Modulation of Blood Pressure by Central Melanocortinergic Pathways

Greenfield, Jerry R., Miller, Jeffrey W., Keogh, Julia M., Henning, Elana, Satterwhite, Julie H., Cameron, Gregory S., Astruc, Beatrice, Mayer, John P. +5 more·2009·New England Journal of Medicine
DOI 10.1056/nejmoa0803085

Cited by (490)

Items 401–490 of 490

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  29. High resolution deep mutational scanning of the melanocortin-4 receptor enables target characterization for drug discovery
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  30. Neural mechanisms of sympathetic activation during hyperinsulinemia and obesity-induced hypertension
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  64. Targeting the hypothalamic MC4 receptor: A novel approach to senolytic therapy?
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  65. Melanocortin Signaling in the Carotid Body as a Putative Cause of Hypertension
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  66. Additional file 1 of Are there any interactions between modified Nordic-style diet score and MC4R polymorphism on cardiovascular risk factors among overweight and obese women? A cross-sectional study
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  67. Additional file 1 of PDX1 and MC4R genetic polymorphisms are associated with type 2 diabetes mellitus risk in the Chinese Han population
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    Marion S. Bonnet · 2013 · theses.fr (ABES)
  70. Impact of LYL1 deficiency on adipocyte differentiation
    Abid Hussain · 2015
  71. Rationale of renewed efforts in developing MC4R modulators to treat metabolic disorders
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  73. The Synthetic Melanocortin Agonist NDP ‐ MSH Ameliorates THSD 7 A ‐Associated Membranous Nephropathy in an Active Immunization Mouse Model
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  74. Small molecule ligands for the melanocortin-4 receptor: pharmacology, biased signaling, and pharmacoperone potential
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  75. Impact of setmelanotide on metabolic syndrome risk in patients with proopiomelanocortin or leptin receptor deficiencies
    S. Brandt, I. Sadaf Farooqi, Wendy K. Chung, Erica L T van den Akker, Peter Kühnen, James M. Swain, Jill Garrison, Nicolas Touchot, Jesús Argente, Karine Clément · 2026 · The Journal of Clinical Endocrinology & Metabolism
  76. BindingDB Entry 50014427: Discovery of Nanomolar Melanocortin-3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High-Throughput "Unbiased" Screening Campaign.
    BindingDB · 2022 · UC San Diego
  77. BindingDB Entry 50014265: Functional Mixture-Based Positional Scan Identifies a Library of Antagonist Tetrapeptide Sequences (LAtTeS) with Nanomolar Potency for the Melanocortin-4 Receptor and Equipotent with the Endogenous AGRP(86-132) Antagonist.
    BindingDB · 2022 · UC San Diego
  78. BindingDB Entry 50007656: Single Nucleotide Polymorphisms in the Melanocortin His-Phe-Arg-Trp Sequences Decrease Tetrapeptide Potency and Efficacy.
    BindingDB · 2021 · UC San Diego
  79. BindingDB Entry 50006524: Discovery of Novel Potent and Selective Agonists at the Melanocortin-3 Receptor.
    BindingDB · 2020 · UC San Diego
  80. BindingDB Entry 50046729: A fragment of the Escherichia coli ClpB heat-shock protein is a micromolar melanocortin 1 receptor agonist.
    BindingDB · 2016 · UC San Diego
  81. BindingDB Entry 50047392: An in Vitro and in Vivo Investigation of Bivalent Ligands That Display Preferential Binding and Functional Activity for Different Melanocortin Receptor Homodimers.
    BindingDB · 2017 · UC San Diego
  82. BindingDB Entry 50000432: Click-Chemistry-Mediated Synthesis of Selective Melanocortin Receptor 4 Agonists.
    BindingDB · 2019 · UC San Diego
  83. BindingDB Entry 50023415: N-Branched Tricyclic Guanidines as Novel Melanocortin-3 Receptor Agonists and Melanocortin-4 Receptor Antagonists.
    BindingDB · 2026 · UC San Diego
  84. BindingDB Entry 50007962: Incorporation of Agouti-Related Protein (AgRP) Human Single Nucleotide Polymorphisms (SNPs) in the AgRP-Derived Macrocyclic Scaffold c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-dPro] Decreases Melanocortin-4 Receptor Antagonist Potency and Results in the Discovery of Melanocortin-5 Receptor Antagonists.
    BindingDB · 2021 · UC San Diego
  85. BindingDB Entry 50045775: Melanocortin antagonist tetrapeptides with minimal agonist activity at the mouse melanocortin-3 receptor.
    BindingDB · 2016 · UC San Diego
  86. BindingDB Entry 50042549: Structure-activity relationships of peptides incorporating a bioactive reverse-turn heterocycle at the melanocortin receptors: identification of a 5800-fold mouse melanocortin-3 receptor (mMC3R) selective antagonist/partial agonist versus the mouse melanocortin-4 receptor (mMC4R).
    BindingDB · 2013 · UC San Diego
  87. BindingDB Entry 50048982: A Macrocyclic Agouti-Related Protein/[Nle
    BindingDB · 2019 · UC San Diego
  88. BindingDB Entry 50006771: Developing a Biased Unmatched Bivalent Ligand (BUmBL) Design Strategy to Target the GPCR Homodimer Allosteric Signaling (cAMP over β-Arrestin 2 Recruitment) Within the Melanocortin Receptors.
    BindingDB · 2021 · UC San Diego
  89. BindingDB Entry 50011659: Multiresidue Tetrapeptide Substitutions Yield a 140-fold Selective Melanocortin-3 over Melanocortin-4 Receptor Agonist.
    BindingDB · 2022 · UC San Diego
  90. BindingDB Entry 50033095: Incorporation of a bioactive reverse-turn heterocycle into a peptide template using solid-phase synthesis to probe melanocortin receptor selectivity and ligand conformations by 2D 1H NMR.
    BindingDB · 2011 · UC San Diego