Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non–Small-Cell Lung Cancer to Gefitinib

Lynch, Thomas J., Bell, Daphne W., Sordella, Raffaella, Gurubhagavatula, Sarada, Okimoto, Ross A., Brannigan, Brian W., Harris, Patricia L., Haserlat, Sara M. +6 more·2004·New England Journal of Medicine

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    Wang, Wei, Li, Qi, Yamada, Tadaaki, Matsumoto, Kunio, Matsumoto, Isao, Oda, Makoto, Watanabe, Go, Kayano, Yoshiyuki, Nishioka, Yasuhiko, Sone, Saburo et al. · 2009 · Clinical Cancer Research
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  43. Survival signalling and apoptosis resistance in glioblastomas: opportunities for targeted therapeutics
    Camilla Krakstad, Martha Chekenya · 2010 · Molecular Cancer
  44. Biomarkers of Response to Epidermal Growth Factor Receptor Inhibitors in Non–Small-Cell Lung Cancer Working Group: Standardization for Use in the Clinical Trial Setting
    David A. Eberhard, Giuseppe Giaccone, Bruce Evan Johnson · 2008 · Journal of Clinical Oncology
  45. Translating insights from the cancer genome into clinical practice
    Lynda Chin, Joe W. Gray · 2008 · Nature
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  49. EGFR protein overexpression and gene amplification in squamous cell carcinomas of the esophagus
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  73. Acquired resistance to tyrosine kinase inhibitors during cancer therapy
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  86. Basket Trials and the Evolution of Clinical Trial Design in an Era of Genomic Medicine
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  87. An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance.
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  89. Antibody‐dependent cellular cytotoxicity of cetuximab against tumor cells with wild‐type or mutant epidermal growth factor receptor
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  94. Predictive value of EGFR and HER2 overexpression in advanced non-small-cell lung cancer
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  95. Broad, Hybrid Capture–Based Next-Generation Sequencing Identifies Actionable Genomic Alterations in Lung Adenocarcinomas Otherwise Negative for Such Alterations by Other Genomic Testing Approaches
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  96. Multicenter Phase II trial of high‐dose imatinib mesylate in metastatic melanoma
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