Modulation of Blood Pressure by Central Melanocortinergic Pathways

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Items 301–400 of 490

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6. Melanocortinergic circuits from medial vestibular nuclei to the kidney defined by transneuronal transport of pseudorabies virus.
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7. Comparative Intracerebroventricular and Intrathecal Administration of a Nanomolar Macrocyclic Melanocortin Receptor Agonist MDE6-5-2c (c[Pro-His-DPhe-Arg-Trp-Dap-Ala-DPro]) Decreases Food Intake in Mice
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8. Obesity-associated GNAS mutations and the melanocortin pathway
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10. Genetic Obesity Syndromes
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11. Postprandial Total Ghrelin Suppression Is Modulated by Melanocortin Signaling in Humans
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14. Melanocortin-4 Receptor Modulators for the Treatment of Obesity: a Patent Analysis (2008–2014)
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15. Cardiovascular Regulation by the Neuronal BBSome
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16. Cardiovascular Side Effects of Antiobesity Drugs
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18. Melanocortin System Activates Carotid Body Arterial Chemoreceptors in Hypertension
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20. Discovery of Nanomolar Melanocortin-3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High-Throughput “Unbiased” Screening Campaign
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21. Role of the Melanocortin System in the Central Regulation of Cardiovascular Functions
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22. Negative association of MC3R variants with weight and blood pressure in Cape Town pupils aged 11 - 16 years.
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23. Obesity, metabolic syndrome, and disorders of energy balance
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24. Peripheral actions and direct central–local communications of melanocortin 4 receptor signaling
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29. The anti-inflammatory selective melanocortin receptor subtype 4 agonist, RO27-3225, fails to prevent acoustic trauma-induced tinnitus in rats
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30. High urinary glucose is associated with improved renal prognosis in patients with diabetes mellitus
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31. Neuroendocrine Control of Body Energy Homeostasis
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32. PDX1 and MC4R genetic polymorphisms are associated with type 2 diabetes mellitus risk in the Chinese Han population
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33. EJE PRIZE 2012: Obesity: from genes to behaviour
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34. Incorporation of Agouti-Related Protein (AgRP) Human Single Nucleotide Polymorphisms (SNPs) in the AgRP-Derived Macrocyclic Scaffold c[Pro-Arg-Phe-Phe-Asn-Ala-Phe- d Pro] Decreases Melanocortin-4 Receptor Antagonist Potency and Results in the Discovery of Melanocortin-5 Receptor Antagonists
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35. Both overexpression of agouti-related peptide or neuropeptide Y in the paraventricular nucleus or lateral hypothalamus induce obesity in a neuropeptide- and nucleus specific manner
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36. Hypothalamic GPCR Signaling Pathways in Cardiometabolic Control
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37. Cardiac Phenotype and Tissue Sodium Content in Adolescents With Defects in the Melanocortin System
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38. Are there any interactions between modified Nordic-style diet score and MC4R polymorphism on cardiovascular risk factors among overweight and obese women? A cross-sectional study
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39. Development of Melanocortin 4 Receptor Agonists by Exploiting Animal-Derived Macrocyclic, Disulfide-Rich Peptide Scaffolds
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40. Contribution of regional brain melanocortin receptor subtypes to elevated activity energy expenditure in lean, active rats
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41. Genetic strategies to understand physiological pathways regulating body weight
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45. Hormone-Replacement Therapy for Melanocyte-Stimulating Hormone Deficiency
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46. Monogenic obesity due to MC4R deficiency: lessons from a multigenerational case
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47. Associations Between Obesity-Related Gene MC4R rs17782313 Locus Polymorphism and Components of Metabolic Syndrome: A Systematic Review and Meta-Analysis
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48. Functional Mixture-Based Positional Scan Identifies a Library of Antagonist Tetrapeptide Sequences (LAtTeS) with Nanomolar Potency for the Melanocortin-4 Receptor and Equipotent with the Endogenous AGRP(86-132) Antagonist
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49. Importance of the heart rate in ultra-high-resolution coronary CT angiography with 0.35 s gantry rotation time
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50. Drug-induced activation of the nervous control of inflammation: A novel possibility for the treatment of hypoxic damage
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51. The Melanocortin Signal System of the Hypothalamus and Its Functional State in Type 2 Diabetes Mellitus and Metabolic Syndrome
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52. The Sympathetic Nervous System in Hypertension
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53. Reversion of MRAP2 Protein Sequence Generates a Functional Novel Pharmacological Modulator for MC4R Signaling
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54. Cardiovascular Risk and Diseases in Patients With and Without Leptin-Melanocortin Pathway Variants
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56. Discovery and Development of 5-HT2CReceptor Agonists for Obesity: Is There Light at the End of the Tunnel?
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57. Causes of Severe Obesity: Genes to Environment
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58. Metabolic Syndrome
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59. Structure–Activity Relationships of the Tetrapeptide Ac-His-Arg-(pI)DPhe-Tic-NH2 at the Mouse Melanocortin Receptors: Modification at the (pI)DPhe Position Leads to mMC3R Versus mMC4R Selective Ligands
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60. Role of hindbrain melanocortin-4 receptor activity in controlling cardiovascular and metabolic functions in spontaneously hypertensive rats
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61. Role of the Kidney in Hypertension
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62. Leptin and melanocortin signalling in the response to infection
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63. Autonomic dysfunction in polycystic ovary syndrome
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64. The Genetics of Obesity
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65. Cardiometabolic Risk Markers in Children With Obesity and Variants in MC4R Pathway-related Genes
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66. Synthesis and Structure–Activity Relationships of Substituted Urea Derivatives on Mouse Melanocortin Receptors
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67. Regulation of Blood Pressure, Appetite, and Glucose by CNS Melanocortin System in Hyperandrogenemic Female SHR
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68. Single Nucleotide Polymorphisms in the Melanocortin His-Phe-Arg-Trp Sequences Decrease Tetrapeptide Potency and Efficacy
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73. The Metabolic Syndrome
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77. Current pharmacological approaches in obesity treatment
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79. Central melanocortin signaling regulates cholesterol
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80. Genetic and pharmacological mouse models of chronic melanocortin activation show enhanced baroreflex control of heart rate
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84. Adiposity and Risk for Hypertension
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85. Melanocortins
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90. High-resolution deep mutational scanning of the melanocortin-4 receptor enables target characterization for drug discovery
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93. Incorporation of Three Extracyclic Arginine Residues into a Melanocortin Macrocyclic Agonist (c[Pro-His-DPhe-Arg-Trp-Dap-Lys(Arg-Arg-Arg-Ac)-DPro]) Decreases Food Intake When Administered Intrathecally or Subcutaneously Compared to a Macrocyclic Ligand Lacking Extracyclic Arginine Residues (c[Pro-His-DPhe-Arg-Trp-Dap-Ala-DPro)]
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95. The Hypothalamic Melanocortin Pathway and the Regulation of Glucose Handling in the Kidney: A Sympathetic Look at Brain-Kidney Connection
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98. Neuroendocrine Control of Energy Stores
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99. Genetic Syndromes Associated with Obesity
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100. Genetic Syndromes Associated with Obesity
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