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Cited by 532

The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.

Arterial Blood Gases and Oxygen Content in Climbers on Mount Everest

Open access
Grocott, Michael P.W., Martin, Daniel S., Levett, Denny Z.H., McMorrow, Roger, Windsor, Jeremy, Montgomery, Hugh E.·2009·New England Journal of Medicine
DOI 10.1056/nejmoa0801581
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Abstract

BACKGROUND: The level of environmental hypobaric hypoxia that affects climbers at the summit of Mount Everest (8848 m [29,029 ft]) is close to the limit of tolerance by humans. We performed direct field measurements of arterial blood gases in climbers breathing ambient air on Mount Everest. METHODS: We obtained samples of arterial blood from 10 climbers during their ascent to and descent from the summit of Mount Everest. The partial pressures of arterial oxygen (PaO(2)) and carbon dioxide (PaCO(2)), pH, and hemoglobin and lactate concentrations were measured. The arterial oxygen saturation (SaO(2)), bicarbonate concentration, base excess, and alveolar-arterial oxygen difference were calculated. RESULTS: PaO(2) fell with increasing altitude, whereas SaO(2) was relatively stable. The hemoglobin concentration increased such that the oxygen content of arterial blood was maintained at or above sea-level values until the climbers reached an elevation of 7100 m (23,294 ft). In four samples taken at 8400 m (27,559 ft)--at which altitude the barometric pressure was 272 mm Hg (36.3 kPa)--the mean PaO(2) in subjects breathing ambient air was 24.6 mm Hg (3.28 kPa), with a range of 19.1 to 29.5 mm Hg (2.55 to 3.93 kPa). The mean PaCO(2) was 13.3 mm Hg (1.77 kPa), with a range of 10.3 to 15.7 mm Hg (1.37 to 2.09 kPa). At 8400 m, the mean arterial oxygen content was 26% lower than it was at 7100 m (145.8 ml per liter as compared with 197.1 ml per liter). The mean calculated alveolar-arterial oxygen difference was 5.4 mm Hg (0.72 kPa). CONCLUSIONS: The elevated alveolar-arterial oxygen difference that is seen in subjects who are in conditions of extreme hypoxia may represent a degree of subclinical high-altitude pulmonary edema or a functional limitation in pulmonary diffusion.

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Metadata

Authors
Grocott, M. P. W., Martin, D. S., Levett, D. Z. H., McMorrow, R., Windsor, J., & Montgomery, H. E.
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
2009-01-08
Volume
360
Issue
2
Pages
140-149
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejmoa0801581
OpenAlex
W2150858502
Cited by
532
References
21
FWCI
22.46
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Arterial Blood Gases and Oxygen Content in Climbers on Mount Everest. https://app.cochat.ai/papers/10.1056/nejmoa0801581
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Grocott, M. P. W., Martin, D. S., Levett, D. Z. H., McMorrow, R., Windsor, J., & Montgomery, H. E. (2009). Arterial Blood Gases and Oxygen Content in Climbers on Mount Everest. New England Journal of Medicine. https://doi.org/10.1056/nejmoa0801581

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