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Oseltamivir Resistance during Treatment of Influenza A (H5N1) Infection
Open accessAbstract
Influenza A (H5N1) virus with an amino acid substitution in neuraminidase conferring high-level resistance to oseltamivir was isolated from two of eight Vietnamese patients during oseltamivir treatment. Both patients died of influenza A (H5N1) virus infection, despite early initiation of treatment in one patient. Surviving patients had rapid declines in the viral load to undetectable levels during treatment. These observations suggest that resistance can emerge during the currently recommended regimen of oseltamivir therapy and may be associated with clinical deterioration and that the strategy for the treatment of influenza A (H5N1) virus infection should include additional antiviral agents.
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Cited by
Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia.
de Jong, M. D., Simmons, C. P., Thanh, T. T., Hien, V. M., Smith, G. J. D., Chau, T. N. B., Hoang, D. M., Van Vinh Chau, N., Khanh, T. H., Dong, V. C., et al. (2006) · Nature Medicine · doi:10.1038/nm1477 · Cited by 1,858
Self-citationUpdate on Avian Influenza A (H5N1) Virus Infection in Humans
(2008) · New England Journal of Medicine · doi:10.1056/nejmra0707279 · Cited by 860
Respiratory Viral Infections in Infants: Causes, Clinical Symptoms, Virology, and Immunology
Tregoning, J. S., & Schwarze, J. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00032-09 · Cited by 747
Antiviral agents active against influenza A viruses
De Clercq, E. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2175 · Cited by 668
Neuraminidase inhibitors for preventing and treating influenza in healthy adults and children
Jefferson, T., Jones, M. A., Doshi, P., Del Mar, C. B., Heneghan, C. J., Hama, R., & Thompson, M. J. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008965.pub3 · Cited by 594
Metadata
- Authors
- de Jong, M. D., Thanh, T. T., Khanh, T. H., Hien, V. M., Smith, G. J. D., Chau, N. V., Cam, B. V., Qui, P. T., Ha, D. Q., Guan, Y., Peiris, J. S. M., Hien, T. T., & Farrar, J.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2005-12-22
- Volume
- 353
- Issue
- 25
- Pages
- 2667-2672
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2149087734
- Cited by
- 901
- References
- 0
- FWCI
- 61.51
- Type
- journal article
- Language
- en
- Open access
- bronze
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- de Jong, M. D., Thanh, T. T., Khanh, T. H., Hien, V. M., Smith, G. J. D., Chau, N. V., Cam, B. V., Qui, P. T., Ha, D. Q., Guan, Y., Peiris, J. S. M., Hien, T. T., & Farrar, J. (2005). Oseltamivir Resistance during Treatment of Influenza A (H5N1) Infection. New England Journal of Medicine. https://doi.org/10.1056/nejmoa054512
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
