Cited by 1,585Atrial Fibrillation Management and OutcomesCardiac pacing and defibrillation studiesHeart Failure Treatment and Management

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

Rhythm Control versus Rate Control for Atrial Fibrillation and Heart Failure

Roy, Denis, Talajic, Mario, Nattel, Stanley, Wyse, D. George, Dorian, Paul, Lee, Kerry L., Bourassa, Martial G., Arnold, J. Malcolm O., Buxton, Alfred E., Camm, A. John, Connolly, Stuart J., Dubuc, Marc, Ducharme, Anique, Guerra, Peter G., Hohnloser, Stefan H., Lambert, Jean, Le Heuzey, Jean-Yves, O'Hara, Gilles, Pedersen, Ole Dyg, Rouleau, Jean-Lucien, Singh, Bramah N., Stevenson, Lynne Warner, Stevenson, William G., Thibault, Bernard, Waldo, Albert L.·2008·New England Journal of Medicine

DOI 10.1056/nejmoa0708789

Open this paper in CoChat — free account

Abstract

BACKGROUND: It is common practice to restore and maintain sinus rhythm in patients with atrial fibrillation and heart failure. This approach is based in part on data indicating that atrial fibrillation is a predictor of death in patients with heart failure and suggesting that the suppression of atrial fibrillation may favorably affect the outcome. However, the benefits and risks of this approach have not been adequately studied. METHODS: We conducted a multicenter, randomized trial comparing the maintenance of sinus rhythm (rhythm control) with control of the ventricular rate (rate control) in patients with a left ventricular ejection fraction of 35% or less, symptoms of congestive heart failure, and a history of atrial fibrillation. The primary outcome was the time to death from cardiovascular causes. RESULTS: A total of 1376 patients were enrolled (682 in the rhythm-control group and 694 in the rate-control group) and were followed for a mean of 37 months. Of these patients, 182 (27%) in the rhythm-control group died from cardiovascular causes, as compared with 175 (25%) in the rate-control group (hazard ratio in the rhythm-control group, 1.06; 95% confidence interval, 0.86 to 1.30; P=0.59 by the log-rank test). Secondary outcomes were similar in the two groups, including death from any cause (32% in the rhythm-control group and 33% in the rate-control group), stroke (3% and 4%, respectively), worsening heart failure (28% and 31%), and the composite of death from cardiovascular causes, stroke, or worsening heart failure (43% and 46%). There were also no significant differences favoring either strategy in any predefined subgroup. CONCLUSIONS: In patients with atrial fibrillation and congestive heart failure, a routine strategy of rhythm control does not reduce the rate of death from cardiovascular causes, as compared with a rate-control strategy. (ClinicalTrials.gov number, NCT00597077.)

Integrity signals

Registry

Crossref · 10.1056/nejmoa0708789

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Amiodarone or an Implantable Cardioverter–Defibrillator for Congestive Heart Failure
Bardy, G. H., Lee, K. L., Mark, D. B., Poole, J. E., Packer, D. L., Boineau, R., Domanski, M., Troutman, C., Anderson, J., Johnson, G., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043399 · Cited by 6,552
Effects of Enalapril on Mortality in Severe Congestive Heart Failure
The Consensus Trial Study Group* (1987) · New England Journal of Medicine · doi:10.1056/nejm198706043162301 · Cited by 5,109
Impact of Atrial Fibrillation on the Risk of Death: The Framingham Heart Study
Benjamin, E. J., Wolf, P. A., D’Agostino, R. B., Silbershatz, H., Kannel, W. B., & Levy, D. (1998) · Circulation · doi:10.1161/01.cir.98.10.946 · Cited by 4,575
A comparison of rate control and rhythm control in patients with atrial fibrillation
(2002) · New England Journal of Medicine · doi:10.1056/nejmoa021328 · Cited by 4,405
ACC/AHA/ESC 2006 Guidelines for the Management of Patients With Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients With Atrial Fibrillation): Developed in Collaboration With the European Heart Rhythm Association and the Heart Rhythm Society
Fuster, V., Rydén, L. E., Cannom, D. S., Crijns, H. J., Curtis, A. B., Ellenbogen, K. A., Halperin, J. L., Le Heuzey, J.-Y., Kay, G. N., Lowe, J. E., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.177292 · Cited by 2,805
Self-citation
A Comparison of Rate Control and Rhythm Control in Patients with Recurrent Persistent Atrial Fibrillation
Gelder, I. C. V., Hagens, V. E., Bosker, H. A., Kingma, J. H., Otto Kamp, B., Kingma, T., Said, S. A., Darmanata, J. I., Timmermans, A. J. M., Tijssen, J. G. P., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa021375 · Cited by 2,355
Prevalence, age distribution, and gender of patients with atrial fibrillation. Analysis and implications
Feinberg, W. M. (1995) · Archives of Internal Medicine · doi:10.1001/archinte.155.5.469 · Cited by 2,282
ACC/AHA/ESC 2006 Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death
Zipes, D. P., Camm, A. J., Borggrefe, M., Buxton, A. E., CHAITMAN, B. R., FROMER, M. A., Gregoratos, G., Klein, G. J., Myerburg, R. J., Quiñones, M. A., et al. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.07.010 · Cited by 1,975
Temporal Relations of Atrial Fibrillation and Congestive Heart Failure and Their Joint Influence on Mortality: The Framingham Heart Study
Wang, T. J., Larson, M. G., Levy, D., Vasan, R. S., Leip, E. P., Wolf, P. A., D’Agostino, R. B., Murabito, J. M., Kannel, W. B., & Benjamin, E. J. (2003) · Circulation · doi:10.1161/01.cir.0000072767.89944.6e · Cited by 1,970
Cardiovascular Medicine at the Turn of the Millennium: Triumphs, Concerns, and Opportunities
Braunwald, E. (1997) · New England Journal of Medicine · doi:10.1056/nejm199711063371906 · Cited by 1,426

Show all 41 references

Research works printed but not linked: 1

Carson PE, 1993, Circulation, 87, VI

Sorted by citations

Items 301–400 of 999

The burden of proof: The current state of atrial fibrillation prevention and treatment trials
Zakeri, R., Wagoner, D. R. V., Calkins, H. G., Wong, T., Ross, H., Heist, E. K., Meyer, T. E., Kowey, P. R., Mentz, R. J., Cleland, J. G. F., et al. (2017) · Heart Rhythm · doi:10.1016/j.hrthm.2017.01.032 · Cited by 42
Comparative Effectiveness of Early Rhythm Control Versus Rate Control for Cardiovascular Outcomes in Patients With Atrial Fibrillation
Kim, D., Yang, P., You, S. C., Jang, E., Yu, H. T., Kim, T., Pak, H., Lee, M., Lip, G. Y. H., Sung, J., et al. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.121.023055 · Cited by 44
Electrical management of heart failure: from pathophysiology to treatment
Prinzen, F. W., Auricchio, A., Müllens, W., Linde, C. M., & Huizar, J. F. (2022) · European Heart Journal · doi:10.1093/eurheartj/ehac088 · Cited by 43
European Heart Rhythm Association (EHRA)/Heart Rhythm Society (HRS)/Asia Pacific Heart Rhythm Society (APHRS)/Latin American Heart Rhythm Society (LAHRS) expert consensus on risk assessment in cardiac arrhythmias: use the right tool for the right outcome, in the right population
Nielsen, J. C., Lin, Y., Figueiredo, M. J. D. O., Shamloo, A. S., Alfie, A., Bovéda, S., Dagres, N., Toro, D. D., Eckhardt, L. L., Ellenbogen, K. A., et al. (2020) · Heart Rhythm · doi:10.1016/j.hrthm.2020.05.004 · Cited by 42
Atrial Fibrillation in the Elderly
Nantsupawat, T., NUGENT, K. M., & Phrommintikul, A. (2013) · Drugs & Aging · doi:10.1007/s40266-013-0094-8 · Cited by 40
Atrial-selective pharmacological therapy for atrial fibrillation: hype or hope?
Ehrlich, J. R., & Nattel, S. (2008) · Current Opinion in Cardiology · doi:10.1097/hco.0b013e32831bc336 · Cited by 41
Fibroblast Electrical Remodeling in Heart Failure and Potential Effects on Atrial Fibrillation
Aguilar, M., Qi, X. Y., Huang, H., Comtois, P., & Nattel, S. (2014) · Biophysical Journal · doi:10.1016/j.bpj.2014.10.014 · Cited by 42
Management of tachycardia
Gopinathannair, R., & Olshansky, B. (2015) · F1000Prime Reports · doi:10.12703/p7-60 · Cited by 44
A review of the epidemiology of atrial fibrillation in sub‐Saharan Africa
Noubiap, J. J., & Nyaga, U. F. (2019) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.14222 · Cited by 44
Treatment of atrial fibrillation
Bajpai, A., Savelieva, I., & Camm, A. J. (2008) · British Medical Bulletin · doi:10.1093/bmb/ldn046 · Cited by 42
Atrial fibrillation in dilated cardiomyopathy: Outcome prediction from an observational registry
Nuzzi, V., Cannata, A. N., Manca, P., Castrichini, M., Barbati, G., Aleksova, A., Fabris, E., Zecchin, M., Merlo, M., Boriani, G., et al. (2020) · International Journal of Cardiology · doi:10.1016/j.ijcard.2020.08.062 · Cited by 42
Prognostic Value of the Physical Examination in Patients With Heart Failure and Atrial Fibrillation
Caldentey, G., Khairy, P., Roy, D., Leduc, H., Talajic, M. R., Racine, N., White, M., O’Meara, E., Guertin, M., Rouleau, J. L., et al. (2014) · JACC Heart Failure · doi:10.1016/j.jchf.2013.10.004 · Cited by 42
Pathophysiology of concomitant atrial fibrillation and heart failure: implications for management
Morrison, T. B., Bunch, T. J., & Gersh, B. J. (2008) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio1414 · Cited by 42
Atrial fibrillation and heart failure in the elderly
Kazemian, P., Oudit, G. Y., & Jugdutt, B. I. (2011) · Heart Failure Reviews · doi:10.1007/s10741-011-9290-y · Cited by 42
Tachycardia-mediated cardiomyopathy: Recognition and management
Gopinathannair, R., Sullivan, R. M., & Olshansky, B. (2009) · Current Heart Failure Reports · doi:10.1007/s11897-009-0035-3 · Cited by 42
Atrial fibrillation in aging population
Chen, Q., Zhong, Y., & Cheng, J. (2018) · Aging Medicine · doi:10.1002/agm2.12015 · Cited by 41
Atrial Fibrillation
Al‐Khatib, S. M. (2023) · Annals of Internal Medicine · doi:10.7326/aitc202307180 · Cited by 41
Real-life global survey evaluating patients with atrial fibrillation (REALISE-AF): results of an international observational registry
Alam, M., Bandeali, S. J., Shahzad, S. A., & Lakkis, N. M. (2012) · Expert Review of Cardiovascular Therapy · doi:10.1586/erc.12.8 · Cited by 41
Rhythm Control Versus Rate Control and Clinical Outcomes in Patients With Atrial Fibrillation
Noheria, A., Shrader, P. J., Piccini, J. P., Fonarow, G. C., Kowey, P. R., Mahaffey, K. W., Naccarelli, G. V., Noseworthy, P. A., Reiffel, J. A., Steinberg, B. A., et al. (2015) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2015.11.001 · Cited by 41
A randomized ablation-based atrial fibrillation rhythm control versus rate control trial in patients with heart failure and high burden atrial fibrillation: The RAFT-AF trial rationale and design
Parkash, R., Wells, G. A., Rouleau, J. L., Talajic, M. R., Essebag, V., Skanes, A. C., Wilton, S. B., Verma, A., Healey, J. S., & TANG, A. S. L. (2021) · American Heart Journal · doi:10.1016/j.ahj.2021.01.012 · Cited by 42
Atrial fibrillation and the risk of death in patients with heart failure: a literature‐based meta‐analysis
Wasywich, C. A., Pope, A., Somaratne, J., Poppe, K., WHALLEY, G. A., & Doughty, R. N. (2009) · Internal Medicine Journal · doi:10.1111/j.1445-5994.2009.01991.x · Cited by 41
Augmented single‐unit muscle sympathetic nerve activity in heart failure with chronic atrial fibrillation
Ikeda, T., Murai, H., Kaneko, S., Usui, S., Kobayashi, D., Nakano, M., Ikeda, K., Takashima, S., Kato, T., Okajima, M., et al. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.223842 · Cited by 41
Diagnostic accuracy of NT-proBNP ratio (BNP-R) for early diagnosis of tachycardia-mediated cardiomyopathy: a pilot study
Nia, A. M., Gassanov, N., Dahlem, K. M., Caglayan, E., Hellmich, M., Erdmann, E., & Er, F. (2011) · Clinical Research in Cardiology · doi:10.1007/s00392-011-0319-y · Cited by 41
Thirty-Day and 1-Year Outcomes of Emergency Department Patients With Atrial Fibrillation and No Acute Underlying Medical Cause
Scheuermeyer, F. X., Grafstein, E., Stenstrom, R., Innes, G. D., Heslop, C., MacPhee, J., Pourvali, R., Heilbron, B. G., McGrath, L., & Christenson, J. M. (2012) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2012.05.007 · Cited by 42
Atrial fibrillation is associated with increased mortality: causation or association?
Leong, D. P., Eikelboom, J. W., Healey, J. S., & Connolly, S. J. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht044 · Cited by 41
Stroke and Cardiovascular Events After Ablation or Antiarrhythmic Drugs for Treatment of Patients With Atrial Fibrillation
MANSOUR, M. C., Heist, E. K., Agarwal, R., Bunch, T. J., Karst, E., Ruskin, J. N., & Mahapatra, S. (2018) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2018.01.043 · Cited by 39
Interventional heart failure therapy: A new concept fighting against heart failure
Saku, K., Yokota, S., Nishikawa, T., & Kinugawa, K. (2021) · Journal of Cardiology · doi:10.1016/j.jjcc.2021.11.018 · Cited by 41
A New Scoring System for Evaluating the Risk of Heart Failure Events in Japanese Patients With Atrial Fibrillation
Suzuki, S. S., Sagara, K., Otsuka, T., Matsuno, S., Funada, R., Uejima, T., Oikawa, Y., Yajima, J., Koike, A., Nagashima, K., et al. (2012) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2012.04.049 · Cited by 40
Atrial fibrillation and congestive heart failure
Roy, D., Talajic, M. R., Dubuc, M., Thibault, B., Guerra, P. G., Macle, L., & Khairy, P. (2008) · Current Opinion in Cardiology · doi:10.1097/hco.0b013e32831c8c58 · Cited by 40
Impact of Atrial Fibrillation on Healthcare Utilization in the Community: The Atherosclerosis Risk in Communities Study
Bengtson, L. G. S., Lutsey, P. L., Loehr, L. R., Kucharska‐Newton, A., Chen, L. Y., Chamberlain, A. M., Wruck, L. M., Duval, S., Stearns, S. C., & Alonso, Á. (2014) · Journal of the American Heart Association · doi:10.1161/jaha.114.001006 · Cited by 40
Atrial fibrillation and arterial hypertension: A common duet with dangerous consequences where the renin angiotensin-aldosterone system plays an important role
Seccia, T. M., Caroccia, B., Muiesan, M. L., & Rossi, G. P. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.01.007 · Cited by 42
Cancer Mortality in Trials of Heart Failure With Reduced Ejection Fraction: A Systematic Review and Meta‐Analysis
Tini, G., Bertero, E., Signori, A., Sormani, M. P., Maack, C., de Boer, R. A., Canepa, M., & Ameri, P. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.119.016309 · Cited by 40
Early atrial fibrillation detection and the transition to comprehensive management
Linz, D., Hermans, A. N. L., & Tieleman, R. G. (2020) · EP Europace · doi:10.1093/europace/euaa424 · Cited by 41
The physics of heart rhythm disorders
Rappel, W. (2022) · Physics Reports · doi:10.1016/j.physrep.2022.06.003 · Cited by 41
Comorbidity of patients with noncommunicable diseases in general practice. Eurasian guidelines
Drapkina, O. M., Васильевна, К. А., Калинина, А. М., Avdeev, S. N., Викторович, А. М., Алексеева, Л. И., Almazova, I. I., Andreenko, Е. Y., Antipushina, D. N., Balanova, Y. А., et al. (2024) · CARDIOVASCULAR THERAPY AND PREVENTION · doi:10.15829/1728-8800-2024-3996 · Cited by 55
Effect of Bucindolol on Heart Failure Outcomes and Heart Rate Response in Patients with Reduced Ejection Fraction Heart Failure and Atrial Fibrillation
Kao, D. P., Davis, G. W., Aleong, R. G., O’Connor, C. M., Fiuzat, M., Carson, P. E., Anand, I. S., Plehn, J. F., Gottlieb, S. S., Silver, M. A., et al. (2012) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfs181 · Cited by 39
Dronedarone: A New Antiarrhythmic Agent
Oyetayo, O. O., Rogers, C. E., & Hofmann, P. O. (2010) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.30.9.904 · Cited by 39
Risk factors for atrial fibrillation: Not always severe heart disease, not always so 'lonely'.
Rosiak, M., Dziuba, M., Chudzik, M., Cygankiewicz, I., Bartczak, K., Dróżdż, J., & Wranicz, J. K. (2010) · PubMed · Cited by 38
Should We Perform Catheter Ablation for Asymptomatic Atrial Fibrillation?
Kalman, J. M., Sanders, P., Rosso, R., & Calkins, H. G. (2017) · Circulation · doi:10.1161/circulationaha.116.024926 · Cited by 42
Impact of dronedarone on hospitalization burden in patients with atrial fibrillation: results from the ATHENA study
Torp-Pedersen, C., Crijns, H. J. G. M., Gaudin, C., Page, R. L., Connolly, S. J., Hohnloser, S. H., & for the ATHENA Investigators (2011) · EP Europace · doi:10.1093/europace/eur102 · Cited by 38
Atrial-selective sodium channel block for the treatment of atrial fibrillation
Burashnikov, A., & Antzelevitch, C. N. (2009) · Expert Opinion on Emerging Drugs · doi:10.1517/14728210902997939 · Cited by 39
The role of rotors in atrial fibrillation.
Krummen, D. E., Swarup, V., & Narayan, S. M. (2015) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2072-1439.2014.11.15 · Cited by 40
Atrial fibrillation and long-term prognosis in patients hospitalized for heart failure: results from heart failure survey in Israel (HFSIS)
Shotan, A., Garty, M., Blondhein, D. S., Meisel, S. R., Lewis, B. S., Shochat, M. K., Grossman, E., Porath, A., Boyko, V., Zimlichman, R., et al. (2009) · European Heart Journal · doi:10.1093/eurheartj/ehp422 · Cited by 38
Informed Choice of Composite End Points in Cardiovascular Trials
Melis, G. G., Mateu, M. G., & Dafni, U. G. (2014) · Circulation Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.113.000149 · Cited by 38
Elevated Circulating Fibrocytes Is a Marker of Left Atrial Fibrosis and Recurrence of Persistent Atrial Fibrillation
Liu, Y., Niu, X., Yin, X., Liu, Y., Han, C., Yang, J., Huang, X., Yu, X., Gao, L., Yang, Y., et al. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.117.008083 · Cited by 38
2025 Clinical practice guidelines for Atrial fibrillation and flutter
Golukhova, E. Z., Sp, G., Михайлов, Е. Н., Revishvili, A. S. H., Arakelyan, M. G., Vasilyeva, E. Y., Davtyan, K. V., Drapkina, O. M., Drozdova, L. Y., Станиславовна, К. Е., et al. (2026) · Russian Journal of Cardiology · doi:10.15829/1560-4071-2025-6668 · Cited by 44
Falling Cardiovascular Mortality in Heart Failure With Reduced Ejection Fraction and Implications for Clinical Trials
Rush, C. J., Campbell, R. T., Jhund, P. S., Connolly, E. C., Preiss, D., Gardner, R. S., Petrie, M. C., & McMurray, J. J. V. (2015) · JACC Heart Failure · doi:10.1016/j.jchf.2015.03.013 · Cited by 37
Rationale and design of PRIMA II: A multicenter, randomized clinical trial to study the impact of in-hospital guidance for acute decompensated heart failure treatment by a predefined NT-PRoBNP target on the reduction of readmIssion and Mortality rAtes
Stienen, S., Salah, K., Moons, A. H. M., Bakx, A. L. M., van Pol, P. E. J., Schroeder‐Tanka, J. M., Voogel, A. J., Keijer, J. T., Kortz, R. A. M., Dickhoff, C., et al. (2014) · American Heart Journal · doi:10.1016/j.ahj.2014.04.008 · Cited by 37
Addressing Comorbidities in Heart Failure
Bavishi, A. A., & Patel, R. B. (2020) · Heart Failure Clinics · doi:10.1016/j.hfc.2020.06.005 · Cited by 40
Antiarrhythmic therapy and risk of death in patients with atrial fibrillation: a nationwide study
Andersen, S. S., Hansen, M. L., Gislason, G., Schramm, T. K., Folke, F., Fosbøl, E. L., Abildstrom, S. Z., Madsen, M., Køber, L., & Torp-Pedersen, C. T. (2009) · EP Europace · doi:10.1093/europace/eup119 · Cited by 37
Improving guideline adherence in the treatment of atrial fibrillation by implementing an integrated chronic care program
Nieuwlaat, R., Vrijhoef, H. J., de Wit, R., Crijns, H. J. G. M., Tieleman, R. G., & Hendriks, J. (2010) · Netherlands Heart Journal · doi:10.1007/bf03091818 · Cited by 36
The safety of flecainide treatment of atrial fibrillation: long-term incidence of sudden cardiac death and proarrhythmic events
Almroth, H., Andersson, T., Fengsrud, E., Friberg, L., Linde, P., Rosenqvist, M., & Englund, A. (2011) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2011.02395.x · Cited by 37
Management of Atrial Fibrillation in the Year 2033: New Concepts, Tools, and Applications Leading to Personalized Medicine
Gillis, A. M., Krahn, A. D., Skanes, A. C., & Nattel, S. (2013) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2013.07.006 · Cited by 36
Biatrial Electrical and Structural Atrial Changes in Heart Failure
Prabhu, S., Voskoboinik, A., McLellan, A. J. A., Peck, K. Y., Pathik, B., Nalliah, C. J., Wong, G. R., Azzopardi, S. M., Lee, G., Mariani, J. A., et al. (2017) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2017.08.012 · Cited by 36
Long-term management of end-stage heart failure
Habal, M. V., & Garan, A. R. (2017) · Best practice & research. Clinical anaesthesiology · doi:10.1016/j.bpa.2017.07.003 · Cited by 40
HeartQuake
Park, J.-Y., Cho, H. K., Balan, R. K., & Ko, J. (2020) · Proceedings of the ACM on Interactive Mobile Wearable and Ubiquitous Technologies · doi:10.1145/3411843 · Cited by 36
The crosstalk between cardiomyocyte calcium and inflammasome signaling pathways in atrial fibrillation
Wang, X., Chen, X., Dobrev, D., & Li, N. (2021) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-021-02515-4 · Cited by 36
Heart rate and adverse outcomes in patients with atrial fibrillation: A combined AFFIRM and AF-CHF substudy
Andrade, J. G., Roy, D., Wyse, D. G., Tardif, J., Talajic, M. R., Leduc, H., Cadrin‐Tourigny, J., Shohoudi, A., Dubuc, M., Rivard, L., et al. (2015) · Heart Rhythm · doi:10.1016/j.hrthm.2015.08.028 · Cited by 36
Relationship of Paroxysmal Atrial Tachyarrhythmias to Volume Overload
Jhanjee, R., Templeton, G. A., Sattiraju, S., Nguyen, J., Sakaguchi, S., Lü, F., Ermiş, C., Milstein, S., Heel, L. V., Lurie, K. G., et al. (2009) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.109.860221 · Cited by 36
Rate vs rhythm control in patients with atrial fibrillation and heart failure: A systematic review and meta-analysis of randomised controlled trials
Caldeira, D., David, C., & Sampaio, C. (2011) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2011.05.001 · Cited by 35
Effect of dronedarone on clinical end points in patients with atrial fibrillation and coronary heart disease: insights from the ATHENA trial
Pisters, R., Hohnloser, S. H., Connolly, S. J., Torp-Pedersen, C. T., Naditch‐Brûlé, L., Page, R. L., Crijns, H. J. G. M., & for the ATHENA Investigators (2013) · EP Europace · doi:10.1093/europace/eut293 · Cited by 35
Current Evidence-Based Understanding of the Epidemiology, Prevention, and Treatment of Atrial Fibrillation
Rogers, P. A., Bernard, M. L., Madias, C. A., Thihalolipavan, S., Estes, N. A. M., & Morin, D. P. (2017) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2017.06.001 · Cited by 36
A Knowledge-Modeling Approach to Integrate Multiple Clinical Practice Guidelines to Provide Evidence-Based Clinical Decision Support for Managing Comorbid Conditions
Abidi, S. (2017) · Journal of Medical Systems · doi:10.1007/s10916-017-0841-1 · Cited by 35
Atrial fibrillation and heart failure with preserved ejection fraction: Insights on a unique clinical phenotype from a nationally-representative United States cohort
Goyal, P., Almarzooq, Z., Cheung, J. W., Kamel, H., Krishnan, U., Feldman, D. N., Horn, E. M., & Kim, L. K. (2018) · International Journal of Cardiology · doi:10.1016/j.ijcard.2018.02.007 · Cited by 36
Update on management of atrial fibrillation in heart failure: a focus on ablation
Mulder, B. A., Rienstra, M., Gelder, I. C. V., & Blaauw, Y. (2021) · Heart · doi:10.1136/heartjnl-2020-318081 · Cited by 35
Acute management of atrial fibrillation in congestive heart failure with reduced ejection fraction in the emergency department
Hasbrouck, M., & Nguyen, T. (2022) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2022.03.058 · Cited by 35
Pharmacological and Electrical Conversion of Atrial Fibrillation to Sinus Rhythm Is Worth the Effort
Anter, E., & Callans, D. J. (2009) · Circulation · doi:10.1161/circulationaha.108.824847 · Cited by 34
Evaluation of Time Course and Predicting Factors of Progression of Paroxysmal or Persistent Atrial Fibrillation to Permanent Atrial Fibrillation
SISTI, A. D., Leclercq, J. F., Halimi, F., FIORELLO, P., Bertrand, C., & ATTUEL, P. (2013) · Pacing and Clinical Electrophysiology · doi:10.1111/pace.12264 · Cited by 34
Guía de práctica clínica de la ESC sobre diagnóstico y tratamiento de la insuficiencia cardiaca aguda y crónica 2012
McMurray, J. J. V., Adamopoulos, S. N., Anker, S. D., Auricchio, A., Böhm, M., Dickstein, K., Falk, V., Filippatos, G. S., Fonseca, C., Sánchez, M. Á. G., et al. (2012) · Revista Española de Cardiología · doi:10.1016/j.recesp.2012.08.003 · Cited by 36
Atrial fibrillation management strategies and early mortality after myocardial infarction: results from the Valsartan in Acute Myocardial Infarction (VALIANT) Trial
Nilsson, K. R., Al‐Khatib, S. M., Zhou, Y., Pieper, K. S., White, H. D., Maggioni, A. P., Køber, L., Granger, C. B., Lewis, E. F., McMurray, J. J. V., et al. (2010) · Heart · doi:10.1136/hrt.2009.180182 · Cited by 34
Management of arrhythmia in sepsis and septic shock
Balík, M., Matoušek, V., Malý, M., & Brožek, T. (2017) · Anaesthesiology Intensive Therapy · doi:10.5603/ait.a2017.0061 · Cited by 34
Catheter Ablation Versus Medical Therapy for Atrial Fibrillation in Patients With Heart Failure: A Meta-Analysis of Randomised Controlled Trials
Virk, S. A., Bennett, R. G., Chow, C. K., Sanders, P., Kalman, J. M., Thomas, S. P., & Kumar, S. (2018) · Heart Lung and Circulation · doi:10.1016/j.hlc.2018.10.022 · Cited by 36
Incidence and complications of perioperative atrial fibrillation after non-cardiac surgery for malignancy
Higuchi, S., Kabeya, Y., Matsushita, K., Arai, N., Tachibana, K., Tanaka, R., Kawachi, R., Takei, H., Suzuki, Y., Kogure, M., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0216239 · Cited by 34
Left atrial fibrosis predicts left ventricular ejection fraction response after atrial fibrillation ablation in heart failure patients: the Fibrosis-HF Study
Kirstein, B., Neudeck, S., Gaspar, T., Piorkowski, J., Wechselberger, S., Kronborg, M. B., Zedda, A. M., Hankel, A., El‐Armouche, A., Tomala, J., et al. (2020) · EP Europace · doi:10.1093/europace/euaa179 · Cited by 34
Atrial Fibrillation and Acute Decompensated Heart Failure
Dimarco, J. (2009) · Circulation Heart Failure · doi:10.1161/circheartfailure.108.830349 · Cited by 34
Canadian Cardiovascular Society Atrial Fibrillation Guidelines 2010: Implementing GRADE and Achieving Consensus
Gillis, A. M., & Skanes, A. C. (2011) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2010.11.003 · Cited by 32
Adding Serial N-Terminal Pro Brain Natriuretic Peptide Measurements to Optimal Clinical Management in Outpatients with Systolic Heart Failure: A Multicentre Randomized Clinical Trial (NorthStar Monitoring Study)
Schou, M., Gustafsson, F., Videbæk, L. M., Andersen, H., Toft, J. C., Nyvad, O., Ryde, H., Fog, L., Jensen, J. C. H., Nielsen, O. W., et al. (2013) · European Journal of Heart Failure · doi:10.1093/eurjhf/hft037 · Cited by 33
Dilated Cardiomyopathy: From Genetics to Clinical Management
(2019) · doi:10.1007/978-3-030-13864-6 · Cited by 32
Atrial Fibrillation in Heart Failure: Novel Insights, Challenges, and Treatment Opportunities
Bidaoui, G., Assaf, A. Y. M., & MARROUCHE, N. F. (2024) · Current Heart Failure Reports · doi:10.1007/s11897-024-00691-9 · Cited by 41
Atrial Fibrillation in Heart Failure
Lardizabal, J. A., & DEEDWANIA, P. C. (2012) · Medical Clinics of North America · doi:10.1016/j.mcna.2012.07.007 · Cited by 32
Management of atrial fibrillation
Lafuente‐Lafuente, C., Mahé, I., & Extramiana, F. (2009) · BMJ · doi:10.1136/bmj.b5216 · Cited by 32
Genetics of atrial fibrillation—practical applications for clinical management: if not now, when and how?
Kany, S., Reißmann, B., Metzner, A., Kirchhof, P. F., Darbar, D., & Schnabel, R. B. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab153 · Cited by 32
Efficacy of Amiodarone in Patients with Atrial Fibrillation with and without Left Ventricular Dysfunction: A Pooled Analysis of AFFIRM and AF‐CHF Trials
Cadrin‐Tourigny, J., Wyse, D. G., Roy, D., Blondeau, L., Lévesque, S., Talajic, M. R., Andrade, J. G., Dubuc, M., Thibault, B., Guerra, P. G., et al. (2014) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.12535 · Cited by 32
Atrial fibrillation management in Asia: From the Asian expert forum on atrial fibrillation
Chiang, C., Zhang, S., Tse, H., Teo, W. S., Omar, R., & Sriratanasathavorn, C. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2011.12.033 · Cited by 32
Atrial Fibrillation in Heart Failure is Associated with an Increased Risk of Death Only in Patients with Ischaemic Heart Disease
Raunsø, J., Pedersen, O. D., Domínguez, H., Hansen, M. L., Møller, J. E., Kjærgaard, J., Hassager, C., Torp-Pedersen, C. T., & Køber, L. (2010) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfq052 · Cited by 32
Digoxin significantly improves all-cause mortality in atrial fibrillation patients with severely reduced left ventricular systolic function
Patel, N., Hoosien, M., Deshmukh, A. J., Badheka, A. O., Grover, P. M., Shah, N. N., Singh, V., Mehta, K. D., Chothani, A., Savani, G. T., et al. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2013.10.040 · Cited by 31
Meta-Analysis Comparing Catheter-Guided Ablation Versus Conventional Medical Therapy for Patients With Atrial Fibrillation and Heart Failure With Reduced Ejection Fraction
Elgendy, A. Y., Mahmoud, A. N., Khan, M. S., Sheikh, M. R., Mojadidi, M. K., Omer, M. A., Elgendy, I. Y., Bavry, A. A., Ellenbogen, K. A., Miles, W. M., et al. (2018) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2018.05.009 · Cited by 31
Catheter ablation of atrial fibrillation with heart failure: An updated meta-analysis of randomized trials
Kheiri, B., Osman, M., Abdalla, A., Haykal, T., Ahmed, S. A., Bachuwa, G. I., Hassan, M., & Bhatt, D. L. (2018) · International Journal of Cardiology · doi:10.1016/j.ijcard.2018.07.024 · Cited by 31
Catheter Ablation of Atrial Fibrillation in Heart Failure
Kirubakaran, S., & O'Neill, M. D. (2013) · Heart Failure Clinics · doi:10.1016/j.hfc.2013.07.006 · Cited by 30
Atrial Fibrillation and Heart Failure: A Review of the Intersection of Two Cardiac Epidemics.
Park, K. L., & Anter, E. (2013) · Europe PMC (PubMed Central) · doi:10.4022/jafib.751 · Cited by 31
Atrial Fibrillation and Heart Failure in Women
Madan, N., Itchhaporia, D., Albert, C. M., Aggarwal, N. T., & Volgman, A. S. (2018) · Heart Failure Clinics · doi:10.1016/j.hfc.2018.08.006 · Cited by 31
Pharmacological rhythm versus rate control in patients with atrial fibrillation and heart failure: the CASTLE-AF trial
Zhao, Y. D., Krupadev, V., Dagher, L., Mahnkopf, C., Sohns, C., Sehner, S., Suling, A. I., Sanders, P., Boersma, L. V. A., Schunkert, H., et al. (2020) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-020-00856-1 · Cited by 29
Atrial fibrillation and heart failure: A contemporary review of current management approaches
Lee, J. Z., & Cha, Y. (2021) · Heart Rhythm O2 · doi:10.1016/j.hroo.2021.11.006 · Cited by 30
Association of rhythm control with incident dementia among patients with atrial fibrillation: a nationwide population-based cohort study
Kim, D., Yang, P., You, S. C., Sung, J., Jang, E., Yu, H. T., Kim, T., Pak, H., Lee, M., Lip, G. Y. H., et al. (2021) · Age and Ageing · doi:10.1093/ageing/afab248 · Cited by 30
Early rhythm control vs. rate control in atrial fibrillation: A systematic review and meta-analysis
Han, S., Jia, R., Cen, Z., Guo, R., Zhao, S., Bai, Y., Xie, M., & Cui, K. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.978637 · Cited by 30
New-Onset Atrial Fibrillation Is a Predictor of Subsequent Hyperthyroidism: A Nationwide Cohort Study
Selmer, C., Hansen, M. L., Olesen, J. B., Mérie, C., Lindhardsen, J., Olsen, A. S., Madsen, J. C., Schmidt, U., Faber, J. O., Hansen, P. R., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057893 · Cited by 29
Focal Impulse and Rotor Modulation for the Treatment of Atrial Fibrillation: Locations and 1 Year Outcomes of Human Rotors Identified Using a 64‐Electrode Basket Catheter
Tilz, R. R., Lin, T., Rillig, A., Heeger, C.-H. H., Scholz, L., Wohlmuth, P., Bucur, T., Metzner, A., Mathew, S., Wißner, E., et al. (2016) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.13157 · Cited by 29
Management of cardiovascular complications of bruton tyrosine kinase inhibitors
Tang, C. P. S., Lip, G. Y. H., McCormack, T., Lyon, A. R., Hillmen, P., Iyengar, S., Martínez‐Calle, N., Parry‐Jones, N., Patten, P., Schuh, A., et al. (2021) · British Journal of Haematology · doi:10.1111/bjh.17788 · Cited by 29
Is Rhythm‐Control Superior to Rate‐Control in Patients with Atrial Fibrillation and Diastolic Heart Failure?
Kong, M. H., Shaw, L. K., O’Connor, C. J., Califf, R. M., Blazing, M. A., & Al‐Khatib, S. M. (2010) · Annals of Noninvasive Electrocardiology · doi:10.1111/j.1542-474x.2010.00365.x · Cited by 29
Novel pharmacological targets for the rhythm control management of atrial fibrillation
Burashnikov, A., & Antzelevitch, C. N. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.08.002 · Cited by 31

Authors: Roy, D., Talajic, M., Nattel, S., Wyse, D. G., Dorian, P., Lee, K. L., Bourassa, M. G., Arnold, J. M. O., Buxton, A. E., Camm, A. J., Connolly, S. J., Dubuc, M., Ducharme, A., Guerra, P. G., Hohnloser, S. H., Lambert, J., Le Heuzey, J.-Y., O'Hara, G., Pedersen, O. D., Rouleau, J.-L., Singh, B. N., Stevenson, L. W., Stevenson, W. G., Thibault, B., & Waldo, A. L.
Affiliations: Montreal Heart Institute (CA)
Libin Cardiovascular Institute of Alberta (CA)
St. Michael's Hospital (CA)
Duke Medical Center (US)
London Health Sciences Centre (CA)
Rhode Island Hospital (US)
St George's Hospital (GB)
Population Health Research Institute (CA)
Goethe University Frankfurt (DE)
Bispebjerg Hospital (DK)
VA West Los Angeles Medical Center (US)
Brigham and Women's Hospital (US)
University Hospitals Cleveland Medical Center (US)
ORCID: Roy, Denis
Talajic, Mario
Nattel, Stanley
Dorian, Paul
Bourassa, Martial G.
Buxton, Alfred E.
Camm, A. John
Connolly, Stuart J.
Ducharme, Anique
Guerra, Peter G.
Hohnloser, Stefan H.
Lambert, Jean
Pedersen, Ole Dyg
Rouleau, Jean-Lucien
Stevenson, Lynne Warner
Stevenson, William G.
Thibault, Bernard
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2008-06-19
Volume: 358
Issue: 25
Pages: 2667-2677
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmoa0708789
OpenAlex: W2131260805
Cited by: 1,585
References: 41
Citations by year: 2026: 42 · 2025: 33 · 2024: 69 · 2023: 55 · 2022: 76 · 2021: 86 · 2020: 77 · 2019: 82 · 2018: 96 · 2017: 87 · 2016: 73 · 2015: 75 · 2014: 87 · 2013: 123 · 2012: 114
FWCI: 97.76
Type: journal article
Language: en
Open access: closed
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
Keywords: atrial fibrillation, heart failure, rhythm control, rate control, sinus rhythm maintenance, ventricular rate control, cardiovascular mortality, congestive heart failure, stroke, worsening heart failure, left ventricular ejection fraction
MeSH terms: Adrenergic beta-Antagonists, Aged, Amiodarone, Angiotensin-Converting Enzyme Inhibitors, Anti-Arrhythmia Agents, Atrial Fibrillation, Cardiovascular Diseases, Combined Modality Therapy, Digitalis Glycosides, Electric Countershock, Female, Follow-Up Studies, Heart Failure, Heart Rate, Hospitalization, Humans, Male, Middle Aged, Prospective Studies, Ventricular Dysfunction, Left, Kaplan-Meier Estimate

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Rhythm Control versus Rate Control for Atrial Fibrillation and Heart Failure

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks