Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non–Small-Cell Lung Cancer to Gefitinib
Lynch, Thomas J., Bell, Daphne W., Sordella, Raffaella, Gurubhagavatula, Sarada, Okimoto, Ross A., Brannigan, Brian W., Harris, Patricia L., Haserlat, Sara M. +6 more·2004·New England Journal of Medicine
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Items 101–200 of 1,079
- Strategies to improve radiotherapy with targeted drugsAdrian C. Begg, Fiona A. Stewart, Conchita Vens · 2011 · Nature reviews. Cancer
- Structural basis for inhibition of the epidermal growth factor receptor by cetuximabShiqing Li, Karl R. Schmitz, Philip D. Jeffrey, Jed J. W. Wiltzius, Paul H. Kussie, Kathryn M. Ferguson · 2005 · Cancer Cell
- Advances in understanding cancer genomes through second-generation sequencingMatthew M. Meyerson, Stacey Gabriel, Gad A. Getz · 2010 · Nature Reviews Genetics
- Characterizing the cancer genome in lung adenocarcinomaWeir, Barbara A., Woo, Michele S., Getz, Gad, Perner, Sven, Ding, Li, Beroukhim, Rameen, Lin, William M., Province, Michael A., Kraja, Aldi, Johnson, Laura A. et al. · 2007 · Nature
- Single-molecule and single-nanoparticle SERS: from fundamental mechanisms to biomedical applicationsX.-M. Qian, Shuming Nie · 2008 · Chemical Society Reviews
- Establishing the diagnosis of lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines.M. Rivera, A. Mehta, M. Wahidi · 2013 · Chest
- Circulating tumor cells: approaches to isolation and characterizationMin Yu, Shannon L. Stott, Mehmet Toner, Shyamala Maheswaran, Daniel A. Haber · 2011 · The Journal of Cell Biology
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- Rational, biologically based treatment of EGFR-mutant non-small-cell lung cancerPao, William, Chmielecki, Juliann · 2010 · Nature Reviews Cancer
- Kinase drug discovery 20 years after imatinib: progress and future directionsPhilip Cohen, Darren A.E. Cross, Pasi Antero Janne · 2021 · Nature Reviews Drug Discovery
- Determinants of Tumor Response and Survival With Erlotinib in Patients With Non—Small-Cell Lung CancerRoman Perez-Soler, Abraham Chachoua, Lisa A. Hammond, Eric Keith Rowinsky, Mark S. Huberman, Daniel D. Karp, James R. Rigas, Gary M. Clark, Pedro Santabarbara, Philip Bonomi · 2004 · Journal of Clinical Oncology
- Co-occurring genomic alterations in non-small-cell lung cancer biology and therapySkoulidis, Ferdinandos, Heymach, John V. · 2019 · Nature Reviews Cancer
- The quest to overcome resistance to EGFR-targeted therapies in cancerCurtis Robert Chong, Pasi Antero Janne · 2013 · Nature Medicine
- ERBB Receptors: From Oncogene Discovery to Basic Science to Mechanism-Based Cancer TherapeuticsArteaga, Carlos L., Engelman, Jeffrey A. · 2014 · Cancer Cell
- The Next-Generation Sequencing Revolution and Its Impact on GenomicsDaniel C. Koboldt, Karyn Meltz Steinberg, David E. Larson, Richard K. Wilson, Elaine R. Mardis · 2013 · Cell
- Whole-genome analysis informs breast cancer response to aromatase inhibitionMatthew J. Ellis, Li Ding, Dong Shen, Jingqin Rosy Luo, Vera Jean Suman, John W. Wallis, Brian Andrew Van Tine, Jeremy Hoog, Reece Goiffon, Theodore C. Goldstein et al. · 2012 · Nature
- Lung cancer: Biology and treatment optionsHassan Lemjabbar‐Alaoui, Omer Ul Hassan, Yiwei Yang, Petra C. Buchanan · 2015 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
- Role of Tyrosine Kinase Inhibitors in Cancer TherapyAmit Arora, Eric M. Scholar · 2005 · Journal of Pharmacology and Experimental Therapeutics
- Dissecting Therapeutic Resistance to RAF Inhibition in Melanoma by Tumor Genomic ProfilingNikhil Wagle, Caroline Emery, Michael F. Berger, Matthew J. Davis, Allison M. Sawyer, Panisa Pochanard, Sarah M. Kehoe, Cory M. Johannessen, Laura E. MacConaill, William C. Hahn et al. · 2011 · Journal of Clinical Oncology
- Clinical activity of afatinib in patients with advanced non-small-cell lung cancer harbouring uncommon EGFR mutations: a combined post-hoc analysis of LUX-Lung 2, LUX-Lung 3, and LUX-Lung 6Yang, James C-H, Sequist, Lecia V, Geater, Sarayut Lucien, Tsai, Chun-Ming, Mok, Tony Shu Kam, Schuler, Martin, Yamamoto, Nobuyuki, Yu, Chong-Jen, Ou, Sai-Hong I, Zhou, Caicun et al. · 2015 · The Lancet Oncology
- Activating and resistance mutations of EGFR in non-small-cell lung cancer: role in clinical response to EGFR tyrosine kinase inhibitorsGazdar, A F · 2009 · Oncogene
- Routine molecular profiling of patients with advanced non-small-cell lung cancer: results of a 1-year nationwide programme of the French Cooperative Thoracic Intergroup (IFCT)Fabrice Barlési, Julien Mazières, Jean‐Philippe Merlio, Didier Debieuvre, Jean Mosser, H. Léna, L’Houcine Ouafik, Benjamin Besse, Isabelle Rouquette, Virginie Westeel et al. · 2016 · The Lancet
- The ERBB network: at last, cancer therapy meets systems biologyYosef Yarden, Gur Pines · 2012 · Nature reviews. Cancer
- ErbB receptors and signaling pathways in cancerHynes, Nancy E, MacDonald, Gwen · 2009 · Current Opinion in Cell Biology
- The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapyIsabel M. Chu, Ludger Hengst, Joyce M. Slingerland · 2008 · Nature reviews. Cancer
- High-throughput oncogene mutation profiling in human cancerRoman Kurt Thomas, Alissa C. Baker, Ralph M. Debiasi, Wendy Winckler, Thomas LaFramboise, William M. Lin, Meng Wang, Whei Feng, Thomas Zander, Laura E. MacConaill et al. · 2007 · Nature Genetics
- Understanding and targeting resistance mechanisms in NSCLCJulia K. Rotow, Trever Grant Bivona · 2017 · Nature reviews. Cancer
- VarDict: a novel and versatile variant caller for next-generation sequencing in cancer researchZhongwu Lai, Aleksandra A. Markovets, Miika J. Ahdesmaki, Brad Chapman, Oliver Hofmann, Robert K. McEwen, Justin Johnson, Brian Andrew Dougherty, J. Carl Barrett, Jonathan R. Dry · 2016 · Nucleic Acids Research
- Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer: Results of the randomised phase 3 MRC COIN trialMaughan, Timothy S, Adams, Richard A, Smith, Christopher G, Meade, Angela M, Seymour, Matthew T, Wilson, Richard H, Idziaszczyk, Shelley, Harris, Rebecca, Fisher, David, Kenny, Sarah L et al. · 2011 · The Lancet
- Lung cancer in never smokers – A reviewS. Couraud, Gérard Zalcman, Bernard J. Milleron, Franck Morin, Pierre-Jean Souquet · 2012 · European Journal of Cancer
- The MAPK pathway across different malignancies: A new perspectiveMauricio Burotto, Victoria L. Chiou, Jung‐Min Lee, Elise C. Kohn · 2014 · Cancer
- Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinibEunice Lee Kwak, Raffaella Sordella, Daphne W. Bell, Nadia Godin-Heymann, Ross A. Okimoto, Brian W. Brannigan, Patricia L. Harris, David R. Driscoll, Panos M. Fidias, Thomas James Lynch et al. · 2005 · Proceedings of the National Academy of Sciences
- Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: a cohort studyMoroni, Mauro, Veronese, Silvio, Benvenuti, Silvia, Marrapese, Giovanna, Sartore-Bianchi, Andrea, Di Nicolantonio, Federica, Gambacorta, Marcello, Siena, Salvatore, Bardelli, Alberto · 2005 · The Lancet Oncology
- EGFR Mutations and Lung CancerGilda da Cunha Santos, Frances A. Shepherd, Ming‐Sound Tsao · 2011 · Annual Review of Pathology Mechanisms of Disease
- Mutations of the Epidermal Growth Factor Receptor Gene Predict Prolonged Survival After Gefitinib Treatment in Patients With Non–Small-Cell Lung Cancer With Postoperative RecurrenceTetsuya Mitsudomi, Takayuki Kosaka, Hideki Endoh, Yoshitsugu Horio, Toyoaki Hida, Shoichi Mori, Shunzo Hatooka, Masayuki Shinoda, Takashi Takahashi, Yasushi Yatabe · 2005 · Journal of Clinical Oncology
- Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approachZender, Lars, Spector, Mona S., Xue, Wen, Flemming, Peer, Cordon-Cardo, Carlos, Silke, John, Fan, Sheung-Tat, Luk, John M., Wigler, Michael, Hannon, Gregory J. et al. · 2006 · Cell
- Current Challenges in Cancer TreatmentJon Zugazagoitia, Cristiano Guedes, Santiago Ponce, Irene Ferrer, Sonia Molina‐Pinelo, Luis G Paz-Ares · 2016 · Clinical Therapeutics
- Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitorsYong Jia, Cai‐Hong Yun, Eunyoung Park, Dalia Ercan, Mari Manuia, Jose Juarez, Chunxiao Xu, Kevin Rhee, Ting Chen, Haikuo Zhang et al. · 2016 · Nature
- Targeting the EGFR signaling pathway in cancer therapyParthasarathy Seshacharyulu, Moorthy Palanimuthu Ponnusamy, Dhanya Haridas, Maneesh Jain, Apar Kishor Ganti, Surinder K. Batra · 2012 · Expert Opinion on Therapeutic Targets
- Mechanisms of Disease: understanding resistance to HER2-targeted therapy in human breast cancerRita Nahta, Dihua Yu, Mien‐Chie Hung, Gabriel N. Hortobágyi, Francisco J. Esteva · 2006 · Nature Clinical Practice Oncology
- American Society of Clinical Oncology Clinical Practice Guideline Update on Chemotherapy for Stage IV Non–Small-Cell Lung CancerAzzoli, Christopher G., Baker, Sherman, Temin, Sarah, Pao, William, Aliff, Timothy, Brahmer, Julie, Johnson, David H., Laskin, Janessa L., Masters, Gregory, Milton, Daniel et al. · 2009 · Journal of Clinical Oncology
- Awakening guardian angels: drugging the p53 pathwayBrown, Christopher J., Lain, Sonia, Verma, Chandra S., Fersht, Alan R., Lane, David P. · 2009 · Nature Reviews Cancer
- Transcriptome sequencing to detect gene fusions in cancerChristopher A. Maher, Chandan Kumar‐Sinha, Xuhong Cao, Shanker Kalyana Sundaram, Bo Han, Xiaojun Jing, Lee T. Sam, Terrence R. Barrette, Nallasivam Palanisamy, Arul M. Chinnaiyan · 2009 · Nature
- Clinical drug response can be predicted using baseline gene expression levels and in vitro drug sensitivity in cell linesPaul Geeleher, Nancy Jean Cox, R. Stephanie Huang · 2014 · Genome biology
- The BATTLE Trial: Personalizing Therapy for Lung CancerEdward S. Kim, Roy S. Herbst, Ignacio Ivan Wistuba, J. Jack Lee, George R. Blumenschein, Anne S. Tsao, David J. Stewart, Marshall E. Hicks, Jeremy J. Erasmus, Sanjay Kumar Gupta et al. · 2011 · Cancer Discovery
- Triple-negative breast cancer: therapeutic optionsSusan Jane Cleator, Wolfgang Heller, R. Charles Coombes · 2007 · The Lancet Oncology
- Target Binding Properties and Cellular Activity of Afatinib (BIBW 2992), an Irreversible ErbB Family BlockerSolca, Flavio, Dahl, Goeran, Zoephel, Andreas, Bader, Gerd, Sanderson, Michael, Klein, Christian, Kraemer, Oliver, Himmelsbach, Frank, Haaksma, Eric, Adolf, Guenther R. · 2012 · The Journal of Pharmacology and Experimental Therapeutics
- Phase III Study of Erlotinib in Combination With Cisplatin and Gemcitabine in Advanced Non–Small-Cell Lung Cancer: The Tarceva Lung Cancer Investigation TrialUlrich Gatzemeier, Anna Pluzanska, Aleksandra Szczęsna, Eckhard Kaukel, Jaromı́r Roubec, Flavio De Rosa, Janusz Milanowski, Hanna Karnicka-Mlodkowski, Miloš Pešek, Piotr Serwatowski et al. · 2007 · Journal of Clinical Oncology
- Activating HER2 Mutations in HER2 Gene Amplification Negative Breast CancerRon Bose, Shyam M. Kavuri, Adam C. Searleman, Wei Shen, Dong Shen, Daniel C. Koboldt, John D. Monsey, Nicholas J. Goel, Adam B. Aronson, Shunqiang Li et al. · 2012 · Cancer Discovery
- Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung AdenocarcinomaGillette, Michael A., Satpathy, Shankha, Cao, Song, Dhanasekaran, Saravana M., Vasaikar, Suhas V., Krug, Karsten, Petralia, Francesca, Li, Yize, Liang, Wen-Wei, Reva, Boris et al. · 2020 · Cell
- First-Line Gefitinib in Patients With Advanced Non–Small-Cell Lung Cancer Harboring Somatic
<i>EGFR</i>
MutationsSequist, Lecia V., Martins, Renato G., Spigel, David, Grunberg, Steven M., Spira, Alexander, Jänne, Pasi A., Joshi, Victoria A., McCollum, David, Evans, Tracey L., Muzikansky, Alona et al. · 2008 · Journal of Clinical Oncology
- A framework to rank genomic alterations as targets for cancer precision medicine: the ESMO Scale for Clinical Actionability of molecular Targets (ESCAT)Joaquı́n Mateo, Debyani Chakravarty, Rodrigo Dienstmann, S. Jezdic, Abel González-Pérez, Núria López-Bigas, Charlotte K.Y. Ng, Philippe Lucien Bedard, Giampaolo Tortora, J.-Y. Douillard et al. · 2018 · Annals of Oncology
- Tumour-targeting bacteria engineered to fight cancerZhou, Shibin, Gravekamp, Claudia, Bermudes, David, Liu, Ke · 2018 · Nature Reviews Cancer
- Novel D761Y and Common Secondary T790M Mutations in Epidermal Growth Factor Receptor–Mutant Lung Adenocarcinomas with Acquired Resistance to Kinase InhibitorsMarissa N. Balak, Yixuan Gong, Gregory J. Riely, Romel Somwar, Allan R. Li, Maureen Frances Zakowski, Anne C. Chiang, Guangli Yang, Ouathek Ouerfelli, Mark G. Kris et al. · 2006 · Clinical Cancer Research
- Frequent and Focal FGFR1 Amplification Associates with Therapeutically Tractable FGFR1 Dependency in Squamous Cell Lung CancerJonathan M. Weiss, Martin L. Sos, Danila Seidel, Martin Peifer, Thomas Zander, Johannes M. Heuckmann, Roland Tillmann Ullrich, Roopika Menon, Sebastian H. Maier, Alex Soltermann et al. · 2010 · Science Translational Medicine
- Trends in kinase drug discovery: targets, indications and inhibitor designMisty M. Attwood, Doriano Fabbro, Aleksandr V. Sokolov, Stefan Knapp, Helgi B. Schiöth · 2021 · Nature Reviews Drug Discovery
- Advances in covalent drug discoveryBoike, Lydia, Henning, Nathaniel J., Nomura, Daniel K. · 2022 · Nature Reviews Drug Discovery
- Role of epidermal growth factor receptor in breast cancerHiroko Masuda, Dongwei Zhang, Chandra Bartholomeusz, Hiroyoshi Doihara, Gabriel N. Hortobágyi, Naoto Tada Ueno · 2012 · Breast Cancer Research and Treatment
- Comparing antibody and small-molecule therapies for cancerKohzoh Imai, Akinori Takaoka · 2006 · Nature reviews. Cancer
- Intragenic ERBB2 kinase mutations in tumoursStephens, Philip, Hunter, Chris, Bignell, Graham, Edkins, Sarah, Davies, Helen, Teague, Jon, Stevens, Claire, O'Meara, Sarah, Smith, Raffaella, Parker, Adrian et al. · 2004 · Nature
- Oncogenic PI3K deregulates transcription and translationAndreas G. Bader, Sohye Kang, Li Zhao, Peter K. Vogt · 2005 · Nature reviews. Cancer
- Clinical definition of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer.Jackman, David, Pao, William, Riely, Gregory J., Engelman, Jeffrey A., Kris, Mark G., Jänne, Pasi A., Lynch, Thomas, Johnson, Bruce E., Miller, Vincent A. · 2010 · Journal of Clinical Oncology
- EGFR Mutations in Non–Small-Cell Lung Cancer: Analysis of a Large Series of Cases and Development of a Rapid and Sensitive Method for Diagnostic Screening With Potential Implications on Pharmacologic TreatmentAntonio Marchetti, Carla Martella, Lara Felicioni, Fabio Barassi, Simona Salvatore, Antonio Chella, Pierpaolo Camplese, Teodorico Iarussi, Felice Mucilli, Andrea Mezzetti et al. · 2005 · Journal of Clinical Oncology
- Management of acquired resistance to EGFR TKI–targeted therapy in advanced non-small cell lung cancerShang‐Gin Wu, Jin‐Yuan Shih · 2018 · Molecular Cancer
- Targeted Therapies for Lung Cancer Patients With Oncogenic Driver Molecular AlterationsAaron C. Tan, Daniel S.W. Tan · 2022 · Journal of Clinical Oncology
- Activating mutations in ALK provide a therapeutic target in neuroblastomaGeorge, Rani E., Sanda, Takaomi, Hanna, Megan, Fröhling, Stefan, II, William Luther, Zhang, Jianming, Ahn, Yebin, Zhou, Wenjun, London, Wendy B., McGrady, Patrick et al. · 2008 · Nature
- Predictive and Prognostic Impact of Epidermal Growth Factor Receptor Mutation in Non–Small-Cell Lung Cancer Patients Treated With GefitinibSae‐Won Han, Tae‐You Kim, Pil Gyu Hwang, Soohyun Jeong, Jeongmi Kim, In Sil Choi, Do‐Youn Oh, Jee Hyun Kim, Dong‐Wan Kim, Doo Hyun Chung et al. · 2005 · Journal of Clinical Oncology
- The epidermal growth factor receptor family: Biology driving targeted therapeuticsMatthew Joseph Wieduwilt, Mark M. Moasser · 2008 · Cellular and Molecular Life Sciences
- Erlotinib alone or with bevacizumab as first-line therapy in patients with advanced non-squamous non-small-cell lung cancer harbouring EGFR mutations (JO25567): an open-label, randomised, multicentre, phase 2 studySeto, Takashi, Kato, Terufumi, Nishio, Makoto, Goto, Koichi, Atagi, Shinji, Hosomi, Yukio, Yamamoto, Noboru, Hida, Toyoaki, Maemondo, Makoto, Nakagawa, Kazuhiko et al. · 2014 · The Lancet Oncology
- Molecular Mechanisms of Resistance to Cetuximab and Panitumumab in Colorectal CancerBardelli, Alberto, Siena, Salvatore · 2010 · Journal of Clinical Oncology
- Epidermal Growth Factor Receptor Biology in Head and Neck CancerShailaja Kalyankrishna, Jennifer Rubin Grandis · 2006 · Journal of Clinical Oncology
- Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: a systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancerLinardou, Helena, Dahabreh, Issa J, Kanaloupiti, Dimitra, Siannis, Fotios, Bafaloukos, Dimitrios, Kosmidis, Paris, Papadimitriou, Christos A, Murray, Samuel · 2008 · The Lancet Oncology
- First-SIGNAL: First-Line Single-Agent Iressa Versus Gemcitabine and Cisplatin Trial in Never-Smokers With Adenocarcinoma of the LungHan, Ji-Youn, Park, Keunchil, Kim, Sang-We, Lee, Dae Ho, Kim, Hyae Young, Kim, Heung Tae, Ahn, Myung Ju, Yun, Tak, Ahn, Jin Seok, Suh, Cheolwon et al. · 2012 · Journal of Clinical Oncology
- Non–Small Cell Lung Cancer_ _ · 2008 · Journal of the National Comprehensive Cancer Network
- Clinical Course of Patients with Non–Small Cell Lung Cancer and Epidermal Growth Factor Receptor Exon 19 and Exon 21 Mutations Treated with Gefitinib or ErlotinibGregory J. Riely, William J. Pao, DuyKhanh P. Ceppa, Allan R. Li, Naiyer A. Rizvi, Ennapadam S. Venkatraman, Maureen Frances Zakowski, Mark G. Kris, Marc Ladanyi, Vincent A. Miller · 2006 · Clinical Cancer Research
- Nanomedicine therapeutic approaches to overcome cancer drug resistanceMarkman, Janet L., Rekechenetskiy, Arthur, Holler, Eggehard, Ljubimova, Julia Y. · 2013 · Advanced Drug Delivery Reviews
- Non–Small Cell Lung CancerDavid S. Ettinger, Wallace Akerley, Gerold Bepler, Matthew G. Blum, Andrew C. Chang, Richard T. Cheney, Lucian R. Chirieac, Thomas Anthony D’Amico, Todd L. Demmy, Apar Kishor Ganti et al. · 2010 · Journal of the National Comprehensive Cancer Network
- Precision Diagnosis and Treatment for Advanced Non–Small-Cell Lung CancerMartin Reck, Klaus Friedrich Rabe · 2017 · New England Journal of Medicine
- PF00299804, an Irreversible Pan-ERBB Inhibitor, Is Effective in Lung Cancer Models with
<i>EGFR</i>
and
<i>ERBB2</i>
Mutations that Are Resistant to GefitinibEngelman, Jeffrey A., Zejnullahu, Kreshnik, Gale, Christopher-Michael, Lifshits, Eugene, Gonzales, Andrea J., Shimamura, Takeshi, Zhao, Feng, Vincent, Patrick W., Naumov, George N., Bradner, James E. et al. · 2007 · Cancer Research
- Critical Update and Emerging Trends in Epidermal Growth Factor Receptor Targeting in CancerJose M Baselga, Carlos L. Arteaga · 2005 · Journal of Clinical Oncology
- Targeted therapy for non-small cell lung cancer: current standards and the promise of the future.2015 · Europe PMC (PubMed Central)
- Management of non-small-cell lung cancer: recent developmentsMartin Reck, David Felix Heigener, Tony S.K. Mok, Jean‐Charles Soria, Klaus Friedrich Rabe · 2013 · The Lancet
- Glioblastoma: pathology, molecular mechanisms and markersAldape, Kenneth, Zadeh, Gelareh, Mansouri, Sheila, Reifenberger, Guido, von Deimling, Andreas · 2015 · Acta Neuropathologica
- <i>HER2</i>
Amplification: A Potential Mechanism of Acquired Resistance to EGFR Inhibition in
<i>EGFR</i>
-Mutant Lung Cancers That Lack the Second-Site
<i>EGFR</i>
T790M MutationTakezawa, Ken, Pirazzoli, Valentina, Arcila, Maria E., Nebhan, Caroline A., Song, Xiaoling, de Stanchina, Elisa, Ohashi, Kadoaki, Janjigian, Yelena Y., Spitzler, Paula J., Melnick, Mary Ann et al. · 2012 · Cancer Discovery
- Mechanisms of Disease: oncogene addiction—a rationale for molecular targeting in cancer therapyI. Bernard Weinstein, Andrew K. Joe · 2006 · Nature Clinical Practice Oncology
- Molecular predictors of outcome with gefitinib in a phase III placebo-controlled study in advanced non-small-cell lung cancerHirsch, Fred R., Varella-Garcia, Marileila, Bunn, Paul A., Franklin, Wilbur A., Dziadziuszko, Rafal, Thatcher, Nick, Chang, Alex, Parikh, Purvish, Pereira, José Rodrigues, Ciuleanu, Tudor et al. · 2006 · Journal of Clinical Oncology
- Lung Cancer in Never Smokers: A ReviewJanakiraman Subramanian, Ramaswamy Govindan · 2007 · Journal of Clinical Oncology
- Mechanisms of Acquired Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Non–Small Cell Lung CancerJeffrey A. Engelman, Pasi Antero Janne · 2008 · Clinical Cancer Research
- Epidermal Growth Factor Receptor Targeting in CancerJohn M. Mendelsohn, Jose M Baselga · 2006 · Seminars in Oncology
- Epidermal Growth Factor Receptor Gene Mutations and Increased Copy Numbers Predict Gefitinib Sensitivity in Patients With Recurrent Non–Small-Cell Lung CancerToshimi Takano, Yuichiro Ohe, Hiromi Sakamoto, Koji Tsuta, Yoshihiro Matsuno, Ukihide Tateishi, Seiichiro Yamamoto, Hiroshi Nokihara, Noboru Yamamoto, Ikuo Sekine et al. · 2005 · Journal of Clinical Oncology
- MET Exon 14 Mutations in Non–Small-Cell Lung Cancer Are Associated With Advanced Age and Stage-Dependent MET Genomic Amplification and c-Met OverexpressionMark Magdi Awad, Geoffrey R. Oxnard, David Michael Jackman, Daniel O. Savukoski, Dimity Hall, Priyanka Shivdasani, Jennifer C. Heng, Suzanne Eleanor Dahlberg, Pasi Antero Janne, Suman Verma et al. · 2016 · Journal of Clinical Oncology
- Mechanisms of acquired resistance to first- and second-generation EGFR tyrosine kinase inhibitorsWestover, D., Zugazagoitia, J., Cho, B.C., Lovly, C.M., Paz-Ares, L. · 2018 · Annals of Oncology
- Clinical Characteristics of Patients With Lung Adenocarcinomas Harboring BRAF MutationsPaul K. Paik, Maria E. Arcila, Michael G. Fara, Camelia S. Sima, Vincent A. Miller, Mark G. Kris, Marc Ladanyi, Gregory J. Riely · 2011 · Journal of Clinical Oncology
- Understanding resistance to EGFR inhibitors—impact on future treatment strategiesWheeler, Deric L., Dunn, Emily F., Harari, Paul M. · 2010 · Nature Reviews Clinical Oncology
- The emerging treatment landscape of targeted therapy in non-small-cell lung cancerMin Yuan, Lili Huang, Jianhua Chen, Jie Wu, Qing Xu · 2019 · Signal Transduction and Targeted Therapy
- Randomized Phase III Trial Comparing Irinotecan/Cisplatin With Etoposide/Cisplatin in Patients With Previously Untreated Extensive-Stage Disease Small-Cell Lung CancerNasser H. Hanna, Paul A. Bunn, Corey Jay Langer, Lawrence H. Einhorn, Troy H. Guthrie, Thaddeus Beck, Rafat Ansari, Peter Ellis, Michael Byrne, Mark E. Morrison et al. · 2006 · Journal of Clinical Oncology
- Somatic Mutations of the <i>HER2</i> Kinase Domain in Lung AdenocarcinomasShigematsu, Hisayuki, Takahashi, Takao, Nomura, Masaharu, Majmudar, Kuntal, Suzuki, Makoto, Lee, Huei, Wistuba, Ignacio I., Fong, Kwun M., Toyooka, Shinichi, Shimizu, Nobuyoshi et al. · 2005 · Cancer Research
- Oncogenic Transformation by Inhibitor-Sensitive and -Resistant EGFR MutantsGreulich, Heidi, Chen, Tzu-Hsiu, Feng, Whei, Jänne, Pasi A, Alvarez, James V, Zappaterra, Mauro, Bulmer, Sara E, Frank, David A, Hahn, William C, Sellers, William R et al. · 2005 · PLoS Medicine
- Unique Clinicopathologic Features Characterize ALK -Rearranged Lung Adenocarcinoma in the Western PopulationScott J. Rodig, Mari A. Mino-Kenudson, Sanja Đačić, Beow Yong Yeap, Alice Tsang Shaw, Justine A. Barletta, Hannah Stubbs, Kenny Law, Neal Ian Lindeman, Eugene Jerome Mark et al. · 2009 · Clinical Cancer Research
- Preclinical Mouse Cancer Models: A Maze of Opportunities and ChallengesDay, Chi-Ping, Merlino, Glenn, Van Dyke, Terry · 2015 · Cell