The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Progesterone and the Risk of Preterm Birth among Women with a Short Cervix
Abstract
BACKGROUND: Previous randomized trials have shown that progesterone administration in women who previously delivered prematurely reduces the risk of recurrent premature delivery. Asymptomatic women found at midgestation to have a short cervix are at greatly increased risk for spontaneous early preterm delivery, and it is unknown whether progesterone reduces this risk in such women. METHODS: Cervical length was measured by transvaginal ultrasonography at a median of 22 weeks of gestation (range, 20 to 25) in 24,620 pregnant women seen for routine prenatal care. Cervical length was 15 mm or less in 413 of the women (1.7%), and 250 (60.5%) of these 413 women were randomly assigned to receive vaginal progesterone (200 mg each night) or placebo from 24 to 34 weeks of gestation. The primary outcome was spontaneous delivery before 34 weeks. RESULTS: Spontaneous delivery before 34 weeks of gestation was less frequent in the progesterone group than in the placebo group (19.2% vs. 34.4%; relative risk, 0.56; 95% confidence interval [CI], 0.36 to 0.86). Progesterone was associated with a nonsignificant reduction in neonatal morbidity (8.1% vs. 13.8%; relative risk, 0.59; 95% CI, 0.26 to 1.25; P=0.17). There were no serious adverse events associated with the use of progesterone. CONCLUSIONS: In women with a short cervix, treatment with progesterone reduces the rate of spontaneous early preterm delivery. (ClinicalTrials.gov number, NCT00422526 [ClinicalTrials.gov].).
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Hosmer, D. W., & Lemeshow, S. (2000) · doi:10.1002/0471722146 · Cited by 20,302
Proportional hazards tests and diagnostics based on weighted residuals
GRAMBSCH, P. M., & THERNEAU, T. M. (1994) · Biometrika · doi:10.1093/biomet/81.3.515 · Cited by 5,885
The length of the cervix and the risk of spontaneous premature delivery
Iams, J. D., Goldenberg, R. L., Meis, P. J., Mercer, B. M., Moawad, A., Das, A., Thom, E., McNellis, D., Copper, R. L., Johnson, F., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199602293340904 · Cited by 1,894
Prevention of recurrent preterm delivery by 17 alpha–hydroxyprogesterone caproate
Meis, P. J., Klebanoff, M., Thom, E., Dombrowski, M. P., Sibai, B., Moawad, A. H., Spong, C. Y., Hauth, J. C., Miodovnik, M., Varner, M. W., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa035140 · Cited by 1,555
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Practice guidelines for performance of the routine mid-trimester fetal ultrasound scan
Salomon, L. J., Alfirevic, Z., Berghella, V., Bilardo, C., Hernandez‐Andrade, E., Johnsen, S. L., Kalache, K., Leung, K. ‐., Malinger, G., Munoz, H., et al. (2011) · Ultrasound in Obstetrics & Gynecology · doi:10.1002/uog.8831 · Cited by 1,006
Hassan, S. S., Romero, R., Vidyadhari, D., Fusey, S., Baxter, J. K., Khandelwal, M., Vijayaraghavan, J., Trivedi, Y., Soma‐Pillay, P., Sambarey, P., et al. (2011) · Ultrasound in Obstetrics & Gynecology · doi:10.1002/uog.9017 · Cited by 923
Romero, R., Nicolaides, K., Conde-Agudelo, A., Tabor, A., O'Brien, J. M., Cetingoz, E., Da Fonseca, E., Creasy, G. W., Klein, K., Rode, L., et al. (2012) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2011.12.003 · Cited by 580
Self-citationRomero, R., Conde-Agudelo, A., Da Fonseca, E., O’Brien, J. M., Cetingoz, E., Creasy, G. W., Hassan, S. S., & Nicolaides, K. H. (2018) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.11.576 · Cited by 522
Self-citationNorman, J. E., Marlow, N., Messow, C.-M., Shennan, A., Bennett, P. R., Thornton, S., Robson, S. C., McConnachie, A., Petrou, S., Sebire, N. J., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)00350-0 · Cited by 426
Metadata
- Authors
- Fonseca, E. B., Celik, E., Parra, M., Singh, M., & Nicolaides, K. H.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2007-08-02
- Volume
- 357
- Issue
- 5
- Pages
- 462-469
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2003105309
- Cited by
- 1,086
- References
- 5
- FWCI
- 33.08
- Type
- journal article
- Language
- en
- Open access
- closed
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- Fonseca, E. B., Celik, E., Parra, M., Singh, M., & Nicolaides, K. H. (2007). Progesterone and the Risk of Preterm Birth among Women with a Short Cervix. New England Journal of Medicine. https://doi.org/10.1056/nejmoa067815
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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