Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non–Small-Cell Lung Cancer to Gefitinib
Lynch, Thomas J., Bell, Daphne W., Sordella, Raffaella, Gurubhagavatula, Sarada, Okimoto, Ross A., Brannigan, Brian W., Harris, Patricia L., Haserlat, Sara M. +6 more·2004·New England Journal of Medicine
Cited by (1,079)
Items 601–700 of 1,079
- An Alternative Inhibitor Overcomes Resistance Caused by a Mutation of the Epidermal Growth Factor ReceptorKobayashi, Susumu, Ji, Hongbin, Yuza, Yuki, Meyerson, Matthew, Wong, Kwok-Kin, Tenen, Daniel G., Halmos, Balázs · 2005 · Cancer Research
- PIK3CA mutation status in Japanese lung cancer patientsOsamu Kawano, Hidefumi Sasaki, Katsuhiko Endo, Eriko Suzuki, Hiroshi Haneda, Haruhiro Yukiue, Yoshihiro Kobayashi, Motoki Yano, Yoshitaka Fujii · 2006 · Lung Cancer
- Epidermal Growth Factor Receptor Mutations in Plasma DNA Samples Predict Tumor Response in Chinese Patients With Stages IIIB to IV Non–Small-Cell Lung CancerHua Bai, Li Mao, hang Shu Wang, Jun Zhao, Lu Yang, T. An, Xin Wang, chun Jian Duan, na Mei Wu, zhi Qing Guo et al. · 2009 · Journal of Clinical Oncology
- BRAF targeted therapy changes the treatment paradigm in melanomaAntoni Ribas, Keith T. Flaherty · 2011 · Nature Reviews Clinical Oncology
- Clinical activity of afatinib (BIBW 2992) in patients with lung adenocarcinoma with mutations in the kinase domain of HER2/neuJacques De Grève, Erik Teugels, Caroline Geers, Lore Decoster, D. Galdermans, Johan De Mey, Hendrik Everaert, Ijeoma Adaku Umelo, Pieter In 'T Veld, Denis C. C. Schallier · 2012 · Lung Cancer
- Receptor Tyrosine Kinase-Targeted Cancer TherapyYamaoka, Toshimitsu, Kusumoto, Sojiro, Ando, Koichi, Ohba, Motoi, Ohmori, Tohru · 2018 · International Journal of Molecular Sciences
- Large noncoding RNA HOTAIR enhances aggressive biological behavior and is associated with short disease-free survival in human non-small cell lung cancerTakayuki Nakagawa, Hiroyuki Endo, Misa Yokoyama, Jiro Abe, Keiichi Tamai, Nobuyuki Tanaka, Ikuro Sato, Satomi Takahashi, Takashi Kondo, Kennichi Satoh · 2013 · Biochemical and Biophysical Research Communications
- Plasticity of tumour and immune cells: a source of heterogeneity and a cause for therapy resistance?Michael Hölzel, Anton Bovier, Thomas Tüting · 2013 · Nature reviews. Cancer
- Epithelial to mesenchymal transition predicts gefitinib resistance in cell lines of head and neck squamous cell carcinoma and non–small cell lung carcinomaBarbara A. Frederick, Barbara A. Helfrich, Christopher D. Coldren, Di Zheng, Dan Chan, Paul A. Bunn, David Raben · 2007 · Molecular Cancer Therapeutics
- Erlotinib Versus Gemcitabine Plus Cisplatin as Neoadjuvant Treatment of Stage IIIA-N2 EGFR -Mutant Non–Small-Cell Lung Cancer (EMERGING-CTONG 1103): A Randomized Phase II StudyWen‐Zhao Zhong, Ke‐Neng Chen, Chun Chen, Chundong Gu, Jun Wang, Xue‐Ning Yang, Weimin Mao, Qun Wang, Guibin Qiao, Ying Cheng et al. · 2019 · Journal of Clinical Oncology
- Targeting HER proteins in cancer therapy and the role of the non-target HER3Andrew Caleb Hsieh, Mark M. Moasser · 2007 · British Journal of Cancer
- Acquired Resistance to EGFR Inhibitors Is Associated with a Manifestation of Stem Cell–like Properties in Cancer CellsKazuhiko Shien, Shinichi Toyooka, Hiromasa Yamamoto, Junichi Soh, Masaru Jida, Kelsie L. Thu, Shinsuke Hashida, Yuho Maki, Eiki Ichihara, Hiroaki Asano et al. · 2013 · Cancer Research
- CT Radiogenomic Characterization of EGFR, K-RAS, and ALK Mutations in Non-Small Cell Lung CancerStefania Rizzo, Francesco Petrella, Valentina Buscarino, Federica De Maria, Sara Raimondi, Massimo C.P. Barberis, Caterina Fumagalli, Gianluca Spitaleri, Cristiano Rampinelli, Filippo de Marinis et al. · 2015 · European Radiology
- EGFR Tyrosine Kinase Inhibitors Decrease VEGF Expression by Both Hypoxia-Inducible Factor (HIF)-1–Independent and HIF-1–Dependent MechanismsNabendu Pore, Zibin Jiang, Anjali Gupta, George J. Cerniglia, Gary D. Kao, Amit M. Maity · 2006 · Cancer Research
- Combination of EGFR gene copy number and protein expression predicts outcome for advanced non-small-cell lung cancer patients treated with gefitinibFred R. Hirsch, Marileila Varella‐Garcia, Federico Cappuzzo, J. McCoy, Lynne Bemis, Ana C. Xavier, Rafał Dziadziuszko, Paul H. Gumerlock, Kari Chansky, Howard West et al. · 2007 · Annals of Oncology
- Pharmacogenetics and drug development: the path to safer and more effective drugsAllen D. Roses · 2004 · Nature Reviews Genetics
- EGFR Tyrosine Kinase Domain Mutations Are Detected in Histologically Normal Respiratory Epithelium in Lung Cancer PatientsXiming Tang, Hisayuki Shigematsu, Benjamin Nebiyou Bekele, Jack A. Roth, John Dorrance Minna, Waun Ki Hong, Adi F. Gazdar, Ignacio Ivan Wistuba · 2005 · Cancer Research
- New Paradigms in Anticancer Therapy: Targeting Multiple Signaling Pathways With Kinase InhibitorsSandrine J. Faivre, Siham Djelloul, Éric Raymond · 2006 · Seminars in Oncology
- Impact of Age, Sex, and Comorbidity on Cancer Therapy and Disease ProgressionSumanta Kumar Pal, Arti Hurria · 2010 · Journal of Clinical Oncology
- Analysis of Potential Predictive Markers of Cetuximab Benefit in BMS099, a Phase III Study of Cetuximab and First-Line Taxane/Carboplatin in Advanced Non–Small-Cell Lung CancerShirin Khambata‐Ford, Christopher T. Harbison, Lowell L. Hart, M. Awad, Lian Xu, Christine E. Horak, Shaker R. Dakhil, Robert C. Hermann, Thomas James Lynch, Martin R. Weber · 2010 · Journal of Clinical Oncology
- EGFR mutation status and survival after diagnosis of brain metastasis in nonsmall cell lung cancerApril F. Eichler, Kristopher Thomas Kahle, D. L. Wang, Victoria A. Joshi, Henning Willers, J. A. Engelman, Thomas James Lynch, Lecia Van Dam Sequist · 2010 · Neuro-Oncology
- Differential Crizotinib Response Duration Among ALK Fusion Variants in ALK -Positive Non–Small-Cell Lung CancerTatsuya Yoshida, Yuko Oya, Kosuke Tanaka, Junichi Shimizu, Yoshitsugu Horio, Hiroaki Kuroda, Yukinori Sakao, Toyoaki Hida, Yasushi Yatabe · 2016 · Journal of Clinical Oncology
- Bypass Mechanisms of Resistance to Receptor Tyrosine Kinase Inhibition in Lung CancerMatthew J. Niederst, Jeffrey A. Engelman · 2013 · Science Signaling
- EGFR/KRAS/BRAF Mutations in Primary Lung Adenocarcinomas and Corresponding Locoregional Lymph Node MetastasesKatharina Schmid, Natalie Oehl, Fritz Wrba, Robert Pirker, Christine Pirker, Martin Filipits · 2009 · Clinical Cancer Research
- The complexity of targeting EGFR signalling in cancer: From expression to turnoverSinto Sebastian, Jeffrey E. Settleman, Stephan J. Reshkin, Amalia Azzariti, Antonia Bellizzi, Angelo Paradiso · 2006 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
- Response and resistance in a non-small-cell lung cancer patient with an epidermal growth factor receptor mutation and leptomeningeal metastases treated with high-dose gefitinibJackman, David M., Holmes, Alison J., Lindeman, Neal, Wen, Patrick Y., Kesari, Santosh, Borras, Ana M., Bailey, Christopher, de Jong, Francisca, Jänne, Pasi A., Johnson, Bruce E. · 2006 · Journal of Clinical Oncology
- MicroRNA regulation of core apoptosis pathways in cancerRaquel T. Lima, Sara Busacca, Gabriela M. Almeida, Giovanni Gaudino, Dean Anthony Fennell, M. Helena Vasconcelos · 2010 · European Journal of Cancer
- Gefitinib in Patients with Malignant Mesothelioma: A Phase II Study by the Cancer and Leukemia Group BRamaswamy Govindan, Robert Arthur Kratzke, James E. Herndon, Gloria A. Niehans, Robin T. Vollmer, Dorothy M. Watson, Mark R. Green, Hedy Lee Kindler, on behalf of the Cancer and Leukemia Group B (CALGB 30101) · 2005 · Clinical Cancer Research
- Genomic analysis of single cytokeratin-positive cells from bone marrow reveals early mutational events in breast cancerJulian Schardt, Manfred Meyer, Claudia H. Hartmann, Falk Schubert, Oleg Schmidt‐Kittler, Christine Fuhrmann, Bernhard Michael Polzer, Marco Petronio, Roland Eils, Christoph A. Klein · 2005 · Cancer Cell
- Signaling via ErbB2 and ErbB3 Associates with Resistance and Epidermal Growth Factor Receptor (EGFR) Amplification with Sensitivity to EGFR Inhibitor Gefitinib in Head and Neck Squamous Cell Carcinoma CellsKaisa Erjala, Maria Sundvall, Teemu T. Junttila, Na Zhang, Mika Savisalo, Pekka Mali, Jarmo A.J. Kulmala, Jaakko O. Pulkkinen, Reidar A. Grenman, Klaus Elenius · 2006 · Clinical Cancer Research
- Epidermal Growth Factor Receptors Harboring Kinase Domain Mutations Associate with the Heat Shock Protein 90 Chaperone and Are Destabilized following Exposure to GeldanamycinsTakeshi Shimamura, April M. Lowell, Jeffrey A. Engelman, Geoffrey Ira Shapiro · 2005 · Cancer Research
- Phase II Study of Gefitinib in Patients with Relapsed or Persistent Ovarian or Primary Peritoneal Carcinoma and Evaluation of Epidermal Growth Factor Receptor Mutations and Immunohistochemical Expression: A Gynecologic Oncology Group StudyRussell J. Schilder, Michael W. Sill, Xiaowei Chen, Kathleen M. Darcy, Steven L. Decesare, George S. Lewandowski, Roger B. Lee, Cletus A. Arciero, Hong Wu, Andrew K. Godwin · 2005 · Clinical Cancer Research
- Epidermal growth factor receptor variant III mutations in lung tumorigenesis and sensitivity to tyrosine kinase inhibitorsHongbin Ji, Xiaojun Zhao, Yuki Yuza, Takeshi Shimamura, Danan Li, Alexei I. Protopopov, Boonim L. Jung, Kate L. McNamara, Huili Xia, Karen A. Glatt et al. · 2006 · Proceedings of the National Academy of Sciences
- Predicting drug susceptibility of non–small cell lung cancers based on genetic lesionsMartin L. Sos, Kathrin Michel, Thomas Zander, Jonathan M. Weiss, Peter Frommolt, Martin Peifer, Danan Li, Roland Tillmann Ullrich, Mirjam Koker, Florian Fischer et al. · 2009 · Journal of Clinical Investigation
- Protein kinase inhibitors: contributions from structure to clinical compoundsLouise Napier Johnson · 2009 · Quarterly Reviews of Biophysics
- MicroRNA-126 inhibits invasion in non-small cell lung carcinoma cell linesMelissa Crawford, Emily J. Brawner, Kara Batte, Lianbo Yu, Melissa G Hunter, Gregory A. Otterson, Gerard James Nuovo, Clay B. Marsh, Serge Patrick Nana-Sinkam · 2008 · Biochemical and Biophysical Research Communications
- Intratumor heterogeneity of epidermal growth factor receptor mutations in lung cancer and its correlation to the response to gefitinibKazuya Taniguchi, Jiro Okami, Ken Kodama, Masahiko Higashiyama, Kikuya Kato · 2008 · Cancer Science
- Oncogene addiction: pathways of therapeutic response, resistance, and road maps toward a cureRaymond A. Pagliarini, Wenlin Shao, William R. Sellers · 2015 · EMBO Reports
- NCCN Task Force Report: Evaluating the Clinical Utility of Tumor Markers in OncologyPhillip G. Febbo, Marc Ladanyi, Kenneth Aldape, Angelo Michael De Marzo, M. Elizabeth H. Hammond, Daniel F. Hayes, Anthony John Iafrate, Robin Kate Kelley, Guido Marcucci, Shuji Ogino et al. · 2011 · Journal of the National Comprehensive Cancer Network
- Genetic Predictors of MEK Dependence in Non–Small Cell Lung CancerChristine A. Pratilas, Aphrothiti J. Hanrahan, Ensar Halilovic, Yogindra Persaud, Junichi Soh, Dhananjay Arun Chitale, Hisayuki Shigematsu, Hiromasa Yamamoto, Ayana Sawai, Manickam Janakiraman et al. · 2008 · Cancer Research
- Mechanism of Resistance to Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors and a Potential Treatment StrategyTatsuya Nagano, Motoko Yoshikawa TACHIHARA, Yoshihiro Nishimura · 2018 · Cells
- Genomic Medicine–Progress, Pitfalls, and PromiseJay Shendure, Gregory M. Findlay, Matthew W. Snyder · 2019 · Cell
- Prognostic Implication of EGFR, KRAS, and TP53 Gene Mutations in a Large Cohort of Japanese Patients with Surgically Treated Lung AdenocarcinomaTakayuki Kosaka, Yasushi Yatabe, Ryoichi Onozato, Hiroyuki Kuwano, Tetsuya Mitsudomi · 2009 · Journal of Thoracic Oncology
- Optimization of Patient Selection for Gefitinib in Non–Small Cell Lung Cancer by Combined Analysis of Epidermal Growth Factor Receptor Mutation, K-ras Mutation, and Akt PhosphorylationSae‐Won Han, Tae‐You Kim, Yoon Kyung Jeon, Pil Gyu Hwang, Seock‐Ah Im, Kyung-Hun Lee, Jee Hyun Kim, Dong‐Wan Kim, Dae Seog Heo, Noe Kyeong Kim et al. · 2006 · Clinical Cancer Research
- Synergistic down-regulation of receptor tyrosine kinases by combinations of mAbs: Implications for cancer immunotherapyLilach M. Friedman, Ariel Rinon, Bilha Schechter, Ljuba Lyass, Sara Lavi, Sarah S. Bacus, Michael Sela, Yosef Yarden · 2005 · Proceedings of the National Academy of Sciences
- Targeting TACE-dependent EGFR ligand shedding in breast cancerParaic A. Kenny, Mina J. Bissell · 2007 · Journal of Clinical Investigation
- Molecular Study of Malignant Gliomas Treated with Epidermal Growth Factor Receptor Inhibitors: Tissue Analysis from North American Brain Tumor Consortium Trials 01-03 and 00-01Andrew B. Lassman, Michael R. Rossi, Jeffrey R. Razier, Lauren E. Abrey, Frank Scott Lieberman, Chelsea N. Grefe, Kathleen R. Lamborn, William J. Pao, Alan H. Shih, John G. Kuhn et al. · 2005 · Clinical Cancer Research
- Targeted therapy in cancerApostolia Maria Tsimberidou · 2015 · Cancer Chemotherapy and Pharmacology
- Prognostic Significance of Adenocarcinoma In Situ, Minimally Invasive Adenocarcinoma, and Nonmucinous Lepidic Predominant Invasive Adenocarcinoma of the Lung in Patients With Stage I DiseaseKyuichi Kadota, Jonathan Villena‐Vargas, Akihiko Yoshizawa, Noriko Motoi, Camelia S. Sima, Gregory J. Riely, Valerie W. Rusch, Prasad S. Adusumilli, William David Travis · 2014 · The American Journal of Surgical Pathology
- A mechanism of resistance to gefitinib mediated by cellular reprogramming and the acquisition of an FGF2-FGFR1 autocrine growth loopK E Ware, Trista K. Hinz, Emily K. Kleczko, Katherine R. Singleton, Lindsay A. Marek, Barb Helfrich, Christopher T. Cummings, Douglas K. Graham, David P. Astling, Aik Choon Tan et al. · 2013 · Oncogenesis
- Implication of the Insulin-like Growth Factor-IR Pathway in the Resistance of Non–small Cell Lung Cancer Cells to Treatment with GefitinibFloriana Morgillo, Woo-Young Kim, Edward S. Kim, Fortunato Ciardiello, Waun Ki Hong, Ho‐Young Lee · 2007 · Clinical Cancer Research
- Stratified phase II trial of cetuximab in patients with recurrent high-grade gliomaBart Neyns, Jan Sadones, Eric J. Joosens, Frank Bouttens, Luc Verbeke, Jean‐François Baurain, Lionel A. D'Hondt, Theo Strauven, C. Chaskis, Pieter In 'T Veld et al. · 2009 · Annals of Oncology
- Clinical cancer immunotherapy: Current progress and prospectsChenglong Liu, Mengxuan Yang, Daizhou Zhang, Ming Chen, Di Zhu · 2022 · Frontiers in Immunology
- Tyrosine kinase inhibitors: Multi-targeted or single-targeted?Fleur Broekman · 2010 · World Journal of Clinical Oncology
- Personalizing Cancer Treatment in the Age of Global Genomic Analyses: PALB2 Gene Mutations and the Response to DNA Damaging Agents in Pancreatic CancerMaria C. Villarroel, N.V. Rajeshkumar, Ignacio Garrido‐Laguna, Ana De Jesus‐Acosta, Siân Jones, Anirban Maitra, Ralph H. Hruban, James R. Eshleman, Alison P. Klein, Daniel A. Laheru et al. · 2010 · Molecular Cancer Therapeutics
- Rapid Polymerase Chain Reaction-Based Detection of Epidermal Growth Factor Receptor Gene Mutations in Lung AdenocarcinomasQiulu Pan, William J. Pao, Marc Ladanyi · 2005 · Journal of Molecular Diagnostics
- Molecular Biology of Lung CancerSerge Patrick Nana-Sinkam, Charles A. Powell · 2013 · CHEST Journal
- Raf kinase as a target for anticancer therapeuticsSrikala S. Sridhar, David William Hedley, Lillian L. Siu · 2005 · Molecular Cancer Therapeutics
- Molecular pathology of lung cancer: key to personalized medicineLiang Cheng C, Riley E. Alexander, Gregory T. MacLennan, Oscar W. Cummings, Rodolfo Montironi, Antonio Lopez-beltran B, Harvey M. Cramer, Darrell D. Davidson, Shaobo Zhang · 2012 · Modern Pathology
- Targeting Akt in cancer for precision therapyHui Ming Hua, Hongying Zhang, Jingzhu Chen, Jiao Wang, Jieya Liu, Yangfu Jiang · 2021 · Journal of Hematology & Oncology
- Novel Third-Generation EGFR Tyrosine Kinase Inhibitors and Strategies to Overcome Therapeutic Resistance in Lung CancerMurtuza, Ayesha, Bulbul, Ajaz, Shen, John Paul, Keshavarzian, Parissa, Woodward, Brian D., Lopez-Diaz, Fernando J., Lippman, Scott M., Husain, Hatim · 2019 · Cancer Research
- Ba/F3 cells and their use in kinase drug discoveryWarmuth, Markus, Kim, Sungjoon, Gu, Xiang-ju, Xia, Gang, Adrián, Francisco · 2007 · Current Opinion in Oncology
- Relative Abundance of EGFR Mutations Predicts Benefit From Gefitinib Treatment for Advanced Non–Small-Cell Lung CancerQing Hua Zhou, Xu‐Chao Zhang, Zhihong Chen, Xiaolu Yin, Jin‐Ji Yang, Chong‐Rui Xu, Hong‐Hong Yan, Hua‐Jun Chen, Jian Su, Wen‐Zhao Zhong et al. · 2011 · Journal of Clinical Oncology
- Molecular Biology of Lung Cancer: Clinical ImplicationsJill E. Larsen, John Dorrance Minna · 2011 · Clinics in Chest Medicine
- ALK inhibitors in non-small cell lung cancer: crizotinib and beyond.Mark Magdi Awad, Alice Tsang Shaw · 2014 · PubMed
- A humanized anti-IL-6 antibody (ALD518) in non-small cell lung cancerTrevor J. Bayliss, J. T. Smith, M. Schuster, K. Dragnev, J. Rigas · 2011 · Expert Opinion on Biological Therapy
- Coexistence of EGFR with KRAS, or BRAF, or PIK3CA somatic mutations in lung cancer: a comprehensive mutation profiling from 5125 Chinese cohortsSheng Li, L Li, Yifang Zhu, Cheng Huang, Yan Qin, H Liu, Lifen Ren‐Heidenreich, Bin Shi, Hui Jun Ren, Xiaopeng Chu et al. · 2014 · British Journal of Cancer
- Lack of clinical efficacy of imatinib in metastatic melanomaSelma Ugurel, Ralf Hildenbrand, A Zimpfer, Paul Graf La Rosée, Peter Paschka, Antje Sucker, Petra Keikavoussi, Jürgen Christian Becker, Werner Rittgen, Andreas Hochhaus et al. · 2005 · British Journal of Cancer
- Combination therapy of inhibitors of epidermal growth factor receptor/vascular endothelial growth factor receptor 2 (AEE788) and the mammalian target of rapamycin (RAD001) offers improved glioblastoma tumor growth inhibitionRanjit K. Goudar, Qing Shi, Mark D. Hjelmeland, Stephen Thomas Keir, Roger E. McLendon, Carol J. Wikstrand, Elizabeth Danielle Reese, Charles A. Conrad, Peter M. Traxler, Heidi A. Lane et al. · 2005 · Molecular Cancer Therapeutics
- Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Treatment Response in Advanced Lung Adenocarcinomas with G719X/L861Q/S768I MutationsChiu, Chao-Hua, Yang, Cheng-Ta, Shih, Jin-Yuan, Huang, Ming-Shyan, Su, Wu-Chou, Lai, Ruay-Sheng, Wang, Chin-Chou, Hsiao, Shih-Hsin, Lin, Yu-Ching, Ho, Ching-Liang et al. · 2015 · Journal of Thoracic Oncology
- Chemotherapeutic agents and the skin: An updateNoushin Heidary, Haley Bharat Naik, Susan Burgin · 2008 · Journal of the American Academy of Dermatology
- Cellular Targets of GefitinibDirk Brehmer, Zoltán Greff, Klaus Godl, Stephanie Blencke, Alexander Kurtenbach, Martina Weber, Stefan Müller, Bert Klebl, Matthew L. Cotten, Gÿorgý Kéri et al. · 2005 · Cancer Research
- Signal Transducer and Activator of Transcription 3 Is Required for the Oncogenic Effects of Non–Small-Cell Lung Cancer–Associated Mutations of the Epidermal Growth Factor ReceptorJames V. Alvarez, Heidi E. Greulich, William R. Sellers, Matthew M. Meyerson, David A. Frank · 2006 · Cancer Research
- The Pharmacogenetics Research Network: From SNP Discovery to Clinical Drug ResponseKathleen M. Giacomini, Christopher M. A. Brett, Russ Biagio Altman, Neal L. Benowitz, M. Eileen Dolan, David Alastair Flockhart, Julie A. Johnson, Daniel F. Hayes, Teri E. Klein, Ronald M. Krauss et al. · 2007 · Clinical Pharmacology & Therapeutics
- Progress on pivotal role and application of exosome in lung cancer carcinogenesis, diagnosis, therapy and prognosisMingyue Li, Lizhong Liu, Ming Dong · 2021 · Molecular Cancer
- The ERBB3 receptor in cancer and cancer gene therapyGunamani Sithanandam, Lucy M. Anderson · 2008 · Cancer Gene Therapy
- Landscape of EGFR signaling network in human cancers: Biology and therapeutic response in relation to receptor subcellular locationsWoody Han, Hui‐Wen Lo · 2012 · Cancer Letters
- Genomic Medicine: A Decade of Successes, Challenges, and OpportunitiesJeanette J. McCarthy, Howard L. McLeod, Geoffrey S. Ginsburg · 2013 · Science Translational Medicine
- Personalized Medicine in Non–Small-Cell Lung Cancer: Is KRAS a Useful Marker in Selecting Patients for Epidermal Growth Factor Receptor–Targeted Therapy?Patrick J. Roberts, Thomas E. Stinchcombe, Channing J. Der, Mark A. Socinski · 2010 · Journal of Clinical Oncology
- An Epidermal Growth Factor Receptor Intron 1 Polymorphism Mediates Response to Epidermal Growth Factor Receptor InhibitorsMaria Luz Amador, Darin Oppenheimer, Sofia Hidalgo Perea, Anirban Maitra, G. Cusati, Christi Iacobuzio-Donahue, Sharyn D. Baker, Raheela Ashfaq, Chris H.M. Takimoto, Arlene A. Forastiere et al. · 2004 · Cancer Research
- Association of<i>EGFR</i>L858R Mutation in Circulating Free DNA With Survival in the EURTAC TrialKarachaliou, Niki, Mayo-de las Casas, Clara, Queralt, Cristina, de Aguirre, Itziar, Melloni, Boris, Cardenal, Felipe, Garcia-Gomez, Ramon, Massuti, Bartomeu, Sánchez, José Miguel, Porta, Ruth et al. · 2015 · JAMA Oncology
- Intracellular Signal Transduction Pathway Proteins As Targets for Cancer TherapyAlex A. Adjei, Manuel M. Hidalgo · 2005 · Journal of Clinical Oncology
- EGFR signaling pathway in breast cancers: from traditional signal transduction to direct nuclear translocalizationHui‐Wen Lo, Sheng-Chieh Hsu, Mien‐Chie Hung · 2005 · Breast Cancer Research and Treatment
- A microfluidics platform for combinatorial drug screening on cancer biopsiesEduati, Federica, Utharala, Ramesh, Madhavan, Dharanija, Neumann, Ulf Peter, Longerich, Thomas, Cramer, Thorsten, Saez-Rodriguez, Julio, Merten, Christoph A. · 2018 · Nature Communications
- The mechanism of acquired resistance to irreversible EGFR tyrosine kinase inhibitor-afatinib in lung adenocarcinoma patientsWu, Shang-Gin, Liu, Yi-Nan, Tsai, Meng-Feng, Chang, Yih-Leong, Yu, Chong-Jen, Yang, Pan-Chyr, Yang, James Chih-Hsin, Wen, Yueh-Feng, Shih, Jin-Yuan · 2016 · Oncotarget
- EGFR Mutation Is Specific for Terminal Respiratory Unit Type AdenocarcinomaYasushi Yatabe, Takayuki Kosaka, Takashi Takahashi, Tetsuya Mitsudomi · 2005 · The American Journal of Surgical Pathology
- PTEN and PI3K/AKT in Non-Small-Cell Lung CancerCristina Pérez-Ramírez, Marisa Cañadas‐Garre, Miguel Ángel Molina‐Vila, María José Faus-Dáder, Miguel Ángel Calleja‐Hernández · 2015 · Pharmacogenomics
- Assessing PIK3CA and PTEN in Early-Phase Trials with PI3K/AKT/mTOR InhibitorsFilip Jankú, David S. Hong, Siqing Fu, Sarina Anne Piha-Paul, Aung Naing, Gerald Steven Falchook, Apostolia Maria Tsimberidou, Vanda M. T. Stepanek, Stacy Moulder, J. Jack Lee et al. · 2014 · Cell Reports
- Dynamic Risk Profiling Using Serial Tumor Biomarkers for Personalized Outcome PredictionDavid Matthew Kurtz, Mohammad Shahrokh Esfahani, Florian Scherer, Joanne Soo, Michael Chuwei Jin, Chih Long Liu, Aaron M. Newman, Ulrich Dührsen, Andreas Hüttmann, Olivier Casasnovas et al. · 2019 · Cell
- Epidermal growth factor receptor mutations in lung adenocarcinomaMarkus David Siegelin, Alain Borczuk · 2013 · Laboratory Investigation
- First-Line Erlotinib Followed by Second-Line Cisplatin-Gemcitabine Chemotherapy in Advanced Non–Small-Cell Lung Cancer: The TORCH Randomized TrialCesare Gridelli, Fortunato Ciardiello, Ciro Gallo, Ronald D. Feld, Charles Andrew Butts, Vittorio Gebbia, Paolo Maione, Floriana Morgillo, Giovenzio Genestreti, Adolfo Gino Favaretto et al. · 2012 · Journal of Clinical Oncology
- Specific EGFR Mutations Predict Treatment Outcome of Stage IIIB/IV Patients With Chemotherapy-Naive Non–Small-Cell Lung Cancer Receiving First-Line Gefitinib MonotherapyChih-Hsin Yang, Chong‐Jen Yu, Jin‐Yuan Shih, Yeun‐Chung Chang, Fu‐Chang Hu, Meng-Chi Tsai, Kuan‐Yu Chen, Zhong‐Zhe Lin, Ching-Ju Huang, Chia‐Tung Shun et al. · 2008 · Journal of Clinical Oncology
- Somatic Mutations of EGFR Gene in Squamous Cell Carcinoma of the Head and NeckJong Woo Lee, Young Hwa Soung, Su Young Kim, Hyo Kyung Nam, Won Sang Park, Suk Woo Nam, Min‐Sik Kim, Dong Il Sun, Youn Soo Lee, Ja June Jang et al. · 2005 · Clinical Cancer Research
- Overcoming ABC transporter-mediated multidrug resistance: The dual role of tyrosine kinase inhibitors as multitargeting agentsGiovanni Luca Beretta, Giuliana Cassinelli, Marzia Pennati, Valentina Zuco, Laura Gatti · 2017 · European Journal of Medicinal Chemistry
- Somatic EGFR mutations and efficacy of tyrosine kinase inhibitors in NSCLCHelena Linardou, Issa J Dahabreh, Dimitrios I. Bafaloukos, P. Kosmidis, Samuel J. Murray · 2009 · Nature Reviews Clinical Oncology
- A common signaling cascade may underlie “addiction” to the Src, BCR-ABL, and EGF receptor oncogenesSreenath V. Sharma, Patrycja Gajowniczek, Inna Way, Diana Wing Lee, Jane Jiang, Yuki Yuza, Marie Classon, Daniel A. Haber, Jeffrey E. Settleman · 2006 · Cancer Cell
- Rapamycin synergizes with the epidermal growth factor receptor inhibitor erlotinib in non–small-cell lung, pancreatic, colon, and breast tumorsElizabeth A. Buck, Alexandra Eyzaguirre, Eric Brown, Filippo Petti, Siobhan McCormack, John D. Haley, Kenneth K. Iwata, Neil W. Gibson, Graeme Griffin · 2006 · Molecular Cancer Therapeutics
- Mutation-Specific Antibodies for the Detection of EGFR Mutations in Non–Small-Cell Lung CancerJian Q. Yu, Susan E. Kane, Jiong Wu, Elisa Benedettini, Daiqiang Li, Cynthia Reeves, Gregory Innocenti, Randy Wetzel, Katherine Crosby, Alison Becker et al. · 2009 · Clinical Cancer Research
- LUNG CANCER PRENEOPLASIAIgnacio Ivan Wistuba, Adi F. Gazdar · 2006 · Annual Review of Pathology Mechanisms of Disease
- Recent therapeutic trends and promising targets in triple negative breast cancerSoo‐Yeon Hwang, Seojeong Park, Youngjoo Kwon · 2019 · Pharmacology & Therapeutics