, one of which led to hospitalization. During follow-up, 1 child in the ablation group (5 percent) and 12 in the control group (44 percent) had arrhythmic events. Two children in the control group had ventricular fibrillation, and one died suddenly. The cumulative rate of arrhythmic events was lower among children at high risk who underwent ablation than among those at high risk who did not. The reduction in risk associated with ablation remained significant after adjustment in a Cox regression analysis. In both the ablation and the control groups, the independent predictors of arrhythmic events were the absence of prophylactic ablation and the presence of multiple accessory pathways. CONCLUSIONS: In asymptomatic, high-risk children with the Wolff-Parkinson-White syndrome, prophylactic catheter ablation performed by an experienced operator reduces the risk of life-threatening arrhythmias.
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“The cumulative rate of arrhythmic events was lower among children at high risk who underwent ablation than among those at high risk who did not.The reduction in risk associated with ablation remained significant after adjustment in a Cox regression analysis.”
From European Heart Rhythm Association (EHRA) consensus document on the management of supraventricular arrhythmias, endorsed by Heart Rhythm Society (HRS), Asia-Pacific Heart Rhythm Society (APHRS), and Sociedad Latinoamericana de Estimulacion Cardiaca y Electrofisiologia (SOLAECE) (2017) · cites this paper as [345]
In the citing paper
“During follow-up, 1 child in the ablation group (5%), and 12 in the control group (44%) had arrhythmic events.Two children in the control group had ventricular fibrillation, and one died suddenly.”
From European Heart Rhythm Association (EHRA) consensus document on the management of supraventricular arrhythmias, endorsed by Heart Rhythm Society (HRS), Asia-Pacific Heart Rhythm Society (APHRS), and Sociedad Latinoamericana de Estimulacion Cardiaca y Electrofisiologia (SOLAECE) (2017) · cites this paper as [345]
In the citing paper
“The second randomized study was conducted on asymptomatic children (age range, 5 to 12 years) with WPW syndrome and in whom AVRT or AF were reproducibly inducible.After randomization of 60 children, but before any ablation had been performed, the parents withdrew 13 of them from the study.Of the remaining children, 20 underwent prophylactic ablation and 27 had no treatment.”
From European Heart Rhythm Association (EHRA) consensus document on the management of supraventricular arrhythmias, endorsed by Heart Rhythm Society (HRS), Asia-Pacific Heart Rhythm Society (APHRS), and Sociedad Latinoamericana de Estimulacion Cardiaca y Electrofisiologia (SOLAECE) (2017) · cites this paper as [345]
In the citing paper
“Respiratory arrest and femoral vein thrombosis were seen in two patients, while ablation-related complications were seen in three patients (RBBB, transient AV block and pericardial effusion).345”
From European Heart Rhythm Association (EHRA) consensus document on the management of supraventricular arrhythmias, endorsed by Heart Rhythm Society (HRS), Asia-Pacific Heart Rhythm Society (APHRS), and Sociedad Latinoamericana de Estimulacion Cardiaca y Electrofisiologia (SOLAECE) (2017) · cites this paper as [345]
In the citing paper
“In both ablation and control groups, the independent predictors of arrhythmic events were the absence of prophylactic ablation and the presence of multiple accessory pathways.”
From European Heart Rhythm Association (EHRA) consensus document on the management of supraventricular arrhythmias, endorsed by Heart Rhythm Society (HRS), Asia-Pacific Heart Rhythm Society (APHRS), and Sociedad Latinoamericana de Estimulacion Cardiaca y Electrofisiologia (SOLAECE) (2017) · cites this paper as [345]
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Citations
Cites
Blomstrom-Lundqvist (2003) · doi:10.1161/01.cir.0000091380.04100.84 · Cited by 955
Ventricular fibrillation in the Wolff-Parkinson-White syndrome
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Radiofrequency Catheter Ablation for Tachyarrhythmias in Children and Adolescents
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Benjamin, E. J., Blaha, M. J., Chiuve, S. E., Cushman, M., Das, S. R., Deo, R., de Ferranti, S. D., Floyd, J., Fornage, M., Gillespie, C., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000485 · Cited by 12,591
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Tsao, C. W., Aday, A. W., Almarzooq, Z. I., Anderson, C. A. M., Arora, P., Avery, C. L., Baker-Smith, C. M., Beaton, A. Z., Boehme, A. K., Buxton, A. E., et al. (2023) · Circulation · doi:10.1161/cir.0000000000001123 · Cited by 8,300
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Writing Group Members, Roger, V. L., Go, A. S., Lloyd-Jones, D. M., Benjamin, E. J., Berry, J. D., Borden, W. B., Bravata, D. M., Dai, S., Ford, E. S., et al. (2012) · Circulation · doi:10.1161/cir.0b013e31823ac046 · Cited by 7,333
Metadata
- Authors
- Pappone, C., Manguso, F., Santinelli, R., Vicedomini, G., Sala, S., Paglino, G., Mazzone, P., Lang, C. C., Gulletta, S., Augello, G., Santinelli, O., & Santinelli, V.
- Affiliations
- IRCCS Ospedale San Raffaele (IT)
- ORCID
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2004-09-16
- Volume
- 351
- Issue
- 12
- Pages
- 1197-1205
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2082183477
- Cited by
- 214
- References
- 24
- Citations by year
- 2026: 6 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 7 · 2019: 9 · 2018: 9 · 2017: 6 · 2016: 5 · 2015: 20 · 2014: 8 · 2013: 12 · 2012: 18
- FWCI
- 9.15
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- INFM-OAR (INFN Catania) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Keywords
- Wolff-Parkinson-White syndrome, accessory pathway, ventricular fibrillation, sudden cardiac death, arrhythmic events, children, multiple accessory pathways, arrhythmia risk
- MeSH terms
- Arrhythmias, Cardiac, Child, Child, Preschool, Female, Follow-Up Studies, Heart Conduction System, Humans, Male, Postoperative Complications, Risk Factors, Ventricular Fibrillation, Wolff-Parkinson-White Syndrome, Proportional Hazards Models, Death, Sudden, Cardiac, Catheter Ablation, Disease-Free Survival, Electrophysiologic Techniques, Cardiac
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